Explanipedia

Elevated TFEB expression with limited activation in peripheral blood mononuclear cells reflects altered lysosomal enzyme dynamics in Parkinson's disease Open

Yasuaki Mizutani, Kazuki Nawashiro, Shunichi Ito, T. NAKAI, Reiko Ohdake , et al. · 2025

Elevated TFEB expression in PBMCs may reflect a compensatory response to PD-related cellular stress. However, this response may be functionally insufficient due to limited TFEB activity, potentially leading to reduced lysosomal enzyme rele…

Elevated levels of cerebrospinal fluid soluble triggering receptor expressed on myeloid cells 2 in multiple system atrophy: a marker of disease-associated microglial activation Open

Toshiki Maeda, Yasuaki Mizutani, Reiko Ohdake, Ryunosuke Nagao, Kazuya Kawabata , et al. · 2025

Multiple system atrophy (MSA) is increasingly being recognized to be characterized by neuroinflammation, especially involving the activation of microglia. Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in cerebrospinal f…

CSF Mitochondrial DNA: Biomarker of Body Composition and Energy Metabolism in Parkinson's Disease Open

Yasuaki Mizutani, T. NAKAI, Yasuhiro Maeda, Reiko Ohdake, Atsuhiro Higashi , et al. · 2025

Objective Cerebrospinal fluid (CSF) cell‐free mitochondrial DNA (cf‐mtDNA) is a potential biomarker for Parkinson's disease (PD), but its clinical relevance remains unclear. We investigated associations between CSF cf‐mtDNA levels, body co…

Virtual reality navigation for the early detection of Alzheimer’s disease Open

Sayuri Shima, Reiko Ohdake, Yasuaki Mizutani, Harutsugu Tatebe, Riki Koike , et al. · 2025

Objective The development of non-invasive clinical diagnostics is paramount for the early detection of Alzheimer’s disease (AD). Neurofibrillary tangles in AD originate from the entorhinal cortex, a cortical memory area that mediates navig…

Performance-weighted ensemble learning for detecting patients with FTD and ALS from brief reading speech Open

Yuki Ito, Reiko Ohdake, Shōhei Kato, Michihito Masuda, Maki Suzuki , et al. · 2025

We developed a novel machine learning model named performance-weighted ensemble learning (PWEL) to detect frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) using speech from word and sentence reading tasks. Overall, 197…

CSF GPNMB in Parkinson's disease: A potential association with age and microglial activation Open

Xi-Chen Zhu, Yasuaki Mizutani, Reiko Ohdake, Harutsugu Tatebe, Toshiki Maeda , et al. · 2024

Background Recent evidence suggests a link between glycoprotein non-metastatic melanoma protein B (GPNMB) and Parkinson's disease (PD) pathogenesis. Although elevated plasma GPNMB levels associated with disease severity have been reported …

Uric acid and alterations of purine recycling disorders in Parkinson’s disease: a cross-sectional study Open

Sayuri Shima, Yasuaki Mizutani, Junichiro Yoshimoto, Yasuhiro Maeda, Reiko Ohdake , et al. · 2024

The relationship between reduced serum uric acid (UA) levels and Parkinson’s disease (PD), particularly purine metabolic pathways, is not fully understood. Our study compared serum and cerebrospinal fluid (CSF) levels of inosine, hypoxanth…

Early detection of Alzheimer’s disease pathophysiology using 3D virtual reality navigation: a correlational study with genetic and plasma biomarkers Open

Sayuri Shima, Reiko Ohdake, Yasuaki Mizutani, Harutsugu Tatebe, Riki Koike , et al. · 2024

BACKGROUND We investigated the association between path-integration (PI) errors related to entorhinal cortex function detectable using a 3D virtual reality (VR) navigation system and various biomarkers to explore its potential as an early …

Uric Acid and Purine Recycling Disorders in Parkinson’s Disease: A Cross-Sectional Study Open

Sayuri Shima, Yasuaki Mizutani, Junichiro Yoshimoto, Yasuhiro Maeda, Reiko Ohdake , et al. · 2023

The phenomenon of decreased serum uric acid (UA) levels in patients with Parkinson’s disease (PD) and its relationship with purine metabolic pathways remain unclear. We compared inosine, hy-poxanthine, xanthine, and UA levels in serum and …

