Renjia Zhao
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View article: Synergistic and heterogeneous aging using composite phenotypes and multiple organ systems aging clocks
Synergistic and heterogeneous aging using composite phenotypes and multiple organ systems aging clocks Open
The overlap between composite phenotypes and biological age provides valuable insights into multi-phenotypic aging. The unearthing of the heterogeneity in aging processes could further inform the development of personalized interventions t…
View article: Leveraging Biomarkers and Primary Care Embedding for Scalable Precision Cancer Prevention in China: Insights from the FuSion Study
Leveraging Biomarkers and Primary Care Embedding for Scalable Precision Cancer Prevention in China: Insights from the FuSion Study Open
View article: Development and validation of an integrative 54 biomarker-based risk identification model for multi-cancer in 42,666 individuals: a population-based prospective study to guide advanced screening strategies
Development and validation of an integrative 54 biomarker-based risk identification model for multi-cancer in 42,666 individuals: a population-based prospective study to guide advanced screening strategies Open
View article: Plasma proteomic profiles for early detection and risk stratification of non‐small cell lung carcinoma: A prospective cohort study with 52,913 participants
Plasma proteomic profiles for early detection and risk stratification of non‐small cell lung carcinoma: A prospective cohort study with 52,913 participants Open
Early detection of non‐small cell lung cancer (NSCLC) can improve survival rates, and plasma proteomics may provide effective tools for risk prediction. The population for this study included 52,913 participants and 2911 plasma proteomics …
View article: Development and validation of a multi-cancer risk identification model in 42,666 individuals: a population-based prospective study
Development and validation of a multi-cancer risk identification model in 42,666 individuals: a population-based prospective study Open
Background: Identifying high-risk individuals is crucial for effective cancer screening. However, developing a practical risk prediction model with proper validation for multiple cancer types presents significant challenges. Methods: We in…
View article: Association between red blood cell distribution width and genetic risk in patients with rheumatoid arthritis: a prospective cohort study and Mendelian randomization analysis
Association between red blood cell distribution width and genetic risk in patients with rheumatoid arthritis: a prospective cohort study and Mendelian randomization analysis Open
View article: Shared genetic factors and the interactions with fresh fruit intake contributes to four types squamous cell carcinomas
Shared genetic factors and the interactions with fresh fruit intake contributes to four types squamous cell carcinomas Open
Studies have reported risk factors for a single-squamous cell carcinoma(Single-SCCs). However, the shared common germline genetic factors and environmental factors have not been well elucidated with respect to augmented risk of pan-squamou…
View article: Plasma proteomics-based organ-specific aging for all-cause mortality and cause-specific mortality: a prospective cohort study
Plasma proteomics-based organ-specific aging for all-cause mortality and cause-specific mortality: a prospective cohort study Open
View article: Point-based risk score for the risk stratification and prediction of hepatocellular carcinoma: a population-based random survival forest modeling study
Point-based risk score for the risk stratification and prediction of hepatocellular carcinoma: a population-based random survival forest modeling study Open
View article: Healthy lifestyles are associated with alleviating the single-nucleotide polymorphism-based genetic risks of ischaemic stroke, intracerebral haemorrhage and myocardial infarction
Healthy lifestyles are associated with alleviating the single-nucleotide polymorphism-based genetic risks of ischaemic stroke, intracerebral haemorrhage and myocardial infarction Open
Background Both genetic and lifestyle factors contribute to myocardial infarction (MI) and stroke, including ischaemic stroke (IS) and intracerebral haemorrhage (ICH). We explored how and the extent to which a healthy lifestyle, by conside…
View article: Sleep Pattern, Genetic Susceptibility, and Abdominal Aortic Aneurysm in UK Biobank Participants
Sleep Pattern, Genetic Susceptibility, and Abdominal Aortic Aneurysm in UK Biobank Participants Open
View article: Single extracellular vesicle surface protein‐based blood assay identifies potential biomarkers for detection and screening of five cancers
Single extracellular vesicle surface protein‐based blood assay identifies potential biomarkers for detection and screening of five cancers Open
Extracellular vesicles (EVs) and EV proteins are promising biomarkers for cancer liquid biopsy. Herein, we designed a case–control study involving 100 controls and 100 patients with esophageal, stomach, colorectal, liver, or lung cancer to…
View article: Host Genetic Factors, Comorbidities and the Risk of Severe COVID-19
Host Genetic Factors, Comorbidities and the Risk of Severe COVID-19 Open
View article: Integrated health-related phenotype by Polygenic Risk Scores stratifies risk population for all-cause mortality: A cohort study based on UK Biobank
Integrated health-related phenotype by Polygenic Risk Scores stratifies risk population for all-cause mortality: A cohort study based on UK Biobank Open
Background Genetic predisposition is a key factor that influences individuals’ risk of multiple health-related outcomes. Genome-wide association studies examine each susceptibility variant's association but usually neglect the combined eff…
View article: Investigating the Effect of Metabolic Phenotypes on Health Events in Alcoholic and Nonalcoholic Fatty Liver Disease
Investigating the Effect of Metabolic Phenotypes on Health Events in Alcoholic and Nonalcoholic Fatty Liver Disease Open
Metabolic phenotypes modified the association of AFLD and NAFLD with intrahepatic and extrahepatic diseases.
