Renato Frischknecht
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View article: Development of oxidized hyaluronic acid based hydrogels for neuronal tissue engineering: Effects of matrix stiffness on primary neurons
Development of oxidized hyaluronic acid based hydrogels for neuronal tissue engineering: Effects of matrix stiffness on primary neurons Open
Due to the presence of hyaluronic acid (HA) in the human body, specifically the brain, HA-based hydrogels are promising candidates for neural tissue engineering applications. Providing the right mechanical and biological properties is esse…
View article: Serotonergic Psychedelics Rapidly Modulate Evoked Glutamate Release in Cultured Cortical Neurons
Serotonergic Psychedelics Rapidly Modulate Evoked Glutamate Release in Cultured Cortical Neurons Open
The serotonergic psychedelics psilocybin, LSD and DMT hold great promise for the development of new treatments for psychiatric conditions such as major depressive disorder, addiction and end‐of‐life anxiety. Previous studies in both animal…
View article: The Role of Perineuronal Nets in Physiology and Disease: Insights from Recent Studies
The Role of Perineuronal Nets in Physiology and Disease: Insights from Recent Studies Open
Perineuronal nets (PNNs) are specialized extracellular matrix structures that predominantly surround inhibitory neurons in the central nervous system (CNS). They have been identified as crucial regulators of synaptic plasticity and neurona…
View article: The Role of Perineuronal Nets in Physiology and Disease: Insights from Recent Studies
The Role of Perineuronal Nets in Physiology and Disease: Insights from Recent Studies Open
Perineuronal nets (PNNs) are specialized extracellular matrix structures that predominantly surround inhibitory neurons in the central nervous system (CNS). They have been identified as crucial regulators of synaptic plasticity and neurona…
View article: Activity-dependent extracellular proteolytic cascade remodels ECM to promote structural plasticity
Activity-dependent extracellular proteolytic cascade remodels ECM to promote structural plasticity Open
The brain’s perineuronal extracellular matrix (ECM) is a crucial factor in maintaining the stability of mature brain circuitry. However, how is activity-induced synaptic plasticity achieved in the adult brain with a dense ECM? We hypothesi…
View article: Age‐dependent increase of perineuronal nets in the human hippocampus and precocious aging in epilepsy
Age‐dependent increase of perineuronal nets in the human hippocampus and precocious aging in epilepsy Open
Objective Perineuronal nets (PNN) are specialized extracellular matrix (ECM) components of the central nervous system, frequently accumulating at the surface of inhibitory GABAergic interneurons. While an altered distribution of PNN has be…
View article: Hydroxynorketamine, but not ketamine, acts via α7 nicotinic acetylcholine receptor to control presynaptic function and gene expression
Hydroxynorketamine, but not ketamine, acts via α7 nicotinic acetylcholine receptor to control presynaptic function and gene expression Open
Ketamine is clinically used fast-acting antidepressant. Its metabolite hydroxynorketamine (HNK) shows a robust antidepressant effect in animal studies. It is unclear, how these chemically distinct compounds converge on similar neuronal eff…
View article: Tinten für die Biofabrikation–Druckbarkeit vs. Biokompatibilität?
