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View article: Data from Autocrine TGFβ Is a Survival Factor for Monocytes and Drives Immunosuppressive Lineage Commitment
Data from Autocrine TGFβ Is a Survival Factor for Monocytes and Drives Immunosuppressive Lineage Commitment Open
Transforming growth factor β (TGFβ) is an effector of immune suppression and contributes to a permissive tumor microenvironment that compromises effective immunotherapy. We identified a correlation between TGFB1 and genes expressed by myel…
View article: Supplementary Data from Autocrine TGFβ Is a Survival Factor for Monocytes and Drives Immunosuppressive Lineage Commitment
Supplementary Data from Autocrine TGFβ Is a Survival Factor for Monocytes and Drives Immunosuppressive Lineage Commitment Open
Supplemental tables and figures
View article: Supplementary Data from Autocrine TGFβ Is a Survival Factor for Monocytes and Drives Immunosuppressive Lineage Commitment
Supplementary Data from Autocrine TGFβ Is a Survival Factor for Monocytes and Drives Immunosuppressive Lineage Commitment Open
Supplemental tables and figures
View article: Data from Autocrine TGFβ Is a Survival Factor for Monocytes and Drives Immunosuppressive Lineage Commitment
Data from Autocrine TGFβ Is a Survival Factor for Monocytes and Drives Immunosuppressive Lineage Commitment Open
Transforming growth factor β (TGFβ) is an effector of immune suppression and contributes to a permissive tumor microenvironment that compromises effective immunotherapy. We identified a correlation between TGFB1 and genes expressed by myel…
View article: Supplementary Figure S7. The absence of STING (or p53 or p21) leads to increase in BUB1 and MAD2L1 expression. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability
Supplementary Figure S7. The absence of STING (or p53 or p21) leads to increase in BUB1 and MAD2L1 expression. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability Open
(A-C) BrdU/PI cell cycle profile of MEFs (A), p53-/- HCT116 (B), and CDKN1A-depleted HCT116 cells (C) at 24 hours post-IR. Flow cytometry was used to measure the percent cell population in G1, S, and G2/M phase of single cells stained with…
View article: Supplementary Figure S6. Ionizing radiation induces micronuclei formation in both WT and STING-/- MEFs. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability
Supplementary Figure S6. Ionizing radiation induces micronuclei formation in both WT and STING-/- MEFs. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability Open
WT and STING-/- MEFs examined by cytokinesis-block micronucleus (CBMN) assay by treatment with IR, then cytochalasin at 24 hours and then fixed and stained for DNA and mitochondrial/cytoplasmic compartments using Draq5 and MitoTracker Red …
View article: Supplementary Figure S8. WEE1 inhibitor in combination with IR inhibits cellular proliferation of normal and tumor cells. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability
Supplementary Figure S8. WEE1 inhibitor in combination with IR inhibits cellular proliferation of normal and tumor cells. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability Open
(A) Quantification of bands from Western gel shown in Main Figure 5D using Image J. The pixel units obtained for each protein band was normalized to the pixel units calculated from their respective b-Actin loading control. (B-E) Kinetic an…
View article: Supplementary Figure S4. STING is upstream of CDKN1A signaling, but only has partial control of CDKN1A. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability
Supplementary Figure S4. STING is upstream of CDKN1A signaling, but only has partial control of CDKN1A. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability Open
(A-D) Quantification of bands from Western gels shown in Main Figures 3H (A), 3I (B), 3J (C), and 3K (D) using Image J. The pixel units obtained for each protein band was normalized to the pixel units calculated from their respective b-Act…
View article: Supplementary Figure S5. Quantification of Western blot bands using Image J. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability
Supplementary Figure S5. Quantification of Western blot bands using Image J. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability Open
The pixel units obtained for each protein band from Western gels shown in Main Figures 4B (A), 4C (B), 4D (C), and 4E (D) was normalized to the pixel units calculated from their respective b-Actin loading control. For phosphorylated protei…
View article: Supplementary Figure S1. shRNA constructs targeting STING have varying effects on different tumor cell lines. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability
Supplementary Figure S1. shRNA constructs targeting STING have varying effects on different tumor cell lines. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability Open
Western blot analysis of multiple stable D54 (A), HCT116 (B), and MC-38 (C) cell lines expressing short hairpin RNAs targeting STING or scrambled control (SHCOO2). Quantified bands are shown below each of their respective Western blot pane…
