Reinaldo E. Fernández
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View article: Autoantibodies to interferon alpha, nuclear antigens, cardiolipin, and beta 2 glycoprotein 1 in a Ugandan cohort and their relation to SARS-CoV-2 infection
Autoantibodies to interferon alpha, nuclear antigens, cardiolipin, and beta 2 glycoprotein 1 in a Ugandan cohort and their relation to SARS-CoV-2 infection Open
Our findings contribute to the limited literature on AAb prevalence in East Africa and suggest that SARS-CoV-2 does not induce these AAbs.
View article: Autoantibodies directed against interferon alpha, nuclear antigens, cardiolipin, and beta 2 glycoprotein 1 are not induced by SARS-CoV-2 or associated with long COVID
Autoantibodies directed against interferon alpha, nuclear antigens, cardiolipin, and beta 2 glycoprotein 1 are not induced by SARS-CoV-2 or associated with long COVID Open
These findings do not support the hypotheses that SARS-CoV-2 induces these AAbs or that they are related to long COVID.
View article: The Trajectory of Antibody Responses One Year Following SARS-CoV-2 Infection among Indigenous Individuals in the Southwest United States
The Trajectory of Antibody Responses One Year Following SARS-CoV-2 Infection among Indigenous Individuals in the Southwest United States Open
SARS-CoV-2 antibody kinetics based on immunologic history is not fully understood. We analyzed anti-spike and anti-nucleocapsid antibody responses following acute infection in a cohort of Indigenous persons. The models of peak concentratio…
View article: Discordant performance of mpox serological assays
Discordant performance of mpox serological assays Open
None of the assays could distinguish between mpox-positive and vaccinated samples. The MSD assay targeting the MPXV E8L antigen demonstrated the greatest differentiation between mpox-positive and pre-outbreak negative samples. Our findings…
View article: SARS-CoV-2 seropositivity in African women living with HIV and their infants
SARS-CoV-2 seropositivity in African women living with HIV and their infants Open
View article: A Potential Screening Strategy to Identify Probable Syphilis Infections in the Urban Emergency Department Setting
A Potential Screening Strategy to Identify Probable Syphilis Infections in the Urban Emergency Department Setting Open
Background Syphilis diagnosis in the emergency department (ED) setting is often missed due to the lack of ED-specific testing strategies. We characterized ED patients with high-titer syphilis infections (HTSIs) with the goal of defining a …
View article: Outpatient COVID-19 convalescent plasma recipient antibody thresholds correlated to reduced hospitalizations within a randomized trial
Outpatient COVID-19 convalescent plasma recipient antibody thresholds correlated to reduced hospitalizations within a randomized trial Open
BACKGROUNDCOVID-19 convalescent plasma (CCP) virus-specific antibody levels that translate into recipient posttransfusion antibody levels sufficient to prevent disease progression are not defined.METHODSThis secondary analysis correlated d…
View article: Discordant Performance of Mpox Serological Assays
Discordant Performance of Mpox Serological Assays Open
View article: Erratum for Gebo et al., “Early antibody treatment, inflammation, and risk of post-COVID conditions”
Erratum for Gebo et al., “Early antibody treatment, inflammation, and risk of post-COVID conditions” Open
Volume 14, no. 5, e00618-23, 2023, https://journals.asm.org/doi/10.1128/mbio.00618-23. Page 6, Table 1, last row: "3,041 (2,197, 4,208)" should read "13,774 (8,665, 21,896)," and "13,774 (8,665, 21,896)" should read "3,041 (2,197, 4,208)."
