Renaud Prével
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View article: Vasopressin and its analogues in patients with septic shock: holy Grail or unfulfilled promise?
Vasopressin and its analogues in patients with septic shock: holy Grail or unfulfilled promise? Open
View article: Screening, prevalence, and risk factors for secondary localization during candidemia in intensive care unit patients: the French CandidICU multicenter study
Screening, prevalence, and risk factors for secondary localization during candidemia in intensive care unit patients: the French CandidICU multicenter study Open
In this cohort, 76·4% of ICU patients with candidemia were screened for SL and at least one SL was diagnosed in 21·8%. The severity at ICU admission and duration of positive blood cultures were identified as independent risk factors for SL…
View article: Effects of the urinary urea excretion index on the decision to wean ICU patients with acute kidney injury from renal replacement therapy: a before-after multicentre study (D-STOP)
Effects of the urinary urea excretion index on the decision to wean ICU patients with acute kidney injury from renal replacement therapy: a before-after multicentre study (D-STOP) Open
These results confirm that a UUEI-based protocol is a safe technique to prompt withdrawal of the RRT catheter in patients with AKI requiring RRT during their ICU stay.
View article: β-glucan reprograms alveolar macrophages via neutrophil/IFNγ axis to promote lung injury
β-glucan reprograms alveolar macrophages via neutrophil/IFNγ axis to promote lung injury Open
Alveolar macrophages (AMs) reside in the lower airways and play a crucial role in lung health and response to sterile inflammation and infections. AMs possess remarkable adaptability to different environmental challenges that can persist t…
View article: Author response: β-glucan reprograms alveolar macrophages via neutrophil/IFNγ axis to promote lung injury
Author response: β-glucan reprograms alveolar macrophages via neutrophil/IFNγ axis to promote lung injury Open
View article: Safety of baricitinib in vaccinated patients with severe and critical COVID-19 sub study of the randomised Bari-SolidAct trial
Safety of baricitinib in vaccinated patients with severe and critical COVID-19 sub study of the randomised Bari-SolidAct trial Open
View article: β-Glucan reprograms alveolar macrophages via neutrophil/IFNγ axis in a murine model of lung injury
β-Glucan reprograms alveolar macrophages via neutrophil/IFNγ axis in a murine model of lung injury Open
Alveolar macrophages (AMs) reside in the lower airways and play a crucial role in lung health and response to sterile inflammation and infections. AMs possess remarkable adaptability to different environmental challenges that can persist t…
View article: β-glucan reprograms alveolar macrophages via neutrophil/IFNγ axis to promote lung injury
β-glucan reprograms alveolar macrophages via neutrophil/IFNγ axis to promote lung injury Open
Alveolar macrophages (AMs) reside in the lower airways and play a crucial role in lung health and response to sterile inflammation and infections. AMs possess remarkable adaptability to different environmental challenges that can persist t…
View article: A novel<i>in vitro</i>tubular model to recapitulate features of distal airways: the bronchioid
A novel<i>in vitro</i>tubular model to recapitulate features of distal airways: the bronchioid Open
Background Airflow limitation is the hallmark of obstructive pulmonary diseases, with the distal airways representing a major site of obstruction. Although numerous in vitro models of bronchi already exist, there is currently no culture sy…
View article: β-glucan reprograms alveolar macrophages via neutrophil/IFNγ axis to promote lung injury
β-glucan reprograms alveolar macrophages via neutrophil/IFNγ axis to promote lung injury Open
Alveolar macrophages (AMs) reside in the lower airways and play a crucial role in lung health and response to sterile inflammation and infections. AMs possess remarkable adaptability to different environmental challenges that can persist t…
View article: Sampling and processing matter in airway microbiota discovery
Sampling and processing matter in airway microbiota discovery Open
View article: Lower airway microbiota compositions differ between influenza, COVID-19 and bacteria-related acute respiratory distress syndromes
Lower airway microbiota compositions differ between influenza, COVID-19 and bacteria-related acute respiratory distress syndromes Open
Background Acute respiratory distress syndrome (ARDS) is responsible for 400,000 deaths annually worldwide. Few improvements have been made despite five decades of research, partially because ARDS is a highly heterogeneous syndrome includi…
View article: Impaired balance between neutrophil extracellular trap formation and degradation by DNases in COVID-19 disease
Impaired balance between neutrophil extracellular trap formation and degradation by DNases in COVID-19 disease Open
View article: Impact of dexamethasone in severe COVID-19-induced acute kidney injury: a multicenter cohort study
Impact of dexamethasone in severe COVID-19-induced acute kidney injury: a multicenter cohort study Open
View article: Critically ill patients with infective endocarditis, neurological complications and indication for cardiac surgery: a multicenter propensity-adjusted study
Critically ill patients with infective endocarditis, neurological complications and indication for cardiac surgery: a multicenter propensity-adjusted study Open
