Rendong Zhang
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View article: SLFN11 expression correlates with immune microenvironment and predicts prognosis in melanoma
SLFN11 expression correlates with immune microenvironment and predicts prognosis in melanoma Open
Background Schlafen family member 11 (SLFN11) has been implicated in cancer biology and immune modulation, but its expression patterns, prognostic value, and role in tumor immunity in melanoma remain incompletely defined. Methods Through m…
View article: Collaborative Augmented Reality for Older Adults and Family/Close Friends: Protocol for a Feasibility and Acceptability Study (Preprint)
Collaborative Augmented Reality for Older Adults and Family/Close Friends: Protocol for a Feasibility and Acceptability Study (Preprint) Open
BACKGROUND Loneliness and social isolation are common in older adults and can result in increased risk of mortality, cognitive and physical decline, and reduced quality of life. Studies using interactive communication technology (ICT) int…
View article: Enhancing Clinical Data Management Through Barcode Integration and Research Electronic Data Capture: Scalable and Adaptable Implementation Study
Enhancing Clinical Data Management Through Barcode Integration and Research Electronic Data Capture: Scalable and Adaptable Implementation Study Open
Background Effective data management is crucial in clinical studies for precise tracking, secure storage, and reliable analysis of samples. Traditional systems often encounter challenges like barcode recognition errors, inadequate data det…
View article: Ligand-receptor pair-based signature score Derived from On-treatment Tumor Specimens Predicts Immune Checkpoint Blockade Response in Metastatic Melanoma
Ligand-receptor pair-based signature score Derived from On-treatment Tumor Specimens Predicts Immune Checkpoint Blockade Response in Metastatic Melanoma Open
Immune checkpoint blockade (ICB) therapy has transformed the treatment landscape for metastatic melanoma, yet predicting therapeutic response remains a significant challenge. This study hypothesizes that coordinated ligand-receptor (LR) in…
View article: GSAC: Leveraging Gaussian Splatting for Photorealistic Avatar Creation with Unity Integration
GSAC: Leveraging Gaussian Splatting for Photorealistic Avatar Creation with Unity Integration Open
Photorealistic avatars have become essential for immersive applications in virtual reality (VR) and augmented reality (AR), enabling lifelike interactions in areas such as training simulations, telemedicine, and virtual collaboration. Thes…
View article: Quantitative analysis of colonic epithelial cell aging in a cell-cycle-like model: changes in nucleus and cytoplasm along the crypt axis
Quantitative analysis of colonic epithelial cell aging in a cell-cycle-like model: changes in nucleus and cytoplasm along the crypt axis Open
Understanding epithelial cell aging in bowel tissue can provide critical insights into gastrointestinal (GI) health, potentially leading to improved diagnosis, treatment, and prevention strategies for various GI conditions. Despite the sig…
View article: CASC-AI: Consensus-aware Self-corrective Learning for Noise Cell Segmentation
CASC-AI: Consensus-aware Self-corrective Learning for Noise Cell Segmentation Open
Multi-class cell segmentation in high-resolution gigapixel whole slide images (WSIs) is crucial for various clinical applications. However, training such models typically requires labor-intensive, pixel-wise annotations by domain experts. …
View article: Immunogenic cell death signatures from on-treatment tumor specimens predict immune checkpoint therapy response in metastatic melanoma
Immunogenic cell death signatures from on-treatment tumor specimens predict immune checkpoint therapy response in metastatic melanoma Open
Melanoma is a highly malignant form of skin cancer that typically originates from abnormal melanocytes. Despite significant advances in treating metastatic melanoma with immune checkpoint blockade (ICB) therapy, a substantial number of pat…
View article: C188-9 reduces patient-specific primary breast cancer cells proliferation at the low, clinic-relevant concentration
C188-9 reduces patient-specific primary breast cancer cells proliferation at the low, clinic-relevant concentration Open
