Renqing Feng
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View article: <scp>P</scp>leckstrin‐2‐promoted <scp>PPM1B</scp> degradation plays an important role in transforming growth factor‐β‐induced breast cancer cell invasion and metastasis
<span>P</span>leckstrin‐2‐promoted <span>PPM1B</span> degradation plays an important role in transforming growth factor‐β‐induced breast cancer cell invasion and metastasis Open
Transforming growth factor‐β (TGF‐β) is known to promote breast cancer cell migration, invasion, and dissemination; however, the underlying molecular mechanisms are not yet well characterized. Here, we report that TGF‐β induces pleckstrin‐…
View article: Transcriptional regulation of intermolecular Ca <sup>2+</sup> signaling in hibernating ground squirrel cardiomyocytes: The myocardin–junctophilin axis
Transcriptional regulation of intermolecular Ca <sup>2+</sup> signaling in hibernating ground squirrel cardiomyocytes: The myocardin–junctophilin axis Open
Significance The efficiency of excitation–contraction coupling in heart cells depends partially on the interaction between junctophilin-2 in the sarcoplasmic reticulum and caveolin-3 on T-tubules. Decreased junctophilin-2 has been linked t…
View article: Abrin P2 suppresses proliferation and induces apoptosis of colon cancer cells via mitochondrial membrane depolarization and caspase activation
Abrin P2 suppresses proliferation and induces apoptosis of colon cancer cells via mitochondrial membrane depolarization and caspase activation Open
To explore the cytotoxic mechanism of abrin P2 on human colon cancer HCT-8 cells, abrin P2 was isolated from the seed of Abrus precatorius L. It was found that abrin P2 exhibited cytotoxicity toward 12 different human cancer cell lines. Ou…
View article: STIM1 plays an important role in TGF-β-induced suppression of breast cancer cell proliferation
STIM1 plays an important role in TGF-β-induced suppression of breast cancer cell proliferation Open
Store-operated calcium entry (SOCE) signaling is involved in cancer progression. Stromal interaction molecule 1 (STIM1) triggers store-operated calcium channels to induce SOCE. Transforming growth factor-β (TGF-β) influences a wide range o…