Ren Aoki
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View article: Bilateral Macular Coloboma With Eccentric Fixation Confirmed by Microperimetry: A Case Report
Bilateral Macular Coloboma With Eccentric Fixation Confirmed by Microperimetry: A Case Report Open
The purpose of this report is to describe a case of bilateral macular coloboma with eccentric fixation confirmed by microperimetry. A 21-year-old Vietnamese woman presented with bilateral vision loss and was diagnosed with bilateral macula…
View article: The Temporal Distribution and Microbial Spectrum in Infectious Keratitis: A Comprehensive Single-Center Study
The Temporal Distribution and Microbial Spectrum in Infectious Keratitis: A Comprehensive Single-Center Study Open
Purpose: To elucidate pathogen-specific seasonal patterns in infectious keratitis through a comprehensive long-term analysis of microbiologically proven cases in a Japanese tertiary care center. Methods: This retrospective study analyzed 5…
View article: HIF-1α–dependent regulation of angiogenic factor expression in Müller cells by mechanical stimulation
HIF-1α–dependent regulation of angiogenic factor expression in Müller cells by mechanical stimulation Open
Mechanical stress regulates various biological processes in cells, tissues, and organs as well as contributes to the pathogenesis of various diseases. The retina is subjected to mechanical stress imposed by intraocular pressure as well as …
View article: Investigating the seasonality of infectious keratitis by pathogen: A retrospective study
Investigating the seasonality of infectious keratitis by pathogen: A retrospective study Open
This study aimed to investigate the seasonal trends in infectious keratitis by assessing the month of onset and causative microorganisms. Five hundred consecutive cases of infectious keratitis that were diagnosed and treated by a corneal s…
View article: HIF-1α-dependent upregulation of angiogenic factors by mechanical stimulation in retinal pigment epithelial cells
HIF-1α-dependent upregulation of angiogenic factors by mechanical stimulation in retinal pigment epithelial cells Open
Mechanical stimulation as a mimic of drusen formation in the eye increases the expression of angiogenic factors in retinal pigment epithelial (RPE) cells, but the underlying molecular mechanisms remain unclear. We investigated and characte…
Significance of the p38MAPK-CRP2 axis in myofibroblastic phenotypic transition Open
We have recently demonstrated that a LIM domain protein, cysteine and glycine-rich protein 2 (CSRP2 [CRP2]), plays a vital role in the functional expression of myofibroblasts and cancer-associated fibroblasts. CRP2 binds directly to myocar…
Surgical resection of intraorbital metastasis of a gastrointestinal stromal tumor resistant to chemotherapy Open
Orbital metastases in GISTs are extremely rare, and there is no established standard treatment. Therefore, a comprehensive decision must be made based on the final treatment goal and the patient's background when selecting treatment.
Intravitreal Tissue Plasminogen Activator Injection for Treatment-Resistant Diabetic Macular Edema of the Vitrectomized Eye Open
Diabetic macular edema (DME) is the main cause of visual loss in patients with diabetic retinopathy. DME has been treated using intravitreal anti-vascular endothelial growth factor (VEGF) drugs, steroids, laser photocoagulation, vitreoreti…