Renato Simões Gaspar
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View article: Socioeconomic determinants of low birth weight and its association with peripubertal obesity in Brazil
Socioeconomic determinants of low birth weight and its association with peripubertal obesity in Brazil Open
Introduction Low birth weight (LBW) is an early life adversity associated with various risk factors and metabolic dysfunction throughout life. However, the role of socioeconomic factors in the association between LBW and peripubertal healt…
View article: Diabetes and Cognitive Decline: An Innovative Approach to Analyzing the Biophysical and Vibrational Properties of the Hippocampus
Diabetes and Cognitive Decline: An Innovative Approach to Analyzing the Biophysical and Vibrational Properties of the Hippocampus Open
Diabetes Mellitus (DM) is a disease characterized by high blood glucose levels, known as hyperglycemia. Diabetes represents a risk factor for the development of neurodegenerative diseases, such as Alzheimer's Disease (AD), one of the most …
View article: Explaining the increase of incidence and mortality from cardiovascular disease in Indonesia: A global burden of disease study analysis (2000–2019)
Explaining the increase of incidence and mortality from cardiovascular disease in Indonesia: A global burden of disease study analysis (2000–2019) Open
Background In the last two decades, there has been a discernible shift in the distribution of mortality attributed to cardiovascular disease (CVD) between developing and developed nations; in developed nations, the percentage of deaths cau…
View article: Platelet factor XIII-A regulates platelet function and promotes clot retraction and stability
Platelet factor XIII-A regulates platelet function and promotes clot retraction and stability Open
View article: Nanomechanical and Vibrational Signature of Chikungunya Viral Particles
Nanomechanical and Vibrational Signature of Chikungunya Viral Particles Open
Chikungunya virus (CHIKV) belongs to the genus Alphaviridae, with a single-stranded positive-sense RNA genome of 11.8 kbp encoding a polyprotein that generates both non-structural proteins and structural proteins. The virus is transmitted …
View article: A red wine intervention does not modify plasma trimethylamine N-oxide but is associated with broad shifts in the plasma metabolome and gut microbiota composition
A red wine intervention does not modify plasma trimethylamine N-oxide but is associated with broad shifts in the plasma metabolome and gut microbiota composition Open
View article: Emerging roles of thiol oxidoreductase-dependent mechanisms on vasomotricity regulation
Emerging roles of thiol oxidoreductase-dependent mechanisms on vasomotricity regulation Open
Vasomotricity, defined by measurements of contraction or relaxation, is important to support correct blood supply and needs to be finely regulated during hemodynamic changes. Disruptions in either contraction or relaxation, mainly endothel…
View article: Analysing the impact of modifiable risk factors on cardiovascular disease mortality in Brazil
Analysing the impact of modifiable risk factors on cardiovascular disease mortality in Brazil Open
Objectives We have examined the impact of changes in modifiable risk factors on CVD mortality in 26 Brazilian states from 2005 to 2017. Methods Data were acquired from the Global Burden of Diseases study (GBD) and official sources of the B…
View article: Income inequality and non-communicable disease mortality and morbidity in Brazil States: a longitudinal analysis 2002-2017
Income inequality and non-communicable disease mortality and morbidity in Brazil States: a longitudinal analysis 2002-2017 Open
View article: Early Exposure to High-Sucrose Diet Leads to Deteriorated Ovarian Health
Early Exposure to High-Sucrose Diet Leads to Deteriorated Ovarian Health Open
Background The metabolic syndrome (MetS) is correlated with disorders of the reproductive system, such as the polycystic ovary syndrome (PCOS). While consumption of a diet rich in carbohydrates is linked to the development of MetS, it is s…
View article: Protein Disulphide Isomerase and NADPH Oxidase 1 Cooperate to Control Platelet Function and Are Associated with Cardiometabolic Disease Risk Factors
Protein Disulphide Isomerase and NADPH Oxidase 1 Cooperate to Control Platelet Function and Are Associated with Cardiometabolic Disease Risk Factors Open
Background: Protein disulphide isomerase (PDI) and NADPH oxidase 1 (Nox-1) regulate platelet function and reactive oxygen species (ROS) generation, suggesting potentially interdependent roles. Increased platelet reactivity and ROS producti…
View article: Platelet-derived extracellular vesicles express NADPH oxidase-1 (Nox-1), generate superoxide and modulate platelet function
Platelet-derived extracellular vesicles express NADPH oxidase-1 (Nox-1), generate superoxide and modulate platelet function Open
PDEVs are able to generate superoxide, bind to and activate platelets in a process mediated by Nox-1. These data provide novel mechanisms by which Nox-1 potentiates platelet responses, thus proposing Nox-1 inhibition as a feasible strategy…
View article: Socioeconomic Factors Associated With Reports of Domestic Violence in Large Brazilian Cities
Socioeconomic Factors Associated With Reports of Domestic Violence in Large Brazilian Cities Open
Background: Domestic violence is a traumatic experience that can lead to physical consequences, mental disorders and financial damage. Over 18 cases per 100,000 inhabitants were reported in Brazil between 2013 and 2014. The ministry of hea…
View article: Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring
Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring Open
Maternal over-nutrition increases the risk of diabetes and cardiovascular events in offspring. While prominent effects on cardiovascular health are observed, the impact on platelet physiology has not been studied. Here, we examined whether…
View article: Maternal High-fat Diet During Pregnancy Programs Platelet Hyperactivation in Male Mouse Offspring
Maternal High-fat Diet During Pregnancy Programs Platelet Hyperactivation in Male Mouse Offspring Open
Background: Maternal over-nutrition increases the risk of diabetes and cardiovascular events in offspring. While prominent effects on cardiovascular health are observed, the impact of this on platelet physiology has not been studied. Here,…
View article: Unique Genetic and Histological Signatures of Mouse Pericardial Adipose Tissue
Unique Genetic and Histological Signatures of Mouse Pericardial Adipose Tissue Open
Obesity is a major risk factor for a plethora of metabolic disturbances including diabetes and cardiovascular disease. Accumulating evidence is showing that there is an adipose tissue depot-dependent relationship with obesity-induced metab…
View article: Antiplatelet properties of Pim kinase inhibition are mediated through disruption of thromboxane A2 receptor signaling
Antiplatelet properties of Pim kinase inhibition are mediated through disruption of thromboxane A2 receptor signaling Open
Pim kinases are upregulated in several forms of cancer, contributing to cell survival and tumour development, but their role in platelet function and thrombotic disease has not been explored. We report for the first time that Pim-1 is expr…
View article: Myricetin, the Main Flavonoid in Syzygium cumini Leaf, Is a Novel Inhibitor of Platelet Thiol Isomerases PDI and ERp5
Myricetin, the Main Flavonoid in Syzygium cumini Leaf, Is a Novel Inhibitor of Platelet Thiol Isomerases PDI and ERp5 Open
PESc and its most abundant flavonoid myricetin strongly inhibit platelet function. Additionally, myricetin is a novel inhibitor of ERp5 and PDI, unveiling a new therapeutic perspective for the treatment of thrombotic disorders.
