Renpeng Li
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View article: Evolutionary epidemiology of the monkeypox virus in Shandong Province during the post-global outbreak era
Evolutionary epidemiology of the monkeypox virus in Shandong Province during the post-global outbreak era Open
Introduction Monkeypox virus (MPXV) is an emerging zoonotic pathogen with increasing human-to-human transmission. Since the first case in Shandong Province in June 2023, 61 cases were reported by the end of 2024, predominantly among young …
View article: Activated TBK1 promotes ACSL1-mediated microglia lipid droplet accumulation and neuroinflammation in Parkinson’s disease
Activated TBK1 promotes ACSL1-mediated microglia lipid droplet accumulation and neuroinflammation in Parkinson’s disease Open
Microglia-mediated neuroinflammation plays a crucial role in the progression of Parkinson’s disease (PD). Dysregulation of lipid droplet homeostasis is a significant factor affecting microglial inflammatory responses, but the mechanisms un…
View article: Multi-omics analysis identifies LANCL2 as a potential biomarker for the diagnosis and prognosis of gastric cancer
Multi-omics analysis identifies LANCL2 as a potential biomarker for the diagnosis and prognosis of gastric cancer Open
Gastric cancer (GC) constitutes a significant global public health burden due to its high morbidity rates and poor prognosis, underscoring the critical need for identifying novel therapeutic targets and elucidating their mechanisms. As a k…
View article: Coverage of influenza vaccination and influencing factors among healthcare workers in Shandong Province, China, 2021–2022
Coverage of influenza vaccination and influencing factors among healthcare workers in Shandong Province, China, 2021–2022 Open
Healthcare workers (HCWs) are at increased risk of exposure to the influenza virus in their daily clinical and disease prevention activities, making them a high-risk group for influenza infection. However, the vaccination rate among HCWs h…
View article: Comparison of children and adults in deep brain stimulation for Tourette Syndrome: a large-scale multicenter study of 102 cases with long-term follow-up
Comparison of children and adults in deep brain stimulation for Tourette Syndrome: a large-scale multicenter study of 102 cases with long-term follow-up Open
Background Deep brain stimulation (DBS) is a promising therapy for refractory Gilles de la Tourette syndrome (GTS). However, its long-term efficacy, safety, and recommended surgical age remain controversial, requiring evidence to compare d…
View article: Exploring barriers to influenza vaccine uptake and recommendation among healthcare providers in the community in China: A qualitative study
Exploring barriers to influenza vaccine uptake and recommendation among healthcare providers in the community in China: A qualitative study Open
Healthcare providers (HCPs) are recommended for priority influenza vaccination due to their high risk of contracting influenza. HCPs greatly aid in targeted population immunization campaigns. Therefore, understanding the factors that influ…
View article: Neurosurgical robots in China: State of the art and future prospect
Neurosurgical robots in China: State of the art and future prospect Open
Neurosurgical robots have developed for decades and can effectively assist surgeons to carry out a variety of surgical operations, such as biopsy, stereo-electroencephalography (SEEG), deep brain stimulation (DBS), and so forth. In recent …
View article: The NONRATT023402.2/rno-miR-3065-5p/NGFR axis affects levodopa-induced dyskinesia in a rat model of Parkinson’s disease
The NONRATT023402.2/rno-miR-3065-5p/NGFR axis affects levodopa-induced dyskinesia in a rat model of Parkinson’s disease Open
Levodopa-induced dyskinesia (LID) is a common motor complication in Parkinson’s disease. However, few studies have focused on the pathogenesis of LID at the transcriptional level. NONRATT023402.2, a long non-coding RNA (lncRNA) that may be…
View article: Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF-κB signaling pathway in mice with temporal lobe epilepsy
Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF-κB signaling pathway in mice with temporal lobe epilepsy Open
Impaired activation and regulation of the extinction of inflammatory cells and molecules in injured neuronal tissues are key factors in the development of epilepsy. SerpinA3N is mainly associated with the acute phase response and inflammat…
View article: Identification of Cuproptosis Clusters and Integrative Analyses in Parkinson’s Disease
Identification of Cuproptosis Clusters and Integrative Analyses in Parkinson’s Disease Open
Parkinson’s disease (PD) is the second most common neurodegenerative disease; it mainly occurs in the elderly population. Cuproptosis is a newly discovered form of regulated cell death involved in the progression of various diseases. Combi…
View article: Case report: One human Streptococcus suis infection in Shandong Province, China
Case report: One human Streptococcus suis infection in Shandong Province, China Open
Background: Streptococcus suis is an emerging zoonotic pathogen. Human infections with S suis have been identified in Europe, North America, South America, Oceania, Africa and Asia. As the most common clinical symptom of human S suis , men…
View article: Emotional symptoms and cognitive function outcomes of subthalamic stimulation in Parkinson's disease depend on location of active contacts and the volume of tissue activated
Emotional symptoms and cognitive function outcomes of subthalamic stimulation in Parkinson's disease depend on location of active contacts and the volume of tissue activated Open
Background Subthalamic nucleus (STN) deep brain stimulation (DBS) is an effective treatment for Parkinson's disease (PD), that can improve patients' motor and non‐motor symptoms. However, there are differences in the improvement of patient…
View article: Epidemiology of human papillomavirus on condyloma acuminatum in Shandong Province，China
Epidemiology of human papillomavirus on condyloma acuminatum in Shandong Province，China Open
Condyloma acuminatum (CA) is a sexually transmitted disease (STD) caused by human papillomavirus (HPV) infection. It is important to study the prevalence and distribution of HPV genotypes before implementing the HPV vaccination program. Th…
View article: Additional file 2 of Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF-κB signaling pathway in mice with temporal lobe epilepsy
Additional file 2 of Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF-κB signaling pathway in mice with temporal lobe epilepsy Open
Additional file 2: Table S1. Differential expression genes of hippocampus in temporal lobe epilepsy mice.
View article: Additional file 3 of Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF-κB signaling pathway in mice with temporal lobe epilepsy
Additional file 3 of Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF-κB signaling pathway in mice with temporal lobe epilepsy Open
Additional file 3: Table S2. Differential expression proteins of hippocampus in temporal lobe epilepsy mice.
View article: Additional file 4 of Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF-κB signaling pathway in mice with temporal lobe epilepsy
Additional file 4 of Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF-κB signaling pathway in mice with temporal lobe epilepsy Open
Additional file 4: Table S3. Differential expression genes of hippocampus in mice at 14 days after AAV injection.
View article: Additional file 5 of Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF-κB signaling pathway in mice with temporal lobe epilepsy
Additional file 5 of Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF-κB signaling pathway in mice with temporal lobe epilepsy Open
Additional file 5: Table S4. Primer sequences used for qPCR.
View article: Additional file 6 of Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF-κB signaling pathway in mice with temporal lobe epilepsy
Additional file 6 of Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF-κB signaling pathway in mice with temporal lobe epilepsy Open
Additional file 6: Table S5. GEO datasets for the serpina3n/serpina3 expression analysis.
