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View article: Guide de pratique clinique en soins de première ligne d’Hypertension Canada pour le diagnostic et le traitement de l’hypertension artérielle chez les adultes
Guide de pratique clinique en soins de première ligne d’Hypertension Canada pour le diagnostic et le traitement de l’hypertension artérielle chez les adultes Open
Contexte : Le Canada a longtemps figuré parmi les leaders mondiaux de la prise en charge de l’hypertension artérielle (HTA), mais ses taux de traitement et de maîtrise de l’HTA ont régressé ces dernières années. Le présent guide de pratiqu…
View article: Accelerated vascular ageing after COVID-19 infection: the CARTESIAN study
Accelerated vascular ageing after COVID-19 infection: the CARTESIAN study Open
Background and Aims Increasing evidence suggests that COVID-19 survivors experience long-term cardiovascular complications possibly through development of vascular damage. The study aimed to investigate whether accelerated vascular ageing …
View article: Implementing the 2025 Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: How to Translate Team-Based Care of Hypertension to the Real World
Implementing the 2025 Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: How to Translate Team-Based Care of Hypertension to the Real World Open
View article: Guide de pratique clinique en soins de première ligne d’Hypertension Canada pour le diagnostic et le traitement de l’hypertension artérielle chez les adultes
Guide de pratique clinique en soins de première ligne d’Hypertension Canada pour le diagnostic et le traitement de l’hypertension artérielle chez les adultes Open
Les 9 recommandations pour la prise en charge de l'HTA chez les adultes sont regroupées sous les rubriques « Diagnostic » et « Traitement ». Les recommandations diagnostiques comportent une méthode standardisée de mesure de la pression art…
View article: Hypertension Canada guideline for the diagnosis and treatment of hypertension in adults in primary care
Hypertension Canada guideline for the diagnosis and treatment of hypertension in adults in primary care Open
Our aim is to enhance the standard of hypertension care in the Canadian primary care setting. Accurate diagnosis and optimal treatment of hypertension can reduce adverse cardiovascular events and risk of death.
View article: Guide de pratique clinique en soins de première ligne d’Hypertension Canada pour le diagnostic et le traitement de l’hypertension artérielle chez les adultes
Guide de pratique clinique en soins de première ligne d’Hypertension Canada pour le diagnostic et le traitement de l’hypertension artérielle chez les adultes Open
View article: Hypertension Canada guideline for the diagnosis and treatment of hypertension in adults in primary care
Hypertension Canada guideline for the diagnosis and treatment of hypertension in adults in primary care Open
Background: Canada has historically been among the world leaders in hypertension care, but hypertension treatment and control rates have regressed in recent years. This guideline is intended to provide pragmatic primary care-focused recomm…
View article: Hypertension Canada guideline for the diagnosis and treatment of hypertension in adults in primary care
Hypertension Canada guideline for the diagnosis and treatment of hypertension in adults in primary care Open
Our aim is to enhance the standard of hypertension care in the Canadian primary care setting. Accurate diagnosis and optimal treatment of hypertension can reduce adverse cardiovascular events and risk of death.
View article: The Association Between Daylight Saving Time and Acute Myocardial Infarction in Canada
The Association Between Daylight Saving Time and Acute Myocardial Infarction in Canada Open
Background: Recent studies have suggested an increased risk of acute myocardial infarction (AMI) following daylight saving time (DST) transitions in cohorts of American and European patients. We aim to validate this finding in a Canadian p…
View article: Lower estimated glomerular filtration rate relates to cognitive impairment and brain alterations
Lower estimated glomerular filtration rate relates to cognitive impairment and brain alterations Open
INTRODUCTION Chronic kidney disease (CKD) is associated with cognitive decline and changes in brain structure. However, their associations remain unclear, particularly the selective vulnerability characteristics that make some brain region…
View article: Sex-specific Associations of Aldosterone and Renin With Body Composition: A Population-based Cohort Study
Sex-specific Associations of Aldosterone and Renin With Body Composition: A Population-based Cohort Study Open
Context Renin–angiotensin–aldosterone system (RAAS) activation is closely linked to obesity; however, the sex-specific associations between RAAS activity and body composition among individuals without obesity are not well understood. Objec…
View article: Phenotypic Discordance among Siblings with Autosomal Recessive Polycystic Kidney Disease: Case Report and Review of the Literature
Phenotypic Discordance among Siblings with Autosomal Recessive Polycystic Kidney Disease: Case Report and Review of the Literature Open
Missense variants in the PKHD1 gene are associated with the full spectrum of autosomal recessive polycystic kidney disease severity and exhibit variable expressivity. The study of clinical expressivity is limited by the extensive allelic h…
View article: Impact of Prolonged SARS-CoV-2 Dosing Interval in Hemodialysis Patients
Impact of Prolonged SARS-CoV-2 Dosing Interval in Hemodialysis Patients Open
View article: Influence of Age on Upper Arm Cuff Blood Pressure Measurement Across the Lifespan
Influence of Age on Upper Arm Cuff Blood Pressure Measurement Across the Lifespan Open
View article: Differences in Antihypertensive Medication Prescription Profiles Between 2009 and 2021: A Retrospective Cohort Study of CARTaGENE
Differences in Antihypertensive Medication Prescription Profiles Between 2009 and 2021: A Retrospective Cohort Study of CARTaGENE Open
Background: Although blood pressure (BP) control is critical to prevent cardiovascular diseases, hypertension control rates in Canada are in decline. Objective: To assess this issue, we sought to evaluate the differences in antihypertensiv…