＜Editors' Choice＞ Pattern of THK 5351 retention in normal aging involves core regions of resting state networks associated with higher cognitive function. Open

Yusuke Yoshida, Takamasa Yokoi, Kazuhiro Hara, Hirohisa Watanabe, Hiroshi Yamaguchi , et al. · 2023

We aimed to elucidate the distribution pattern of the positron emission tomography probe [18F]THK 5351, a marker for astrogliosis and tau accumulation, in healthy aging. We also assessed the relationship between THK5351 retention and resti…

Clinical Presentation and Pathogenesis of Visual Perception Impairment in Parkinsonʼs Disease Open

Hirohisa Watanabe, Reiko Ohdake, Yasuaki Mizutani, Sayuri Shima, Mizuki Ito · 2023

パーキンソン病 (以下, PD) では, 高頻度で多様な視知覚障害を認める。視覚的な異常は, 生活の質を低下させると指摘されており, 複視, 錯視, false sense of presence, passage hallucinations などは, 認知症の重要な危険因子とされる。疫学研究, 光干渉断層撮影解析, 脳内ネットワーク解析, incomplete letters や隠し絵課題をはじめとするタスク下の機能的 MRI 解析などを通じ, 視覚処理に関連する網膜や…

Enzymatic properties and clinical associations of serum alpha<span>‐</span>galactosidase A in Parkinson's disease Open

Yasuaki Mizutani, Kazuki Nawashiro, Reiko Ohdake, Harutsugu Tatebe, Sayuri Shima , et al. · 2023

Objective Recent studies have revealed an association between Parkinson's disease (PD) and Fabry disease, a lysosomal storage disorder; however, the underlying mechanisms remain to be elucidated. This study aimed to investigate the enzymat…

Associations of Alzheimer's-related plasma biomarkers with cognitive decline in Parkinson's disease Open

Yasuaki Mizutani, Reiko Ohdake, Harutsugu Tatebe, Atsuhiro Higashi, Sayuri Shima , et al. · 2023

Background Parkinson’s disease (PD) is associated with cognitive decline through multiple mechanisms, including Alzheimer’s disease (AD) pathology and cortical Lewy body involvement. However, its underlying mechanisms remain unclear. Recen…

Comparative examination of the pons and corpus callosum as reference regions for quantitative evaluation in positron emission tomography imaging for Alzheimer’s disease using 11C-Pittsburgh Compound-B Open

Tomohiro Tada, Kazuhiro Hara, Naotoshi Fujita, Yoshinori Ito, Hiroshi Yamaguchi , et al. · 2023

Objectives Standardised uptake value ratio (SUVR) is usually obtained by dividing the SUV of the region of interest (ROI) by that of the cerebellar cortex. Cerebellar cortex is not a valid reference in cases where amyloid β deposition or l…

Connectivity impairment of cerebellar and sensorimotor connector hubs in Parkinson’s disease Open

Epifanio Bagarinao, Kazuya Kawabata, Hirohisa Watanabe, Kazuhiro Hara, Reiko Ohdake , et al. · 2022

Cognitive and movement processes involved integration of several large-scale brain networks. Central to these integrative processes are connector hubs, brain regions characterized by strong connections with multiple networks. Growing evide…

Functional connector hubs in the cerebellum Open

Kazuya Kawabata, Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori , et al. · 2022

Accumulating evidence from anatomical and neuroimaging studies suggests that the cerebellum is engaged in a variety of motor and cognitive tasks. Given its various functions, a key question is whether the cerebellum also plays an important…

Characteristics of Neural Network Changes in Normal Aging and Early Dementia Open

Hirohisa Watanabe, Epifanio Bagarinao, Satoshi Maesawa, Kazuhiro Hara, Kazuya Kawabata , et al. · 2021

To understand the mechanisms underlying preserved and impaired cognitive function in healthy aging and dementia, respectively, the spatial relationships of brain networks and mechanisms of their resilience should be understood. The hub reg…

Resting State Networks Related to the Maintenance of Good Cognitive Performance During Healthy Aging Open