Tinten für die Biofabrikation–Druckbarkeit vs. Biokompatibilität? Open
In biomaterial ink development, achieving optimal performance is a complex process. A biomaterial ink that shows excellent printability may be inferior in terms of cell compatibility. Properties facilitating printability of biomaterial ink…
View article: Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment
Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment Open
Extracellular matrix (ECM) deposition after central nervous system (CNS) injury leads to inhibitory scarring in humans and other mammals, whereas it facilitates axon regeneration in the zebrafish. However, the molecular basis of these diff…
View article: Mice deficient in synaptic protease neurotrypsin show impaired spaced long-term potentiation and blunted learning-induced modulation of dendritic spines
Mice deficient in synaptic protease neurotrypsin show impaired spaced long-term potentiation and blunted learning-induced modulation of dendritic spines Open
Neurotrypsin (NT) is a neuronal trypsin-like serine protease whose mutations cause severe mental retardation in humans. NT is activated in vitro by Hebbian-like conjunction of pre- and postsynaptic activities, which promotes the formation …
View article: Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment
Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment Open
Extracellular matrix (ECM) deposition after central nervous system (CNS) injury leads to inhibitory scarring in mammals, whereas it facilitates axon regeneration in the zebrafish. However, the molecular basis of these different fates is no…
View article: Disturbance in Hebbian-like spinogenesis blunted learning-induced modulation in the number and spatial distribution of dendritic spines
Disturbance in Hebbian-like spinogenesis blunted learning-induced modulation in the number and spatial distribution of dendritic spines Open
Neurotrypsin (NT) is a neuronal trypsin-like serine protease whose mutations cause severe mental retardation in humans. NT is activated by Hebbian-like conjunction of pre- and postsynaptic activities, which promotes the formation of dendri…
View article: Genetic disruption of bassoon in two mutant mouse lines causes divergent retinal phenotypes
Genetic disruption of bassoon in two mutant mouse lines causes divergent retinal phenotypes Open
Bassoon (BSN) is a presynaptic cytomatrix protein ubiquitously present at chemical synapses of the central nervous system, where it regulates synaptic vesicle replenishment and organizes voltage‐gated Ca 2+ channels. In sensory photorecept…
View article: Bassoon inhibits proteasome activity via interaction with PSMB4
Bassoon inhibits proteasome activity via interaction with PSMB4 Open
Proteasomes are protein complexes that mediate controlled degradation of damaged or unneeded cellular proteins. In neurons, proteasome regulates synaptic function and its dysfunction has been linked to neurodegeneration and neuronal cell d…
View article: Auxiliary α2δ1 and α2δ3 Subunits of Calcium Channels Drive Excitatory and Inhibitory Neuronal Network Development
Auxiliary α2δ1 and α2δ3 Subunits of Calcium Channels Drive Excitatory and Inhibitory Neuronal Network Development Open
VGCCs are multisubunit complexes that play a crucial role in neuronal signaling. Auxiliary α2δ subunits of VGCCs modulate trafficking and biophysical properties of the pore-forming α1 subunit and trigger excitatory synaptogenesis. Alterati…
View article: Removal of the extracellular matrix biases auditory cortical layer dynamics towards supragranular frequency integration
Removal of the extracellular matrix biases auditory cortical layer dynamics towards supragranular frequency integration Open
In the adult vertebrate brain, enzymatic removal of the extracellular matrix (ECM) is increasingly recognized to promote learning, memory recall, and restorative plasticity. However, the underlying impact of local removal of the ECM on cor…
View article: Dopamine Receptor Activation Modulates the Integrity of the Perisynaptic Extracellular Matrix at Excitatory Synapses
Dopamine Receptor Activation Modulates the Integrity of the Perisynaptic Extracellular Matrix at Excitatory Synapses Open
In the brain, Hebbian-type and homeostatic forms of plasticity are affected by neuromodulators like dopamine (DA). Modifications of the perisynaptic extracellular matrix (ECM), which control the functions and mobility of synaptic receptors…
View article: Deficits in developmental neurogenesis and dendritic spine maturation in mice lacking the serine protease inhibitor neuroserpin
Deficits in developmental neurogenesis and dendritic spine maturation in mice lacking the serine protease inhibitor neuroserpin Open
Neuroserpin is a serine protease inhibitor of the nervous system required for normal synaptic plasticity and regulating cognitive, emotional and social behavior in mice. The high expression level of neuroserpin detected at late stages of n…
View article: Dopamine modulates the integrity of the perisynaptic extracellular matrix at excitatory synapses
Dopamine modulates the integrity of the perisynaptic extracellular matrix at excitatory synapses Open
Summary In the brain, Hebbian-type and homeostatic forms of plasticity are affected by neuromodulators like dopamine (DA). Modifications of the perisynaptic extracellular matrix (ECM), controlling functions and mobility of synaptic recepto…
View article: Learning Induces Transient Upregulation of Brevican in the Auditory Cortex during Consolidation of Long-Term Memories
Learning Induces Transient Upregulation of Brevican in the Auditory Cortex during Consolidation of Long-Term Memories Open
It is a daily challenge for our brains to establish new memories via learning while providing stable storage of remote memories. In the adult vertebrate brain, bimodal regulation of the extracellular matrix (ECM) may regulate the delicate …
View article: Neuronal Plasticity in the Juvenile and Adult Brain Regulated by the Extracellular Matrix
Neuronal Plasticity in the Juvenile and Adult Brain Regulated by the Extracellular Matrix Open
In brains of higher vertebrates, the delicate balance of structural remodeling and stabilization of neuronal networks changes over the life-span. While the juvenile brain is characterized by high structural plasticity, it is more restricte…