In this study, we tested a novel drug C188-9 at a low, clinic-relevant concentration, together with several traditional chemotherapy agents. PSPCs from ten out of fifteen patient donors were sensitive to C188-9, while some of traditional c…
View article: Immunogenic cell death signatures derived from on-treatment tumor specimens for predicting immune checkpoint blockade therapy response and prognosis in metastatic melanoma
Immunogenic cell death signatures derived from on-treatment tumor specimens for predicting immune checkpoint blockade therapy response and prognosis in metastatic melanoma Open
Melanoma is a highly malignant form of skin cancer that typically originates from abnormal melanocytes. Despite significant advances in treating metastatic melanoma with immune checkpoint blockade (ICB) therapy, a substantial number of pat…
View article: A bibliometric analysis of drug resistance in immunotherapy for breast cancer: trends, themes, and research focus
A bibliometric analysis of drug resistance in immunotherapy for breast cancer: trends, themes, and research focus Open
While breast cancer treatments have advanced significantly nowadays, yet metastatic, especially triple-negative breast cancer (TNBC), remains challenging with low survival. Cancer immunotherapy, a promising approach for HER2-positive and T…
View article: Cell spatial analysis in Crohn's disease: unveiling local cell arrangement pattern with graph-based signatures
Cell spatial analysis in Crohn's disease: unveiling local cell arrangement pattern with graph-based signatures Open
Crohn's disease (CD) is a chronic and relapsing inflammatory condition that affects segments of the gastrointestinal tract. CD activity is determined by histological findings, particularly the density of neutrophils observed on Hematoxylin…
View article: IGFBP5, as a Prognostic Indicator Promotes Tumor Progression and Correlates with Immune Microenvironment in Glioma
IGFBP5, as a Prognostic Indicator Promotes Tumor Progression and Correlates with Immune Microenvironment in Glioma Open
Background: Insulin-like growth factor binding protein 5 (IGFBP5) is highly expressed in multiple human cancers, including glioma. Despite this, it remains unclear what role it plays in glioma. The aim of the present study was to an…
View article: Identification and comprehensive analysis of epithelial–mesenchymal transition related target genes of miR-222-3p in breast cancer
Identification and comprehensive analysis of epithelial–mesenchymal transition related target genes of miR-222-3p in breast cancer Open
Background Epithelial–mesenchymal transition (EMT) is a crucial mechanism that microRNA-222-3p (miR-222-3p) promotes breast cancer (BC) progression. Our study aimed to identify EMT-associated target genes (ETGs) of miR-222-3p for further a…
View article: A Novel Immune-Related Signature to Predict Prognosis and Immune Infiltration of Cervical Cancer
A Novel Immune-Related Signature to Predict Prognosis and Immune Infiltration of Cervical Cancer Open
BACKGROUND Cervical cancer is one of the most common malignances among women globally. This study aimed to construct a novel immune-related signature to predict the prognosis and immune infiltration of cervical cancer. MATERIAL AND METHODS…
View article: The Neural Networks Based Needle Detection for Medical Retinal Surgery
The Neural Networks Based Needle Detection for Medical Retinal Surgery Open
In recent years, deep learning technology has developed rapidly, and the application of deep neural networks in the medical image processing field has become the focus of the spotlight. This paper aims to achieve needle position detection …
View article: Overexpressed VDAC1 in breast cancer as a novel prognostic biomarker and correlates with immune infiltrates
Overexpressed VDAC1 in breast cancer as a novel prognostic biomarker and correlates with immune infiltrates Open
Background More and more evidence suggests that cancer is a mitochondrial metabolic disease recently and mitochondria dysfunction is critical to tumorigenesis. As a gatekeeper of mitochondria, the voltage-dependent anion channel 1 (VDAC1) …
View article: ARSD is responsible for carcinoma and amyloidosis of breast epithelial cells
ARSD is responsible for carcinoma and amyloidosis of breast epithelial cells Open