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View article: Optimal Chimeric Antigen Receptor (CAR)-mRNA for Transient CAR T Cell Generation
Optimal Chimeric Antigen Receptor (CAR)-mRNA for Transient CAR T Cell Generation Open
Genetically modified T lymphocytes expressing chimeric antigen receptors (CARs) are becoming increasingly important in the treatment of hematologic malignancies and are also intensively being investigated for other diseases such as autoimm…
View article: Lipid nanoparticles outperform electroporation in mRNA-based CAR T cell engineering
Lipid nanoparticles outperform electroporation in mRNA-based CAR T cell engineering Open
Engineered T cells expressing chimeric antigen receptors (CARs) have been proven as efficacious therapies against selected hematological malignancies. However, the approved CAR T cell therapeutics strictly rely on viral transduction, a tim…
View article: How to improve mRNA-based CAR-T cell generation and functionality? A lab-scale comparison
How to improve mRNA-based CAR-T cell generation and functionality? A lab-scale comparison Open
Process development for transferring lab-scale research workflows to automated manufacturing procedures is critical chimeric antigen receptor (CAR)-T cell therapies. Thereby, the key factor for cell viability, expansion, modification, and …
View article: Anticancer Activity of Natural and Semi-Synthetic Drimane and Coloratane Sesquiterpenoids
Anticancer Activity of Natural and Semi-Synthetic Drimane and Coloratane Sesquiterpenoids Open
Drimane and coloratane sesquiterpenoids are present in several plants, microorganisms, and marine life. Because of their cytotoxic activity, these sesquiterpenoids have received increasing attention as a source for new anticancer drugs and…
View article: Cancer Stem Cells—Origins and Biomarkers: Perspectives for Targeted Personalized Therapies
Cancer Stem Cells—Origins and Biomarkers: Perspectives for Targeted Personalized Therapies Open
The use of biomarkers in diagnosis, therapy and prognosis has gained increasing interest over the last decades. In particular, the analysis of biomarkers in cancer patients within the pre- and post-therapeutic period is required to identif…
View article: Cancer Stem Cells—Origins and Biomarkers: Perspectives for Targeted Personalized Therapies
Cancer Stem Cells—Origins and Biomarkers: Perspectives for Targeted Personalized Therapies Open
The use of biomarkers in diagnosis, therapy and prognosis has gained increasing interest over the last decades. In particular, the analysis of biomarkers in cancer patients within the pre- and post-therapeutic period is required to identif…
View article: Foxp3+ Regulatory T Cells in Bone and Hematopoietic Homeostasis
Foxp3+ Regulatory T Cells in Bone and Hematopoietic Homeostasis Open
The bone represents surprisingly dynamic structures that are subject to constant remodeling by the concerted action of bone-forming osteoblasts and bone-resorbing osteoclasts - two cell subsets of distinct developmental origin that are key…