View article: Syzygium cumini (L.) Skeels improves metabolic and ovarian parameters in female obese rats with malfunctioning hypothalamus-pituitary-gonadal axis
Syzygium cumini (L.) Skeels improves metabolic and ovarian parameters in female obese rats with malfunctioning hypothalamus-pituitary-gonadal axis Open
View article: Corrigendum to “Protective Effects of a Polyphenol-Rich Extract from <i>Syzygium cumini</i> (L.) Skeels Leaf on Oxidative Stress-Induced Diabetic Rats”
Corrigendum to “Protective Effects of a Polyphenol-Rich Extract from <i>Syzygium cumini</i> (L.) Skeels Leaf on Oxidative Stress-Induced Diabetic Rats” Open
[This corrects the article DOI: 10.1155/2018/5386079.].
View article: Evolução da notificação de violência sexual no Brasil de 2009 a 2013
Evolução da notificação de violência sexual no Brasil de 2009 a 2013 Open
O objetivo foi analisar a evolução das notificações de violência sexual no Brasil entre 2009 e 2013, dando especial enfoque ao estupro. Realizou-se um estudo observacional de série temporal, analisando dados entre 2009 e 2013, provenientes…
View article: Protective Effects of a Polyphenol‐Rich Extract from <i>Syzygium cumini</i> (L.) Skeels Leaf on Oxidative Stress‐Induced Diabetic Rats
Protective Effects of a Polyphenol‐Rich Extract from <i>Syzygium cumini</i> (L.) Skeels Leaf on Oxidative Stress‐Induced Diabetic Rats Open
Syzygium cumini (L.) Skeels has been reported to exert anti‐inflammatory and cardiometabolic activities due to its high content of polyphenols. We characterized the chemical composition and assessed the antidiabetic effects of a novel poly…
View article: Novel antiplatelet role for a protein disulfide isomerase‐targeted peptide: evidence of covalent binding to the C‐terminal CGHC redox motif
Novel antiplatelet role for a protein disulfide isomerase‐targeted peptide: evidence of covalent binding to the C‐terminal CGHC redox motif Open
View article: Temporal analysis of reported cases of tuberculosis and of tuberculosis-HIV co-infection in Brazil between 2002 and 2012
Temporal analysis of reported cases of tuberculosis and of tuberculosis-HIV co-infection in Brazil between 2002 and 2012 Open
Objective: To investigate the reported cases of tuberculosis and of tuberculosis-HIV co-infection in Brazil between 2002 and 2012. Methods: This was an observational study based on secondary time series data collected from the Brazilian Ca…
View article: Polyphenol-Rich Extract of Syzygium cumini Leaf Dually Improves Peripheral Insulin Sensitivity and Pancreatic Islet Function in Monosodium L-Glutamate-Induced Obese Rats
Polyphenol-Rich Extract of Syzygium cumini Leaf Dually Improves Peripheral Insulin Sensitivity and Pancreatic Islet Function in Monosodium L-Glutamate-Induced Obese Rats Open
Syzygium cumini (L.) Skeels (Myrtaceae) has been traditionally used to treat a number of illnesses. Ethnopharmacological studies have particularly addressed antidiabetic and metabolic-related effects of extracts prepared from its different…
View article: Reproductive alterations in hyperinsulinemic but normoandrogenic MSG obese female rats
Reproductive alterations in hyperinsulinemic but normoandrogenic MSG obese female rats Open
Obesity and metabolic syndrome are the common causes of reproductive and fertility disorders in women. In particular, polycystic ovary syndrome, which is clinically characterized by hyperandrogenism, oligo/anovulation, and polycystic ovari…
View article: Potential Role of Protein Disulfide Isomerase in Metabolic Syndrome‐Derived Platelet Hyperactivity
Potential Role of Protein Disulfide Isomerase in Metabolic Syndrome‐Derived Platelet Hyperactivity Open
Metabolic Syndrome (MetS) has become a worldwide epidemic, alongside with a high socioeconomic cost, and its diagnostic criteria must include at least three out of the five features: visceral obesity, hypertension, dyslipidemia, insulin re…