René Hen
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View article: Hybrid Solid-Liquid Optics Enable Scalable, High-Resolution, Multi-Immersion Light-Sheet Microscopy
Hybrid Solid-Liquid Optics Enable Scalable, High-Resolution, Multi-Immersion Light-Sheet Microscopy Open
Modern biology increasingly depends on data-driven discovery, requiring scalable and affordable high-content 3D imaging across molecular to organ scales. Although tissue clearing, expansion microscopy, and light-sheet microscopy (LSM) enab…
View article: A rare variant in <i>GPR156</i> associated with depression in a Mennonite pedigree causes habenula hyperactivity and stress sensitivity in mice
A rare variant in <i>GPR156</i> associated with depression in a Mennonite pedigree causes habenula hyperactivity and stress sensitivity in mice Open
Major depressive disorder (MDD) is a leading cause of disability worldwide. Risk for MDD is heritable, and the genetic structure of founder populations enables investigation of rare susceptibility alleles with large effect. In an extended …
View article: Distinct representations of an anxiogenic environment in different cell types of the ventral hippocampus
Distinct representations of an anxiogenic environment in different cell types of the ventral hippocampus Open
In addition to its role in episodic memory and spatial navigation, the hippocampus has also been found to influence mood-related disorders such as anxiety and depression. These seemingly distinct roles are consistent with a functional diss…
View article: Optimal sparsity in autoencoder memory models of the hippocampus
Optimal sparsity in autoencoder memory models of the hippocampus Open
Storing complex correlated memories is significantly more efficient when memories are recoded to obtain compressed representations. Previous work has shown that compression can be implemented in a simple neural circuit, which can be descri…
View article: Antidepressants reactivate developmental plasticity through remodeling of extracellular matrix
Antidepressants reactivate developmental plasticity through remodeling of extracellular matrix Open
Selective serotonin reuptake inhibitors (SSRIs) are widely used to treat mood and anxiety disorders, yet their molecular mechanisms of action remain poorly understood. Here, we show that chronic treatment with the SSRI fluoxetine reinstate…
View article: Psilocybin Induces Sex- and Context-Specific Recruitment of the Stress Axis
Psilocybin Induces Sex- and Context-Specific Recruitment of the Stress Axis Open
View article: Pharmacological Enhancement of Adult Hippocampal Neurogenesis Improves Behavioral Pattern Separation in Young and Aged Male Mice
Pharmacological Enhancement of Adult Hippocampal Neurogenesis Improves Behavioral Pattern Separation in Young and Aged Male Mice Open
View article: Effects of electroconvulsive shock on the function, circuitry, and transcriptome of dentate gyrus granule neurons
Effects of electroconvulsive shock on the function, circuitry, and transcriptome of dentate gyrus granule neurons Open
Therapeutic use of electroconvulsive shock (ECS) is particularly effective for treatment-resistant depression. Like other more common forms of antidepressant treatment such as SSRIs, ECS has been shown to increase neurogenesis in the hippo…
View article: Pharmacological Enhancement of Adult Hippocampal Neurogenesis Improves Behavioral Pattern Separation in Young and Aged Mice
Pharmacological Enhancement of Adult Hippocampal Neurogenesis Improves Behavioral Pattern Separation in Young and Aged Mice Open
BACKGROUND Impairments in behavioral pattern separation (BPS)—the ability to distinguish between similar contexts or experiences—contribute to memory interference and overgeneralization seen in many neuropsychiatric conditions, including d…
View article: Cover Image, Volume 33, Issue 10
Cover Image, Volume 33, Issue 10 Open
The cover image is based on the Research Article A complex relation between levels of adult hippocampal neurogenesis and expression of the immature neuron marker doublecortin by Indira Mendez-David et al., https://doi.org/10.1002/hipo.2356…
View article: Ventral CA1 Population Codes for Anxiety
Ventral CA1 Population Codes for Anxiety Open
SUMMARY The ventral hippocampus is a critical node in the distributed brain network that controls anxiety. Using miniature microscopy and calcium imaging, we recorded ventral CA1 (vCA1) neurons in freely moving mice as they explored varian…
View article: Heterozygous and homozygous gene knockout of the 5-HT1B receptor have different effects on methamphetamine-induced behavioral sensitization
Heterozygous and homozygous gene knockout of the 5-HT1B receptor have different effects on methamphetamine-induced behavioral sensitization Open
The psychostimulant drug methamphetamine (METH) causes euphoria in humans and locomotor hyperactivity in rodents by acting on the mesolimbic dopamine (DA) pathway and has severe abuse and addiction liability. Behavioral sensitization, an i…
View article: 5-Hydroxytryptamine receptors in GtoPdb v.2023.1
5-Hydroxytryptamine receptors in GtoPdb v.2023.1 Open
5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors [198] and subsequently revised [180]) are, with the exception of the ionotropic 5-HT3 class, GPCRs where the endogenous agonist is 5-hydroxytryptamine. …
View article: An Open-Source Virtual Reality System for the Measurement of Spatial Learning in Head-Restrained Mice
An Open-Source Virtual Reality System for the Measurement of Spatial Learning in Head-Restrained Mice Open
