Renée L. Flaherty
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View article: LOX inhibition disrupts a collagen-integrin–MYC axis as a translatable targeting strategy in invasive lobular carcinoma
LOX inhibition disrupts a collagen-integrin–MYC axis as a translatable targeting strategy in invasive lobular carcinoma Open
Invasive lobular carcinoma (ILC) accounts for 15% of breast cancers yet lacks specific therapy because ILCs are underrepresented in clinical trials and preclinical models are lacking. We established intraductal xenograft models to test whe…
View article: Is There a Special Role for Ovarian Hormones in the Pathogenesis of Lobular Carcinoma?
Is There a Special Role for Ovarian Hormones in the Pathogenesis of Lobular Carcinoma? Open
Lobular carcinoma represent the most common special histological subtype of breast cancer, with the majority classed as hormone receptor positive. Rates of invasive lobular carcinoma in postmenopausal women have been seen to increase globa…
View article: A Prodrug Strategy for the In Vivo Imaging of Aldehyde Dehydrogenase Activity
A Prodrug Strategy for the In Vivo Imaging of Aldehyde Dehydrogenase Activity Open
Therapy resistance is one of the biggest challenges facing clinical oncology. Despite a revolution in new anti-cancer drugs targeting multiple components of the tumour microenvironment, acquired or innate resistance frequently blunts the e…
View article: A Prodrug Strategy for the In Vivo Imaging of Aldehyde Dehydrogenase Activity
A Prodrug Strategy for the In Vivo Imaging of Aldehyde Dehydrogenase Activity Open
Therapy resistance is one of the biggest challenges facing clinical oncology. Despite a revolution in new anti-cancer drugs targeting multiple components of the tumour microenvironment, acquired or innate resistance frequently blunts the e…
View article: A prodrug strategy for the <i>in vivo</i> imaging of aldehyde dehydrogenase activity
A prodrug strategy for the <i>in vivo</i> imaging of aldehyde dehydrogenase activity Open
An in vivo aldehyde protection strategy for the non-invasive imaging of ALDH1A1 using a fluorine-18 labelled substrate.
View article: Stress and drug resistance in cancer
Stress and drug resistance in cancer Open
Patients diagnosed with cancer often undergo considerable psychological distress, and the induction of the psychological stress response has been linked with a poor response to chemotherapy. The psychological stress response is mediated by…
View article: The role of psychological stress and nitric oxide synthase inhibition in breast cancer
The role of psychological stress and nitric oxide synthase inhibition in breast cancer Open
Psychological stress has been implicated as a risk factor in the progression of breast cancer, however the biological mechanisms are not well understood. In animal models of psychological stress, anincrease in mammary tumour burden and met…
View article: Glucocorticoids induce production of reactive oxygen species/reactive nitrogen species and DNA damage through an iNOS mediated pathway in breast cancer
Glucocorticoids induce production of reactive oxygen species/reactive nitrogen species and DNA damage through an iNOS mediated pathway in breast cancer Open
These results demonstrate that glucocorticoids may interact with iNOS in a non-genomic manner to produce damaging levels of RNS, thus allowing an insight into the potential mechanisms by which psychological stress may impact breast cancer.
View article: Additional file 2: Figure S2. of Glucocorticoids induce production of reactive oxygen species/reactive nitrogen species and DNA damage through an iNOS mediated pathway in breast cancer
Additional file 2: Figure S2. of Glucocorticoids induce production of reactive oxygen species/reactive nitrogen species and DNA damage through an iNOS mediated pathway in breast cancer Open
Stress hormones do not induce DNA damage or iNOS expression in a non-tumourigenic mammary epithelial cell line. a MCF10A cells were exposed to cortisol (1 μM) and NE (1 μM) for 30 minutes and assessed for DNA damage using the Comet assay. …