Ying Wang
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View article: High-fructose diet induces depressive-like behaviors and short-term memory deficits through hippocampal neurogenesis impairment via neural stem cell dysfunction
High-fructose diet induces depressive-like behaviors and short-term memory deficits through hippocampal neurogenesis impairment via neural stem cell dysfunction Open
Background Neural stem cells (NSCs), crucial for brain function and repair, are disrupted by high-fructose diet (HFrD) in proliferation and survival, linking to neurogenesis impairment and neuropsychiatric risks. Mechanistic insights remai…
View article: The role of actin cytoskeleton component Arp2/3 in inflammatory response
The role of actin cytoskeleton component Arp2/3 in inflammatory response Open
Actin regulatory protein plays an important role in immune-related diseases and affects cellular behavior by regulating the dynamic changes of the cytoskeleton. This regulation is crucial for maintaining the fine balance in the body’s biol…
View article: Myocardial histopathology by cardiac biopsy enhances phenotyping of heart failure with preserved ejection fraction
Myocardial histopathology by cardiac biopsy enhances phenotyping of heart failure with preserved ejection fraction Open
Background In patients with heart failure with preserved ejection fraction (HFpEF), studies have described different HFpEF phenogroups based on medical comorbidities and variable echocardiographic, invasive hemodynamic, and biomarker data.…
View article: Effects of Different Pollination Treatments on the Appearance and Cell Development Characteristics of Blueberry Fruit
Effects of Different Pollination Treatments on the Appearance and Cell Development Characteristics of Blueberry Fruit Open
The method of pollination significantly affects the growth and development of blueberry fruit. However, there remains a deficiency in systematic research regarding the impact of various pollination treatments on the cellular structure of b…
View article: Vascular Endothelial Growth Factor B Modulates Cardiac Functions via Ferroptosis Pathways in Post-Myocardial Infarction
Vascular Endothelial Growth Factor B Modulates Cardiac Functions via Ferroptosis Pathways in Post-Myocardial Infarction Open
Myocardial infarction (MI) remains a leading cause of mortality worldwide, yet effective cardioprotective strategies remain limited in clinical settings. Vascular endothelial growth factor B (VEGFB) has emerged as a promising therapeutic c…
View article: Draft genome sequence of <i>Bacillus velezensis</i> strain Cas367 isolated from rhizosphere soil in China
Draft genome sequence of <i>Bacillus velezensis</i> strain Cas367 isolated from rhizosphere soil in China Open
A bacterial strain Bacillus velezensis Cas367 was isolated from the rhizosphere soils of tobacco in China. Here, we present the draft genome sequence of B. velezensis Cas367. The genome comprises a 3,889,832 bp, with G + C contents of 46.4…
View article: Novel tetrameric bispecific KK-LC-1×CD16A-armed memory-like NK cells enhance antitumor efficacy in gastric cancer
Novel tetrameric bispecific KK-LC-1×CD16A-armed memory-like NK cells enhance antitumor efficacy in gastric cancer Open
Background Cytokine-induced memory-like natural killer (CIML NK) cells demonstrate potent antitumor efficacy against hematological malignancies. Nevertheless, the therapeutic potential of adoptive NK cell transfer remains constrained in so…
View article: Ischemic postconditioning ameliorates diabetic cerebral ischemia via activating the brain-derived neurotrophic factor–tropomyosin receptor kinase B–hypoxia-inducible factor 1α–Bcl-2/adenovirus E1B 19-kDa-interacting protein 3 pathway to induce microglial mitophagy and suppress A1 astrocyte-mediated neuroinflammation
Ischemic postconditioning ameliorates diabetic cerebral ischemia via activating the brain-derived neurotrophic factor–tropomyosin receptor kinase B–hypoxia-inducible factor 1α–Bcl-2/adenovirus E1B 19-kDa-interacting protein 3 pathway to induce microglial mitophagy and suppress A1 astrocyte-mediated neuroinflammation Open
