Renata Priscila Barros de Menezes
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View article: Structure‐Based Screening of Amides with Potential to Overcome <i>Aedes aegypti</i> Insecticide Resistance
Structure‐Based Screening of Amides with Potential to Overcome <i>Aedes aegypti</i> Insecticide Resistance Open
Several natural and synthetic compounds applied as insecticides are amide derivatives. Within the broad spectrum of insecticidal activity of this class of compounds, the activity against Aedes aegypti stands out. The aim of this study was …
View article: Predicting the Anti-SARS-CoV-2 Potential of Isoquinoline Alkaloids from Brazilian Siparunaceae Species Using Chemometric Tools
Predicting the Anti-SARS-CoV-2 Potential of Isoquinoline Alkaloids from Brazilian Siparunaceae Species Using Chemometric Tools Open
The COVID-19 pandemic has caused over 7 million deaths globally in the past four years. Siparuna spp. (Siparunaceae), which is used in Brazilian folk medicine, is considered a genus with potential antiviral alternatives. This study explore…
View article: Guanidines Conjugated with Cell-Penetrating Peptides: A New Approach for the Development of Antileishmanial Molecules
Guanidines Conjugated with Cell-Penetrating Peptides: A New Approach for the Development of Antileishmanial Molecules Open
Leishmaniasis is a neglected tropical disease caused by a protozoan of the genus Leishmania, which has visceral and cutaneous forms. The symptoms of leishmaniasis include high fever and weakness, and the cutaneous infection also causes les…
View article: Novel Indole-Based Marinoquinolines as Promising Candidates Against Toxoplasma Gondii
Novel Indole-Based Marinoquinolines as Promising Candidates Against Toxoplasma Gondii Open
View article: First Description of Marinoquinoline Derivatives’ Activity against Toxoplasma gondii
First Description of Marinoquinoline Derivatives’ Activity against Toxoplasma gondii Open
Toxoplasmosis is a globally prevalent zoonotic disease with significant clinical implications, including neurotoxoplasmosis, a leading cause of cerebral lesions in AIDS patients. The current pharmacological treatments for toxoplasmosis fac…
View article: APRENDIZADO DE MÁQUINA APLICADO A QSAR
APRENDIZADO DE MÁQUINA APLICADO A QSAR Open
MACHINE LEARNING APLLIED TO QSAR. Over the years the study of the quantitative structure-activity relationship (QSAR) has transformed from a simple regression analysis to the implementation of machine learning (ML) with multiple statistics…
View article: ALCALOIDES SESQUITERPÊNICOS ISOLADOS DE Maytenus distichophylla (CELASTRACEAE)
ALCALOIDES SESQUITERPÊNICOS ISOLADOS DE Maytenus distichophylla (CELASTRACEAE) Open
SESQUITERPENES ALKALOIDS FROM Maytenus distichophylla (CELASTRACEAE). The phytochemical study of the roots of Maytenus distichophylla Mart. ex Reissek (Celastraceae), resulted in the isolation of the seven sesquiterpenes pyridine alkaloids…
View article: Anti-<i>Toxoplasma gondii</i> screening of MMV pandemic response box and evaluation of RWJ-67657 efficacy in chronically infected mice
Anti-<i>Toxoplasma gondii</i> screening of MMV pandemic response box and evaluation of RWJ-67657 efficacy in chronically infected mice Open
Toxoplasmosis is a significant public health concern with limited therapeutic options. The medicines for malaria venture (MMV) developed the pandemic response box (PRB) containing 400 drug-like molecules with broad pathogen activity. The a…
View article: Methyleugenol Has an Antidepressant Effect in a Neuroendocrine Model: In Silico and In Vivo Evidence
Methyleugenol Has an Antidepressant Effect in a Neuroendocrine Model: In Silico and In Vivo Evidence Open
Major depressive disorder is a severe mood disorder characterized by different emotions and feelings. This study investigated the antidepressant activity of the phenylpropanoid methyleugenol (ME) in adult female mice exposed to a stress mo…
View article: Repurposing the Medicines for Malaria Venture’s COVID Box to discover potent inhibitors of Toxoplasma gondii, and in vivo efficacy evaluation of almitrine bismesylate (MMV1804175) in chronically infected mice
Repurposing the Medicines for Malaria Venture’s COVID Box to discover potent inhibitors of Toxoplasma gondii, and in vivo efficacy evaluation of almitrine bismesylate (MMV1804175) in chronically infected mice Open
Toxoplasmosis, caused by the obligate intracellular parasite Toxoplasma gondii , affects about one-third of the world’s population and can cause severe congenital, neurological and ocular issues. Current treatment options are limited, and …
View article: Kaurane-Type Diterpenoids as Potential Inhibitors of Dihydrofolate Reductase-Thymidylate Synthase in New World Leishmania Species
Kaurane-Type Diterpenoids as Potential Inhibitors of Dihydrofolate Reductase-Thymidylate Synthase in New World Leishmania Species Open
The bifunctional enzyme Dihydrofolate reductase-thymidylate synthase (DHFR-TS) plays a crucial role in the survival of the Leishmania parasite, as folates are essential cofactors for purine and pyrimidine nucleotide biosynthesis. However, …
View article: Discovery of novel acetylcholinesterase inhibitors through integration of machine learning with genetic algorithm based in silico screening approaches
Discovery of novel acetylcholinesterase inhibitors through integration of machine learning with genetic algorithm based in silico screening approaches Open
Introduction Alzheimer’s disease (AD) is the most studied progressive eurodegenerative disorder, affecting 40–50 million of the global population. This progressive neurodegenerative disease is marked by gradual and irreversible declines in…