View article: Subclinical Primary Aldosteronism and Cardiovascular Health: A Population-Based Cohort Study
Subclinical Primary Aldosteronism and Cardiovascular Health: A Population-Based Cohort Study Open
BACKGROUND: Primary aldosteronism, characterized by overt renin-independent aldosterone production, is a common but underrecognized form of hypertension and cardiovascular disease. Growing evidence suggests that milder and subclinical form…
View article: Outcomes of Integrated Home Dialysis Care: Results From the Canadian Organ Replacement Register
Outcomes of Integrated Home Dialysis Care: Results From the Canadian Organ Replacement Register Open
View article: Impact of Successive Office Blood Pressure Measurements During a Single Visit on Cardiovascular Risk Prediction: Analysis of CARTaGENE
Impact of Successive Office Blood Pressure Measurements During a Single Visit on Cardiovascular Risk Prediction: Analysis of CARTaGENE Open
BACKGROUND: Multiple office blood pressure (BP) readings correlate more closely with ambulatory BP than single readings. Whether they are associated with long-term outcomes and improve cardiovascular risk prediction is unknown. Our objecti…
View article: Influence of Age on Upper Arm Cuff Blood Pressure Measurement Across the Lifespan
Influence of Age on Upper Arm Cuff Blood Pressure Measurement Across the Lifespan Open
View article: Accuracy of cuff blood pressure and systolic blood pressure amplification
Accuracy of cuff blood pressure and systolic blood pressure amplification Open
Automated cuff measured blood pressure (BP) is the global standard used for diagnosing hypertension, but there are concerns regarding the accuracy of the method. Individual variability in systolic BP (SBP) amplification from central (aorta…
View article: Screening for Primary Aldosteronism Among Hypertensive Adults with Obstructive Sleep Apnea: A Retrospective Population-Based Study
Screening for Primary Aldosteronism Among Hypertensive Adults with Obstructive Sleep Apnea: A Retrospective Population-Based Study Open
BACKGROUND Hypertension plus obstructive sleep apnea (OSA) is recommended in some guidelines as an indication to screen for primary aldosteronism (PA), yet prior data has brought the validity of this recommendation into question. Given thi…
View article: A third SARS-CoV-2 mRNA vaccine dose in people receiving hemodialysis overcomes B cell defects but elicits a skewed CD4+ T cell profile
A third SARS-CoV-2 mRNA vaccine dose in people receiving hemodialysis overcomes B cell defects but elicits a skewed CD4+ T cell profile Open
Cellular immune defects associated with suboptimal responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination in people receiving hemodialysis (HD) are poorly understood. We longitudinally analyze antibody, …
View article: CENtral blood pressure Targeting: a pragmatic RAndomized triaL in advanced Chronic Kidney Disease (CENTRAL-CKD): A Clinical Research Protocol
CENtral blood pressure Targeting: a pragmatic RAndomized triaL in advanced Chronic Kidney Disease (CENTRAL-CKD): A Clinical Research Protocol Open
Background: Emerging data favor central blood pressure (BP) over brachial cuff BP to predict cardiovascular and kidney events, as central BP more closely relates to the true aortic BP. Considering that patients with advanced chronic kidney…
View article: Enhancing central blood pressure accuracy through statistical modeling: A proof-of-concept study
Enhancing central blood pressure accuracy through statistical modeling: A proof-of-concept study Open
Background Non-invasive estimation of central blood pressure (BP) may have better prognostic value than brachial BP. The accuracy of central BP is limited in certain populations, such as in females and the elderly. This study aims to exami…
View article: A third SARS-CoV-2 mRNA vaccine dose in people receiving hemodialysis overcomes B cell defects but elicits a skewed CD4<sup>+</sup>T cell profile
A third SARS-CoV-2 mRNA vaccine dose in people receiving hemodialysis overcomes B cell defects but elicits a skewed CD4<sup>+</sup>T cell profile Open
Cellular immune defects associated with suboptimal responses to SARS-CoV-2 mRNA vaccination in people receiving hemodialysis (HD) are poorly understood. We longitudinally analyzed antibody, B cell, CD4 + and CD8 + T cell vaccine responses …
View article: Prediction of Cardiovascular Events by Pulse Waveform Parameters: Analysis of CARTaGENE
Prediction of Cardiovascular Events by Pulse Waveform Parameters: Analysis of CARTaGENE Open
Background Waveform parameters provide approximate data about aortic wave reflection. However, their association with cardiovascular events remains controversial and their role in cardiovascular prediction is unknown. Methods and Results W…
View article: Accuracy Difference of Noninvasive Blood Pressure Measurements by Sex and Height
Accuracy Difference of Noninvasive Blood Pressure Measurements by Sex and Height Open
In this cross-sectional study, women had higher true aortic SBP than men with similar brachial cuff SBP, an association that was mostly mediated by a shorter stature. This difference in BP measurement may lead to unrecognized undertreatmen…
View article: Modulation of Arterial Stiffness Gradient by Acute Administration of Nitroglycerin
Modulation of Arterial Stiffness Gradient by Acute Administration of Nitroglycerin Open
Background: Physiologically, the aorta is less stiff than peripheral conductive arteries, creating an arterial stiffness gradient, protecting microcirculation from high pulsatile pressure. However, the pharmacological manipulation of arter…
View article: Increased Excess Pressure After Creation of an Arteriovenous Fistula in End-Stage Renal Disease
Increased Excess Pressure After Creation of an Arteriovenous Fistula in End-Stage Renal Disease Open
BACKGROUND Reservoir-wave analysis (RWA) separates the arterial waveform into reservoir and excess pressure (XSP) components, where XSP is analogous to flow and related to left ventricular workload. RWA provides more detailed information a…
View article: The feasibility of home self-assessment of vital signs and symptoms: A new key to telehealth for individuals?
The feasibility of home self-assessment of vital signs and symptoms: A new key to telehealth for individuals? Open