Aim Diabetes mellitus exacerbates cerebral ischemic injury. However, effective interventions remain limited. Ischemic postconditioning (IPOC) is a potential neuroprotective strategy; however, its efficacy and mechanisms in diabetes remain …
View article: The regulatory mechanisms and treatment of HDAC6 in immune dysregulation diseases
The regulatory mechanisms and treatment of HDAC6 in immune dysregulation diseases Open
Histone deacetylase 6 (HDAC6) is a class IIb histone deacetylase that contains two catalytic domains and a zinc finger ubiquitin binding domain (ZnF-UBP). The deacetylation function of HDAC6 has been extensively studied with well-character…
View article: Deep learning-based prediction of axillary pathological complete response in patients with breast cancer using longitudinal multiregional ultrasound
Deep learning-based prediction of axillary pathological complete response in patients with breast cancer using longitudinal multiregional ultrasound Open
This study was supported by (1) Noncommunicable Chronic Diseases-National Science and Technology Major Project (No. 2024ZD0531100); (2) Key-Area Research and Development Program of Guangdong Province (No. 2021B0101420006); (3) National Nat…
View article: Senecavirus a can replicate in apical-out porcine intestinal organoids and induce stress granules and innate immune response
Senecavirus a can replicate in apical-out porcine intestinal organoids and induce stress granules and innate immune response Open
Senecavirus A (SVA) causes clinical blistering and ulcerative lesions resembling foot-and-mouth disease (FMD), often with mixed infections that exacerbate the disease and impact pig industry development. SVA has been demonstrated to induce…
View article: Hijacking the Host Cell for Replication: Pro-Viral Host Factors Involved in EVA71 Infection
Hijacking the Host Cell for Replication: Pro-Viral Host Factors Involved in EVA71 Infection Open
Enterovirus A71 (EVA71) is a major pathogen that causes hand, foot, and mouth disease (HFMD). Although the symptoms of HFMD can be self-limiting, severe meningitis, encephalitis, myocarditis, and acute flaccid paralysis may occur. Upon EVA…
View article: ChipSeek-R1: Generating Human-Surpassing RTL with LLM via Hierarchical Reward-Driven Reinforcement Learning
ChipSeek-R1: Generating Human-Surpassing RTL with LLM via Hierarchical Reward-Driven Reinforcement Learning Open
Large Language Models (LLMs) show significant potential for automating Register-Transfer Level (RTL) code generation. However, current approaches face a critical challenge: they can not simultaneously optimize for functional correctness an…
View article: Site‐Blocking Strategy Boosts H <sub>2</sub> S Tolerance in Platinum‐Based Hydrogen Oxidation Catalysts
Site‐Blocking Strategy Boosts H <sub>2</sub> S Tolerance in Platinum‐Based Hydrogen Oxidation Catalysts Open
Proton exchange membrane fuel cells (PEMFCs) show great potential for energy conversion, but their platinum‐based hydrogen oxidation reaction (HOR) catalysts are easily and irreversibly poisoned by trace impurities like H 2 S, causing perf…
View article: Correlation between Noise and Anxiety/Depression in Patients with Haemophiliac Osteoarthropathy after Hip and Knee Replacement
Correlation between Noise and Anxiety/Depression in Patients with Haemophiliac Osteoarthropathy after Hip and Knee Replacement Open
Objective: This study aimed to investigate the correlation between postoperative noise exposure and anxiety/depression in patients with haemophilic osteoarthropathy undergoing hip/knee replacement. Methods: This retrospective study include…
View article: P-576 Zp3 deficiency activate oocyte ferroptosis via XCT/glutathione/GPX4 pathway
P-576 Zp3 deficiency activate oocyte ferroptosis via XCT/glutathione/GPX4 pathway Open