Head-restrained behavioral experiments in mice allow neuroscientists to observe neural circuit activity with high-resolution electrophysiological and optical imaging tools while delivering precise sensory stimuli to a behaving animal. Rece…
View article: Protocol for in vivo imaging and analysis of brainstem neuronal activity in the dorsal raphe nucleus of freely behaving mice
Protocol for in vivo imaging and analysis of brainstem neuronal activity in the dorsal raphe nucleus of freely behaving mice Open
In vivo brainstem imaging with miniature microscopy has been challenging due to surgical difficulty, high motion, and correlated activity between neurons. Here, we present a protocol for brainstem imaging in freely moving mice using the do…
View article: Adult born hippocampal granule cells promote pattern separation by bidirectionally modulating the remapping of place and cue cells
Adult born hippocampal granule cells promote pattern separation by bidirectionally modulating the remapping of place and cue cells Open
The hippocampal dentate gyrus (DG) exhibits a unique form of neural plasticity that results from continuous integration of adult born neurons, referred to as ‘adult neurogenesis’. Recent studies have proposed that adult neurogenesis promot…
View article: Single-cell activity and network properties of dorsal raphe nucleus serotonin neurons during emotionally salient behaviors
Single-cell activity and network properties of dorsal raphe nucleus serotonin neurons during emotionally salient behaviors Open
View article: Dysregulation of adult hippocampal neuroplasticity in major depression: pathogenesis and therapeutic implications
Dysregulation of adult hippocampal neuroplasticity in major depression: pathogenesis and therapeutic implications Open
View article: Mu opioid receptors on hippocampal GABAergic interneurons are critical for the antidepressant effects of tianeptine
Mu opioid receptors on hippocampal GABAergic interneurons are critical for the antidepressant effects of tianeptine Open
View article: Increasing Adult Hippocampal Neurogenesis Promotes Resilience in a Mouse Model of Depression
Increasing Adult Hippocampal Neurogenesis Promotes Resilience in a Mouse Model of Depression Open
Many studies evaluated the functional role of adult hippocampal neurogenesis (AHN) and its key role in cognitive functions and mood regulation. The effects of promoting AHN on the recovery of stress-induced symptoms have been well studied,…
View article: Blunted Neurogenesis in Major Depression and Normal Levels in High Functioning Antidepressant-Treated Subjects
Blunted Neurogenesis in Major Depression and Normal Levels in High Functioning Antidepressant-Treated Subjects Open
View article: Augmenting Neurogenesis Rescues Memory Impairments in Alzheimer's Disease by Restoring the Engram
Augmenting Neurogenesis Rescues Memory Impairments in Alzheimer's Disease by Restoring the Engram Open
View article: Parallel Processing of Sensory Cue and Spatial Information in the Dentate Gyrus
Parallel Processing of Sensory Cue and Spatial Information in the Dentate Gyrus Open
View article: Adult neurogenesis augmentation attenuates anhedonia and HPA axis dysregulation in a mouse model of chronic stress and depression
Adult neurogenesis augmentation attenuates anhedonia and HPA axis dysregulation in a mouse model of chronic stress and depression Open
View article: Parallel processing of sensory cue and spatial information in the Dentate Gyrus
Parallel processing of sensory cue and spatial information in the Dentate Gyrus Open
During exploration, animals form an internal map of an environment by combining information about specific sensory cues or landmarks with the animal’s motion through space, a process which critically depends on the mammalian hippocampus. T…
View article: Changes in the functional connectome and behavior after exposure to chronic stress and increasing neurogenesis
Changes in the functional connectome and behavior after exposure to chronic stress and increasing neurogenesis Open
Addition of new neurons to the dentate gyrus might change the activity of neural circuitry in the areas which the hippocampus projects to. The size of the hippocampus and the number of adult newborn granule cells are decreased by unpredict…
View article: A Distributed Neural Code in the Dentate Gyrus and in CA1
A Distributed Neural Code in the Dentate Gyrus and in CA1 Open
View article: A non-linear relation between levels of adult hippocampal neurogenesis and expression of the immature neuron marker doublecortin
A non-linear relation between levels of adult hippocampal neurogenesis and expression of the immature neuron marker doublecortin Open
We investigated the mechanisms underlying the effects of the antidepressant fluoxetine on behavior and adult hippocampal neurogenesis (AHN). After confirming our earlier report that the signaling molecule β2-arrestin is required for the an…
View article: Parallel processing of sensory cue and spatial information in the Dentate Gyrus
Parallel processing of sensory cue and spatial information in the Dentate Gyrus Open
During exploration, animals form an internal map of an environment by combining information about specific sensory cues or landmarks with the animal’s motion through space, a process which critically depends on the mammalian hippocampus. T…
View article: A Non-Linear Relation between Levels of Adult Hippocampal Neurogenesis and Expression of the Immature Neuron Marker Doublecortin
A Non-Linear Relation between Levels of Adult Hippocampal Neurogenesis and Expression of the Immature Neuron Marker Doublecortin Open