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View article: Convergent evolution of glutathione metabolism pathway genes in marine mammals
Convergent evolution of glutathione metabolism pathway genes in marine mammals Open
Oxidative stress, triggered by hypoxia during repetitive diving, represents a notable environmental adaptation of marine mammals. Glutathione (GSH) is a widely acknowledged antioxidant that protects crucial cellular elements from damage by…
View article: Remnant Cholesterol is Associated with Blood Pressure Control in US Adults with Hypertension: NHANES 2007–2018 Analysis
Remnant Cholesterol is Associated with Blood Pressure Control in US Adults with Hypertension: NHANES 2007–2018 Analysis Open
Remnant cholesterol is associated with blood pressure control. Targeting remnant cholesterol through lifestyle modifications or lipid-lowering therapies may improve blood pressure control in high-risk patients.
View article: Impact of a 24/7 on-site percutaneous coronary intervention team strategy on door-to-wire time
Impact of a 24/7 on-site percutaneous coronary intervention team strategy on door-to-wire time Open
Background Current guidelines recommend that the door-to-wire (D2W) time should be 10 min (p=0.027) and time-to-make STEMI diagnosis >9 min (p = 0.001) were independent predictors of delayed PCI after implementing the strategy. Conclusions…
View article: Case Report: Surgery for proximal gastric cancer with splenic artery aneurysm: approach and complication mangement
Case Report: Surgery for proximal gastric cancer with splenic artery aneurysm: approach and complication mangement Open
Introduction Gastric cancer surgery is gradually shifting from extensive, standardized operations to individual, precise procedures. The two surgical options for proximal gastric cancer are total gastrectomy and proximal gastrectomy. In re…
View article: Flash-VL 2B: Optimizing Vision-Language Model Performance for Ultra-Low Latency and High Throughput
Flash-VL 2B: Optimizing Vision-Language Model Performance for Ultra-Low Latency and High Throughput Open
In this paper, we introduce Flash-VL 2B, a novel approach to optimizing Vision-Language Models (VLMs) for real-time applications, targeting ultra-low latency and high throughput without sacrificing accuracy. Leveraging advanced architectur…
View article: Impact of Annually Variable Dust Activity on the Recession of the Martian South Polar Seasonal Cap
Impact of Annually Variable Dust Activity on the Recession of the Martian South Polar Seasonal Cap Open
Suspended dust is a vital component of Martian climatic system and its temporal-spatial variation can influence the recession of the South Polar Seasonal Cap (SPSC). However, dust activity varies across different stages and years, affectin…
View article: Clinical outcomes of endovascular treatment in hemodialysis patients with central venous stenosis: A retrospective analysis
Clinical outcomes of endovascular treatment in hemodialysis patients with central venous stenosis: A retrospective analysis Open
Introduction Endovascular treatment is one of treatment options for hemodialysis patients with central venous stenosis (CVS), but clinical outcomes and risk factors remain inadequately studied. This study seeks to investigate the occurrenc…
View article: Vehicle-Based Moving Observation of Atmospheric CO <sub>2</sub> Mixing Ratio and Carbon Isotope in China: Imprint of Human Activities
Vehicle-Based Moving Observation of Atmospheric CO <sub>2</sub> Mixing Ratio and Carbon Isotope in China: Imprint of Human Activities Open
Atmospheric CO 2 represents a crucial greenhouse gas, while in situ observation excluded a full recognition of the spatial scape of such data, and thus prevent a detailed understanding of the specific source contribution to the atmosphere.…
View article: Gut Commensal Bacteroides thetaiotaomicron Promote Atherothrombosis via Regulating L-Tryptophan Metabolism
Gut Commensal Bacteroides thetaiotaomicron Promote Atherothrombosis via Regulating L-Tryptophan Metabolism Open
Background: Coronary thrombosis events continue to be the leading cause of morbidity and mortality worldwide. Recently, emerging evidence has highlighted the role of gut microbiota in cardiovascular disease, but few studies have systematic…
View article: Sex-specific decline in prefrontal cortex mitochondrial bioenergetics in aging baboons correlates with walking speed
Sex-specific decline in prefrontal cortex mitochondrial bioenergetics in aging baboons correlates with walking speed Open
Mitochondria play a crucial role in brain aging due to their involvement in bioenergetics, neuroinflammation and brain steroid synthesis. Mitochondrial dysfunction is linked to age-related neurodegenerative diseases, including Alzheimer’s …
View article: The spectrum of rare monogenic diseases in patients with premature coronary artery disease
The spectrum of rare monogenic diseases in patients with premature coronary artery disease Open
To the Editor: The global burden of premature coronary artery disease (CAD) is increasing among the young population. Premature CAD generally refers to the occurrence of obstructive coronary atherothrombotic lesions in men and women aged 5…
View article: Sirenian genomes illuminate the evolution of fully aquatic species within the mammalian superorder Afrotheria
Sirenian genomes illuminate the evolution of fully aquatic species within the mammalian superorder Afrotheria Open
Sirenians of the diverse superorder Afrotheria were the first mammals to retransition from land to water and are the sole herbivorous marine mammals, but little is known about the underlying genomic changes. Here, we generated a chromosome…
