Reilly T. Enos
YOU?
Author Swipe
View article: OR01-04 Microglial NF-κB pathway protects reproductive capacity during high-fat diet feeding in female mice.
OR01-04 Microglial NF-κB pathway protects reproductive capacity during high-fat diet feeding in female mice. Open
Disclosure: I. Velasco: None. V. Baglaev: None. T. Huang: None. T.Z. Jafari: None. S. Schwie: None. J.M. Frey: None. R. Enos: None. M. Tena-Sempere: None. J. Thaler: None. M.D. Dorfman: None. Obesity is linked to reproductive dysfunction. …
View article: Cannabis improves metabolic dysfunction and macrophage signatures in obese mice
Cannabis improves metabolic dysfunction and macrophage signatures in obese mice Open
We examined the effects of the cannabis plant with high cannabidiol (CBD) content or high Δ 9 -tetrahydrocannabinol (THC) content on metabolic and immune dysregulation in obese mice. Both CBD and THC mitigated the obesity-induced increase …
View article: Adipose Tissue Estrogen Receptor-Alpha Overexpression Ameliorates High-Fat Diet–Induced Adipose Tissue Inflammation
Adipose Tissue Estrogen Receptor-Alpha Overexpression Ameliorates High-Fat Diet–Induced Adipose Tissue Inflammation Open
Context We created an innovative mouse model that enables inducible overexpression of estrogen receptor-alpha (ERα), specifically in adipose tissue (Adipo-ERα↑). Objective We aimed to investigate how elevated Adipo-ERα↑ influences the deve…
View article: Overexpression of adipose tissue ERα enhances PVAT anticontractility via NOX4-derived H<sub>2</sub>O<sub>2</sub> and is protective against high-fat diet-induced dysfunction
Overexpression of adipose tissue ERα enhances PVAT anticontractility via NOX4-derived H<sub>2</sub>O<sub>2</sub> and is protective against high-fat diet-induced dysfunction Open
We have revealed for the first time that overexpression of adipose tissue estrogen receptor α (ERα OE ) amplifies the anticontractile effect of mesenteric PVAT via the biosynthesis of NADPH oxidase 4 (NOX4)-derived hydrogen peroxide (H 2 O…
View article: Chronic Stress Induces Sex-Specific Renal Mitochondrial Dysfunction in Mice
Chronic Stress Induces Sex-Specific Renal Mitochondrial Dysfunction in Mice Open
Chronic psychological stress has been linked to renal disease and is also associated with the development of hypertension. However, the mechanisms by which chronic stress alters renal function and promotes hypertension is unclear. This stu…
View article: The impact of diet-induced obesity on 5 fluorouracil-induced tumor and liver immune cell cytotoxicity
The impact of diet-induced obesity on 5 fluorouracil-induced tumor and liver immune cell cytotoxicity Open
The current study aimed to examine the impact of obesity on tumorigenesis and 5FU safety and efficacy with two established murine models of colorectal cancer. Diet-induced obesity increased tumor burden in both models, and 5FU’s antitumor …
View article: The deuterated glucose insulin tolerance test: a new tool to delineate insulin-stimulated glucose uptake from suppression of endogenous glucose production
The deuterated glucose insulin tolerance test: a new tool to delineate insulin-stimulated glucose uptake from suppression of endogenous glucose production Open
Graphical Abstract.
