Ren Sun
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View article: Ratio of haemorrhagic area to retinal area as a novel indicator for AI-based screening of diabetic retinopathy in type 2 diabetes: a community-based cross-sectional study
Ratio of haemorrhagic area to retinal area as a novel indicator for AI-based screening of diabetic retinopathy in type 2 diabetes: a community-based cross-sectional study Open
Background The application of artificial intelligence (AI) technology in the screening of diabetic retinopathy (DR) has made significant strides. However, there remains a lack of comprehensive validation and evaluation of AI-derived quanti…
View article: Research Progress on Non-Destructive Testing Technology and Equipment for Poultry Eggshell Quality
Research Progress on Non-Destructive Testing Technology and Equipment for Poultry Eggshell Quality Open
Eggshell quality inspection plays a pivotal role in enhancing the commercial value of poultry eggs and ensuring their safety. It effectively enables the screening of high-quality eggs to meet consumer demand for premium egg products. This …
View article: Permissive central tolerance plus defective peripheral checkpoints license pathogenic memory B cells in CASPR2-antibody encephalitis
Permissive central tolerance plus defective peripheral checkpoints license pathogenic memory B cells in CASPR2-antibody encephalitis Open
Autoantibody-mediated diseases targeting one autoantigen provide a unique opportunity to comprehensively understand the development of disease-causing B cells and autoantibodies. Convention suggests that such autoreactivities are generated…
SAG-YOLO: A Lightweight Real-Time One-Day-Old Chick Gender Detection Method Open
Feather sexing, based on wing feather growth rate, is a widely used method for chick sex identification. However, it still relies on manual sorting, necessitating automation. This study proposes an improved SAG-YOLO method for chick sex de…
View article: Permissive central tolerance plus defective peripheral checkpoints licence pathogenic memory B cells in CASPR2-antibody encephalitis
Permissive central tolerance plus defective peripheral checkpoints licence pathogenic memory B cells in CASPR2-antibody encephalitis Open
Autoimmunity affects 10% of the population. Within this umbrella, autoantibody-mediated diseases targeting one autoantigen provide a unique opportunity to comprehensively understand the developmental pathway of disease-causing B cells and …
View article: Figure S1 from Hyper-Interferon Sensitive Influenza Induces Adaptive Immune Responses and Overcomes Resistance to Anti–PD-1 in Murine Non–Small Cell Lung Cancer
Figure S1 from Hyper-Interferon Sensitive Influenza Induces Adaptive Immune Responses and Overcomes Resistance to Anti–PD-1 in Murine Non–Small Cell Lung Cancer Open
In vitro cell viability assay and the safety profile of HIS
View article: Table S1 from Hyper-Interferon Sensitive Influenza Induces Adaptive Immune Responses and Overcomes Resistance to Anti–PD-1 in Murine Non–Small Cell Lung Cancer
Table S1 from Hyper-Interferon Sensitive Influenza Induces Adaptive Immune Responses and Overcomes Resistance to Anti–PD-1 in Murine Non–Small Cell Lung Cancer Open
Primer sequences for real-time PCR
View article: Figure S2 from Hyper-Interferon Sensitive Influenza Induces Adaptive Immune Responses and Overcomes Resistance to Anti–PD-1 in Murine Non–Small Cell Lung Cancer
Figure S2 from Hyper-Interferon Sensitive Influenza Induces Adaptive Immune Responses and Overcomes Resistance to Anti–PD-1 in Murine Non–Small Cell Lung Cancer Open
HIS inhibits NSCLC tumors growth in mice
View article: Table S2 from Hyper-Interferon Sensitive Influenza Induces Adaptive Immune Responses and Overcomes Resistance to Anti–PD-1 in Murine Non–Small Cell Lung Cancer
Table S2 from Hyper-Interferon Sensitive Influenza Induces Adaptive Immune Responses and Overcomes Resistance to Anti–PD-1 in Murine Non–Small Cell Lung Cancer Open
Flow antibodies and Fixable Viability dye
View article: Figure S3 from Hyper-Interferon Sensitive Influenza Induces Adaptive Immune Responses and Overcomes Resistance to Anti–PD-1 in Murine Non–Small Cell Lung Cancer
Figure S3 from Hyper-Interferon Sensitive Influenza Induces Adaptive Immune Responses and Overcomes Resistance to Anti–PD-1 in Murine Non–Small Cell Lung Cancer Open
In vitro studies with Irf3KO 1940A-KPL, B16F10-ΔS, B16F10-ΔL, B16F10-Jak2KO, B16F10-Jak1KO cell lines
View article: Figure S4 from Hyper-Interferon Sensitive Influenza Induces Adaptive Immune Responses and Overcomes Resistance to Anti–PD-1 in Murine Non–Small Cell Lung Cancer
Figure S4 from Hyper-Interferon Sensitive Influenza Induces Adaptive Immune Responses and Overcomes Resistance to Anti–PD-1 in Murine Non–Small Cell Lung Cancer Open
Gating strategy for flow cytometry and supplementary flow and scRNA-seq data
View article: Data from Hyper-Interferon Sensitive Influenza Induces Adaptive Immune Responses and Overcomes Resistance to Anti–PD-1 in Murine Non–Small Cell Lung Cancer