Background The benefit–risk balance and optimal timing of surgery for severe infective endocarditis (IE) with ischemic or hemorrhagic strokes is unknown. The study aim was to compare the neurological outcome between patients receiving surg…
View article: Invasive group A streptococcal infections requiring admission to ICU: a nationwide, multicenter, retrospective study (ISTRE study)
Invasive group A streptococcal infections requiring admission to ICU: a nationwide, multicenter, retrospective study (ISTRE study) Open
View article: Safety of Baricitinib in Vaccinated Patients with Severe and Critical COVID-19. Sub Study of the Randomised Bari-SolidAct Trial
Safety of Baricitinib in Vaccinated Patients with Severe and Critical COVID-19. Sub Study of the Randomised Bari-SolidAct Trial Open
View article: Clinical and bronchial parameters associated with the exacerbation frequency of severe preschool wheezers
Clinical and bronchial parameters associated with the exacerbation frequency of severe preschool wheezers Open
View article: A novel in vitro tubular model to recapitulate features of distal airways: The bronchioid
A novel in vitro tubular model to recapitulate features of distal airways: The bronchioid Open
Background Airflow limitation is the hallmark of obstructive pulmonary diseases, with the distal airways representing a major site of obstruction. Although numerous in vitro models of bronchi already exist, there is currently no culture sy…
View article: Food-borne botulism outbreak during the Rugby World Cup linked to marinated sardines in Bordeaux, France, September 2023
Food-borne botulism outbreak during the Rugby World Cup linked to marinated sardines in Bordeaux, France, September 2023 Open
In September 2023, a botulism outbreak affecting 15 individuals occurred in Bordeaux, France, during the Rugby World Cup. We report on eight individuals from four different countries on two continents admitted to the intensive care unit at…
View article: PB0602 Plasma NET Markers Kinetics in COVID-19 Patients Receiving Immunomodulatory Treatments
PB0602 Plasma NET Markers Kinetics in COVID-19 Patients Receiving Immunomodulatory Treatments Open
View article: OC 55.1 Balance between Neutrophil Extracellular Trap Formation and DNase Activity in COVID-19 Patients
OC 55.1 Balance between Neutrophil Extracellular Trap Formation and DNase Activity in COVID-19 Patients Open
View article: The gut microbiota composition is linked to subsequent occurrence of ventilator-associated pneumonia in critically ill patients
The gut microbiota composition is linked to subsequent occurrence of ventilator-associated pneumonia in critically ill patients Open
Ventilator-associated pneumonia (VAP) is the most frequent nosocomial infection in critically ill-ventilated patients. Oropharyngeal and lung microbiota have been demonstrated to be associated with VAP occurrence, but the involvement of gu…
View article: Bronchial smooth muscle remodelling impacts the exacerbation frequency of severe preschool wheezers
Bronchial smooth muscle remodelling impacts the exacerbation frequency of severe preschool wheezers Open
INTRODUCTION: Exacerbations in preschool wheezers increase the risk of impaired lung function and asthma persistence at school age. Bronchial remodelling-based latent classes identify severe preschool wheezers at increased risk of frequent…
View article: Bridging gut microbiota composition with extended-spectrum beta-lactamase Enterobacteriales faecal carriage in critically ill patients (microbe cohort study)
Bridging gut microbiota composition with extended-spectrum beta-lactamase Enterobacteriales faecal carriage in critically ill patients (microbe cohort study) Open
View article: Lung Mycobiota α-Diversity Is Linked to Severity in Critically Ill Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Lung Mycobiota α-Diversity Is Linked to Severity in Critically Ill Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease Open
In AECOPD with acidemia, more severe patients— i.e. , nonsurvivors and patients requiring invasive mechanical ventilation—have lower lung mycobiota α-diversity than survivors and patients receiving only noninvasive ventilation, respectivel…
View article: Efficacy of carbapenem vs non carbapenem β-lactam therapy as empiric antimicrobial therapy in patients with extended-spectrum β-lactamase-producing Enterobacterales urinary septic shock: a propensity-weighted multicenter cohort study
Efficacy of carbapenem vs non carbapenem β-lactam therapy as empiric antimicrobial therapy in patients with extended-spectrum β-lactamase-producing Enterobacterales urinary septic shock: a propensity-weighted multicenter cohort study Open
Background The rise in antimicrobial resistance is a global threat responsible for about 33,000 deaths in 2015 with a particular concern for extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E) and has led to a major increa…
View article: CXCR4 blockade alleviates pulmonary and cardiac outcomes in early COPD
CXCR4 blockade alleviates pulmonary and cardiac outcomes in early COPD Open
Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory disease lacking effective treatment. Focusing on early COPD should help to discover disease modifying therapies. We aimed to examine the role of the CXCL12/CXCR4 axis …
View article: Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE
Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE Open
View article: Gut bacteriobiota and mycobiota are both associated with Day-28 mortality among critically ill patients
Gut bacteriobiota and mycobiota are both associated with Day-28 mortality among critically ill patients Open