René Rizzoli
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View article: Regular Proton-Pump Inhibitor Intake is Associated with Deterioration of Peripheral Bone Mineral Density, Microarchitecture, and Strength in Older Patients as Assessed by High-Resolution Peripheral Quantitative Computed Tomography (HR-pQCT)
Regular Proton-Pump Inhibitor Intake is Associated with Deterioration of Peripheral Bone Mineral Density, Microarchitecture, and Strength in Older Patients as Assessed by High-Resolution Peripheral Quantitative Computed Tomography (HR-pQCT) Open
Proton-pump inhibitors (PPI) are widely used among older adults and PPI intake has been associated with increased fracture risk. However, their association with bone microarchitecture and strength remains unclear as prior clinical PPI stud…
View article: Mediterranean diet and Cantonese cuisine for human health: report from a Sino-Italian bilateral meeting
Mediterranean diet and Cantonese cuisine for human health: report from a Sino-Italian bilateral meeting Open
This article explores the traditional Mediterranean and Cantonese diets through historical, cultural, and scientific lenses. Drawing from expert presentations delivered during a multi-day international symposium, we examine the culinary pr…
View article: Author Correction: Parathyroid hormone receptor agonists in the management of osteoporosis
Author Correction: Parathyroid hormone receptor agonists in the management of osteoporosis Open
View article: Barriers and solutions for global access to osteoporosis management: a Position Paper from the International Osteoporosis Foundation
Barriers and solutions for global access to osteoporosis management: a Position Paper from the International Osteoporosis Foundation Open
Our ability to optimally manage bone health across the lifecourse, and so minimise the risk of fractures, has advanced substantially in recent decades. Whilst fractures and osteoporosis in older age were historically viewed simply as inher…
View article: Best practice recommendations for the diagnosis and management of hypoparathyroidism
Best practice recommendations for the diagnosis and management of hypoparathyroidism Open
View article: Management of aromatase inhibitor-associated bone loss (AIBL) in women with hormone-sensitive breast cancer: An updated joint position statement of the IOF, CABS, ECTS, IEG, ESCEO, IMS, and SIOG
Management of aromatase inhibitor-associated bone loss (AIBL) in women with hormone-sensitive breast cancer: An updated joint position statement of the IOF, CABS, ECTS, IEG, ESCEO, IMS, and SIOG Open
View article: Effects of vitamin D3, omega-3s, and a simple home exercise program on incident vertebral fractures: the DO-HEALTH randomized controlled trial
Effects of vitamin D3, omega-3s, and a simple home exercise program on incident vertebral fractures: the DO-HEALTH randomized controlled trial Open
Vertebral fractures (VFs) are among the most common osteoporotic fractures. The effect of vitamin D3, omega-3s or a simple home exercise program (SHEP) on VFs is unclear. We examined whether vitamin D3, omega-3s, or SHEP, alone or in combi…
View article: Antiresorptive Therapy to Reduce Fracture Risk and Effects on Dental Implant Outcomes in Patients With Osteoporosis: A Systematic Review and Osteonecrosis of the Jaw Taskforce Consensus Statement
Antiresorptive Therapy to Reduce Fracture Risk and Effects on Dental Implant Outcomes in Patients With Osteoporosis: A Systematic Review and Osteonecrosis of the Jaw Taskforce Consensus Statement Open
View article: Prevalence and incidence of osteoporotic vertebral fractures in community-dwelling European older adults: an observational analysis of the DO-HEALTH trial
Prevalence and incidence of osteoporotic vertebral fractures in community-dwelling European older adults: an observational analysis of the DO-HEALTH trial Open
This study suggests a high prevalence and incidence of VFs in community-dwelling European older adults. Underdiagnosis may be even more prevalent than previously observed, and treatment rates were low.
