Renato Pascale
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View article: From clinical trials to daily practice: how to adequately administer sulbactam-durlobactam? alone or combined with imipenem?
From clinical trials to daily practice: how to adequately administer sulbactam-durlobactam? alone or combined with imipenem? Open
Purpose of review Sulbactam-durlobactam (SUL-DUR) is a novel β-lactam/β-lactamase inhibitor combination recently approved for carbapenem-resistant Acinetobacter baumannii (CRAB) infections. This review summarizes current knowledge on the o…
View article: How to manage patients receiving long-term suppressive antibiotic treatment for infective endocarditis: The role of [18F]-FDGCT/CT imaging—An international multidisciplinary survey
How to manage patients receiving long-term suppressive antibiotic treatment for infective endocarditis: The role of [18F]-FDGCT/CT imaging—An international multidisciplinary survey Open
View article: Epidemiological characteristics and management of Gram-negative bacteraemia in different immunocompromised hosts: Observational single-center study
Epidemiological characteristics and management of Gram-negative bacteraemia in different immunocompromised hosts: Observational single-center study Open
Importance Patients with Gram-negative bloodstream infections (GN-BSI) are classified as non-immunocompromised (n-IC) or immunocompromised (IC). However, immunosuppressive condition should not be considered univocally. Objective To investi…
View article: Current Practice Patterns and Educational Needs of the ESCMID Study Group for Infections in Compromised Hots
Current Practice Patterns and Educational Needs of the ESCMID Study Group for Infections in Compromised Hots Open
Background The ESCMID Study Group for Infection in Compromised Hosts (ESGICH) conducted a survey to assess its members' demographics, clinical focus, training pathways, research activities, and educational needs. The primary objective was …
View article: What Is the Impact of Anti-Enterococcal Empirical Therapy on Survival of Patients With Enterococcal Bloodstream Infections?
What Is the Impact of Anti-Enterococcal Empirical Therapy on Survival of Patients With Enterococcal Bloodstream Infections? Open
Background The impact of early administration of active anti-enterococcal empirical therapy (EET) on outcomes of patients with enterococcal bloodstream infections (EBSIs) is unclear. We compared the outcome of patients with EBSIs receiving…
View article: 9F - Incidence of urinary tract infections after urodynamics or videourodynamics in SCI patients with application of a preparation protocol for urodynamics
9F - Incidence of urinary tract infections after urodynamics or videourodynamics in SCI patients with application of a preparation protocol for urodynamics Open
View article: Artificial Intelligence model to predict resistances in Gram-negative bloodstream infections
Artificial Intelligence model to predict resistances in Gram-negative bloodstream infections Open
Artificial intelligence (AI) models are promising tools for predicting antimicrobial susceptibility in gram-negative bloodstream infections (GN-BSI). Single-center study on hospitalized patients with GN-BSI, over 7-year period, aimed to pr…
View article: Pseudomonas aeruginosa bloodstream infections in internal medicine wards: A large Italian multicenter retrospective study
Pseudomonas aeruginosa bloodstream infections in internal medicine wards: A large Italian multicenter retrospective study Open
Introduction This large, multicenter, Italian retrospective study aimed to describe clinical characteristics and risk factors associated with 30-day mortality in patients with Pseudomonas aeruginosa bloodstream infections (PA-BSI) admitted…
View article: Why Do People Get Infections After Organ Transplantation?
