René Stein
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View article: Loading monocytes with magnetic nanoparticles enables their magnetic control without toxicity
Loading monocytes with magnetic nanoparticles enables their magnetic control without toxicity Open
Background With the help of superparamagnetic iron oxide nanoparticles (SPIONs), cells can be magnetically directed so that they can be accumulated at target sites. This principle can be used to make monocytes magnetically steerable in ord…
View article: Loading of CAR‐T cells with magnetic nanoparticles for controlled targeting suppresses inflammatory cytokine release and switches tumor cell death mechanism
Loading of CAR‐T cells with magnetic nanoparticles for controlled targeting suppresses inflammatory cytokine release and switches tumor cell death mechanism Open
Therapies against hematological malignancies using chimeric antigen receptors (CAR)‐T cells have shown great potential; however, therapeutic success in solid tumors has been constrained due to limited tumor trafficking and infiltration, as…
View article: Magnetite Nanodiscs as Vortex-Enhanced MRI Contrast Agents: A Novel Approach in Medical Imaging
Magnetite Nanodiscs as Vortex-Enhanced MRI Contrast Agents: A Novel Approach in Medical Imaging Open
Magnetic nanoparticles can serve as contrast agents for magnetic resonance imaging (MRI) to enhance sensitivity and improve imaging contrast. This study investigated anisotropic magnetite nanodiscs (MNDs) with vortex magnetization, which e…
View article: Magnetite Nanodiscs as Vortex-Enhanced MRI Contrast Agents: A Novel Approach in Medical Imaging
Magnetite Nanodiscs as Vortex-Enhanced MRI Contrast Agents: A Novel Approach in Medical Imaging Open
Magnetic nanoparticles can serve as contrast agents for magnetic resonance imaging (MRI) to enhance sensitivity and improve imaging contrast. This study investigated anisotropic magnetite nanodiscs (MNDs) with vortex magnetization, which e…
View article: Magnetite Nanodiscs as Vortex-Enhanced MRI Contrast Agents: A Novel Approach in Medical Imaging
Magnetite Nanodiscs as Vortex-Enhanced MRI Contrast Agents: A Novel Approach in Medical Imaging Open
Magnetic nanoparticles can serve as contrast agents for magnetic resonance imaging (MRI) to enhance sensitivity and improve imaging contrast. This study investigated anisotropic magnetite nanodiscs (MNDs) with vortex magnetization, which e…
View article: Human T cells loaded with superparamagnetic iron oxide nanoparticles retain antigen-specific TCR functionality
Human T cells loaded with superparamagnetic iron oxide nanoparticles retain antigen-specific TCR functionality Open
Background Immunotherapy of cancer is an emerging field with the potential to improve long-term survival. Thus far, adoptive transfer of tumor-specific T cells represents an effective treatment option for tumors of the hematological system…
View article: Simulation and experimental validation of magnetic nanoparticle accumulation in a bloodstream mimicking flow system
Simulation and experimental validation of magnetic nanoparticle accumulation in a bloodstream mimicking flow system Open
In this paper, a mathematical model for the dynamics of superparamagnetic iron oxide nanoparticles (SPIONs) in a laminar flow through a pipe under the influence of an external magnetic field of a single electromagnet is derived. The model …
View article: Effect of Citrate- and Gold-Stabilized Superparamagnetic Iron Oxide Nanoparticles on Head and Neck Tumor Cell Lines during Combination Therapy with Ionizing Radiation
Effect of Citrate- and Gold-Stabilized Superparamagnetic Iron Oxide Nanoparticles on Head and Neck Tumor Cell Lines during Combination Therapy with Ionizing Radiation Open
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. They are associated with alcohol and tobacco consumption, as well as infection with human papillomaviruses (HPV). Therapeutic options include radioche…
View article: In Vitro Setup for Determination of Nanoparticle-Mediated Magnetic Cell and Drug Accumulation in Tumor Spheroids under Flow Conditions
In Vitro Setup for Determination of Nanoparticle-Mediated Magnetic Cell and Drug Accumulation in Tumor Spheroids under Flow Conditions Open
Superparamagnetic iron oxide nanoparticles (SPIONs) are used in nanomedicine as transporter systems for therapeutic cargos, or to magnetize cells to make them magnetically guidable. In cancer treatment, the site-directed delivery of chemot…
View article: Plasmid-DNA Delivery by Covalently Functionalized PEI-SPIONs as a Potential ‘Magnetofection’ Agent
Plasmid-DNA Delivery by Covalently Functionalized PEI-SPIONs as a Potential ‘Magnetofection’ Agent Open
Nanoformulations for delivering nucleotides into cells as vaccinations as well as treatment of various diseases have recently gained great attention. Applying such formulations for a local treatment strategy, e.g., for cancer therapy, is s…
View article: Superparamagnetic Iron Oxide Nanoparticles for Targeted Cell Seeding: Magnetic Patterning and Magnetic 3D Cell Culture
Superparamagnetic Iron Oxide Nanoparticles for Targeted Cell Seeding: Magnetic Patterning and Magnetic 3D Cell Culture Open
In regenerative medicine, noncontact manipulation of cells enables new possibilities for tissue engineering. Due to their physicochemical properties, superparamagnetic iron oxide nanoparticles (SPIONs) are used in biomedicine for various a…
View article: Polydopamine and gelatin coating for rapid endothelialization of vascular scaffolds
Polydopamine and gelatin coating for rapid endothelialization of vascular scaffolds Open
Rapid endothelialization helps overcome the limitations of small-diameter vascular grafts. To develop biomimetic non-thrombogenic coatings supporting endothelialization, medical-grade polyurethane (PU) nanofibrous mats and tubular scaffold…
View article: Citrate-Coated Superparamagnetic Iron Oxide Nanoparticles Enable a Stable Non-Spilling Loading of T Cells and Their Magnetic Accumulation
Citrate-Coated Superparamagnetic Iron Oxide Nanoparticles Enable a Stable Non-Spilling Loading of T Cells and Their Magnetic Accumulation Open
T cell infiltration into a tumor is associated with a good clinical prognosis of the patient and adoptive T cell therapy can increase anti-tumor immune responses. However, immune cells are often excluded from tumor infiltration and can lac…
View article: Synthesis and Characterization of Citrate-Stabilized Gold-Coated Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications
Synthesis and Characterization of Citrate-Stabilized Gold-Coated Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications Open
Surface-functionalized gold-coated superparamagnetic iron oxide nanoparticles (Au-SPIONs) may be a useful tool in various biomedical applications. To obtain Au-SPIONs, gold salt was precipitated onto citrate-stabilized SPIONs (Cit-SPIONs) …
View article: Ag modified mesoporous bioactive glass nanoparticles for enhanced antibacterial activity in 3D infected skin model
Ag modified mesoporous bioactive glass nanoparticles for enhanced antibacterial activity in 3D infected skin model Open
Bioactive glasses (BG) are versatile materials for various biomedical applications, including bone regeneration and wound healing, due to their bone bonding, antibacterial, osteogenic, and angiogenic properties. In this study, we aimed to …
View article: Timber-frame facade elements for hybrid construction
Timber-frame facade elements for hybrid construction Open
In the interdisciplinary research project three chairs of TUM (Chair of Timber Structures and Buildung
Construction, of Energy Efficient and Sustainable Design and Building and of Concrete and Masonry
Structures) as well as Ift Rosenheim…