View article: Gene annotations of Amphibolurus muricatus (jacky dragon), Intellagama lesueurii (Australian water dragon), Phrynocephalus przewalskii (Przewalski's toadhead agama), and Phrynocephalus vlangalii (Ching Hai toadhead agama)
Gene annotations of Amphibolurus muricatus (jacky dragon), Intellagama lesueurii (Australian water dragon), Phrynocephalus przewalskii (Przewalski's toadhead agama), and Phrynocephalus vlangalii (Ching Hai toadhead agama) Open
Annotation file and associated FASTA files for A. muricatus assembly AmpMurF_3.0 • AmpMurF3.gff3.tar.gz: EVidenceModeler (EVM) gene model annotation file. • AmpMurF3.cds.tar.gz: EVM gene models coding sequences. • AmpMurF3.pep.tar.gz: EVM …
View article: Draft de novo genome assemblies of a male and female Amphibolurus muricatus (jacky dragon)
Draft de novo genome assemblies of a male and female Amphibolurus muricatus (jacky dragon) Open
Four de novo nuclear genome assemblies of Amphibolurus muricatus Assembly 1.0: A 10x Genomics linked-read sequencing assembly • AmpMurF_1.0.fa.tar.gz (female A. muricatus) • AmpMurM_1.0.fa.tar.gz (male A. muricatus) Assembly 1.1: Further s…
View article: Draft de novo genome assemblies of a male and female Amphibolurus muricatus (jacky dragon)
Draft de novo genome assemblies of a male and female Amphibolurus muricatus (jacky dragon) Open
Four de novo nuclear genome assemblies of Amphibolurus muricatus Assembly 1.0: A 10x Genomics linked-read sequencing assembly • AmpMurF_1.0.fa.tar.gz (female A. muricatus) • AmpMurM_1.0.fa.tar.gz (male A. muricatus) Assembly 1.1: Further s…
View article: Gene annotations of Amphibolurus muricatus (jacky dragon), Intellagama lesueurii (Australian water dragon), Phrynocephalus przewalskii (Przewalski's toadhead agama), and Phrynocephalus vlangalii (Ching Hai toadhead agama)
Gene annotations of Amphibolurus muricatus (jacky dragon), Intellagama lesueurii (Australian water dragon), Phrynocephalus przewalskii (Przewalski's toadhead agama), and Phrynocephalus vlangalii (Ching Hai toadhead agama) Open
Annotation file and associated FASTA files for A. muricatus assembly AmpMurF_3.0 • AmpMurF3.gff3.tar.gz: EVidenceModeler (EVM) gene model annotation file. • AmpMurF3.cds.tar.gz: EVM gene models coding sequences. • AmpMurF3.pep.tar.gz: EVM …
View article: Coronary artery ectasia associated with IgG4-related disease: a case report and literature review
Coronary artery ectasia associated with IgG4-related disease: a case report and literature review Open
Background Coronary artery ectasia is defined as a local or diffuse dilatation of the coronary artery more than 1.5 times the diameter of the adjacent normal segment. The etiology of coronary artery ectasia is diverse, and rarely complicat…
View article: Large‐scale across species transcriptomic analysis identifies genetic selection signatures associated with longevity in mammals
Large‐scale across species transcriptomic analysis identifies genetic selection signatures associated with longevity in mammals Open
Lifespan varies significantly among mammals, with more than 100‐fold difference between the shortest and longest living species. This natural difference may uncover the evolutionary forces and molecular features that define longevity. To u…
View article: Diversified Mammalian Visual Adaptations to Bright- or Dim-Light Environments
Diversified Mammalian Visual Adaptations to Bright- or Dim-Light Environments Open
Photic niche shifts of mammals are associated with changing visual capabilities, primarily mediated by three visual pigments, two (SWS1 and M/LWS) of them for color vision and rhodopsin (RH1) for dim-light vision. To further elucidate mole…
View article: Dek219 encodes the DICER-LIKE1 protein that affects chromatin accessibility and kernel development in maize
Dek219 encodes the DICER-LIKE1 protein that affects chromatin accessibility and kernel development in maize Open
Chromatin accessibility plays a vital role in gene transcriptional regulation. However, the regulatory mechanism of chromatin accessibility, as well as its role in regulating crucial gene expression and kernel development in maize (Zea may…
View article: Evolutionary transcriptomics reveals longevity mostly driven by polygenic and indirect selection in mammals
Evolutionary transcriptomics reveals longevity mostly driven by polygenic and indirect selection in mammals Open
The maximum lifespan varies more than 100-fold in mammals. This experiment of nature may uncover of the evolutionary forces and molecular features that define longevity. To understand the relationship between gene expression variation and …
View article: Glutamine-dependent effects of nitric oxide on cancer cells subjected to hypoxia-reoxygenation
Glutamine-dependent effects of nitric oxide on cancer cells subjected to hypoxia-reoxygenation Open
Limited O2 availability can decrease essential processes in energy metabolism. However, cancers have developed distinct metabolic adaptations to these conditions. For example, glutaminolysis can maintain energy metabolism and hypoxia signa…
View article: Application of a Hybrid CEEMD-LSTM Model Based on the Standardized Precipitation Index for Drought Forecasting: The Case of the Xinjiang Uygur Autonomous Region, China
Application of a Hybrid CEEMD-LSTM Model Based on the Standardized Precipitation Index for Drought Forecasting: The Case of the Xinjiang Uygur Autonomous Region, China Open
Accurate forecasting of droughts can effectively reduce the risk of drought. We propose a hybrid model based on complementary ensemble empirical mode decomposition (CEEMD) and long short-term memory (LSTM) to improve drought prediction acc…