Renan Marinho Braga
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View article: Umbelliferone presents orofacial antinociceptive and anti-inflammatory activity via reduction of TNF-α in mice
Umbelliferone presents orofacial antinociceptive and anti-inflammatory activity via reduction of TNF-α in mice Open
Pain is a normal response of the central nervous system to trauma, infections, neoplasms, neuropathies, and inflammation. It can arise from physical, emotional, or cognitive conditions, and is classified as orofacial pain when it affects t…
View article: A 9-aminoacridine derivative induces growth inhibition of Ehrlich ascites carcinoma cells and antinociceptive effect in mice
A 9-aminoacridine derivative induces growth inhibition of Ehrlich ascites carcinoma cells and antinociceptive effect in mice Open
Acridine derivatives have been found with anticancer and antinociceptive activities. Herein, we aimed to evaluate the toxicological, antitumor, and antinociceptive actions of N’-(6-chloro-2-methoxyacridin-9-yl)-2-cyanoacetohydrazide (ACS-A…
View article: Dispensação dos produtos medicamentosos derivados da Cannabis sativa L. em uma associação no município de João Pessoa-PB entre julho e dezembro de 2020
Dispensação dos produtos medicamentosos derivados da Cannabis sativa L. em uma associação no município de João Pessoa-PB entre julho e dezembro de 2020 Open
O estudo objetivou analisar a dispensação de fármacos derivados da C. sativa L. em uma Associação no município de João Pessoa-PB. Trata-se de um estudo descritivo, exploratório com abordagem quantitativa, no qual foram coletados os relatór…
View article: Analgesic-like activity of perillyl acetate
Analgesic-like activity of perillyl acetate Open
Objective: To evaluate the antinociceptive activity of perillyl acetate in mice and in silico simulations. Methods: The vehicle, perillyl acetate (100, 150 and/or 200 mg/ kg, i.p.) , diazepam (2 mg/kg, i.p.) or morphine (6 mg/kg, i.p.) was…
View article: Orofacial antinociceptive effects of perillyl alcohol associated with codeine and its possible modes of action
Orofacial antinociceptive effects of perillyl alcohol associated with codeine and its possible modes of action Open
This study evaluated the orofacial antinociceptive effect of (S)-(-)-perillyl alcohol (PA) associated with codeine (C) and investigated the possible molecular anchorage mechanisms of PA. Mice (n = 5 per group) were treated with PA alone an…
View article: Orofacial antinociceptive effects of perillyl alcohol associated with codeine and its possible modes of action
Orofacial antinociceptive effects of perillyl alcohol associated with codeine and its possible modes of action Open
This study evaluated the orofacial antinociceptive effect of (S)-(-)-perillyl alcohol (PA) associated with codeine (C) and investigated the possible molecular anchorage mechanisms of PA. Mice (n = 5 per group) were treated with PA alone an…
View article: Antinociceptive and anti-inflammatory effect of Lippia pedunculosa Hayek essential oil and its β-cyclodextrin inclusion complex
Antinociceptive and anti-inflammatory effect of Lippia pedunculosa Hayek essential oil and its β-cyclodextrin inclusion complex Open
Lippia pedunculosa Hayek (EOLp) presents tripanocid and amebicid effects. However essential oil needs to be further studied in experimental models of analgesia and inflammation once the prevalence of pain in the population generates great …
View article: RMD86, a thiophene derivative, promotes antinociceptive and antipyretic activities in mice
RMD86, a thiophene derivative, promotes antinociceptive and antipyretic activities in mice Open
View article: Antinociceptive Activity of Chemical Components of Essential Oils That Involves Docking Studies: A Review
Antinociceptive Activity of Chemical Components of Essential Oils That Involves Docking Studies: A Review Open
The studies revealed that through the advancement of more robust computational techniques that complement the experimental studies, they may allow some notes on the identification of a new candidate molecule for therapeutic use.
View article: Anxiolytic and antinociceptive-like effects of cinnamic alcohol by possible GABAergic pathway modulation: In vivo and in silico studies
Anxiolytic and antinociceptive-like effects of cinnamic alcohol by possible GABAergic pathway modulation: In vivo and in silico studies Open
View article: Orofacial antinociceptive activity and anchorage molecular mechanism in silico of geraniol
Orofacial antinociceptive activity and anchorage molecular mechanism in silico of geraniol Open
We aimed to evaluate the orofacial antinociceptive effect of geraniol in mice and its molecular anchorage mechanism. Seven mice per group (probabilistic sample) were treated with geraniol (12.5, 25 and 50 mg/kg, i.p.), morphine (6 mg/kg, i…
View article: 2-Allylphenol Reduces IL-1<i>β</i>and TNF-<i>α</i>, Promoting Antinociception through Adenosinergic, Anti-Inflammatory, and Antioxidant Mechanisms
2-Allylphenol Reduces IL-1<i>β</i>and TNF-<i>α</i>, Promoting Antinociception through Adenosinergic, Anti-Inflammatory, and Antioxidant Mechanisms Open
2-Allylphenol (2-AP) is a synthetic phenylpropanoid, structurally related to cardanol, thymol, and ortho-eugenol. Phenylpropanoids are described in the literature as being capable of promoting biological activity. Due to the similarity bet…
View article: Effects of bark flour of Passiflora edulis on food intake, body weight and behavioral response of rats
Effects of bark flour of Passiflora edulis on food intake, body weight and behavioral response of rats Open
Effects of treatment with the bark flour of Passiflora edulis Sims, Passifloraceae, were evaluated. Adult male Wistar rats were treated for 30 days (130 mg/kg, p.o.) with the albedo flour, flavedo and full bark of P. edulis, corresponding …
View article: Avaliação da atividade antinociceptiva e anti-Inflamatória do óleo essencial de Lippia pedunculosa
Avaliação da atividade antinociceptiva e anti-Inflamatória do óleo essencial de Lippia pedunculosa Open
Pain is a relevant homeostasis element, its main role is to warn about stimuli that can cause tissue damage, allowing that defense or escape mechanisms are adopted. Although numerous substances and progress in the development of pain contr…
View article: Comparative Anticonvulsant Study of Epoxycarvone Stereoisomers
Comparative Anticonvulsant Study of Epoxycarvone Stereoisomers Open
Stereoisomers of the monoterpene epoxycarvone (EC), namely (+)-cis-EC, (−)-cis-EC, (+)-trans-EC, and (−)-trans-EC, were comparatively evaluated for anticonvulsant activity in specific methodologies. In the pentylenetetrazole (PTZ)-induced …