Remi Weber
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View article: DARPin-fused T cell engager for adenovirus-mediated cancer therapy
DARPin-fused T cell engager for adenovirus-mediated cancer therapy Open
Bispecific T cell engagers are a promising class of therapeutic proteins for cancer therapy. Their potency and small size often come with systemic toxicity and short half-life, making intravenous administration cumbersome. These limitation…
Epigenetic modification and characterization of the MGMT promoter region using CRISPRoff in glioblastoma cells Open
The methylation status of the O6-methylguanine DNA methyltransferase (MGMT) promoter region is a critical predictor of response to alkylating agents in glioblastoma. However, current approaches to study the MGMT status focus on analyzing m…
Targeting the <i>IDH1</i>R132H mutation in gliomas by CRISPR/Cas precision base editing Open
Background Gliomas, the most frequent malignant primary brain tumors, lack curative treatments. Understanding glioma-specific molecular alterations is crucial to develop novel therapies. Among them, the biological consequences of the isoci…
Epigenetic modification and characterization of the <i>MGMT</i> promoter region using CRISPRoff in glioblastoma cells Open
The methylation status of the O6-methylguanine DNA methyltransferase ( MGMT ) promoter region is a critical predictor of response to alkylating agents in glioblastoma. However, current approaches to study the MGMT status focus on analyzing…
EXTH-37. TARGETING THE IDH1R132H MUTATION IN GLIOMAS BY CRISPR-CAS PRECISION BASE EDITING Open
Gliomas are the most frequent malignant primary brain tumors and continue to lack curative therapies. To aid the development of novel therapeutic approaches, a better understanding of glioma-specific molecular patterns is essential. We the…