Rémy F. Lalisse
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View article: Multi-Site Proton-Coupled Electron Transfer Enables Iodanyl Radical Catalysis
Multi-Site Proton-Coupled Electron Transfer Enables Iodanyl Radical Catalysis Open
The utility of hypervalent iodine reagents in synthesis is often ascribed to the selective two-electron redox events that interconvert I(I), I(III), and I(V) species during oxidative substrate functionalization. We recently reported that 1…
View article: Development, Application, and Mechanistic Interrogation of a Dual Ni Catalysis Approach to Photoredox-Based C(sp3)–C(sp3) Cross-Coupling
Development, Application, and Mechanistic Interrogation of a Dual Ni Catalysis Approach to Photoredox-Based C(sp3)–C(sp3) Cross-Coupling Open
The installation of alkyl substituents, such as methyl groups, is a crucial tactic for the synthesis and diversification of medicinal compounds with improved pharmacological profiles. However, strategies that leverage methyl radical for C(…
View article: A Voltage-Controlled Redox Mediator Strategy Enables Electrocatalytic Z-Selective Semi-Hydrogenation
A Voltage-Controlled Redox Mediator Strategy Enables Electrocatalytic Z-Selective Semi-Hydrogenation Open
Selective semi-hydrogenation to generate alkenes from alkynes is an invaluable method to access olefins for materials, pharmaceuticals, and nat-ural products. Electrochemical transition-metal-catalyzed hydrogenation is an attractive altern…
View article: Light‐Induced Living Polymer Networks with Adaptive Functional Properties
Light‐Induced Living Polymer Networks with Adaptive Functional Properties Open
The advent of covalent adaptable networks (CANs) through the incorporation of dynamic covalent bonds has led to unprecedented properties of macromolecular systems, which can be engineered at the molecular level. Among the various types of …
View article: Linear and Nonlinear Optical Properties of All-<i>cis</i> and All-<i>trans</i> Poly(<i>p</i>-phenylenevinylene)
Linear and Nonlinear Optical Properties of All-<i>cis</i> and All-<i>trans</i> Poly(<i>p</i>-phenylenevinylene) Open
Poly(p-phenylenevinylene) (PPV) is a staple of the family of conjugated polymers with desirable optoelectronic properties for applications including light-emitting diodes (LEDs) and photovoltaic devices. Although the significant imp…
View article: Site-Selective Electrochemical Arene C–H Amination
Site-Selective Electrochemical Arene C–H Amination Open
Here we present the discovery and development of a highly selective aromatic C-H amination reaction. This electrochemical strategy involves a cathodic reduction process that generates highly electrophilic dicationic N-centered radic…
View article: CCDC 2262556: Experimental Crystal Structure Determination
CCDC 2262556: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Ring expansion of indene by photoredox-enabled functionalized carbon-atom insertion
Ring expansion of indene by photoredox-enabled functionalized carbon-atom insertion Open
View article: Evidence for Dearomatizing Spirocyclization and Dynamic Effects in the Nitrogen Deletion of Tetrahydroisoquinolines
Evidence for Dearomatizing Spirocyclization and Dynamic Effects in the Nitrogen Deletion of Tetrahydroisoquinolines Open
A detailed mechanistic analysis of the nitrogen deletion of 1-aryl-tetrahydroisoquinolines is presented, suggesting that the anticipated diradical mechanism undergoes dynamically controlled partitioning to both the normal 1,5-coupling prod…
View article: Highly Enantioselective Catalytic Alkynylation of Quinolones: Substrate Scope, Mechanistic Studies, and Applications in the Syntheses of Chiral <i>N</i>-Heterocyclic Alkaloids and Diamines
Highly Enantioselective Catalytic Alkynylation of Quinolones: Substrate Scope, Mechanistic Studies, and Applications in the Syntheses of Chiral <i>N</i>-Heterocyclic Alkaloids and Diamines Open
The alkynylation of 4-siloxyquinolinium triflates has been achieved under the influence of copper bis(oxazoline) catalysis. The identification of the optimal bis(oxazoline) ligand was informed through a computational approach that enabled …
View article: Breaking the <i>tert</i> -Butyllithium Contact Ion Pair: A Gateway to Alternate Selectivity in Lithiation Reactions
Breaking the <i>tert</i> -Butyllithium Contact Ion Pair: A Gateway to Alternate Selectivity in Lithiation Reactions Open
The effects of Lewis basic phosphoramides on the aggregate structure of t-BuLi have been investigated in detail by NMR and DFT methods. It was determined that hexamethylphosphoramide (HMPA) can shift the equilibrium of t-BuLi…
View article: In-silico guided design, screening, and molecular dynamic simulation studies for the identification of potential SARS-CoV-2 main protease inhibitors for the targeted treatment of COVID-19
