Rena Yadlapati
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View article: Correction: Effectiveness of transoral endoscopic fundoplication with or without hiatal hernia repair in patients with gerd and chronic cough
Correction: Effectiveness of transoral endoscopic fundoplication with or without hiatal hernia repair in patients with gerd and chronic cough Open
View article: Validation of Padova Classification of Post‐Fundoplication Outflow Obstruction on High‐Resolution Manometry in an International Multi‐Center Study
Validation of Padova Classification of Post‐Fundoplication Outflow Obstruction on High‐Resolution Manometry in an International Multi‐Center Study Open
Background Dysphagia after laparoscopic Nissen fundoplication (LNF) is common and may be due to post‐fundoplication outflow obstruction (PFOO) as defined by high‐resolution manometry (HRM) using the Padova Classification. This study aimed …
View article: Vonoprazan Improves Nocturnal Gastroesophageal Reflux Symptoms in Nonerosive Reflux Disease
Vonoprazan Improves Nocturnal Gastroesophageal Reflux Symptoms in Nonerosive Reflux Disease Open
INTRODUCTION: This analysis of a phase 3 randomized trial evaluated the efficacy of vonoprazan on prespecified end points for nighttime symptoms in patients with nonerosive reflux disease. METHODS: Adults with heartburn ≥4 d/wk and without…
View article: Guide to Endoscope Selection for Peroral Endoscopic Myotomy Procedures
Guide to Endoscope Selection for Peroral Endoscopic Myotomy Procedures Open
View article: pH Impedance Monitoring on Proton Pump Inhibitor Therapy Impacts Management Decisions in Proven GERD but Not in Unproven GERD
pH Impedance Monitoring on Proton Pump Inhibitor Therapy Impacts Management Decisions in Proven GERD but Not in Unproven GERD Open
View article: Review Article: Individualised Management of Reflux‐Like Symptoms—Strategies Beyond Acid Suppression
Review Article: Individualised Management of Reflux‐Like Symptoms—Strategies Beyond Acid Suppression Open
Background Reflux‐like symptoms and reflux oesophagitis are often perceived as having the same acid‐related aetiology and responsiveness to antisecretory therapy. However, the frequency of residual symptom reporting on proton pump inhibito…
View article: American Foregut Society White Paper Report on the Use of Potassium-Competitive Acid Blockers in the Treatment of Gastroesophageal Reflux Disease
American Foregut Society White Paper Report on the Use of Potassium-Competitive Acid Blockers in the Treatment of Gastroesophageal Reflux Disease Open
Background: Suppression of gastric acid secretion with proton pump inhibitors (PPIs) has been the mainstay of medical treatment for gastroesophageal reflux disease (GERD) for more than 30 years. Members of a newer class of medication, the …
View article: Management of Patients With Refractory Reflux‐Like Symptoms Despite Proton Pump Inhibitor Therapy: Evidence‐Based Consensus Statements
Management of Patients With Refractory Reflux‐Like Symptoms Despite Proton Pump Inhibitor Therapy: Evidence‐Based Consensus Statements Open
Background Many patients diagnosed with gastro‐oesophageal reflux disease (GERD) have persistent symptoms despite proton pump inhibitor (PPI) therapy. Aims The aim of this consensus is to provide evidence‐based statements to guide clinicia…
View article: International Validation of a Novel PEACE Scale to Improve the Quality of Upper Gastrointestinal Mucosal Inspection During Endoscopy
International Validation of a Novel PEACE Scale to Improve the Quality of Upper Gastrointestinal Mucosal Inspection During Endoscopy Open
