Renée Laufer Amorim
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View article: Tyrosine kinase inhibitors in canine solid tumours: a systematic review of indications, response and safety
Tyrosine kinase inhibitors in canine solid tumours: a systematic review of indications, response and safety Open
View article: Prognostic significance of Ki-67, BAX, Caspase-3, and VEGF expression in feline intestinal lymphoma
Prognostic significance of Ki-67, BAX, Caspase-3, and VEGF expression in feline intestinal lymphoma Open
Feline intestinal lymphoma is the most common gastrointestinal neoplasm in cats and presents variable biological behavior and treatment responses. Despite its clinical importance, reliable prognostic biomarkers for this neoplasm are still …
View article: Antitumor Effect of Curcumin, D6 Turmeric, and Hydrochloride Mitoxantrone on Canine and Human Urothelial Cancer Cells
Antitumor Effect of Curcumin, D6 Turmeric, and Hydrochloride Mitoxantrone on Canine and Human Urothelial Cancer Cells Open
Bladder urothelial carcinoma (UC) is an aggressive malignancy in both humans and dogs, with limited treatment options. Owing to their biological and environmental similarities with humans, dogs serve as a valuable model for UC research. St…
View article: Editorial: Tumor microenvironment complexity and its therapeutic implications
Editorial: Tumor microenvironment complexity and its therapeutic implications Open
View article: Melittin inhibits proliferation, migration, and invasion in osteosarcoma cell lines using 2D and 3D models
Melittin inhibits proliferation, migration, and invasion in osteosarcoma cell lines using 2D and 3D models Open
We conclude that melittin has antitumor and antimetastatic properties in canine, murine and human osteosarcoma cell lines. Consequently, we believe that further research on this promising compound will facilitate its application in the dev…
View article: Canine Adipose-Derived Mesenchymal Stromal Cells Reduce Cell Viability and Migration of Metastatic Canine Oral Melanoma Cell Lines In Vitro
Canine Adipose-Derived Mesenchymal Stromal Cells Reduce Cell Viability and Migration of Metastatic Canine Oral Melanoma Cell Lines In Vitro Open
Canine oral melanoma (COM) is a promising target for immunomodulatory therapies aimed at enhancing the immune system’s antitumor response. Given that adipose-derived mesenchymal stem cells (Ad-MSCs) possess immunomodulatory properties thro…
View article: In Vitro Antitumor Effect of Oils Rich in CBD and THC Cannabis Extract in Canine Prostate Carcinoma Cell Lines
In Vitro Antitumor Effect of Oils Rich in CBD and THC Cannabis Extract in Canine Prostate Carcinoma Cell Lines Open
Prostate cancer is one of the leading causes of cancer-related deaths worldwide, even when diagnosed at an early stage in humans and dogs. Dogs have a significant incidence of spontaneous prostate cancer, which is highly similar to human a…
View article: GENES BRCA1 E BRCA2 COMO BIOMARCADORES EM CARCINOMAS MAMÁRIOS CANINOS – REVISÃO DE LITERATURA
GENES BRCA1 E BRCA2 COMO BIOMARCADORES EM CARCINOMAS MAMÁRIOS CANINOS – REVISÃO DE LITERATURA Open
Os carcinomas mamários caninos são a neoplasia mais comumente diagnosticada em cadelas não castradas, e são a segunda neoplasia mais comumente encontrada dentre todas as neoplasias em cães. Assim como observado em tumores de mama em humano…
View article: Increased VEGF, COX-2 and CDH-1 Expression Favor TVT Implantation?
Increased VEGF, COX-2 and CDH-1 Expression Favor TVT Implantation? Open
Background: The transmissible venereal tumor (TVT) is a round cell neoplasm that can be implanted by physical contact between the affected dog and a susceptible host, and can affect males and females. It mainly affects the genital areas, b…
View article: Resveratrol and Viscum album anticancer effect in canine mammary tumor cell lines
Resveratrol and Viscum album anticancer effect in canine mammary tumor cell lines Open
Mammary gland tumors are the most common neoplasms in female intact dogs and share some biological and histopathological aspects with those in women with breast cancer, making them a good model in comparative oncology. Resveratrol is a pol…
View article: Brain Abscesses in Domestic Ruminants: Clinicopathological and Bacteriological Approaches
Brain Abscesses in Domestic Ruminants: Clinicopathological and Bacteriological Approaches Open
Brain abscesses in ruminants often arise from primary infection foci, leading to an unfavorable prognosis for affected animals. This highlights the need for comprehensive studies on brain abscesses across different ruminant species. We ret…
View article: Tumor Venéreo Transmissível (TVT) Intraocular Bilateral em um Cão
Tumor Venéreo Transmissível (TVT) Intraocular Bilateral em um Cão Open
Introdução: O tumor venéreo transmissível canino (TVT) é um tumor transplantável da genitália externa do cão para outros caninos que geralmente é transmitido durante o coito. A inoculação de células tumorais também é possível em locais ext…
View article: Lapatinib antitumor effect is associated with PI3K and MAPK pathway: An analysis in human and canine prostate cancer cells
Lapatinib antitumor effect is associated with PI3K and MAPK pathway: An analysis in human and canine prostate cancer cells Open
The aberrant activation of HER2 has a pivotal role in bone metastasis implantation and progression in several tumor types, including prostate cancer (PC). Trastuzumab and other anti-HER2 therapies, such as lapatinib, have been used in huma…
View article: Cytotoxic effects of crotoxin from Crotalus durissus terrificus snake in canine mammary tumor cell lines
Cytotoxic effects of crotoxin from Crotalus durissus terrificus snake in canine mammary tumor cell lines Open
Therefore, this work showed that crotoxin and CB-PLA2 had cytotoxic activity, migration inhibition, and pro-apoptotic potential in canine mammary gland carcinoma cell lines, making their possible use in cancer research.