View article: Daily fluctuations in blood glucose with normal aging are inversely related to hippocampal synaptic mitochondrial proteins
Daily fluctuations in blood glucose with normal aging are inversely related to hippocampal synaptic mitochondrial proteins Open
Defective brain glucose utilization is a hallmark of Alzheimer's disease (AD) while Type II diabetes and elevated blood glucose escalate the risk for AD in later life. Isolating contributions of normal aging from coincident metabolic or br…
View article: Obesity worsens mitochondrial quality control and does not protect against skeletal muscle wasting in murine cancer cachexia
Obesity worsens mitochondrial quality control and does not protect against skeletal muscle wasting in murine cancer cachexia Open
Background More than 650 million people are obese (BMI > 30) worldwide, which increases their risk for several metabolic diseases and cancer. While cachexia and obesity are at opposite ends of the weight spectrum, leading many to suggest a…
View article: A Novel Tissue-Specific Insight into Sex Steroid Fluctuations Throughout the Murine Estrous Cycle
A Novel Tissue-Specific Insight into Sex Steroid Fluctuations Throughout the Murine Estrous Cycle Open
Serum sex steroid levels fluctuate throughout the reproductive cycle. However, the degree to which sex steroid tissue content mimics circulating content is unknown. Understanding the flux and physiological quantity of tissue steroid conten…
View article: Platelet status in cancer cachexia progression in ApcMin/+ mice
Platelet status in cancer cachexia progression in ApcMin/+ mice Open
Cachexia, a complex wasting syndrome, significantly affects the quality of life and treatment options for cancer patients. Studies have reported a strong correlation between high platelet count and decreased survival in cachectic individua…
View article: Skeletal Muscle Endogenous Estrogen Production Ameliorates the Metabolic Consequences of a High-Fat Diet in Male Mice
Skeletal Muscle Endogenous Estrogen Production Ameliorates the Metabolic Consequences of a High-Fat Diet in Male Mice Open
Aims The role of skeletal muscle estrogen and its ability to mitigate the negative impact of a high-fat diet (HFD) on obesity-associated metabolic impairments is unknown. To address this, we developed a novel mouse model to determine the r…
View article: Acute Administration of Ojeok-san Ameliorates Pain-like Behaviors in Pre-Clinical Models of Inflammatory Bowel Diseases
Acute Administration of Ojeok-san Ameliorates Pain-like Behaviors in Pre-Clinical Models of Inflammatory Bowel Diseases Open
(1) Background: Gastrointestinal pain and fatigue are the most reported concerns of patients with inflammatory bowel disease (IBD). Commonly prescribed drugs focus on decreasing excessive inflammation. However, up to 20% of IBD patients in…
View article: How stable is your vivarium's temperature? Fluctuations in vivarium temperature significantly impact metabolism and behavior impeding scientific reproducibility
How stable is your vivarium's temperature? Fluctuations in vivarium temperature significantly impact metabolism and behavior impeding scientific reproducibility Open
View article: Sub-chronic oral toxicity screening of quercetin in mice
Sub-chronic oral toxicity screening of quercetin in mice Open
View article: Congenital adiponectin deficiency mitigates high-fat-diet-induced obesity in gonadally intact male and female, but not in ovariectomized mice
Congenital adiponectin deficiency mitigates high-fat-diet-induced obesity in gonadally intact male and female, but not in ovariectomized mice Open
Epidemiological literature indicates that women are less susceptible to type II diabetes (T2D) than males. The general consensus is that estrogen is protective, whereas its deficiency in post-menopause is associated with adiposity and impa…
View article: miR155 deficiency reduces breast tumor burden in the MMTV-PyMT mouse model
miR155 deficiency reduces breast tumor burden in the MMTV-PyMT mouse model Open
To examine the effects of miR155 in a transgenic model of breast cancer, we developed an MMTV-PyMT mouse-deficient in miR155. We demonstrate that global loss of miR155 resulted in blunted tumor growth through modulating the tumor microenvi…
View article: Augmenting Skeletal Muscle Estrogen Does not Prevent or Rescue Obesity-linked Metabolic Impairments in Female Mice
Augmenting Skeletal Muscle Estrogen Does not Prevent or Rescue Obesity-linked Metabolic Impairments in Female Mice Open
Aims We developed a novel mouse model with increased skeletal muscle estrogen content via inducible, skeletal-muscle–specific aromatase overexpression (SkM-Arom↑). We proposed to examine the effect that increased skeletal muscle estrogen b…
View article: Obesity reduced survival with 5-fluorouracil and did not protect against chemotherapy-induced cachexia or immune cell cytotoxicity in mice
Obesity reduced survival with 5-fluorouracil and did not protect against chemotherapy-induced cachexia or immune cell cytotoxicity in mice Open
