Reiner Schulz
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View article: The DEAD box RNA helicase DDX42 is an intrinsic inhibitor of positive‐strand RNA viruses
The DEAD box RNA helicase DDX42 is an intrinsic inhibitor of positive‐strand RNA viruses Open
Genome-wide screens are powerful approaches to unravel new regulators of viral infections. Here, we used a CRISPR/Cas9 screen to reveal new HIV-1 inhibitors. This approach led us to identify the RNA helicase DDX42 as an intrinsic antiviral…
View article: The <scp>DEAD</scp> box <scp>RNA</scp> helicase <scp>DDX42</scp> is an intrinsic inhibitor of positive‐strand <scp>RNA</scp> viruses
The <span>DEAD</span> box <span>RNA</span> helicase <span>DDX42</span> is an intrinsic inhibitor of positive‐strand <span>RNA</span> viruses Open
Genome-wide screens are powerful approaches to unravel regulators of viral infections. Here, a CRISPR screen identifies the RNA helicase DDX42 as an intrinsic antiviral inhibitor of HIV-1. Depletion of endogenous DDX42 increases HIV-1 DNA …
View article: Extraction and high-throughput sequencing of oak heartwood DNA: Assessing the feasibility of genome-wide DNA methylation profiling
Extraction and high-throughput sequencing of oak heartwood DNA: Assessing the feasibility of genome-wide DNA methylation profiling Open
Tree ring features are affected by environmental factors and therefore are the basis for dendrochronological studies to reconstruct past environmental conditions. Oak wood often provides the data for these studies because of the durability…
View article: Extraction and high-throughput sequencing of oak heartwood DNA: assessing the feasibility of genome-wide DNA methylation profiling
Extraction and high-throughput sequencing of oak heartwood DNA: assessing the feasibility of genome-wide DNA methylation profiling Open
Tree ring features are affected by environmental factors and therefore are the basis for dendrochronological studies to reconstruct past environmental conditions. Oak wood often provides the data for these studies because of the durability…
View article: Hydroxycarbamide effects on DNA methylation and gene expression in myeloproliferative neoplasms
Hydroxycarbamide effects on DNA methylation and gene expression in myeloproliferative neoplasms Open
Hydroxycarbamide (HC, hydroxyurea) is a cytoreductive drug inducing cell cycle blockade. However, emerging evidence suggests that HC plays a role in the modulation of transcription through the activity of transcription factors and DNA meth…
View article: HIV-1 Vpr Induces Widespread Transcriptomic Changes in CD4 <sup>+</sup> T Cells Early Postinfection
HIV-1 Vpr Induces Widespread Transcriptomic Changes in CD4 <sup>+</sup> T Cells Early Postinfection Open
HIV-1, while now treatable, remains an important human pathogen causing significant morbidity and mortality globally. The virus predominantly infects CD4 + T cells and, if not treated with medication, ultimately causes their depletion, res…
View article: Imprinted Gene Expression and Function of the Dopa Decarboxylase Gene in the Developing Heart
Imprinted Gene Expression and Function of the Dopa Decarboxylase Gene in the Developing Heart Open
Dopa decarboxylase (DDC) synthesizes serotonin in the developing mouse heart where it is encoded by Ddc_exon1a , a tissue-specific paternally expressed imprinted gene. Ddc_exon1a shares an imprinting control region (ICR) with the imprinted…
View article: Extraction and high-throughput sequencing of oak heartwood DNA: Assessing the feasibility of genome-wide DNA methylation profiling
Extraction and high-throughput sequencing of oak heartwood DNA: Assessing the feasibility of genome-wide DNA methylation profiling Open
Tree ring features are affected by environmental factors and therefore are the basis for dendrochronological studies to reconstruct past environmental conditions. Oak wood often provides the data for these studies because of the durability…
View article: Transcription of intragenic CpG islands influences spatiotemporal host gene pre-mRNA processing
Transcription of intragenic CpG islands influences spatiotemporal host gene pre-mRNA processing Open
Alternative splicing (AS) and alternative polyadenylation (APA) generate diverse transcripts in mammalian genomes during development and differentiation. Epigenetic marks such as trimethylation of histone H3 lysine 36 (H3K36me3) and DNA me…
View article: Transcription of intragenic CpG islands influences spatiotemporal host gene pre-mRNA processing
Transcription of intragenic CpG islands influences spatiotemporal host gene pre-mRNA processing Open
Alternative splicing (AS) and alternative polyadenylation (APA) generate diverse transcripts in mammalian genomes during development and differentiation. Epigenetic factors such as trimethylation of histone H3 lysine 36 (H3K36me3) and DNA …
View article: CpG Dinucleotides Inhibit HIV-1 Replication through Zinc Finger Antiviral Protein (ZAP)-Dependent and -Independent Mechanisms
CpG Dinucleotides Inhibit HIV-1 Replication through Zinc Finger Antiviral Protein (ZAP)-Dependent and -Independent Mechanisms Open
Some RNA virus genomes are suppressed in the nucleotide combination of a cytosine followed by a guanosine (CpG), indicating that they are detrimental to the virus. The antiviral protein ZAP binds viral RNA containing CpGs and prevents the …
View article: PS1451 THE EFFECT OF HYDROXYUREA ON DNA METHYLATION AND GENE EXPRESSION IN POLYCYTHEMIA VERA AND ESSENTIAL THROMBOCYTHEMIA
PS1451 THE EFFECT OF HYDROXYUREA ON DNA METHYLATION AND GENE EXPRESSION IN POLYCYTHEMIA VERA AND ESSENTIAL THROMBOCYTHEMIA Open
Background: Polycythemia vera (PV) and essential thrombocythemia (ET) are bone marrow disorder that gives rise to a high production of red blood cells and platelets leading to thrombosis and haemorrhage. Hydroxyurea is the first‐line treat…
View article: Effects of maternal obesity on Wharton’s Jelly mesenchymal stromal cells
Effects of maternal obesity on Wharton’s Jelly mesenchymal stromal cells Open
We investigated whether maternal metabolic environment affects mesenchymal stromal/stem cells (MSCs) from umbilical cord’s Wharton’s Jelly (WJ) on a molecular level, and potentially render them unsuitable for clinical use in multiple recip…
View article: Network-Informed Gene Ranking Tackles Genetic Heterogeneity in Exome-Sequencing Studies of Monogenic Disease
Network-Informed Gene Ranking Tackles Genetic Heterogeneity in Exome-Sequencing Studies of Monogenic Disease Open
Genetic heterogeneity presents a significant challenge for the identification of monogenic disease genes. Whole-exome sequencing generates a large number of candidate disease-causing variants and typical analyses rely on deleterious varian…
View article: Promiscuous RNA Binding Ensures Effective Encapsidation of APOBEC3 Proteins by HIV-1
Promiscuous RNA Binding Ensures Effective Encapsidation of APOBEC3 Proteins by HIV-1 Open
The apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) proteins are cell-encoded cytidine deaminases, some of which, such as APOBEC3G (A3G) and APOBEC3F (A3F), act as potent human immunodeficiency virus type-1 (HIV…