View article: Canine urothelial carcinoma: expression of Periostin in spontaneous canine urothelial carcinoma and its correlation with histological features
Canine urothelial carcinoma: expression of Periostin in spontaneous canine urothelial carcinoma and its correlation with histological features Open
The tumor microenvironment is considered one of the main players in cancer development and progression and may influence the behavior of cancer cells. Periostin (POSTN) is an extracellular matrix protein, and its main functions are inducti…
View article: EFEITO ANTITUMORAL INVITRO DA CURCUMINA NO CARCINOMA UROTELIAL DE BEXIGA CANINO E HUMANO – REVISÃO DE LITERATURA
EFEITO ANTITUMORAL INVITRO DA CURCUMINA NO CARCINOMA UROTELIAL DE BEXIGA CANINO E HUMANO – REVISÃO DE LITERATURA Open
Estudos recentes vêm demonstrando a eficácia de produtos naturais como agentes terapêuticos anti-tumorais, avaliando-se o mecanismo de ação frente a diferentes células neoplásicas na medicina humana e veterinária. Dentre eles, a cúrcuma, c…
View article: Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer Open
View article: Editorial: Precision medicine in veterinary oncology: volume II
Editorial: Precision medicine in veterinary oncology: volume II Open
Precision Medicine in Veterinary Oncology: Volume II 14 15 Cancer is one of the most common causes of death in dogs, with an incidence ten times higher in this 16 species compared to humans (1) Altogether, these manuscripts bring new knowl…
View article: Proposing Clinicopathological Staging and Mitotic Count as Prognostic Factors for Canine Soft Tissue Sarcomas
Proposing Clinicopathological Staging and Mitotic Count as Prognostic Factors for Canine Soft Tissue Sarcomas Open
Soft tissue sarcomas (STSs) are a heterogeneous group of malignant mesenchymal tumors with similar histological features and biological behaviors. They are characterized by a low to moderate local recurrence rate and low metastasis, affect…
View article: In Vitro Transdifferentiation Potential of Equine Mesenchymal Stem Cells into Schwann-Like Cells
In Vitro Transdifferentiation Potential of Equine Mesenchymal Stem Cells into Schwann-Like Cells Open
Schwann cells (SCs) are essential for the regenerative processes of peripheral nerve injuries. However, their use in cell therapy is limited. In this context, several studies have demonstrated the ability of mesenchymal stem cells (MSCs) t…
View article: Epididymal Primary Mast Cell Tumor in a Dog
Epididymal Primary Mast Cell Tumor in a Dog Open
Background: In the literature, there are a few descriptions of epididymis neoplasia in domestic animals, especially considering primary tumors. In the few reports found in literature, the lesions were a consequence of the invasion of testi…
View article: Diagnosis, Prognosis, and Treatment of Canine Hemangiosarcoma: A Review Based on a Consensus Organized by the Brazilian Association of Veterinary Oncology, ABROVET
Diagnosis, Prognosis, and Treatment of Canine Hemangiosarcoma: A Review Based on a Consensus Organized by the Brazilian Association of Veterinary Oncology, ABROVET Open
Hemangiosarcoma is a mesenchymal neoplasm originating in the endothelial cells of blood vessels; they can be classified as non-visceral and visceral types. Non-visceral hemangiosarcomas can affect the skin, subcutaneous tissues, and muscle…
View article: Additional file 3 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
Additional file 3 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer Open
Additional file 3: Table S2. Somatic mutations in urinary bladder canine UC.
View article: Additional file 5 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
Additional file 5 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer Open
Additional file 5: Table S4. Somatic mutations in urinary bladder bovine UC.
View article: Characterization of nonpathological intrascleral cartilage in the domestic sheep (Ovis aries)
Characterization of nonpathological intrascleral cartilage in the domestic sheep (Ovis aries) Open
Birds, cartilaginous and teleost fish, reptiles, and some amphibians have intrascleral cartilage and/or bone; however, these are rarely reported in therian mammals. This study aimed to investigate and characterize a nonpathological formati…
View article: Additional file 1 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
Additional file 1 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer Open
Additional file 1: Table S1. Clinical details of the patients in the study.
View article: Additional file 22 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
Additional file 22 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer Open
Additional file 22: Table S10. Germline variants in urinary bladder feline UC.
View article: Additional file 21 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
Additional file 21 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer Open
Additional file 21: Table S9. Germline variants in urinary bladder canine UC.
View article: Additional file 4 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
Additional file 4 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer Open
Additional file 4: Table S3. Somatic mutations in urinary bladder feline UC.
View article: Additional file 23 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
Additional file 23 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer Open
Additional file 23: Table S11. Germline variants in urinary bladder bovine UC.