Reinhard E. Friedrich
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View article: The skull base in NF1 phenotypes on lateral cephalograms
The skull base in NF1 phenotypes on lateral cephalograms Open
Neurofibromatosis type 1 (NF1) influences skeletal growth processes. We investigated the effect of the disease and associated neurogenic craniofacial tumors on the skull base. We examined skull base parameters on lateral cephalograms in pa…
View article: Surgical Measures Improving Functional Limitations of the Masticatory System, Aesthetic Deficits, and Skeletal Malformations in Neurofibromatosis Type 1‐associated Hemifacial Diffuse Plexiform Neurofibroma Complicated by Rapidly Growing Midfacial Peripheral Nerve Sheath Tumor
Surgical Measures Improving Functional Limitations of the Masticatory System, Aesthetic Deficits, and Skeletal Malformations in Neurofibromatosis Type 1‐associated Hemifacial Diffuse Plexiform Neurofibroma Complicated by Rapidly Growing Midfacial Peripheral Nerve Sheath Tumor Open
Background/Aim: Neurofibromatosis type 1 (NF1) is a genetic disorder characterized by the development of multiple tumors, including plexiform neurofibromas (PNFs), which often affect the craniofacial region and cause significant functional…
View article: Cephalometric landmark detection using vision transformers with direct coordinate prediction
Cephalometric landmark detection using vision transformers with direct coordinate prediction Open
Cephalometric Landmark Detection (CLD), i.e. annotating interest points in lateral X-ray images, is the crucial first step of every orthodontic therapy. While CLD has immense potential for automation using Deep Learning methods, carefully …
View article: Sclerotherapy With Polidocanol Is Highly Effective for Treating Oral Cavernous Hemangiomas in Children
Sclerotherapy With Polidocanol Is Highly Effective for Treating Oral Cavernous Hemangiomas in Children Open
Sclerotherapy using polidocanol provides an effective, safe, and relatively simple treatment for hemangiomas in the oral cavity of children and may be recommended to replace the conventional pingyangmicine treatment.
View article: Recurrent Diffuse Neurofibroma of the Mandibular Anterior Lingual Alveolar Process Associated With Dental and Skeletal Changes in Neurofibromatosis Type 1
Recurrent Diffuse Neurofibroma of the Mandibular Anterior Lingual Alveolar Process Associated With Dental and Skeletal Changes in Neurofibromatosis Type 1 Open
Background/Aim: Neurofibromatosis type 1 (NF1) is a tumor predisposition syndrome and a bone disease. Dystrophic facial skull often is topographically related to diffuse neurofibromas (DNFs). The report traces the diagnosis and treatment o…
View article: Facial Diffuse Plexiform Neurofibroma‐associated Mandibular Deformities: Surgical Interventions and Monitoring of Treatment Results in a Patient for Over 40 Years
Facial Diffuse Plexiform Neurofibroma‐associated Mandibular Deformities: Surgical Interventions and Monitoring of Treatment Results in a Patient for Over 40 Years Open
Background/Aim: Neurofibromatosis type 1 (NF1) is an autosomal dominant hereditary tumor-predisposition syndrome and a genetic bone disease. The case report describes tumor-associated mandibular changes, their therapy and follow-up over se…
View article: Radiomics for Growth Prediction of Vestibular Schwannomas in Neurofibromatosis Type 2
Radiomics for Growth Prediction of Vestibular Schwannomas in Neurofibromatosis Type 2 Open
Bimodally distributed radiomics features from initial MRIs did not reliably predict rapid tumor growth (error probability: 23%) but may aid in planning MRI follow-up intervals.
