Rende Gu
YOU?
Author Swipe
View article: Development of Tinnitus and Hyperacusis in a Mouse Model of Tobramycin Cochleotoxicity
Development of Tinnitus and Hyperacusis in a Mouse Model of Tobramycin Cochleotoxicity Open
Aminoglycosides (AG) antibiotics are a common treatment for recurrent infections in cystic fibrosis (CF) patients. AGs are highly ototoxic, resulting in a range of auditory dysfunctions. It was recently shown that the acoustic startle refl…
View article: A Novel Mouse Model of Aminoglycoside-Induced Hyperacusis and Tinnitus
A Novel Mouse Model of Aminoglycoside-Induced Hyperacusis and Tinnitus Open
Aminoglycosides (AG) such as amikacin are commonly used in cystic fibrosis patients with opportunistic pulmonary infections including multi-drug resistant mycobacterium tuberculous and non-tuberculous mycobacterium. Unfortunately, this cla…
View article: Transcriptomic Analysis of Mouse Cochlear Supporting Cell Maturation Reveals Large-Scale Changes in Notch Responsiveness Prior to the Onset of Hearing
Transcriptomic Analysis of Mouse Cochlear Supporting Cell Maturation Reveals Large-Scale Changes in Notch Responsiveness Prior to the Onset of Hearing Open
Neonatal mouse cochlear supporting cells have a limited ability to divide and trans-differentiate into hair cells, but this ability declines rapidly in the two weeks after birth. This decline is concomitant with the morphological and funct…
View article: Changes in the regulation of the Notch signaling pathway are temporally correlated with regenerative failure in the mouse cochlea
Changes in the regulation of the Notch signaling pathway are temporally correlated with regenerative failure in the mouse cochlea Open
Sensorineural hearing loss is most commonly caused by the death of hair cells in the organ of Corti, and once lost, mammalian hair cells do not regenerate. In contrast, other vertebrates such as birds can regenerate hair cells by stimulati…