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View article: Molecular requirements for C. elegans transgenerational epigenetic inheritance of pathogen avoidance
Molecular requirements for C. elegans transgenerational epigenetic inheritance of pathogen avoidance Open
Bacteria are Caenorhabditis elegans’ food, and worms are naturally attracted to many bacteria, including pathogenic Pseudomonas , preferring PA14 over laboratory Escherichia coli (OP50). Despite this natural attraction to PA14, prior PA14 …
View article: <i>C. elegans</i> transgenerational avoidance of <i>P. fluorescens</i> is mediated by the Pfs1 sRNA and <i>vab-1</i>
<i>C. elegans</i> transgenerational avoidance of <i>P. fluorescens</i> is mediated by the Pfs1 sRNA and <i>vab-1</i> Open
In its natural habitat, Caenorhabditis elegans must distinguish friend from foe. Pseudomonas are abundant in the worm’s environment and can be nutritious or pathogenic. Previously, we found that worms learn to avoid Pseudomonas aeruginosa …
View article: Molecular requirements for C. elegans transgenerational epigenetic inheritance of pathogen avoidance
Molecular requirements for C. elegans transgenerational epigenetic inheritance of pathogen avoidance Open
Bacteria are Caenorhabditis elegans’ food, and worms are naturally attracted to many bacteria, including pathogenic Pseudomonas , preferring PA14 over laboratory Escherichia coli (OP50). Despite this natural attraction to PA14, prior PA14 …
View article: Molecular Requirements for C. elegans Transgenerational Epigenetic Inheritance of Pathogen Avoidance
Molecular Requirements for C. elegans Transgenerational Epigenetic Inheritance of Pathogen Avoidance Open
C. elegans’ major food source is bacteria, and worms are naturally attracted to many bacterial species, including pathogenic Pseudomonas; in fact, worms prefer PA14 as well as wild bacteria over the lab E. coli strain (OP50) standardly use…
View article: <i>Absence of Evidence is Not Evidence of Absence:</i>The many flaws in the case against transgenerational epigenetic inheritance of pathogen avoidance in<i>C. elegans</i>
<i>Absence of Evidence is Not Evidence of Absence:</i>The many flaws in the case against transgenerational epigenetic inheritance of pathogen avoidance in<i>C. elegans</i> Open
After examining the data and methods presented in Gainey, et al., bioRxiv , 2024 1 we conclude that the authors did not use an experimental paradigm that would have allowed them to replicate our results on transgenerational epigenetic inhe…
View article: <i>Pseudomonas fluorescens 15</i>small RNA Pfs1 mediates transgenerational epigenetic inheritance of pathogen avoidance in<i>C. elegans</i>through the Ephrin receptor VAB-1
<i>Pseudomonas fluorescens 15</i>small RNA Pfs1 mediates transgenerational epigenetic inheritance of pathogen avoidance in<i>C. elegans</i>through the Ephrin receptor VAB-1 Open
C. elegans are exposed to a variety of pathogenic and non-pathogenic bacteria species in their natural environment. Correspondingly, C. elegans has evolved an ability to discern between nutritive and infectious bacterial food sources. Here…
View article: A natural bacterial pathogen of C. elegans uses a small RNA to induce transgenerational inheritance of learned avoidance
A natural bacterial pathogen of C. elegans uses a small RNA to induce transgenerational inheritance of learned avoidance Open
C . elegans can learn to avoid pathogenic bacteria through several mechanisms, including bacterial small RNA-induced learned avoidance behavior, which can be inherited transgenerationally. Previously, we discovered that a small RNA from a …
View article: Analysis of vertebrate vision in a 384-well imaging system
Analysis of vertebrate vision in a 384-well imaging system Open
Visual impairment affects 253 million people worldwide and new approaches for prevention and treatment are urgently needed. While small molecules with potential beneficial effects can be examined in various model systems, the in vivo evalu…
View article: Embryonic Exposure to 2,2′,3,5′,6-pentachlorobiphenyl (PCB-95) Causes Developmental Malformations in Zebrafish
Embryonic Exposure to 2,2′,3,5′,6-pentachlorobiphenyl (PCB-95) Causes Developmental Malformations in Zebrafish Open
2,2′,3,5′,6-Pentachlorobiphenyl (PCB-95) is an environmental neurotoxicant. There is accumulated evidence that some neurotoxic effects of PCB-95 are caused by increased spontaneous Ca2+ oscillations in neurons resulting from modifying ryan…