Why Do People Get Infections After Organ Transplantation? Open
Sometimes, when organs like the kidneys or liver get sick, the only way to make people better is by replacing the sick organ with a healthy one. This special surgery is called organ transplantation, and the person who gets the new organ is…
View article: Cefiderocol for the Treatment of Nosocomial Bloodstream Infections Caused by Stenotrophomonas maltophilia: A Case Series and Literature Review
Cefiderocol for the Treatment of Nosocomial Bloodstream Infections Caused by Stenotrophomonas maltophilia: A Case Series and Literature Review Open
View article: ORCHESTRA Delphi consensus: diagnostic and therapeutic management of SARS-CoV-2 infection in solid organ transplant recipients
ORCHESTRA Delphi consensus: diagnostic and therapeutic management of SARS-CoV-2 infection in solid organ transplant recipients Open
View article: Current role of ceftobiprole in the treatment of hospital-acquired and community-acquired pneumonia: expert opinion based on literature and real-life experiences
Current role of ceftobiprole in the treatment of hospital-acquired and community-acquired pneumonia: expert opinion based on literature and real-life experiences Open
Ceftobiprole represents a valid option for the patients with CAP and HAP. Its main advantages include its broad spectrum of activity, making it a valuable therapeutic choice for treating polymicrobial infections, and its favorable safety p…
View article: Infections Management in the Lung Transplant Setting in Italy: A Web‐Survey
Infections Management in the Lung Transplant Setting in Italy: A Web‐Survey Open
Introduction Infections significantly impact morbidity and mortality in lung transplant (LuTx) recipients. This survey focused on documenting current practices regarding the prevention and management of infections in LuTx in Italy. Methods…
View article: Prognostic role of aetiological agent vs. clinical pattern in candidates to lead extraction for cardiac implantable electronic device infections
Prognostic role of aetiological agent vs. clinical pattern in candidates to lead extraction for cardiac implantable electronic device infections Open
View article: Antibiotic Prophylaxis in Patients Undergoing Lung Transplant: Single-Center Cohort Study
Antibiotic Prophylaxis in Patients Undergoing Lung Transplant: Single-Center Cohort Study Open
Perioperative antibiotic prophylaxis (PAP) in lung transplant recipients (LuTRs) has high heterogeneity between centers. Our aim was to investigate retrospectively the approach to PAP in our center over a 20-year period (2002–2023), and it…
View article: The Role of Microbes in Surgical Decision Making for Infective Endocarditis: Mitral Valve Repair or Replacement?
The Role of Microbes in Surgical Decision Making for Infective Endocarditis: Mitral Valve Repair or Replacement? Open
Background: The benefits of mitral repair versus replacement for endocarditis are inconclusive. This study compares outcomes of patients with infective endocarditis undergoing mitral valve repair versus replacement and investigates the imp…
View article: Outcomes and Predictors of Mortality in Patients With KPC-Kp Infections Treated With Meropenem Vaborbactam: An Observational Multicenter Study
Outcomes and Predictors of Mortality in Patients With KPC-Kp Infections Treated With Meropenem Vaborbactam: An Observational Multicenter Study Open
Background Meropenem-vaborbactam is a recent and promising option for the treatment of KPC-producing Klebsiella pneumoniae (KPC-Kp) infections, including those resistant to ceftazidime-avibactam. Methods We conducted a retrospective analys…
View article: CMV-RNAemia as new marker of active viral replication in transplant recipients
CMV-RNAemia as new marker of active viral replication in transplant recipients Open
View article: Gut microbiome dynamics and Enterobacterales infection in liver transplant recipients: A prospective observational study
Gut microbiome dynamics and Enterobacterales infection in liver transplant recipients: A prospective observational study Open
View article: Real-Time TDM-Guided Optimal Joint PK/PD Target Attainment of Continuous Infusion Piperacillin–Tazobactam Monotherapy Is an Effective Carbapenem-Sparing Strategy for Treating Non-Severe ESBL-Producing Enterobacterales Secondary Bloodstream Infections: Findings from a Prospective Pilot Study
Real-Time TDM-Guided Optimal Joint PK/PD Target Attainment of Continuous Infusion Piperacillin–Tazobactam Monotherapy Is an Effective Carbapenem-Sparing Strategy for Treating Non-Severe ESBL-Producing Enterobacterales Secondary Bloodstream Infections: Findings from a Prospective Pilot Study Open
(1) Objectives: To assess the impact of optimal joint pharmacokinetic/pharmacodynamic (PK/PD) target attainment of continuous infusion (CI) piperacillin–tazobactam monotherapy on the microbiological outcome of documented ESBL-producing Ent…
