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View article: DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms
DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms Open
View article: OS03.5.A FUNCTIONAL PRECISION MEDICINE SCREENING REVEALS PERSONALIZED THERAPEUTIC VULNERABILITIES IN HIGH-GRADE GLIOMA SUBTYPES
OS03.5.A FUNCTIONAL PRECISION MEDICINE SCREENING REVEALS PERSONALIZED THERAPEUTIC VULNERABILITIES IN HIGH-GRADE GLIOMA SUBTYPES Open
BACKGROUND Precision medicine has transformed cancer treatment by tailoring therapies to the specific molecular aberrations of an individual patient’s tumor. The integration of high-resolution multi-omics with high-throughput functional pr…
View article: Integrative multi-omics combined with functional pharmacological profiling in patient-derived organoids identifies personalized therapeutic vulnerabilities of adult high-grade gliomas
Integrative multi-omics combined with functional pharmacological profiling in patient-derived organoids identifies personalized therapeutic vulnerabilities of adult high-grade gliomas Open
Background: Precision medicine has transformed cancer treatment by tailoring therapies to specific molecular aberrations. Integrating high-resolution multi-omics with high-throughput functional profiling in patient-derived organoids offers…
View article: Comprehensive multi-omics profiling of a healthy human cohort
Comprehensive multi-omics profiling of a healthy human cohort Open
Multi-omics investigations hold promise for uncovering biomarker profiles crucial for disease diagnosis, prognosis, and monitoring interventions. However, these profiles are susceptible to technical and biological variation. Capturing biol…
View article: Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts
Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts Open
View article: <scp>AllergoOncology</scp>: Biomarkers and refined classification for research in the allergy and glioma nexus—A joint <scp>EAACI‐EANO</scp> position paper
<span>AllergoOncology</span>: Biomarkers and refined classification for research in the allergy and glioma nexus—A joint <span>EAACI‐EANO</span> position paper Open
Epidemiological studies have explored the relationship between allergic diseases and cancer risk or prognosis in AllergoOncology. Some studies suggest an inverse association, but uncertainties remain, including in IgE‐mediated diseases and…
View article: Enhancing the opportunities for cholangiocarcinoma precision therapy
Enhancing the opportunities for cholangiocarcinoma precision therapy Open
Cholangiocarcinoma (CCA), the second most prevalent liver cancer, encompasses a heterogenous group of bile duct malignancies. It predominantly arises from the epithelial cells lining the bile ducts termed cholangiocytes. Most CCA are highl…
View article: consICA: an R package for robust reference-free deconvolution of multi-omics data
consICA: an R package for robust reference-free deconvolution of multi-omics data Open
Motivation Deciphering molecular signals from omics data helps understanding cellular processes and disease progression. Effective algorithms for extracting these signals are essential, with a strong emphasis on robustness and reproducibil…
View article: The Dimensions of Parent-School Partnership
The Dimensions of Parent-School Partnership Open
Bibliography of the reviewed special issue: Pusztai, G., & Engler, Á. (Eds.) (2020). Value-Creating Pedagogy in School and Family. Kapocs, Special Issue. Maria Kopp Institute for Demography and Families (KINCS).
View article: AllergoOncology: Biomarkers and Refined Classification for Research in the Allergy and Glioma Nexus - a Joint EAACI-EANO Position Paper
AllergoOncology: Biomarkers and Refined Classification for Research in the Allergy and Glioma Nexus - a Joint EAACI-EANO Position Paper Open
Epidemiological studies have explored the relationship between allergic diseases and cancer risk or prognosis in AllergoOncology. Some studies suggest an inverse association, but uncertainties remain, including in IgE-mediated diseases and…
View article: DNAR-13. TARGETING THE DNA DAMAGE RESPONSE IN GLIOBLASTOMA PROPAGATING CELLS: FROM MOLECULAR MECHANISMS TO PRECISION MEDICINE
DNAR-13. TARGETING THE DNA DAMAGE RESPONSE IN GLIOBLASTOMA PROPAGATING CELLS: FROM MOLECULAR MECHANISMS TO PRECISION MEDICINE Open
Glioblastoma (GBM) is the most aggressive and lethal primary tumor of the central nervous system (CNS). Despite surgical resection and a combination of radiotherapy and alkylation chemotherapy, the median survival for patients with newly d…
View article: Assessing the Level of Knowledge and Experience Regarding Cervical Cancer Prevention and Screening among Roma Women in Romania
Assessing the Level of Knowledge and Experience Regarding Cervical Cancer Prevention and Screening among Roma Women in Romania Open
Background and Objectives: Romania ranks among the countries with a notably high rate of preventable deaths due to inadequacies in prevention, screening, early detection, and timely management processes. Cervical cancer (CC) is a significa…
View article: P02.18.B INTEGRATIVE OMICS ANALYSIS OF IDH1 MUTANT GLIOMA PATIENTS REVEALS ALTERATIONS IN BUTYRATE METABOLISM
P02.18.B INTEGRATIVE OMICS ANALYSIS OF IDH1 MUTANT GLIOMA PATIENTS REVEALS ALTERATIONS IN BUTYRATE METABOLISM Open
BACKGROUND Mutations in isocitrate dehydrogenase (IDH) 1 or 2 define glioma classification and determine the biology of these tumors. Although IDH is an essential enzyme in the cellular metabolism, powerful genome-wide analyses focus mostl…
View article: Sample Analysis Using Individual Omic Techniques and Data Outputs
Sample Analysis Using Individual Omic Techniques and Data Outputs Open
The biological samples from the Czech cohort (n=127) were analysed by individual “omics” approaches (genomics, transcriptomics, epigenomics, proteomics, metabolomics) at the particular EATRIS sites across Europe. Study subjects were inform…
View article: Report on the Evaluation of Methods for Improving Comparability of Cross-Omics Data from Different Cohorts
Report on the Evaluation of Methods for Improving Comparability of Cross-Omics Data from Different Cohorts Open
The key scientific output of the EATRIS-Plus project is to develop a Multi-omic Toolbox available for researchers in order to have a better understanding of the molecular profiles in personalised medicine. Within work packages 1, 2, and 3,…
View article: Supplementary Table S1 from Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium
Supplementary Table S1 from Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium Open
Genes selected for the study using GO and GeneCard databases and literature search to represent 10 epigenetic sub-pathways, specifically DNA methylation, DNA demethylation, histone acetylation, histone deacetylation, chromatin remodeling, …
View article: Data from Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium
Data from Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium Open
Background: Epigenetic disturbances are crucial in cancer initiation, potentially with pleiotropic effects, and may be influenced by the genetic background.Methods: In a subsets (ASSET) meta-analytic approach, we investigated…
View article: Supplementary Table S5 from Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium
Supplementary Table S5 from Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium Open
Summary of candidate genes with identified risk associations, chromosomal region, previously through GWAS identified risk associations in these regions and list of additional genes located in the selected regions.