View article: COVID-19 convalescent plasma therapy decreases inflammatory cytokines: a randomized controlled trial
COVID-19 convalescent plasma therapy decreases inflammatory cytokines: a randomized controlled trial Open
Early COVID-19 convalescent plasma (CCP) transfusion to outpatients with COVID-19 decreases progression to hospitalization, but the mechanism of how CCP reduces severity is unknown. Among 882 COVID-19 participants transfused with CCP or co…
View article: 401. Risk of Post-COVID Conditions Correlates with IL-6 Plasma Levels and Is Reduced by Early Antibody Therapy
401. Risk of Post-COVID Conditions Correlates with IL-6 Plasma Levels and Is Reduced by Early Antibody Therapy Open
Background Post-COVID conditions (PCC) are common, and risk factors include older age and female sex. While high interleukin (IL)-6 and C-reactive protein are associated with more severe disease, it is unclear whether other cytokines are a…
View article: Early antibody treatment, inflammation, and risk of post-COVID conditions
Early antibody treatment, inflammation, and risk of post-COVID conditions Open
Post-COVID conditions (PCCs) are common and have significant morbidity. Risk factors for PCC include advancing age, female sex, obesity, and diabetes mellitus. Little is known about treatment, inflammation, and PCC. Among 882 individuals w…
View article: Prevalence and correlates of SARS-CoV-2 seropositivity among people who inject drugs in Baltimore, Maryland
Prevalence and correlates of SARS-CoV-2 seropositivity among people who inject drugs in Baltimore, Maryland Open
SARS-CoV-2 seroprevalence increased over time among current and former PWID, suggesting cumulative increases in the incidence of SARS-CoV-2 infection and vaccination; however, there were disparities in infection-induced seroprevalence and …
View article: Dynamics of inflammatory responses after SARS-CoV-2 infection by vaccination status in the USA: a prospective cohort study
Dynamics of inflammatory responses after SARS-CoV-2 infection by vaccination status in the USA: a prospective cohort study Open
US Department of Defense, National Institutes of Health, Bloomberg Philanthropies, State of Maryland, Mental Wellness Foundation, Moriah Fund, Octapharma, HealthNetwork Foundation, and the Shear Family Foundation.
View article: HIV-Positive Liver Transplant Does not Alter the Latent Viral Reservoir in Recipients With Antiretroviral Therapy-Suppressed HIV
HIV-Positive Liver Transplant Does not Alter the Latent Viral Reservoir in Recipients With Antiretroviral Therapy-Suppressed HIV Open
The latent viral reservoir (LVR) remains a major barrier to HIV-1 curative strategies. It is unknown whether receiving a liver transplant from a donor with HIV might lead to an increase in the LVR because the liver is a large lymphoid orga…
View article: <scp>SARS‐CoV</scp>‐2 seroprevalence among blood donors in Uganda: 2019–2022
<span>SARS‐CoV</span>‐2 seroprevalence among blood donors in Uganda: 2019–2022 Open
Background The true burden of COVID‐19 in low‐ and middle‐income countries remains poorly characterized, especially in Africa. Even prior to the availability of SARS‐CoV‐2 vaccines, countries in Africa had lower numbers of reported COVID‐1…
View article: Outpatient COVID-19 convalescent plasma recipient antibody thresholds correlated to reduced hospitalizations within a randomized trial
Outpatient COVID-19 convalescent plasma recipient antibody thresholds correlated to reduced hospitalizations within a randomized trial Open
BACKGROUND The COVID-19 convalescent plasma (CCP) viral specific antibody levels that translate into recipient post-transfusion antibody levels sufficient to prevent disease progression is not defined. METHODS This secondary analysis corre…
View article: Early Treatment, Inflammation and Post-COVID Conditions
Early Treatment, Inflammation and Post-COVID Conditions Open
Background Post-COVID conditions (PCC) are common and have significant morbidity. Risk factors for PCC include advancing age, female sex, obesity, and diabetes mellitus. Little is known about early treatment, inflammation, and PCC. Methods…
View article: High Burden of Undiagnosed Hepatitis B and Liver Disease in an Urban Emergency Department—Baltimore, 2020
High Burden of Undiagnosed Hepatitis B and Liver Disease in an Urban Emergency Department—Baltimore, 2020 Open
View article: The effect of induction immunosuppression for kidney transplant on the latent HIV reservoir
The effect of induction immunosuppression for kidney transplant on the latent HIV reservoir Open
The HIV latent viral reservoir (LVR) remains a major challenge in the effort to find a cure for HIV. There is interest in lymphocyte-depleting agents, used in solid organ and bone marrow transplantation to reduce the LVR. This study evalua…