Study question How does Zp3 deficiency lead to oocyte degeneration and infertility? Summary answer Zp3 deficiency leads to zona-pellucida-free oocytes, which impairs communication between oocytes and granulosa cells.This is associated with…
View article: Observation on the Efficacy of Self-formulated Huatan Chushi Zhuyu Decoction in the Treatment of Adenoid Hypertrophy in Children and Literature Research on Traditional Chinese Medicine Treatment
Observation on the Efficacy of Self-formulated Huatan Chushi Zhuyu Decoction in the Treatment of Adenoid Hypertrophy in Children and Literature Research on Traditional Chinese Medicine Treatment Open
To observe the clinical efficacy of the self-formulated Huatan Chushi Zhuyu Decoction (HCZ Decoction) combined with basic Western medical treatment in children with moderate to severe adenoid hypertrophy (AH) accompanied by allergic rhinit…
View article: Proposed Enhancement Plan Towards Quality Health Care and Patient Satisfaction in the Colposcopy Clinic
Proposed Enhancement Plan Towards Quality Health Care and Patient Satisfaction in the Colposcopy Clinic Open
Objective: To assess the correlation between the quality of care in colposcopy clinics and patient satisfaction, and to explore personalized optimization paths based on demographic characteristics. Methods: A cross-sectional study design w…
View article: Hydrophobic residue substitutions enhance the stability and <i>in vivo</i> immunogenicity of respiratory syncytial virus fusion protein
Hydrophobic residue substitutions enhance the stability and <i>in vivo</i> immunogenicity of respiratory syncytial virus fusion protein Open
Respiratory syncytial virus (RSV) entry into host cells is facilitated by viral fusion, wherein the metastable RSV fusion (F) protein undergoes a conformational change from a prefusion state to a highly stable postfusion structure. The pre…
View article: Stenotic Lesions of the Intracranial Arteries in Relation to the Average Level and Variability of the Home Blood Pressure: A Cross-Sectional Study
Stenotic Lesions of the Intracranial Arteries in Relation to the Average Level and Variability of the Home Blood Pressure: A Cross-Sectional Study Open
BACKGROUND This study assessed the presence of intracranial arterial stenosis (ICAS) in relation to home systolic blood pressure (SBP) and its variability (BPV). METHODS In 1510 untreated patients, ICAS was assessed by transcranial Doppler…
View article: Pharmacokinetics and bioequivalence assessment of two prucalopride formulations in healthy Chinese women: a randomized, open-label, two-period, two-sequence, self-crossover study
Pharmacokinetics and bioequivalence assessment of two prucalopride formulations in healthy Chinese women: a randomized, open-label, two-period, two-sequence, self-crossover study Open
Objective This study aimed to evaluate the pharmacokinetic (PK) bioequivalence of generic and branded prucalopride formulations. Methods Twenty-four healthy female subjects were enrolled in both fasted and fed trials, with each subject rec…
View article: Quantitative analysis and pharmacokinetic study of phellopterin in rat plasma by UPLC-MS/MS
Quantitative analysis and pharmacokinetic study of phellopterin in rat plasma by UPLC-MS/MS Open
Phellopterin, a naturally derived furanocoumarin, is widely distributed in medicinal plants like Angelica dahurica and Toddalia asiatica , as well as in citrus fruits. In this experiment, an UPLC-MS/MS bioanalytical method over the concent…
View article: Four-Color Pseudovirus-Based Neutralization Assay: A Rapid Method for Evaluating Neutralizing Antibodies Against Quadrivalent Hand, Foot, and Mouth Disease Vaccine
Four-Color Pseudovirus-Based Neutralization Assay: A Rapid Method for Evaluating Neutralizing Antibodies Against Quadrivalent Hand, Foot, and Mouth Disease Vaccine Open
Background/Objectives: Enterovirus 71 (EV71) and coxsackieviruses A16 (CA16), A10 (CA10), and A6 (CA6) are the primary pathogens that cause hand, foot, and mouth disease (HFMD). Currently, many manufacturers are developing bivalent, trival…