View article: First-line biological versus conventional synthetic disease-modifying antirheumatic drug therapy in adult-onset Still's disease: a multicentre, retrospective, propensity weighted cohort study
First-line biological versus conventional synthetic disease-modifying antirheumatic drug therapy in adult-onset Still's disease: a multicentre, retrospective, propensity weighted cohort study Open
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View article: Malignant Peripheral Nerve Sheath Tumor (MPNST) Arising from Orbital Plexiform Neurofibroma in a Small Child With Neurofibromatosis Type 1
Malignant Peripheral Nerve Sheath Tumor (MPNST) Arising from Orbital Plexiform Neurofibroma in a Small Child With Neurofibromatosis Type 1 Open
Background/Aim: Neurofibromatosis type 1 (NF1) is an autosomal dominant hereditary tumor predisposition syndrome. In approximately 30% of cases, plexiform neurofibromas (PNFs) are identified, which are precursor lesions for malignant perip…
View article: An Unexpected Relationship Between Human Papillomavirus and Head and Neck Squamous Cell Carcinoma: A Mendelian Randomization Study
An Unexpected Relationship Between Human Papillomavirus and Head and Neck Squamous Cell Carcinoma: A Mendelian Randomization Study Open
The analysis does not support a causal relationship between HPV infection and HNC, as indicated by the lack of evidence linking HPV16/18 E7 proteins to the development of this cancer.
View article: Global, Regional and National Burden of Edentulism and Periodontal Diseases from 1990 to 2021: Analysis of Risk Factors and Prediction of Trends in 2050
Global, Regional and National Burden of Edentulism and Periodontal Diseases from 1990 to 2021: Analysis of Risk Factors and Prediction of Trends in 2050 Open
This study underscores the need for targeted public health interventions, particularly in resource-limited regions, to improve access to oral healthcare and integrate preventive strategies into broader health initiatives.
View article: Two Different<i>NF1</i>Pathogenic Variants in a Family With Neurofibromatosis Type 1
Two Different<i>NF1</i>Pathogenic Variants in a Family With Neurofibromatosis Type 1 Open
Two different NF1-variants in one family is an extremely rare phenomenon: yet its occurrence is not impossible and therefore should be considered in genetic diagnosis and counselling. For an offspring with the indication for neurofibromato…
View article: Retinol-binding protein type 1 expression predicts poor prognosis in head and neck squamous cell carcinoma
Retinol-binding protein type 1 expression predicts poor prognosis in head and neck squamous cell carcinoma Open
Background Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent malignancy worldwide, with high incidence and poor survival rates. RBP1 is highly expressed in several kinds of cancer and plays a potential prognostic fa…
View article: Nanosecond infrared laser (NIRL) for cutting roots of human teeth: thermal effects and quality of cutting edges
Nanosecond infrared laser (NIRL) for cutting roots of human teeth: thermal effects and quality of cutting edges Open
View article: The role of herpes simplex virus infection in the etiology of head and neck cancer–a Mendelian randomization study
The role of herpes simplex virus infection in the etiology of head and neck cancer–a Mendelian randomization study Open
Introduction Head and neck cancer (HNC) is a complex disease, and multiple risk factors can lead to its progression. Observational studies indicated that herpes simplex virus (HSV) may be correlated with the risk of HNC. However, the causa…
View article: <i>PIK3CA</i>Hotspot Mutations in Saliva as a Diagnostic Marker in Oral Squamous Cell Carcinoma Patients
<i>PIK3CA</i>Hotspot Mutations in Saliva as a Diagnostic Marker in Oral Squamous Cell Carcinoma Patients Open
Overall, a PIK3CA variant was found in seven of the 29 tumor tissue samples (24%) by ClearSEEK™; UltraSEEK® additionally confirmed the variant in four of these seven positive samples. Of the three variants not detected by UltraS…
View article: Raman difference spectroscopy and U-Net convolutional neural network for molecular analysis of cutaneous neurofibroma
Raman difference spectroscopy and U-Net convolutional neural network for molecular analysis of cutaneous neurofibroma Open
In Neurofibromatosis type 1 (NF1), peripheral nerve sheaths tumors are common, with cutaneous neurofibromas resulting in significant aesthetic, painful and functional problems requiring surgical removal. To date, determination of adequate …
View article: How to make full use of dental pulp stem cells: an optimized cell culture method based on explant technology
How to make full use of dental pulp stem cells: an optimized cell culture method based on explant technology Open
Introduction: Dental pulp stem cells from humans possess self-renewal and versatile differentiation abilities. These cells, known as DPSC, are promising for tissue engineering due to their outstanding biological characteristics and ease of…