View article: Supplementary Figure S3. STING confers radiosensitivity in a variety of human and mice cell lines. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability
Supplementary Figure S3. STING confers radiosensitivity in a variety of human and mice cell lines. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability Open
(A) Quantification of bands from Western gel shown in Main Figure 3A using Image J. The pixel units obtained for each protein band was normalized to the pixel units calculated from their respective b-Actin loading control. (B-G) Clonogenic…
View article: Supplementary Figure S2. STING-dependent regulation of proliferation is associated with perturbations of cell cycle. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability
Supplementary Figure S2. STING-dependent regulation of proliferation is associated with perturbations of cell cycle. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability Open
Cell cycle profile of pulse EdU-labeled (A) and chase EdU-labeled (B) WT and STING-/- MEFs at different time points post-IR treatment. Flow cytometry was used to measure the percent cell population in G1, S, and G2/M phase of single cells …
View article: Data from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability
Data from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability Open
Given the integral role of stimulator of interferon genes (STING, TMEM173) in the innate immune response, its loss or impairment in cancer is thought to primarily affect antitumor immunity. Here we demonstrate a role for STING in the maint…
View article: Supplementary Figure S3. STING confers radiosensitivity in a variety of human and mice cell lines. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability
Supplementary Figure S3. STING confers radiosensitivity in a variety of human and mice cell lines. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability Open
(A) Quantification of bands from Western gel shown in Main Figure 3A using Image J. The pixel units obtained for each protein band was normalized to the pixel units calculated from their respective b-Actin loading control. (B-G) Clonogenic…
View article: Supplementary Figure S6. Ionizing radiation induces micronuclei formation in both WT and STING-/- MEFs. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability
Supplementary Figure S6. Ionizing radiation induces micronuclei formation in both WT and STING-/- MEFs. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability Open
WT and STING-/- MEFs examined by cytokinesis-block micronucleus (CBMN) assay by treatment with IR, then cytochalasin at 24 hours and then fixed and stained for DNA and mitochondrial/cytoplasmic compartments using Draq5 and MitoTracker Red …
View article: Supplementary Figure S7. The absence of STING (or p53 or p21) leads to increase in BUB1 and MAD2L1 expression. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability
Supplementary Figure S7. The absence of STING (or p53 or p21) leads to increase in BUB1 and MAD2L1 expression. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability Open
(A-C) BrdU/PI cell cycle profile of MEFs (A), p53-/- HCT116 (B), and CDKN1A-depleted HCT116 cells (C) at 24 hours post-IR. Flow cytometry was used to measure the percent cell population in G1, S, and G2/M phase of single cells stained with…
View article: Supplementary Figure S1. shRNA constructs targeting STING have varying effects on different tumor cell lines. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability
Supplementary Figure S1. shRNA constructs targeting STING have varying effects on different tumor cell lines. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability Open
Western blot analysis of multiple stable D54 (A), HCT116 (B), and MC-38 (C) cell lines expressing short hairpin RNAs targeting STING or scrambled control (SHCOO2). Quantified bands are shown below each of their respective Western blot pane…
View article: Supplementary Figure S5. Quantification of Western blot bands using Image J. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability
Supplementary Figure S5. Quantification of Western blot bands using Image J. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability Open
The pixel units obtained for each protein band from Western gels shown in Main Figures 4B (A), 4C (B), 4D (C), and 4E (D) was normalized to the pixel units calculated from their respective b-Actin loading control. For phosphorylated protei…
View article: Supplementary Figure S2. STING-dependent regulation of proliferation is associated with perturbations of cell cycle. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability
Supplementary Figure S2. STING-dependent regulation of proliferation is associated with perturbations of cell cycle. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability Open
Cell cycle profile of pulse EdU-labeled (A) and chase EdU-labeled (B) WT and STING-/- MEFs at different time points post-IR treatment. Flow cytometry was used to measure the percent cell population in G1, S, and G2/M phase of single cells …