Satoshi Maesawa, Satomi Mizuno, Epifanio Bagarinao, Hirohisa Watanabe, Kazuya Kawabata , et al. · 2021

Purpose: Maintenance of cognitive performance is important for healthy aging. This study aims to elucidate the relationship between brain networks and cognitive function in subjects maintaining relatively good cognitive performance. Method…

Bridging large-scale cortical networks: Integrative and function-specific hubs in the thalamus Open

Kazuya Kawabata, Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori , et al. · 2021

Aging Impacts the Overall Connectivity Strength of Regions Critical for Information Transfer Among Brain Networks Open

Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara , et al. · 2020

Recent studies have demonstrated that connector hubs, regions considered critical for the flow of information across neural systems, are mostly involved in neurodegenerative dementia. Considering that aging can significantly affect the bra…

The neural network basis of altered decision‐making in patients with amyotrophic lateral sclerosis Open

Kazunori Imai, Michihito Masuda, Hirohisa Watanabe, Aya Ogura, Reiko Ohdake , et al. · 2020

Objective Amyotrophic lateral sclerosis (ALS) is a multisystem disorder associated with motor impairment and behavioral/cognitive involvement. We examined decision‐making features and changes in the neural hub network in patients with ALS …

Identifying the brain's connector hubs at the voxel level using functional connectivity overlap ratio Open

Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara , et al. · 2020

Changes in white matter fiber density and morphology across the adult lifespan: A cross‐sectional fixel‐based analysis Open

Shao Wei Choy, Epifanio Bagarinao, Hirohisa Watanabe, Eric Tatt Wei Ho, Satoshi Maesawa , et al. · 2020

White matter (WM) fiber bundles change dynamically with age. These changes could be driven by alterations in axonal diameter, axonal density, and myelin content. In this study, we applied a novel fixel‐based analysis (FBA) framework to exa…

Visuoperceptual disturbances in Parkinson's disease Open

Kazuya Kawabata, Reiko Ohdake, Hirohisa Watanabe, Epifanio Bagarinao, Kazuhiro Hara , et al. · 2020

Semantic deficits in ALS related to right lingual/fusiform gyrus network involvement Open

Aya Ogura, Hirohisa Watanabe, Kazuya Kawabata, Reiko Ohdake, Yasuhiro Tanaka , et al. · 2019

Reorganization of brain networks and its association with general cognitive performance over the adult lifespan Open

Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara , et al. · 2019

Semantic Deficits in ALS Related to Right Lingual/Fusiform Gyrus Network Involvement: A Case-Control Study Open

Aya Ogura, Hirohisa Watanabe, Kazuya Kawabata, Reiko Ohdake, Yasuhiro Tanaka , et al. · 2019

Involvement of the Precuneus/Posterior Cingulate Cortex Is Significant for the Development of Alzheimer’s Disease: A PET (THK5351, PiB) and Resting fMRI Study Open

Takamasa Yokoi, Hirohisa Watanabe, Hiroshi Yamaguchi, Epifanio Bagarinao, Michihito Masuda , et al. · 2018

Background: Imaging studies in Alzheimer's disease (AD) have yet to answer the underlying questions concerning the relationship among tau retention, neuroinflammation, network disruption and cognitive decline. We compared the spatia…

Severe hyposmia and aberrant functional connectivity in cognitively normal Parkinson’s disease Open

Noritaka Yoneyama, Hirohisa Watanabe, Kazuya Kawabata, Epifanio Bagarinao, Kazuhiro Hara , et al. · 2018

PD-SH showed extensive decreased amygdala FC. Particularly, decreased FC between the amygdala and inferior parietal lobule, lingual gyrus, and fusiform gyrus were associated with the severity of hyposmia and cognitive performance. In contr…

Memory Loss and Frontal Cognitive Dysfunction in a Patient with Adult-onset Neuronal Intranuclear Inclusion Disease Open

Kunihiko Araki, Jun Sone, Yusuke Fujioka, Michihito Masuda, Reiko Ohdake , et al. · 2016

Neuronal intranuclear inclusion disease (NIID) is an uncommon progressive neurodegenerative disorder. Adult-onset NIID can result in prominent dementia. We herein describe the case of a 74-year-old man who presented with dementia, cerebell…

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