View article: Data from Aspirin Reduces Plasma Concentrations of the Oncometabolite 2-Hydroxyglutarate: Results of a Randomized, Double-Blind, Crossover Trial
Data from Aspirin Reduces Plasma Concentrations of the Oncometabolite 2-Hydroxyglutarate: Results of a Randomized, Double-Blind, Crossover Trial Open
Background: Aspirin use is an effective strategy for the chemoprevention of colorectal cancer, even at low doses. However, in order to implement aspirin interventions, risk–benefit balances and biologic mechanisms need to be better …
View article: Supplementary Material from Aspirin Reduces Plasma Concentrations of the Oncometabolite 2-Hydroxyglutarate: Results of a Randomized, Double-Blind, Crossover Trial
Supplementary Material from Aspirin Reduces Plasma Concentrations of the Oncometabolite 2-Hydroxyglutarate: Results of a Randomized, Double-Blind, Crossover Trial Open
Supplementary Materials and Methods. Supplementary Figure 1: Study design of the ABC intervention study. Supplementary Figure 2: Intracellular concentrations of free salicylate in aspirin treated colorectal cancer cell lines expressed as n…
View article: Data from Aspirin Reduces Plasma Concentrations of the Oncometabolite 2-Hydroxyglutarate: Results of a Randomized, Double-Blind, Crossover Trial
Data from Aspirin Reduces Plasma Concentrations of the Oncometabolite 2-Hydroxyglutarate: Results of a Randomized, Double-Blind, Crossover Trial Open
Background: Aspirin use is an effective strategy for the chemoprevention of colorectal cancer, even at low doses. However, in order to implement aspirin interventions, risk–benefit balances and biologic mechanisms need to be better …
View article: Supplementary Table S1 from Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium
Supplementary Table S1 from Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium Open
Genes selected for the study using GO and GeneCard databases and literature search to represent 10 epigenetic sub-pathways, specifically DNA methylation, DNA demethylation, histone acetylation, histone deacetylation, chromatin remodeling, …
View article: Supplementary Figure S2 from Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium
Supplementary Figure S2 from Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium Open
Venn diagrams showing the number of SNPs associated across all five cancer types, without differentiation for subtypes. A. Including MORF4L1, B. Excluding MORF4L1* *http://bioinformatics.psb.ugent.be/webtools/Venn/
View article: Supplementary Figure S1 from Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium
Supplementary Figure S1 from Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium Open
Diagram of SNP selection and functional look-up of hits within epigenetic pathways. Flow chart of SNP selection and functional follow-up of hits within epigenetic pathways using different databases and software packages.
View article: Supplementary Figure S1 from Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium
Supplementary Figure S1 from Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium Open
Diagram of SNP selection and functional look-up of hits within epigenetic pathways. Flow chart of SNP selection and functional follow-up of hits within epigenetic pathways using different databases and software packages.
View article: Supplementary Figure S3 from Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium
Supplementary Figure S3 from Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium Open
Locuszoom plots of the regions with pleiotropic association. (A) TNP1 (2q35), (B) RUVBL1 and GATA2 (3q21), (C) PHC3 (3q26), (D) TET2 (4q24), (E) POU5F1, BAG6 and EHMT2 (6p21),(F) L3MBTL3 (6q23), (G) HDAC9 (7p21), (H) LOXL2 (8p21), (I) BRCA…
View article: Supplementary Table S5 from Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium
Supplementary Table S5 from Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium Open
Summary of candidate genes with identified risk associations, chromosomal region, previously through GWAS identified risk associations in these regions and list of additional genes located in the selected regions.
View article: Supplementary Table S2 from Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium
Supplementary Table S2 from Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium Open
List of software and databases used for the analysis and functional follow up
View article: Supplementary Figure S3 from Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium
Supplementary Figure S3 from Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium Open
Locuszoom plots of the regions with pleiotropic association. (A) TNP1 (2q35), (B) RUVBL1 and GATA2 (3q21), (C) PHC3 (3q26), (D) TET2 (4q24), (E) POU5F1, BAG6 and EHMT2 (6p21),(F) L3MBTL3 (6q23), (G) HDAC9 (7p21), (H) LOXL2 (8p21), (I) BRCA…
View article: Supplementary table and figure legends from Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium
Supplementary table and figure legends from Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium Open
Supplementary table and figure legends