View article: Data from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability
Data from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability Open
Given the integral role of stimulator of interferon genes (STING, TMEM173) in the innate immune response, its loss or impairment in cancer is thought to primarily affect antitumor immunity. Here we demonstrate a role for STING in the maint…
View article: Supplementary Figure S8. WEE1 inhibitor in combination with IR inhibits cellular proliferation of normal and tumor cells. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability
Supplementary Figure S8. WEE1 inhibitor in combination with IR inhibits cellular proliferation of normal and tumor cells. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability Open
(A) Quantification of bands from Western gel shown in Main Figure 5D using Image J. The pixel units obtained for each protein band was normalized to the pixel units calculated from their respective b-Actin loading control. (B-E) Kinetic an…
View article: Supplementary Figure S4. STING is upstream of CDKN1A signaling, but only has partial control of CDKN1A. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability
Supplementary Figure S4. STING is upstream of CDKN1A signaling, but only has partial control of CDKN1A. from STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability Open
(A-D) Quantification of bands from Western gels shown in Main Figures 3H (A), 3I (B), 3J (C), and 3K (D) using Image J. The pixel units obtained for each protein band was normalized to the pixel units calculated from their respective b-Act…
View article: Data from Identification of a Novel Prostate Tumor Target, Mindin/RG-1, for Antibody-Based Radiotherapy of Prostate Cancer
Data from Identification of a Novel Prostate Tumor Target, Mindin/RG-1, for Antibody-Based Radiotherapy of Prostate Cancer Open
Gene expression analysis showed that a human mindin homologue, mindin/RG-1, is expressed selectively in prostate tissues and that its expression level is elevated in some prostate tumors. Mindin/RG-1 protein expression is maintained in >80…
View article: Color version of Fig. 3 from Identification of a Novel Prostate Tumor Target, Mindin/RG-1, for Antibody-Based Radiotherapy of Prostate Cancer
Color version of Fig. 3 from Identification of a Novel Prostate Tumor Target, Mindin/RG-1, for Antibody-Based Radiotherapy of Prostate Cancer Open
Color version of Fig. 3 from Identification of a Novel Prostate Tumor Target, Mindin/RG-1, for Antibody-Based Radiotherapy of Prostate Cancer
View article: Color version of Fig. 3 from Identification of a Novel Prostate Tumor Target, Mindin/RG-1, for Antibody-Based Radiotherapy of Prostate Cancer
Color version of Fig. 3 from Identification of a Novel Prostate Tumor Target, Mindin/RG-1, for Antibody-Based Radiotherapy of Prostate Cancer Open
Color version of Fig. 3 from Identification of a Novel Prostate Tumor Target, Mindin/RG-1, for Antibody-Based Radiotherapy of Prostate Cancer
View article: Data from Identification of a Novel Prostate Tumor Target, Mindin/RG-1, for Antibody-Based Radiotherapy of Prostate Cancer
Data from Identification of a Novel Prostate Tumor Target, Mindin/RG-1, for Antibody-Based Radiotherapy of Prostate Cancer Open
Gene expression analysis showed that a human mindin homologue, mindin/RG-1, is expressed selectively in prostate tissues and that its expression level is elevated in some prostate tumors. Mindin/RG-1 protein expression is maintained in >80…
View article: Autocrine TGFβ Is a Survival Factor for Monocytes and Drives Immunosuppressive Lineage Commitment
Autocrine TGFβ Is a Survival Factor for Monocytes and Drives Immunosuppressive Lineage Commitment Open
Transforming growth factor β (TGFβ) is an effector of immune suppression and contributes to a permissive tumor microenvironment that compromises effective immunotherapy. We identified a correlation between TGFB1 and genes expressed by myel…
View article: Preliminary Study of the Effect of Stereotactic Body Radiotherapy (SBRT) on the Immune System in Lung Cancer Patients Unfit for Surgery: Immunophenotyping Analysis
Preliminary Study of the Effect of Stereotactic Body Radiotherapy (SBRT) on the Immune System in Lung Cancer Patients Unfit for Surgery: Immunophenotyping Analysis Open
An immunophenotyping analysis was performed in peripheral blood samples from seven patients with lung cancer unfit for surgery treated with stereotactic body radiotherapy (SBRT). The objective was to characterize the effect of SBRT on the …
View article: STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability
STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability Open
Given the integral role of stimulator of interferon genes (STING, TMEM173) in the innate immune response, its loss or impairment in cancer is thought to primarily affect antitumor immunity. Here we demonstrate a role for STING in the maint…