INTRODUCTION: The performance of a high quality esophagogastroduodenoscopy (EGD) is dependent on the mucosal cleanliness. Recently, the Polprep: Effective Assessment of Cleanliness in EGD (PEACE) scale was created to assess the degree of m…
View article: Authors' Reply to Letter—Role of Prokinetics in Ineffective Esophageal Motility: A Call for Broader Consideration and Future Innovations
Authors' Reply to Letter—Role of Prokinetics in Ineffective Esophageal Motility: A Call for Broader Consideration and Future Innovations Open
View article: Neoplastic Progression Risk in Females With Barrett’s Esophagus: A Systematic Review and Meta-Analysis of Individual Patient Data
Neoplastic Progression Risk in Females With Barrett’s Esophagus: A Systematic Review and Meta-Analysis of Individual Patient Data Open
Although females had a lower neoplastic progression risk, sex differences were smaller than previously reported, and time to progression was similar for both sexes. Future research should focus on other factors than sex to identify low- an…
View article: 493. EFFECTIVENESS OF TRANSORAL INCISIONLESS FUNDOPLICATION (TIF) WITHOUT OR WITH HIATAL HERNIA REPAIR (CTIF) IN PATIENTS WITH GERD AND CHRONIC COUGH
493. EFFECTIVENESS OF TRANSORAL INCISIONLESS FUNDOPLICATION (TIF) WITHOUT OR WITH HIATAL HERNIA REPAIR (CTIF) IN PATIENTS WITH GERD AND CHRONIC COUGH Open
Background GERD is a common cause of chronic cough. Although barrier therapy with laparoscopic fundoplication is highly effective for typical GERD symptoms, the response rates are variable for chronic cough. We hypothesized that transoral …
View article: The role of hypervigilance in chronic esophageal diseases: a scoping review
The role of hypervigilance in chronic esophageal diseases: a scoping review Open
The role of hypervigilance in symptom reporting has been investigated in multiple esophageal conditions. Findings suggest potential clinical utility in assessing hypervigilance, such as for disease conceptualization and treatment planning.…
View article: Vonoprazan is Efficacious for Treatment of Heartburn in Non-erosive Reflux Disease: A Randomized Trial
Vonoprazan is Efficacious for Treatment of Heartburn in Non-erosive Reflux Disease: A Randomized Trial Open
Vonoprazan reduced heartburn symptoms in subjects diagnosed with non-erosive reflux disease, with the benefit appearing to begin as early as the first day of therapy. Treatment effect persisted after the initial 4-week placebo-controlled p…
View article: Upper Esophageal Sphincter and Esophageal Motility Pathology on Manometry in Retrograde Cricopharyngeal Dysfunction
Upper Esophageal Sphincter and Esophageal Motility Pathology on Manometry in Retrograde Cricopharyngeal Dysfunction Open
Objective There exists a paucity of data regarding the mechanism and manometric findings in retrograde cricopharyngeal dysfunction (RCPD). In this study, we aimed to compare esophageal physiologic findings between patients with RCPD compar…
View article: Behavioral Therapy for Functional Heartburn: Recommendation Statements
Behavioral Therapy for Functional Heartburn: Recommendation Statements Open
View article: Validation of the Laryngeal Cognitive-Affective Tool
Validation of the Laryngeal Cognitive-Affective Tool Open
View article: Validated Clinical Score to Predict Gastroesophageal Reflux in Patients With Chronic Laryngeal Symptoms: COuGH RefluX
Validated Clinical Score to Predict Gastroesophageal Reflux in Patients With Chronic Laryngeal Symptoms: COuGH RefluX Open
The externally validated COuGH RefluX score is a clinically practical model to predict the likelihood of proven GERD. The score classifies most patients with chronic laryngeal symptoms as low/high likelihood of proven GERD, with only 38% r…
View article: Esophagogastric Junction Outflow Obstruction: A Diagnosis in Evolution.
