Renée X. de Menezes
YOU?
Author Swipe
View article: Reanalysis of in vivo drug synergy validation study rules out synergy in most cases
Reanalysis of in vivo drug synergy validation study rules out synergy in most cases Open
View article: A quantitative comparison between human experts and AI at estimating tumor-stroma ratio
A quantitative comparison between human experts and AI at estimating tumor-stroma ratio Open
The tumor–stroma ratio (TSR) is an established prognostic biomarker across several cancer types, yet its manual assessment remains labour-intensive and subject to inter-observer variability. An artificial intelligence (AI)-based estimate c…
View article: Epigenetic profiling identifies markers of endocrine resistance and therapeutic options for metastatic castration-resistant prostate cancer
Epigenetic profiling identifies markers of endocrine resistance and therapeutic options for metastatic castration-resistant prostate cancer Open
Androgen receptor (AR) signaling inhibitors, including enzalutamide, are treatment options for patients with metastatic castration-resistant prostate cancer (mCRPC), but resistance inevitably develops. Using metastatic samples from a prosp…
View article: Health-related quality of life of patients with metastatic melanoma treated with tumor-infiltrating lymphocytes compared with ipilimumab in a randomized phase III trial
Health-related quality of life of patients with metastatic melanoma treated with tumor-infiltrating lymphocytes compared with ipilimumab in a randomized phase III trial Open
Patients with metastatic melanoma treated with TIL-IMP experienced similar HRQoL compared with IPI monotherapy, with indications of better HRQoL outcomes over time. Ongoing follow-up is essential to assess longer-term HRQoL and its general…
View article: The class II myosin MYH4 safeguards genome integrity and suppresses tumor progression
The class II myosin MYH4 safeguards genome integrity and suppresses tumor progression Open
Loss-of-function mutations in genome maintenance genes fuel tumorigenesis through increased genomic instability. A subset of these tumor suppressors are challenging to identify due to context dependency, including functional interactions w…
View article: Financial toxicity and socioeconomic impact of cancer in Europe
Financial toxicity and socioeconomic impact of cancer in Europe Open
View article: 3MO Immunohistochemical biomarkers to predict adjuvant chemotherapy response in patients with early breast cancer in the MATADOR trial
3MO Immunohistochemical biomarkers to predict adjuvant chemotherapy response in patients with early breast cancer in the MATADOR trial Open
View article: G6PC3 promotes genome maintenance and is a candidate mammary tumor suppressor
G6PC3 promotes genome maintenance and is a candidate mammary tumor suppressor Open
Mutations in genome maintenance factors drive sporadic and hereditary breast cancers. Here, we searched for potential drivers based on germline DNA analysis from a cohort consisting of patients with early-onset breast cancer negative for B…
View article: A morphometric signature to identify ductal carcinoma in situ with a low risk of progression
A morphometric signature to identify ductal carcinoma in situ with a low risk of progression Open
View article: ECTIL: Label-efficient Computational Tumour Infiltrating Lymphocyte (TIL) assessment in breast cancer: Multicentre validation in 2,340 patients with breast cancer
ECTIL: Label-efficient Computational Tumour Infiltrating Lymphocyte (TIL) assessment in breast cancer: Multicentre validation in 2,340 patients with breast cancer Open
The level of tumour-infiltrating lymphocytes (TILs) is a prognostic factor for patients with (triple-negative) breast cancer (BC). Computational TIL assessment (CTA) has the potential to assist pathologists in this labour-intensive task, b…
View article: The oestrous cycle stage affects mammary tumour sensitivity to chemotherapy
The oestrous cycle stage affects mammary tumour sensitivity to chemotherapy Open
View article: OCEAN: Flexible Feature Set Aggregation for Analysis of Multi-omics Data
OCEAN: Flexible Feature Set Aggregation for Analysis of Multi-omics Data Open
Integrated analysis of multi-omics datasets holds great promise for uncovering complex biological processes. However, the large dimension of omics data poses significant interpretability and multiple testing challenges. Simultaneous Enrich…
View article: Mechanisms that clear mutations drive field cancerization in mammary tissue
Mechanisms that clear mutations drive field cancerization in mammary tissue Open
View article: Predictive gene expression profile for adjuvant taxane benefit in breast cancer in the MATADOR trial
Predictive gene expression profile for adjuvant taxane benefit in breast cancer in the MATADOR trial Open
The primary objective of the prospective, randomized, multicenter, phase 3 biomarker Microarray Analysis in breast cancer to Taylor Adjuvant Drugs Or Regimens trial (MATADOR: ISRCTN61893718) is to generate a gene expression profile that ca…
View article: Artificial intelligence-assisted double reading of chest radiographs to detect clinically relevant missed findings: a two-centre evaluation
Artificial intelligence-assisted double reading of chest radiographs to detect clinically relevant missed findings: a two-centre evaluation Open
View article: A new approach to describe the taxonomic structure of microbiome and its application to assess the relationship between microbial niches
A new approach to describe the taxonomic structure of microbiome and its application to assess the relationship between microbial niches Open
View article: Artificial intelligence-based morphometric signature to identify ductal carcinoma in situ with low risk of progression to invasive breast cancer
Artificial intelligence-based morphometric signature to identify ductal carcinoma in situ with low risk of progression to invasive breast cancer Open
View article: Locus-specific proteome decoding reveals Fpt1 as a chromatin-associated negative regulator of RNA polymerase III assembly