View article: Case report: One human Streptococcus suis occurred in Shandong Province, China
Case report: One human Streptococcus suis occurred in Shandong Province, China Open
Background: Streptococcus suis ( S suis ) is a major pathogen of bacterial infectious diseases, which can be transmitted to human beings through close contact with sick pigs or carriers, and can cause toxic shock, meningitis, septicemia, p…
View article: Genomic diversity of human papillomavirus type 6 from patients with condyloma acuminatum in Eastern China
Genomic diversity of human papillomavirus type 6 from patients with condyloma acuminatum in Eastern China Open
Human papillomavirus type 6 (HPV6) is the major etiological agent of anogenital warts both men and women. However, there is limited data on its genomic characterization in mainland China. The aim of this study was to understand the complet…
View article: An MRI radiomics approach to predict survival and tumour-infiltrating macrophages in gliomas
An MRI radiomics approach to predict survival and tumour-infiltrating macrophages in gliomas Open
Preoperative MRI is one of the most important clinical results for the diagnosis and treatment of glioma patients. The objective of this study was to construct a stable and validatable preoperative T2-weighted MRI-based radiomics model for…
View article: Case Report: One Human Streptococcus Suis Infection in Shandong Province, China
Case Report: One Human Streptococcus Suis Infection in Shandong Province, China Open
Background: Streptococcus suis (S. suis) is an emerging zoonotic pathogen. Case presentation: A 56-year-old woman was infected with S. suis. The patient reared pigs in her backyard. At admission, her blood examinations showed a leukocyte c…
View article: Research Progress of Decitabine in the Treatment of Drug Resistance to Myelodysplastic Syndrome Based on the Information of Literature Database
Research Progress of Decitabine in the Treatment of Drug Resistance to Myelodysplastic Syndrome Based on the Information of Literature Database Open
Objective: To summarize the progress of drug resistance in the treatment of myelodysplastic syndrome with Decitabine. Methods: To review the mechanism of action of DAC , the mechanism of action of DAC in the treatment of MDS resistance and…
View article: Uronic acid metabolic process–related gene expression–based signature predicts overall survival of glioma
Uronic acid metabolic process–related gene expression–based signature predicts overall survival of glioma Open
Glioma is the most common and malignant cancer of the central nervous system, and the prognosis is poor. Metabolic reprogramming is a common phenomenon that plays an important role in tumor progression including gliomas. Searching the repr…
View article: A novel methylation signature predicts radiotherapy sensitivity in glioma
A novel methylation signature predicts radiotherapy sensitivity in glioma Open
Glioblastoma (GBM) is the most common and malignant cancer of the central nervous system, and radiotherapy is widely applied in GBM treatment; however, the sensitivity to radiotherapy varies in different patients. To solve this clinical di…
View article: Single-Cell RNA-Sequencing Shift in the Interaction Pattern Between Glioma Stem Cells and Immune Cells During Tumorigenesis
Single-Cell RNA-Sequencing Shift in the Interaction Pattern Between Glioma Stem Cells and Immune Cells During Tumorigenesis Open
Glioblastoma is one of the most common neoplasms in the central nervous system characterized by limited immune response and unlimited expansion capability. Cancer stem cells (GSCs), a small fraction of the tumor cells, possess a pivotal re…
View article: Characterization and prognostic significance of alternative splicing events in lower‐grade diffuse gliomas
Characterization and prognostic significance of alternative splicing events in lower‐grade diffuse gliomas Open
Alternative splicing (AS) is assumed to play important roles in the progression and prognosis of cancer. Currently, the comprehensive analysis and clinical relevance of AS in lower‐grade diffuse gliomas have not been systematically address…
View article: Molecular subtyping reveals immune alterations in <scp><i>IDH</i></scp> wild‐type lower‐grade diffuse glioma
Molecular subtyping reveals immune alterations in <span><i>IDH</i></span> wild‐type lower‐grade diffuse glioma Open
Isocitrate dehydrogenase ( IDH ) wild‐type diffuse lower‐grade glioma (LGG) is usually associated with poor outcome, but there have been disputes over its clinical outcome and classification. We present here a robust gene expression‐based …
View article: Lactobionic Acid-Modified Chitosan Thermosensitive Hydrogels that Lift Lesions and Promote Repair in Endoscopic Submucosal Dissection
Lactobionic Acid-Modified Chitosan Thermosensitive Hydrogels that Lift Lesions and Promote Repair in Endoscopic Submucosal Dissection Open
View article: Postoperative standard chemoradiotherapy benefits primary glioblastoma patients of all ages
Postoperative standard chemoradiotherapy benefits primary glioblastoma patients of all ages Open
Background Glioblastoma is the most malignant tumor of the central nervous system. Several prediction models have been produced to aid in prognosis assessment. Age, a primary decision factor for prognosis, is associated with increased geno…