Esophagogastric Junction Outflow Obstruction: A Diagnosis in Evolution. Open
Esophagogastric junction outflow obstruction (EGJOO) is a rapidly evolving diagnosis that can represent early or variant achalasia. Since the publication of the Chicago Classification version 4.0, the criteria for this diagnosis have been …
View article: High Diagnostic Yield of Abnormal Endoscopic Findings in the Evaluation of Laryngopharyngeal Reflux
High Diagnostic Yield of Abnormal Endoscopic Findings in the Evaluation of Laryngopharyngeal Reflux Open
Esophagogastroduodenoscopy (EGD) is recommended in patients with typical gastroesophageal reflux disease (GERD) symptoms (heartburn, regurgitation, chest pain) in the setting of proton pump inhibitor (PPI) nonresponse. EGD evaluates for er…
View article: Review article: Diagnosis and management of laryngopharyngeal reflux
Review article: Diagnosis and management of laryngopharyngeal reflux Open
Summary Background Laryngopharyngeal reflux has classically referred to gastroesophageal reflux leading to chronic laryngeal symptoms such as throat clearing, dysphonia, cough, globus sensation, sore throat or mucus in the throat. Current …
View article: Proton Pump Inhibitors: Rational Use and Use-Reduction – The Windsor Workshop
Proton Pump Inhibitors: Rational Use and Use-Reduction – The Windsor Workshop Open
Background: Despite deprescribing initiatives to curb overutilization of proton pump inhibitors (PPIs), achieving meaningful reductions in PPI use is proving a challenge. Summary: An international group of prima…
View article: Esophageal anatomy and physiology vary across spastic and non‐spastic phenotypes of disorders of esophagogastric junction outflow
Esophageal anatomy and physiology vary across spastic and non‐spastic phenotypes of disorders of esophagogastric junction outflow Open
Background Pathophysiologic mechanisms of disorders of esophagogastric junction (EGJ) outflow are poorly understood. We aimed to compare anatomic and physiologic characteristics among patients with disorders of EGJ outflow and normal motil…
View article: Management advice for patients with reflux-like symptoms: an evidence-based consensus
Management advice for patients with reflux-like symptoms: an evidence-based consensus Open
Patients with reflux-like symptoms (heartburn and regurgitation) are often not well advised on implementing individualised strategies to help control their symptoms using dietary changes, lifestyle modifications, behavioural changes or fas…
View article: Incidence of Esophageal Adenocarcinoma Among Symptomatic Reflux Patients Without Erosive Disease on Endoscopy is Similar to the General Population
Incidence of Esophageal Adenocarcinoma Among Symptomatic Reflux Patients Without Erosive Disease on Endoscopy is Similar to the General Population Open
View article: Optimizing the Management Algorithm for Esophageal Dysphagia After Index Endoscopy: Cost-Effectiveness and Cost-Minimization Analysis
Optimizing the Management Algorithm for Esophageal Dysphagia After Index Endoscopy: Cost-Effectiveness and Cost-Minimization Analysis Open
INTRODUCTION: Guidelines advise esophageal motility testing for dysphagia when structural disorders are ruled out, but cost concerns impede adoption. We evaluated cost-effective positioning of esophageal motility testing in the algorithm t…
View article: A Linked Electronic Medical Record-Claims Analysis of the Clinical and Economic Outcomes of Patients Coded for Erosive Esophagitis in the United States
A Linked Electronic Medical Record-Claims Analysis of the Clinical and Economic Outcomes of Patients Coded for Erosive Esophagitis in the United States Open
Patients with EE are commonly treated with prescription PPIs; however, 19.0% of patients cycled through multiple PPIs. Higher PPI use was associated with a higher comorbidity burden and higher healthcare costs compared to 0 PPI use.
View article: Randomised clinical trial: Efficacy and safety of <scp>on‐demand</scp> vonoprazan versus placebo for non‐erosive reflux disease
Randomised clinical trial: Efficacy and safety of <span>on‐demand</span> vonoprazan versus placebo for non‐erosive reflux disease Open
Summary Background Non‐erosive reflux disease (NERD) symptoms are often episodic, making on‐demand treatment an attractive treatment approach. Aims We compared the efficacy and safety of on‐demand vonoprazan versus placebo in patients with…
View article: Healthcare costs among patients with newly diagnosed <i>helicobacter pylori</i> infection in the United States: a linked claims-EHR study
Healthcare costs among patients with newly diagnosed <i>helicobacter pylori</i> infection in the United States: a linked claims-EHR study Open
The healthcare costs of patients with HP are partially confounded by their burden of high-cost comorbidities. In the subset of patients with available results, confirmed vs. failed eradication of HP was associated with short-term cost offs…
View article: Updates to the modern diagnosis of GERD: Lyon consensus 2.0
Updates to the modern diagnosis of GERD: Lyon consensus 2.0 Open
The Lyon Consensus provides conclusive criteria for and against the diagnosis of gastro-oesophageal reflux disease (GERD), and adjunctive metrics that consolidate or refute GERD diagnosis when primary criteria are borderline or inconclusiv…