View article: Multiple central giant cell granuloma of the jaws: diagnostic signposts of Noonan syndrome and RASopathy
Multiple central giant cell granuloma of the jaws: diagnostic signposts of Noonan syndrome and RASopathy Open
View article: The Role of Protein Expression Levels in Rheumatoid Arthritis Risk: Novel Drug Targets Revealed
The Role of Protein Expression Levels in Rheumatoid Arthritis Risk: Novel Drug Targets Revealed Open
View article: Dental Developmental Stages and Decayed, Missing, and Restored Teeth in Neurofibromatosis Type 1-affected Children and Adolescents
Dental Developmental Stages and Decayed, Missing, and Restored Teeth in Neurofibromatosis Type 1-affected Children and Adolescents Open
Development of dentition of NF1 patients does not differ from the general population. However, FPNF with oral tumor components often prevent mesial movement of permanent molars and premolars, so these teeth do not develop contact (spacing)…
View article: First-Line Biological vs. Conventional Therapy in Adult-Onset Still's Disease a Multicentre, Retrospective, Propensity Weighted Analysis
First-Line Biological vs. Conventional Therapy in Adult-Onset Still's Disease a Multicentre, Retrospective, Propensity Weighted Analysis Open
View article: The causal association between COVID-19 and herpes simplex virus: a Mendelian randomization study
The causal association between COVID-19 and herpes simplex virus: a Mendelian randomization study Open
Introduction The coronavirus disease 2019 (COVID-19) has emerged as a main global public health challenge. Additionally, herpes simplex virus type-1 (HSV-1) and type 2 (HSV-2) are widespread viruses that can cause orolabial herpes and geni…
View article: Mandibular symmetry on posterior-anterior cephalograms of neurofibromatosis type 1 patients with facial plexiform neurofibroma
Mandibular symmetry on posterior-anterior cephalograms of neurofibromatosis type 1 patients with facial plexiform neurofibroma Open
Introduction: Neurofibromatosis type 1 (NF1) is an is an autosomal dominant heritable tumor predisposition syndrome.. Peripheral nerve sheath tumors (PNST) are a hallmark of NF1. Plexiform neurofibromas (PNF) are neoplasms that are charact…
View article: Association between hypertension and gingival bleeding: a two-sample Mendelian randomization study
Association between hypertension and gingival bleeding: a two-sample Mendelian randomization study Open
Objectives To investigate whether there is a causal relationship between hypertension and gingival bleeding using Mendelian randomization analysis. Materials and methods We performed a two-sample two-way Mendelian randomization (MR) analys…
View article: Correlations between gut microbiota and lichen planus: a two-sample Mendelian randomization study
Correlations between gut microbiota and lichen planus: a two-sample Mendelian randomization study Open
Purpose Several existing studies have revealed that the occurrence of lichen planus (LP) is relevant to the gut microbiota, and the causal relationship between gut microbiota and LP was analyzed using the Mendelian randomization (MR) metho…
View article: Analysis of 5-Year-old children’s oral health service utilization and influencing factors in Guizhou Province, China (2019–2020)
Analysis of 5-Year-old children’s oral health service utilization and influencing factors in Guizhou Province, China (2019–2020) Open
Background This study aimed to investigate the utilization patterns and factors related to oral health care for 5-year-old preschoolers based on Andersen’s Behavioural Model in Guizhou Province, Western China. Method A cross-sectional stud…
View article: Raman spectroscopy and <scp>U</scp>‐Net deep neural network in antiresorptive drug‐related osteonecrosis of the jaw
Raman spectroscopy and <span>U</span>‐Net deep neural network in antiresorptive drug‐related osteonecrosis of the jaw Open
Objective Application of an optical method for the identification of antiresorptive drug‐related osteonecrosis of the jaw (ARONJ). Methods We introduce shifted‐excitation Raman difference spectroscopy followed by U‐Net deep neural network …
View article: Association between C-Reactive protein and periodontitis in an obese population from the NHANES 2009–2010
Association between C-Reactive protein and periodontitis in an obese population from the NHANES 2009–2010 Open
Background Various data have been obtained on the relationship between body mass index (BMI) and C-reactive protein (CRP) and periodontitis. The aim of this study was to determine whether CRP/BMI are associated with periodontitis using dat…
View article: Neurofibromatosis type 1-associated plexiform neurofibromas of the neck: topography of lesions and surgical treatment data of 69 patients
Neurofibromatosis type 1-associated plexiform neurofibromas of the neck: topography of lesions and surgical treatment data of 69 patients Open