Data from Hyper-Interferon Sensitive Influenza Induces Adaptive Immune Responses and Overcomes Resistance to Anti–PD-1 in Murine Non–Small Cell Lung Cancer Open
Despite recent advances in immunotherapy with immune checkpoint inhibitors, many patients with non–small cell lung cancer (NSCLC) fail to respond or develop resistance after an initial response. In situ vaccination (ISV) with engineered vi…
View article: Figure S5 from Hyper-Interferon Sensitive Influenza Induces Adaptive Immune Responses and Overcomes Resistance to Anti–PD-1 in Murine Non–Small Cell Lung Cancer
Figure S5 from Hyper-Interferon Sensitive Influenza Induces Adaptive Immune Responses and Overcomes Resistance to Anti–PD-1 in Murine Non–Small Cell Lung Cancer Open
Assessment of synergy and flow phenotyping of immune cells following combination therapy
View article: RETRACTED: The Influence of the Sports Events Industry on Sichuan's Economic Growth
RETRACTED: The Influence of the Sports Events Industry on Sichuan's Economic Growth Open
The sports industry occupies an important position in China's national economy, and the sports event industry is its core industry, and its role in regional economic development has received more and more attention from all parties. This p…
View article: Hyper-Interferon Sensitive Influenza Induces Adaptive Immune Responses and Overcomes Resistance to Anti–PD-1 in Murine Non–Small Cell Lung Cancer
Hyper-Interferon Sensitive Influenza Induces Adaptive Immune Responses and Overcomes Resistance to Anti–PD-1 in Murine Non–Small Cell Lung Cancer Open
Despite recent advances in immunotherapy with immune checkpoint inhibitors, many patients with non–small cell lung cancer (NSCLC) fail to respond or develop resistance after an initial response. In situ vaccination (ISV) with engineered vi…
View article: Structures of Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus virions reveal species-specific tegument and envelope features
Structures of Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus virions reveal species-specific tegument and envelope features Open
Epstein-Barr virus (EBV) and Kaposi’s sarcoma-associated herpesvirus (KSHV) are classified into the gammaherpesvirus subfamily of Herpesviridae , which stands out from its alpha- and betaherpesvirus relatives due to the tumorigenicity of i…
View article: Hepatitis B virus clinical and virologic characteristics in an HIV perinatal transmission study in sub-Saharan Africa
Hepatitis B virus clinical and virologic characteristics in an HIV perinatal transmission study in sub-Saharan Africa Open
Objectives: To describe the clinical and virologic characteristics of HIV−HBV coinfection, including the predictors of high maternal HBV viral load in pregnant women with HIV in sub-Saharan Africa (SSA). Methods: HPTN 046 was a HIV perinat…
View article: Deep mutational scanning of influenza A virus neuraminidase facilitates the identification of drug resistance mutations <i>in vivo</i>
Deep mutational scanning of influenza A virus neuraminidase facilitates the identification of drug resistance mutations <i>in vivo</i> Open
Neuraminidase (NA) is a pivotal surface enzyme and a key therapeutic target in combating the influenza A virus. Its evolution can lead to potential zoonotic transmission, seasonal epidemics, and the emergence of drug-resistant mutants. To …
View article: Integration of Patient-Derived Organoids and Organ-on-Chip Systems: Investigating Colorectal Cancer Invasion within the Mechanical and GABAergic Tumor Microenvironment
Integration of Patient-Derived Organoids and Organ-on-Chip Systems: Investigating Colorectal Cancer Invasion within the Mechanical and GABAergic Tumor Microenvironment Open
Summary Three-dimensional (3D) in vitro models are essential in cancer research, but they often neglect physical forces. In our study, we combined patient-derived tumor organoids with a microfluidic organ-on-chip system to investigate colo…
Martynoside rescues 5-fluorouracil-impaired ribosome biogenesis by stabilizing RPL27A Open
Martynoside (MAR), a bioactive component in several well-known tonic traditional Chinese herbs, exhibits pro-hematopoietic activity during 5-fluorouracil (5-FU) treatment. However, the molecular target and the mechanism of MAR are poorly u…
View article: The genomic and evolutionary landscapes of anaplastic thyroid carcinoma
The genomic and evolutionary landscapes of anaplastic thyroid carcinoma Open
Anaplastic thyroid carcinoma is arguably the most lethal human malignancy. It often co-occurs with differentiated thyroid cancers, yet the molecular origins of its aggressivity are unknown. We sequenced tumor DNA from 329 regions of thyroi…
View article: Development and Practice of Sports-Related Public Welfare Platform Based on Multi-Sensor Technology
Development and Practice of Sports-Related Public Welfare Platform Based on Multi-Sensor Technology Open
Today, more and more Internet public media platforms allowing people to make donations or seek help are being founded in China. However, there are few specialized sports-related public welfare platforms. In this paper, a sports-related pub…