Fluorouracil/5-flourouracil (5FU) is a first-line chemotherapy drug for many cancer types; however, its associated toxicities contribute to poor quality of life and reduced dose intensities negatively impacting patient prognosis. While obe…
View article: Ojeok-san ameliorates visceral and somatic nociception in a mouse model of colitis induced colorectal cancer
Ojeok-san ameliorates visceral and somatic nociception in a mouse model of colitis induced colorectal cancer Open
Cancer patients can develop visceral, somatic, and neuropathic pain, largely due to the malignancy itself and its treatments. Often cancer patients and survivors turn to the use of complementary and alternative medicine (CAM) to alleviate …
View article: Therapeutic Potential of Emodin for Gastrointestinal Cancers
Therapeutic Potential of Emodin for Gastrointestinal Cancers Open
Gastrointestinal (GI) cancers cause one-third of all cancer-related deaths worldwide. Natural compounds are emerging as alternative or adjuvant cancer therapies given their distinct advantage of manipulating multiple pathways to both suppr…
View article: High Fat Diet-Induced CD8+ T Cells in Adipose Tissue Mediate Macrophages to Sustain Low-Grade Chronic Inflammation
High Fat Diet-Induced CD8+ T Cells in Adipose Tissue Mediate Macrophages to Sustain Low-Grade Chronic Inflammation Open
Obesity in the United States and worldwide reached epidemic proportions within the last 20 years. Obesity is a very powerful health determinant or indicator that facilitates the development and progression of several metabolic diseases, in…
View article: Macrophage tumor necrosis factor‐alpha deletion does not protect against obesity‐associated metabolic dysfunction
Macrophage tumor necrosis factor‐alpha deletion does not protect against obesity‐associated metabolic dysfunction Open
The pro‐inflammatory cytokine, tumor necrosis factor‐alpha (TNF‐α), has been suggested to be a key factor in the induction of obesity‐associated metabolic dysfunction. However, the role that macrophage‐derived TNF‐α has on regulating metab…
View article: Characterization, bio-uptake and toxicity of polymer-coated silver nanoparticles and their interaction with human peripheral blood mononuclear cells
Characterization, bio-uptake and toxicity of polymer-coated silver nanoparticles and their interaction with human peripheral blood mononuclear cells Open
Silver nanoparticles (AgNPs) are widely used in medical applications due to their antibacterial and antiviral properties. Despite the extensive study of AgNPs, their toxicity and their effect on human health is poorly understood, as a resu…
View article: Safety of natural anthraquinone emodin: an assessment in mice
Safety of natural anthraquinone emodin: an assessment in mice Open
View article: High-fat diet-fed ovariectomized mice are susceptible to accelerated subcutaneous tumor growth potentially through adipose tissue inflammation, local insulin-like growth factor release, and tumor associated macrophages
High-fat diet-fed ovariectomized mice are susceptible to accelerated subcutaneous tumor growth potentially through adipose tissue inflammation, local insulin-like growth factor release, and tumor associated macrophages Open
This work provides evidences suggesting adiposity, adipose specific IGF-1, macrophage associated adipose inflammation, and TAMs as potential mechanisms driving obesity-enhanced CRC in females lacking ovarian hormones.
View article: Impact of weight loss and partial weight regain on immune cell and inflammatory markers in adipose tissue in male mice
Impact of weight loss and partial weight regain on immune cell and inflammatory markers in adipose tissue in male mice Open
We examined the immune and inflammatory status of adipose tissue in mice after they underwent weight loss followed by partial weight regain. We show an increase in selected immune cells and inflammatory mediators, in high-fat diet-fed mice…
View article: Gut Antibody Deficiency in a Mouse Model of CVID Results in Spontaneous Development of a Gluten-Sensitive Enteropathy
Gut Antibody Deficiency in a Mouse Model of CVID Results in Spontaneous Development of a Gluten-Sensitive Enteropathy Open
Primary immunodeficiencies are heritable disorders of immune function. CD19 is a B cell co-receptor important for B cell development, and CD19 deficiency is a known genetic risk factor for a rare form of primary immunodeficiency known as "…
View article: Prolonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice
Prolonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice Open
Overall, these data suggest that chronic HFD consumption in mice can mimic pathophysiological and some microbial events observed in NAFLD patients.
View article: Abstract LB-131: Mast cells promote local angiogenic and structural remodeling, a precursor to prostate cancer
Abstract LB-131: Mast cells promote local angiogenic and structural remodeling, a precursor to prostate cancer Open
Prostate cancer (PCa) is the second cancer-cause of death of men in the USA. Upon transformation, prostatic epithelial cells (EC) gradually evolve from benign, premalignant, to malignant phenotypes. Prostatic Intraepithelial Neoplasia (PIN…