View article: Healthy Lifestyles Alleviate the Genetic Risks of Ischemic Stroke, Intracerebral Hemorrhage, and Myocardial Infarction
Healthy Lifestyles Alleviate the Genetic Risks of Ischemic Stroke, Intracerebral Hemorrhage, and Myocardial Infarction Open
View article: Causal Effects of Red Cell Distribution Width on Rheumatoid Arthritis and Congestive Heart Failure: A Phenome-Wide Mendelian Randomization Study
Causal Effects of Red Cell Distribution Width on Rheumatoid Arthritis and Congestive Heart Failure: A Phenome-Wide Mendelian Randomization Study Open
The authors have requested that this preprint be removed from Research Square.
View article: Association of Esophageal Squamous Cell Carcinoma With the Interaction Between Poor Oral Health and Single Nucleotide Polymorphisms in Regulating Cell Cycles and Angiogenesis: A Case-Control Study in High-Incidence Chinese
Association of Esophageal Squamous Cell Carcinoma With the Interaction Between Poor Oral Health and Single Nucleotide Polymorphisms in Regulating Cell Cycles and Angiogenesis: A Case-Control Study in High-Incidence Chinese Open
Introduction Oral health and genetic factors can independently influence the risk of developing esophageal squamous cell carcinoma (ESCC). Objectives The primary objective of this study was to investigate the interactive effects of oral he…
View article: Investigating the Association Between Seven Sleep Traits and Nonalcoholic Fatty Liver Disease: Observational and Mendelian Randomization Study
Investigating the Association Between Seven Sleep Traits and Nonalcoholic Fatty Liver Disease: Observational and Mendelian Randomization Study Open
Background and Aim: Aberrant sleep parameters are associated with the risk of nonalcoholic fatty liver disease (NAFLD). However, existing information is inconsistent among studies and involves reverse causation. Therefore, we aimed to inve…
View article: Phenome-Wide Association Analysis Reveals Novel Links Between Genetically Determined Levels of Liver Enzymes and Disease Phenotypes
Phenome-Wide Association Analysis Reveals Novel Links Between Genetically Determined Levels of Liver Enzymes and Disease Phenotypes Open
View article: Tobacco consumption has interaction effect with protein coding genes to increase esophageal squamous cell Carcinoma risk: A case-control study in Chinese high-incidence region
Tobacco consumption has interaction effect with protein coding genes to increase esophageal squamous cell Carcinoma risk: A case-control study in Chinese high-incidence region Open
Background: Esophageal squamous cell carcinoma (ESCC) has reported that smoking was a major risk factor. Genetic predisposition can partially explain the pathogenesis of esophageal cancer in alcohol drinkers. It would also be interesting t…
View article: Global Burden and Trends in Incidence, Mortality, and Disability of Stomach Cancer From 1990 to 2017
Global Burden and Trends in Incidence, Mortality, and Disability of Stomach Cancer From 1990 to 2017 Open
INTRODUCTION: Stomach cancer is a serious global public health problem. The current burden of stomach cancer and its trends across time and location need to be understood to develop effective preventive strategies. METHODS: Data were obtai…
View article: Tumor infiltrating lymphocyte signature is associated with single nucleotide polymorphisms and predicts survival in esophageal squamous cell carcinoma patients
Tumor infiltrating lymphocyte signature is associated with single nucleotide polymorphisms and predicts survival in esophageal squamous cell carcinoma patients Open
We discovered 10 SNPs associated with sTIL in ESCC and we built a model of sTIL, SNPs and clinical characteristics with improved prediction of survival in ESCC patients.