View article: Update on the role of bone turnover markers in the diagnosis and management of osteoporosis: a consensus paper from The European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO), International Osteoporosis Foundation (IOF), and International Federation of Clinical Chemistry and Laboratory Medicine (IFCC)
Update on the role of bone turnover markers in the diagnosis and management of osteoporosis: a consensus paper from The European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO), International Osteoporosis Foundation (IOF), and International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Open
View article: Bone Effects of Anti-Cancer Treatments in 2024
Bone Effects of Anti-Cancer Treatments in 2024 Open
View article: Correction: PTH1 receptor agonists for fracture risk: a systematic review and network meta-analysis
Correction: PTH1 receptor agonists for fracture risk: a systematic review and network meta-analysis Open
View article: Cognitive function in generally healthy adults age 70 years and older in the 5-country DO-HEALTH study: MMSE and MoCA scores by sex, education and country
Cognitive function in generally healthy adults age 70 years and older in the 5-country DO-HEALTH study: MMSE and MoCA scores by sex, education and country Open
Background Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) are validated and frequently used screening tools for cognitive function. Aims To present MMSE and MoCA scores by sex, age and education among communi…
View article: Effects of vitamin D3, omega-3 fatty acids and a simple home exercise program on change in physical activity among generally healthy and active older adults: The 3-year DO-HEALTH trial
Effects of vitamin D3, omega-3 fatty acids and a simple home exercise program on change in physical activity among generally healthy and active older adults: The 3-year DO-HEALTH trial Open
Among generally healthy, active, and largely vitamin D3 replete adults aged 70 years and older, vitamin D3, omega-3s and SHEP, individually and in combination had no benefits on self-reported PA and objectively measured physical function. …
View article: PTH1 receptor agonists for fracture risk: a systematic review and network meta-analysis
PTH1 receptor agonists for fracture risk: a systematic review and network meta-analysis Open
View article: Musculoskeletal diseases, infections and vaccines: state of the art, research perspectives and educational needs
Musculoskeletal diseases, infections and vaccines: state of the art, research perspectives and educational needs Open
Musculoskeletal disorders are a significant public health burden concern, projected to increase in the coming decades, and will substantially contribute to the rising prevalence of functional impairment, frailty and disability in a growing…
View article: Treatment of Osteoporosis and Osteoarthritis in the Oldest Old
Treatment of Osteoporosis and Osteoarthritis in the Oldest Old Open
View article: Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial
Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial Open
While observational studies and small pilot trials suggest that vitamin D, omega-3 and exercise may slow biological aging, larger clinical trials testing these treatments individually or in combination are lacking. Here, we report the resu…
View article: OSTEOPOROSIS IN THE OLDEST OLD: TIME TO STAND UP AND TO ACT
OSTEOPOROSIS IN THE OLDEST OLD: TIME TO STAND UP AND TO ACT Open
View article: Impact of dementia and mild cognitive impairment on bone health in older people
Impact of dementia and mild cognitive impairment on bone health in older people Open
Mild cognitive impairment, dementia and osteoporosis are common diseases of ageing and, with the increasingly ageing global population, are increasing in prevalence. These conditions are closely associated, with shared risk factors, common…
View article: Effect of vitamin D, omega‐3 supplementation, or a home exercise program on muscle mass and sarcopenia: <scp>DO</scp> ‐ <scp>HEALTH</scp> trial
Effect of vitamin D, omega‐3 supplementation, or a home exercise program on muscle mass and sarcopenia: <span>DO</span> ‐ <span>HEALTH</span> trial Open
Background We aimed to investigate the effect of daily supplemental vitamin D, omega‐3s, and a thrice‐weekly home exercise program, alone or in combination, on change of appendicular lean muscle mass index (ALMI) and incident sarcopenia in…
View article: Comparative Effectiveness of Abaloparatide and Teriparatide in Women 50 Years of Age and Older: Update of a Real-World Retrospective Analysis
Comparative Effectiveness of Abaloparatide and Teriparatide in Women 50 Years of Age and Older: Update of a Real-World Retrospective Analysis Open
There were significantly lower rates of hip and nonvertebral fractures with abaloparatide compared to teriparatide, which were consistent across subgroups. No differences in cardiovascular safety were noted between cohorts.
View article: Nutrition and Osteoporosis Prevention
Nutrition and Osteoporosis Prevention Open
View article: Recommendations for the optimal use of bone forming agents in osteoporosis
Recommendations for the optimal use of bone forming agents in osteoporosis Open
Bone forming agents, also known as anabolic therapies, are essential in managing osteoporosis, particularly for patients at very high-risk of fractures. Identifying candidates who will benefit the most from these treatments is crucial. For…
View article: Race-specific FRAX models are evidence-based and support equitable care: a response to the ASBMR Task Force report on Clinical Algorithms for Fracture Risk
Race-specific FRAX models are evidence-based and support equitable care: a response to the ASBMR Task Force report on Clinical Algorithms for Fracture Risk Open
View article: Radiofrequency echographic multi spectrometry (REMS) in the diagnosis and management of osteoporosis: state of the art
Radiofrequency echographic multi spectrometry (REMS) in the diagnosis and management of osteoporosis: state of the art Open
View article: Optimisation of vitamin D status in global populations
Optimisation of vitamin D status in global populations Open
View article: Effects of Dalcroze Eurhythmics Exercise Versus Multicomponent Exercise on Physical and Cognitive Function, and Falls in Older Adults: The EPHYCOS Randomized Controlled Trial
Effects of Dalcroze Eurhythmics Exercise Versus Multicomponent Exercise on Physical and Cognitive Function, and Falls in Older Adults: The EPHYCOS Randomized Controlled Trial Open
Currently, robust evidence is lacking to support one exercise type over another in the prevention of physical and cognitive decline and falls among older adults, primarily because of the lack of comparative trials of proven interventions. …
View article: Consensus Statement on Vitamin D Status Assessment and Supplementation: Whys, Whens, and Hows
Consensus Statement on Vitamin D Status Assessment and Supplementation: Whys, Whens, and Hows Open
The 6th International Conference, “Controversies in Vitamin D,” was convened to discuss controversial topics, such as vitamin D metabolism, assessment, actions, and supplementation. Novel insights into vitamin D mechanisms of action sugges…
View article: Association Between Visual Acuity and Prospective Fall Risk in Generally Healthy and Active Older Adults: The 3-Year DO-HEALTH Study
Association Between Visual Acuity and Prospective Fall Risk in Generally Healthy and Active Older Adults: The 3-Year DO-HEALTH Study Open
Our findings suggest that decreased VA is an independent predictor of an about 20% increased risk of all and injurious falls, highlighting the importance of regular eye examinations and VA measurements for fall prevention, even in generall…