View article: Population Pharmacokinetic and Pharmacodynamic Analysis for Maximizing the Effectiveness of Ceftobiprole in the Treatment of Severe Methicillin-Resistant Staphylococcal Infections
Population Pharmacokinetic and Pharmacodynamic Analysis for Maximizing the Effectiveness of Ceftobiprole in the Treatment of Severe Methicillin-Resistant Staphylococcal Infections Open
Ceftobiprole is a fifth-generation cephalosporin used for different Gram-positive bacterial infections. A population pharmacokinetic analysis was conducted in real-life clinical patients to assess the adequacy of current dosages. Populatio…
View article: Multidisciplinary Management of Sternal Osteomyelitis Due to Klebsiella aerogenes after Open Heart Surgery in a Patient with Multiple Myeloma: A Case Report and Discussion of the Literature
Multidisciplinary Management of Sternal Osteomyelitis Due to Klebsiella aerogenes after Open Heart Surgery in a Patient with Multiple Myeloma: A Case Report and Discussion of the Literature Open
Sternal wound complications following cardiac surgery, including sternal dehiscence, mediastinitis, and osteomyelitis, pose significant challenges in terms of management and patient outcomes. We present a case report highlighting the compl…
View article: Comparison between available early antiviral treatments in outpatients with SARS-CoV-2 infection: a real-life study
Comparison between available early antiviral treatments in outpatients with SARS-CoV-2 infection: a real-life study Open
View article: Carbapenem-Resistant <i>Acinetobacter</i> spp Infection in Critically Ill Patients With Limited Treatment Options: A Descriptive Study of Cefiderocol Therapy During the COVID-19 Pandemic
Carbapenem-Resistant <i>Acinetobacter</i> spp Infection in Critically Ill Patients With Limited Treatment Options: A Descriptive Study of Cefiderocol Therapy During the COVID-19 Pandemic Open
Background Carbapenem-resistant Acinetobacter baumannii infections are difficult to treat and are a significant public health threat due to intrinsic/acquired resistance and limited treatment options. Methods A retrospective, observational…
View article: Effect of a Fourth Dose of mRNA Vaccine and of Immunosuppression in Preventing SARS-CoV-2 Breakthrough Infections in Heart Transplant Patients
Effect of a Fourth Dose of mRNA Vaccine and of Immunosuppression in Preventing SARS-CoV-2 Breakthrough Infections in Heart Transplant Patients Open
Patients with heart transplantation (HT) have an increased risk of COVID-19 disease and the efficacy of vaccines on antibody induction is lower, even after three or four doses. The aim of our study was to assess the efficacy of four doses …
View article: Corrigendum to: “Development and validation of a prediction model for severe respiratory failure in hospitalized patients with SARS-CoV-2 infection: a multicentre cohort study (PREDI-CO study)” Clinical Microbiology and Infection 26 (2020) 1545–1553
Corrigendum to: “Development and validation of a prediction model for severe respiratory failure in hospitalized patients with SARS-CoV-2 infection: a multicentre cohort study (PREDI-CO study)” Clinical Microbiology and Infection 26 (2020) 1545–1553 Open
View article: Exposure to psychotropic medications and COVID-19 course after hospital admission: Results from a prospective cohort study
Exposure to psychotropic medications and COVID-19 course after hospital admission: Results from a prospective cohort study Open
View article: Risk factors for Gram-negative bacterial infection of cardiovascular implantable electronic devices: multicentre observational study (CarDINe Study)
Risk factors for Gram-negative bacterial infection of cardiovascular implantable electronic devices: multicentre observational study (CarDINe Study) Open
Obesity, high number of comorbidities and right subclavian vein implantation site were associated with increased risk of GNB-CIED infection. A prompt therapeutic intervention that may be guided using FDG PET/CT is suggested in patients wit…
View article: Relationship Between Immune Response to Severe Acute Respiratory Syndrome Coronavirus 2 Vaccines and Development of Breakthrough Infection in Solid Organ Transplant Recipients: The CONTRAST Cohort
Relationship Between Immune Response to Severe Acute Respiratory Syndrome Coronavirus 2 Vaccines and Development of Breakthrough Infection in Solid Organ Transplant Recipients: The CONTRAST Cohort Open
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination in solid organ transplant (SOT) recipients is associated with poorer antibody response (AbR) compared with non-SOT recipients. However, its impact on the r…
View article: Robotic Liver Resection for Liver Neoplasms: The G. Pascale National Cancer Center Experience
Robotic Liver Resection for Liver Neoplasms: The G. Pascale National Cancer Center Experience Open