View article: Differential antibody production by symptomatology in SARS-CoV-2 convalescent individuals
Differential antibody production by symptomatology in SARS-CoV-2 convalescent individuals Open
The association between COVID-19 symptoms and antibody responses against SARS-CoV-2 is poorly characterized. We analyzed antibody levels in individuals with known SARS-CoV-2 infection to identify potential antibody-symptom associations. Co…
View article: A Tale of 3 Pandemics: Severe Acute Respiratory Syndrome Coronavirus 2, Hepatitis C Virus, and Human Immunodeficiency Virus in an Urban Emergency Department in Baltimore, Maryland
A Tale of 3 Pandemics: Severe Acute Respiratory Syndrome Coronavirus 2, Hepatitis C Virus, and Human Immunodeficiency Virus in an Urban Emergency Department in Baltimore, Maryland Open
Background We sought to determine the prevalence and sociodemographic and clinical correlates of acute and convalescent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), hepatitis C virus (HCV), and human immunodeficiency virus…
View article: Differential antibody production by symptomatology in SARS-CoV-2 convalescent individuals
Differential antibody production by symptomatology in SARS-CoV-2 convalescent individuals Open
The association between COVID-19 symptoms and antibody responses against SARS-CoV-2 is poorly characterized. We analyzed antibody levels in individuals with known SARS-CoV-2 infection to identify potential antibody-symptom associations. Co…
View article: Differentiation of Individuals Previously Infected with and Vaccinated for SARS-CoV-2 in an Inner-City Emergency Department
Differentiation of Individuals Previously Infected with and Vaccinated for SARS-CoV-2 in an Inner-City Emergency Department Open
Emergency departments (EDs) can serve as surveillance sites for infectious diseases. The objective of this study was to determine the burden of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and to monitor the preva…
View article: Validation of population‐level HIV‐1 incidence estimation by cross‐sectional incidence assays in the HPTN 071 (PopART) trial
Validation of population‐level HIV‐1 incidence estimation by cross‐sectional incidence assays in the HPTN 071 (PopART) trial Open
Introduction Cross‐sectional incidence testing is used to estimate population‐level HIV incidence and measure the impact of prevention interventions. There are limited data evaluating the accuracy of estimates in settings where antiretrovi…
View article: HOPE in action: A prospective multicenter pilot study of liver transplantation from donors with HIV to recipients with HIV
HOPE in action: A prospective multicenter pilot study of liver transplantation from donors with HIV to recipients with HIV Open
View article: 294. Surveillance for Potential Post-Acute COVID-19 Syndrome Medical Complications in the Emergency Department (ED) – A Retrospective Longitudinal Study of ED Patients Who Had Evidence of SARS-CoV-2 Infection Versus Those Who Did Not
294. Surveillance for Potential Post-Acute COVID-19 Syndrome Medical Complications in the Emergency Department (ED) – A Retrospective Longitudinal Study of ED Patients Who Had Evidence of SARS-CoV-2 Infection Versus Those Who Did Not Open
Background As the COVID-19 pandemic continues, growing attention has been placed on whether patients previously infected with SARS-CoV-2 have an increased risk of developing and/or exacerbating medical complications. Our study aimed to det…
View article: Differentiation of SARS-CoV-2 naturally infected and vaccinated individuals in an inner-city emergency department
Differentiation of SARS-CoV-2 naturally infected and vaccinated individuals in an inner-city emergency department Open
Background Emergency Departments (EDs) can serve as surveillance sites for infectious diseases. Our purpose was to determine the burden of SARS-CoV-2 infection and prevalence of vaccination against COVID-19 among patients attending an urba…
View article: National Landscape of Human Immunodeficiency Virus–Positive Deceased Organ Donors in the United States
National Landscape of Human Immunodeficiency Virus–Positive Deceased Organ Donors in the United States Open
Background Organ transplantation from donors with human immunodeficiency virus (HIV) to recipients with HIV (HIV D+/R+) presents risks of donor-derived infections. Understanding clinical, immunologic, and virologic characteristics of HIV-p…
View article: Dimeric IgA is a specific biomarker of recent SARS-CoV-2 infection
Dimeric IgA is a specific biomarker of recent SARS-CoV-2 infection Open
Current tests for SARS-CoV-2 antibodies (IgG, IgM, IgA) cannot differentiate recent and past infections. We describe a point of care, lateral flow assay for SARS-CoV-2 dIgA based on the highly selective binding of dIgA to a chimeric form o…