Locus-specific proteome decoding reveals Fpt1 as a chromatin-associated negative regulator of RNA polymerase III assembly Open
View article: Taxanes trigger cancer cell killing in vivo by inducing non-canonical T cell cytotoxicity
Taxanes trigger cancer cell killing in vivo by inducing non-canonical T cell cytotoxicity Open
View article: A chromatin-associated regulator of RNA Polymerase III assembly at tRNA genes revealed by locus-specific proteomics
A chromatin-associated regulator of RNA Polymerase III assembly at tRNA genes revealed by locus-specific proteomics Open
Transcription of tRNA genes by RNA Polymerase III (RNAPIII) is tightly regulated by signaling cascades in response to nutrient availability. The emerging notion of differential tRNA gene regulation implies the existence of additional regul…
View article: Microbial Indicators of Dental Health, Dysbiosis, and Early Childhood Caries
Microbial Indicators of Dental Health, Dysbiosis, and Early Childhood Caries Open
Dental caries lesions are a clinical manifestation of disease, preceded by microbial dysbiosis, which is poorly characterized and thought to be associated with saccharolytic taxa. Here, we assessed the associations between the oral microbi…
View article: Data from Functional Genomic Screen in Mesothelioma Reveals that Loss of Function of BRCA1-Associated Protein 1 Induces Chemoresistance to Ribonucleotide Reductase Inhibition
Data from Functional Genomic Screen in Mesothelioma Reveals that Loss of Function of BRCA1-Associated Protein 1 Induces Chemoresistance to Ribonucleotide Reductase Inhibition Open
Loss of function of BRCA1-associated protein 1 (BAP1) is observed in about 50% of malignant pleural mesothelioma (MPM) cases. The aim of this study was to investigate whether this aspect could be exploited for targeted therapy. A genetical…
View article: Supplementary Table S5 from The FA/BRCA Pathway Identified as the Major Predictor of Cisplatin Response in Head and Neck Cancer by Functional Genomics
Supplementary Table S5 from The FA/BRCA Pathway Identified as the Major Predictor of Cisplatin Response in Head and Neck Cancer by Functional Genomics Open
Supplementary Table S5. Characteristics of the patient groups extracted from Wichmann et al.(64) and used in Figure 4. Patients were selected on basis of a negative HPV test result as HPV will confound the prognostic associations. All pati…
View article: Supplementary Table S2 from The FA/BRCA Pathway Identified as the Major Predictor of Cisplatin Response in Head and Neck Cancer by Functional Genomics
Supplementary Table S2 from The FA/BRCA Pathway Identified as the Major Predictor of Cisplatin Response in Head and Neck Cancer by Functional Genomics Open
Supplementary Table S2. List of siRNA SMARTpools that significantly sensitized VU-SCC-120 cells to cisplatin as identified by at least one of two separate statistical analyses.
View article: Supplementary Table S1 from The FA/BRCA Pathway Identified as the Major Predictor of Cisplatin Response in Head and Neck Cancer by Functional Genomics
Supplementary Table S1 from The FA/BRCA Pathway Identified as the Major Predictor of Cisplatin Response in Head and Neck Cancer by Functional Genomics Open
Supplementary Table S1. Primer sequences for quantitative real-time PCR.
View article: Supplementary Table S4 from The FA/BRCA Pathway Identified as the Major Predictor of Cisplatin Response in Head and Neck Cancer by Functional Genomics
Supplementary Table S4 from The FA/BRCA Pathway Identified as the Major Predictor of Cisplatin Response in Head and Neck Cancer by Functional Genomics Open
Supplementary Table S4. Overview of selected probes that target the 102 genes found to sensitize HNSCC cells with two different statistical methods.
View article: Supplementary Table S4 from The FA/BRCA Pathway Identified as the Major Predictor of Cisplatin Response in Head and Neck Cancer by Functional Genomics
Supplementary Table S4 from The FA/BRCA Pathway Identified as the Major Predictor of Cisplatin Response in Head and Neck Cancer by Functional Genomics Open
Supplementary Table S4. Overview of selected probes that target the 102 genes found to sensitize HNSCC cells with two different statistical methods.
View article: Supplementary Table S5 from The FA/BRCA Pathway Identified as the Major Predictor of Cisplatin Response in Head and Neck Cancer by Functional Genomics
Supplementary Table S5 from The FA/BRCA Pathway Identified as the Major Predictor of Cisplatin Response in Head and Neck Cancer by Functional Genomics Open
Supplementary Table S5. Characteristics of the patient groups extracted from Wichmann et al.(64) and used in Figure 4. Patients were selected on basis of a negative HPV test result as HPV will confound the prognostic associations. All pati…
View article: Supplementary Data from Functional Genomic Screen in Mesothelioma Reveals that Loss of Function of BRCA1-Associated Protein 1 Induces Chemoresistance to Ribonucleotide Reductase Inhibition
Supplementary Data from Functional Genomic Screen in Mesothelioma Reveals that Loss of Function of BRCA1-Associated Protein 1 Induces Chemoresistance to Ribonucleotide Reductase Inhibition Open
Supplementary Fig. S1: Characterization of the model used for whole genome silencing, individual screen lethality scores and list of candidate genes with differential lethality scores ; Supplementary Fig. S2: Validation of the RRM1 and RRM…
View article: Data from Functional Genomic Screen in Mesothelioma Reveals that Loss of Function of BRCA1-Associated Protein 1 Induces Chemoresistance to Ribonucleotide Reductase Inhibition
Data from Functional Genomic Screen in Mesothelioma Reveals that Loss of Function of BRCA1-Associated Protein 1 Induces Chemoresistance to Ribonucleotide Reductase Inhibition Open
Loss of function of BRCA1-associated protein 1 (BAP1) is observed in about 50% of malignant pleural mesothelioma (MPM) cases. The aim of this study was to investigate whether this aspect could be exploited for targeted therapy. A genetical…