In-silico guided design, screening, and molecular dynamic simulation studies for the identification of potential SARS-CoV-2 main protease inhibitors for the targeted treatment of COVID-19 Open
COVID-19, the disease responsible for the recent pandemic, is caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The main protease (Mpro) of SARS-CoV-2 is an essential proteolytic enzyme that plays a number of …
View article: CCDC 2151424: Experimental Crystal Structure Determination
CCDC 2151424: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2151425: Experimental Crystal Structure Determination
CCDC 2151425: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Ligand Control in Co-Catalyzed Regio- and Enantioselective Hydroboration: Homoallyl Secondary Boronates via Uncommon 4,3-Hydroboration of 1,3-Dienes
Ligand Control in Co-Catalyzed Regio- and Enantioselective Hydroboration: Homoallyl Secondary Boronates via Uncommon 4,3-Hydroboration of 1,3-Dienes Open
Enantiopure homoallylic boronate esters are versatile intermediates because the C-B bond in these compounds can be stereospecifically transformed into C-C, C-O, and C-N bonds. Regio- and enantioselective synthesis of these precursors from …
View article: CCDC 2196315: Experimental Crystal Structure Determination
CCDC 2196315: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2196314: Experimental Crystal Structure Determination
CCDC 2196314: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2196313: Experimental Crystal Structure Determination
CCDC 2196313: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Highly Selective Radical Relay 1,4-Oxyimination of Two Electronically Differentiated Olefins
Highly Selective Radical Relay 1,4-Oxyimination of Two Electronically Differentiated Olefins Open
Radical addition reactions of olefins have emerged as an attractive tool for the rapid assembly of complex structures, and have plentiful applications in organic synthesis, however, such reactions are often limited to polymerization or 1,2…
View article: Linked PDF of Table of Contents
Linked PDF of Table of Contents Open
View article: Resolving Graphite‐Electrolyte Interphase of Lithium‐Ion Batteries using Air‐Tight Ambient Mass Spectrometry
Resolving Graphite‐Electrolyte Interphase of Lithium‐Ion Batteries using Air‐Tight Ambient Mass Spectrometry Open
The formation of a stable solid electrolyte interphase (SEI) at graphite electrode is necessary for lithium‐ion batteries (LIB) to prevent excessive degradation of electrolytes. Until now, the exact organic composition of SEI has not been …
View article: Enantioselective Dearomative Alkynylation of Chromanones: Opportunities and Obstacles
Enantioselective Dearomative Alkynylation of Chromanones: Opportunities and Obstacles Open
A catalytic and highly enantioselective dearomative alkynylation of chromanones has been discovered that enables the construction of biologically relevant tertiary ether stereogenic centers. This methodology is robust, accommodating a vari…
View article: CCDC 2043444: Experimental Crystal Structure Determination
CCDC 2043444: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2043445: Experimental Crystal Structure Determination
CCDC 2043445: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2043443: Experimental Crystal Structure Determination
CCDC 2043443: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2043447: Experimental Crystal Structure Determination
CCDC 2043447: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Cationic Co(I) Catalysts for Regiodivergent Hydroalkenylation of 1,6-Enynes: An Uncommon <i>cis</i>-β-C–H Activation Leads to <i>Z</i>-Selective Coupling of Acrylates
Cationic Co(I) Catalysts for Regiodivergent Hydroalkenylation of 1,6-Enynes: An Uncommon <i>cis</i>-β-C–H Activation Leads to <i>Z</i>-Selective Coupling of Acrylates Open
Two intermolecular hydroalkenylation reactions of 1,6-enynes are presented which yield substituted 5-membered carbo- and -heterocycles. This reactivity is enabled by a cationic bis-diphenylphosphinopropane (DPPP)CoI speci…
View article: Robust, Enantioselective Construction of Challenging, Biologically Relevant Tertiary Ether Stereocenters
Robust, Enantioselective Construction of Challenging, Biologically Relevant Tertiary Ether Stereocenters Open
A robust, catalytic enantioselective method to construct challenging, biologically relevant, tertiary ether stereocenters has been developed. The process capitalizes on readily accessible bis(oxazoline) ligands to control the facial select…
View article: Corrigendum to: “A Novel, Modified Human Butyrylcholinesterase Catalytically Degrades the Chemical Warfare Nerve Agent, Sarin”
Corrigendum to: “A Novel, Modified Human Butyrylcholinesterase Catalytically Degrades the Chemical Warfare Nerve Agent, Sarin” Open
View article: CCDC 2000033: Experimental Crystal Structure Determination
CCDC 2000033: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …