Explanipedia

Tacrolimus Trough Concentrations are Not Impacted by Epstein–Barr Virus Serology and Viral Load in Pediatric Liver Transplant Recipients Open

Amber M Te Lintelo, Lisa F van Wier, Hubert P. J. van der Doef, Jos G. W. Kosterink, René Scheenstra , et al. · 2025

Absence of Pupillary Reflexes in Pediatric Acute Liver Failure and Neurological Outcome After Liver Transplantation Open

Kirsten J. Schouwstra, René Scheenstra, Ruben H. de Kleine, Vincent E. de Meijer, Sander T. H. Bontemps , et al. · 2025

Background Pediatric Acute Liver Failure (PALF) frequently requires liver transplantation (LTx). The neurological condition can deteriorate rapidly, but the difficulty in assessing the (ir)reversibility of neurological symptoms can hamper …

Hepatic artery stenosis after pediatric liver transplantation: The potential role of conservative management Open

Weihao Li, Thomai Kotsou, Hermien Hartog, René Scheenstra, Vincent E. de Meijer , et al. · 2024

The long-term outcomes of HAS after pLT are excellent. Both EVT and conservative management exhibited high graft survival rates for late HAS, with EVT achieving high technical success.

Long-term Outcome of Asymptomatic Patients With Graft Fibrosis in Protocol Biopsies After Pediatric Liver Transplantation Open

Steffen Hartleif, James Hodson, Carla Lloyd, Vladimir L. Cousin, Piotr Czubkowski , et al. · 2023

Background. The histological prevalence of allograft fibrosis in asymptomatic children after liver transplantation (LT) is well documented. However, long-term graft and patient survival remain unclear. This retrospective multicenter study …

Indeterminate pediatric acute liver failure: Clinical characteristics of a temporal cluster of five children in the Netherlands in the spring of 2022 Open

Willem S. Lexmond, Vincent E. de Meijer, René Scheenstra, Sander T. H. Bontemps, Evelien W. Duiker , et al. · 2022

There is increasing global concern of severe acute hepatitis of unknown etiology in young children. In early 2022, our center for liver transplantation in the Netherlands treated five children who presented in short succession with indeter…

Paraneoplastic pemphigus associated with post‐transplant lymphoproliferative disorder after small bowel transplantation Open

Sander A. R. Fidder, Maria C. Bolling, Gilles F.H. Diercks, Hendri H. Pas, Louise Hooimeijer , et al. · 2021

Background PNP is a malignancy‐associated autoimmune mucocutaneous syndrome due to autoantibodies against plakins, desmogleins, and other components of the epidermis and basement membrane of epithelial tissues. PNP‐causing malignancies com…

Motor development in children 0‐2 years pre‐ and post‐LTX, a prospective study Open

G. J. F. Joyce Bos, Carola Y. Timmer, Otto T. H. M. Lelieveld, René Scheenstra, Pieter J.J. Sauer , et al. · 2020

To determine prospectively gross and fine motor development of children <2 years of age, who undergo LTX. In this prospective study, children aged <2 years who undergo LTX were tested using the motor scale of the Bayley Scales of infant an…

In Vitro Evaluation of Pro- and Anticoagulant Drugs in Children with End-Stage Liver Disease Undergoing Liver Transplantation Open

Maureen J. M. Werner, Jelle Adelmeijer, Vincent E. de Meijer, Ruben H.J. de Kleine, René Scheenstra , et al. · 2020

Background Pro- and anticoagulant drugs are commonly used in pediatric liver transplantation to prevent and treat thrombotic and bleeding complications. However, the combination of baseline hemostatic changes in children with liver disease…

Routine Postoperative Antithrombotic Therapy in Pediatric Liver Transplantation: Impact on Bleeding and Thrombotic Complications Open

Maureen J. M. Werner, Ruben H.J. de Kleine, Marieke T. de Boer, Vincent E. de Meijer, René Scheenstra , et al. · 2020

Background Hepatic artery thrombosis (HAT) and portal vein thrombosis (PVT) are serious causes of morbidity and mortality after pediatric liver transplantation. To reduce thrombotic complications, routine antithrombotic therapy consisting …

Risk factors for thrombosis and bleeding in pediatric liver transplantation in an Era of routine postoperative antithrombotic therapy Open

Maureen J. M. Werner, Ruben H.J. de Kleine, Marieke T. de Boer, Vincent E. de Meijer, René Scheenstra , et al. · 2020

Evidence for a rebalanced hemostatic system in pediatric liver transplantation: A prospective cohort study Open

Maureen J. M. Werner, Vincent E. de Meijer, Jelle Adelmeijer, Ruben H.J. de Kleine, René Scheenstra , et al. · 2019

Time‐to‐reach Target Calprotectin Level in Newly Diagnosed Patients With Inflammatory Bowel Disease Open

Sjoukje‐Marije Haisma, Henkjan J. Verkade, René Scheenstra, Hubert P. J. van der Doef, Frank A.J.A. Bodewes , et al. · 2019

Objectives: Treatment targets in inflammatory bowel disease (IBD) move away from controlling symptoms towards complete recovery of the intestinal mucosa. Currently, the most frequently used noninvasive surrogate marker of mucosal healing i…

Physical activity and aerobic fitness in children after liver transplantation Open

G. J. F. Joyce Bos, Otto T. H. M. Lelieveld, René Scheenstra, Pieter J.J. Sauer, Jan H. B. Geertzen , et al. · 2019

To determine physical activity (PA), aerobic fitness, muscle strength, health‐related quality of life (HRQOL), fatigue, and participation in children after liver transplantation. Children, 6‐12 years, at least one year after liver transpla…

First report of successful transplantation of a pediatric donor liver graft after hypothermic machine perfusion Open

Maureen J. M. Werner, Otto B. van Leeuwen, Iris E. M. de Jong, Frank A.J.A. Bodewes, Masato Fujiyoshi , et al. · 2019

One of the main limiting factors in pediatric liver transplantation is donor availability. For adults, DCD liver grafts are increasingly used to expand the donor pool. To improve outcome after DCD liver transplantation, ex situ machine per…

Intestinal Failure and Aberrant Lipid Metabolism in Patients With DGAT1 Deficiency Open

Jorik M. van Rijn, Rico Chandra Ardy, Zarife Kuloğlu, Bettina Härter, Désirée Y. van Haaften–Visser , et al. · 2018

Levertransplantaties bij kinderen in Nederland Open

Maureen J. M. Werner, Ruben H.J. de Kleine, Frank A.J.A. Bodewes, Marieke T. de Boer, Koert P. de Jong , et al. · 2017

OBJECTIVE: To evaluate the results of the national paediatric liver transplantation programme in the University Medical Centre (UMC) Groningen in the Netherlands during the past two decades. DESIGN: Retrospective cohort study. METHOD: We a…

Variceal Bleeds in Patients with Biliary Atresia Open

Mauri Witt, Niels Bax, Henkjan J. Verkade, René Scheenstra, Ruben H. de Kleine , et al. · 2017

Introduction Portal hypertension often occurs in biliary atresia (BA). The subsequent development of esophageal varices and bleeding from these varices are a well-known complication. We aim to describe the incidence and severity of varicea…

Early life predictive markers of liver disease outcome in an International, Multicentre Cohort of children with Alagille syndrome Open

Marialena Mouzaki, Lee M. Bass, Ronald J. Sokol, David A. Piccoli, Claudia Quammie , et al. · 2015

Background & Aims Liver disease in Alagille syndrome is highly variable. Many of the patients presenting with severe cholestasis early in life improve spontaneously; 10–20%, however, have progressive disease. It is currently not possible t…

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