View article: Selene-Ethylenelacticamides and N-Aryl-Propanamides as Broad-Spectrum Leishmanicidal Agents
Selene-Ethylenelacticamides and N-Aryl-Propanamides as Broad-Spectrum Leishmanicidal Agents Open
The World Health Organization classifies Leishmania as one of the 17 “neglected diseases” that burden tropical and sub-tropical climate regions with over half a million diagnosed cases each year. Despite this, currently available anti-leis…
View article: Virtual Screening Based on Ligand and Structure with in vitro Assessment of Neolignans against Trypanosoma cruzi
Virtual Screening Based on Ligand and Structure with in vitro Assessment of Neolignans against Trypanosoma cruzi Open
Chagas disease, caused by the parasite Trypanosoma cruzi, occurs most commonly in Latin America. As the treatment is highly toxic and ineffective in the chronic phase of the disease, alternative treatments are needed. Through quantitative …
View article: Review on Compounds Isolated from Eriocaulaceae Family and Evaluation of Biological Activities by Machine Learning
Review on Compounds Isolated from Eriocaulaceae Family and Evaluation of Biological Activities by Machine Learning Open
Eriocaulaceae is a pantropical family whose main center of biodiversity is in Brazil. In general, the family has about 1200 species, in which phytochemical and biological studies have shown a variety of structures and activities. The aim o…
View article: Virtual Screening Based on Ligand and Structure with in vitro Assessment of Neolignans against Trypanosoma cruzi
Virtual Screening Based on Ligand and Structure with in vitro Assessment of Neolignans against Trypanosoma cruzi Open
Chagas disease, caused by the parasite Trypanosoma cruzi, occurs most commonly in Latin America. As the treatment is highly toxic and ineffective in the chronic phase of the disease, alternative treatments are needed. Through quantitative …
View article: Annonaceae Terpenoids as Potential Leishmanicidal Agents
Annonaceae Terpenoids as Potential Leishmanicidal Agents Open
View article: Machine Learning Analysis of Essential Oils from Cuban Plants: Potential Activity against Protozoa Parasites
Machine Learning Analysis of Essential Oils from Cuban Plants: Potential Activity against Protozoa Parasites Open
Essential oils (EOs) are a mixture of chemical compounds with a long history of use in food, cosmetics, perfumes, agricultural and pharmaceuticals industries. The main object of this study was to find chemical patterns between 45 EOs and a…
View article: Computer-Assisted Discovery of Alkaloids with Schistosomicidal Activity
Computer-Assisted Discovery of Alkaloids with Schistosomicidal Activity Open
Schistosomiasis is a chronic parasitic disease caused by trematodes of the genus Schistosoma; it is commonly caused by Schistosoma mansoni, which is transmitted by Bioamphalaria snails. Studies show that more than 200 million people are in…
View article: Sidastrum paniculatum (L.) Fryxell (Malvaceae): A Promising Source of Bioactive Sulfated Flavonoids Against Aedes aegypti L
Sidastrum paniculatum (L.) Fryxell (Malvaceae): A Promising Source of Bioactive Sulfated Flavonoids Against Aedes aegypti L Open
Aedes aegypti L. is known as the most relevant vector mosquito for viruses such as yellow fever, chikungunya, dengue, and Zika, especially in places with unplanned urbanization, and erratic water supply. Plants used in folk medicine have b…
View article: Oxazolidine Compounds from Neocalytrocalyx Longifolium (Capparaceae) and Their Activity as Msra (ABC) Efflux Pump Inhibitors: An in Vitro and in Silico Approach
Oxazolidine Compounds from Neocalytrocalyx Longifolium (Capparaceae) and Their Activity as Msra (ABC) Efflux Pump Inhibitors: An in Vitro and in Silico Approach Open
View article: DITERPENOS ENT-ABIETANOS DE Euphorbia phosphorea (EUPHORBIACEAE)
DITERPENOS ENT-ABIETANOS DE Euphorbia phosphorea (EUPHORBIACEAE) Open
ENT-ABIETANE DITERPENES FROM Euphorbia phosphorea (EUPHORBIACEAE). Phytochemical study of the roots of Euphorbia phosphorea Mart. (Euphorbiaceae) was carried out through chromatographic techniques, resulting in the isolation of a new ent-a…
View article: ENT-ABIETANE DITERPENES FROM Euphorbia phosphorea (EUPHORBIACEAE)
ENT-ABIETANE DITERPENES FROM Euphorbia phosphorea (EUPHORBIACEAE) Open
Phytochemical study of the roots of Euphorbia phosphorea Mart. (Euphorbiaceae) was carried out through chromatographic techniques, resulting in the isolation of a new ent-abietane diterpene named 11β,12β-dihydroxy-ent-abieta-8(14),13(15)-d…
View article: Ligand-Based and Structure-based virtual screening for the discovery of natural larvicidal against &lt;em&gt;Aedes aegypti&lt;/em&gt;
Ligand-Based and Structure-based virtual screening for the discovery of natural larvicidal against <em>Aedes aegypti</em> Open
The Aedes aegypti mosquito belongs to the order Diptera and is one of the main vectors of transmission of etiological agents that cause several diseases. This mosquito can transmit diseases such as dengue, yellow fever, Zika, chikungunya, …
View article: Secondary Metabolites Extracted from Annonaceae and Chemotaxonomy Study of Terpenoids
Secondary Metabolites Extracted from Annonaceae and Chemotaxonomy Study of Terpenoids Open
The Annonaceae family of plants is one of the most anatomically and structurally uniform families. Chemotaxonomy is a common practice to determine the chemical patterns within these families at different phylogenetic levels. The aim of thi…