Remya Sreedhar
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View article: Abundance Of Radionuclides And Antibacterial Activity Of Medicinal Plants Against Selected Human Pathogenic Bacteria
Abundance Of Radionuclides And Antibacterial Activity Of Medicinal Plants Against Selected Human Pathogenic Bacteria Open
In the present study few medicinal plants were collected from the Western Ghats. The activity concentration of radionuclides in soil and plant leaves was measured using gamma ray spectrometer. The antimicrobial activity was measured by Aga…
View article: ADDITIVE CYTOTOXIC EFFECT OF CISPLATIN AND ANDROGRAPHIS PANICULATA EXTRACT THROUGH THE MODULATION OF APOPTOTIC MARKERS, CYCLIN-D AND VEGF EXPRESSIONS IN SKOV3 OVARIAN CANCER CELL LINE
ADDITIVE CYTOTOXIC EFFECT OF CISPLATIN AND ANDROGRAPHIS PANICULATA EXTRACT THROUGH THE MODULATION OF APOPTOTIC MARKERS, CYCLIN-D AND VEGF EXPRESSIONS IN SKOV3 OVARIAN CANCER CELL LINE Open
Objective: This study aims to investigate the possibility of additive cytotoxic effects of cisplatin and Andrographis paniculate (Burm. f.) Nees(AP) via apoptotic, cell cycle and angiogenesis pathways. Methods: CC50 cisplatin, AP and Andro…
View article: The onset and the development of cardiometabolic aging: an insight into the underlying mechanisms
The onset and the development of cardiometabolic aging: an insight into the underlying mechanisms Open
Metabolic compromise is crucial in aggravating age-associated chronic inflammation, oxidative stress, mitochondrial damage, increased LDL and triglycerides, and elevated blood pressure. Excessive adiposity, hyperglycemia, and insulin resis…
View article: Brain adaptations of insulin signaling kinases, GLUT 3, p-BADser155 and nitrotyrosine expression in various hypoglycemic models of mice
Brain adaptations of insulin signaling kinases, GLUT 3, p-BADser155 and nitrotyrosine expression in various hypoglycemic models of mice Open
During hypoglycemia, it can be suggested that the brain might decrease glucose metabolism via glycolysis or prefer ketone body metabolism (except the insulin-induced MH in hippocampus) by modifying the p-BADser155 expression. In addition t…
View article: Small molecule disruption of G protein βγ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats
Small molecule disruption of G protein βγ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats Open
The purpose of this study was to determine whether blocking of G protein βγ (Gβγ) signaling halts heart failure (HF) progression by macrophage phenotype manipulation. Cardiac Gβγ signaling plays a crucial role in HF pathogenesis. Previous …
View article: Protective Role of Bokusoku in Dextran Sulphate Sodium Induced Colitis via Inhibition of Epithelial-mesenchymal Transition
Protective Role of Bokusoku in Dextran Sulphate Sodium Induced Colitis via Inhibition of Epithelial-mesenchymal Transition Open
Inflammatory bowel disease (IBD) is referred to as uncontrolled mucosal inflammation resulting from an abnormal immune response against unknown environmental triggers.Fibrosis is considered to be an important feature in the progression of …
View article: Comparative evaluation of torasemide and spironolactone on adverse cardiac remodeling in a rat model of dilated cardiomyopathy
Comparative evaluation of torasemide and spironolactone on adverse cardiac remodeling in a rat model of dilated cardiomyopathy Open
Summary Background Chronic heart failure ( CHF ) involves fluid retention and volume overload, leading to impaired cardiac function. In these conditions, diuretic agents are most commonly used to treat edema and thereby reducing the volume…
View article: Modulation of Macrophage Polarization and HMGB1-TLR2/TLR4 Cascade Plays a Crucial Role for Cardiac Remodeling in Senescence-Accelerated Prone Mice
Modulation of Macrophage Polarization and HMGB1-TLR2/TLR4 Cascade Plays a Crucial Role for Cardiac Remodeling in Senescence-Accelerated Prone Mice Open
The aim of this study was to investigate the role of macrophage polarization in aging heart. Macrophage differentiation is pathogenically linked to many inflammatory and immune disorders. It is often preceded by myocardial inflammation, wh…
View article: Naringenin ameliorates skin inflammation and accelerates phenotypic reprogramming from M1 to M2 macrophage polarization in atopic dermatitis <scp>NC</scp>/Nga mouse model
Naringenin ameliorates skin inflammation and accelerates phenotypic reprogramming from M1 to M2 macrophage polarization in atopic dermatitis <span>NC</span>/Nga mouse model Open
Atopic dermatitis (AD) is a chronic pruritic, inflammatory skin disease caused by various factors. The pathogenesis of AD is a complex mechanism. Patients with AD are sensitive to Dermatophagoides farinae (DfE), and upon exposure, macropha…