Renru Han
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View article: Antimicrobial resistance profile of clinical isolates from hospitals across China: CHINET 2024 surveillance report
Antimicrobial resistance profile of clinical isolates from hospitals across China: CHINET 2024 surveillance report Open
This study aimed to monitor clinical isolate susceptibility to antimicrobial agents in healthcare facilities in 31 provinces or cities of China in 2024. Antimicrobial susceptibility of clinical isolates from 74 hospitals was tested using d…
View article: Epidemiology and resistance mechanisms of tigecycline- and carbapenem-resistant Enterobacteriaceae in China: a multicentre genome-based study
Epidemiology and resistance mechanisms of tigecycline- and carbapenem-resistant Enterobacteriaceae in China: a multicentre genome-based study Open
Objectives To elucidate the molecular epidemiology of tigecycline and carbapenem-resistant Enterobacteriaceae isolates and mechanisms of tigecycline resistance. Methods We gathered 31 unduplicated strains of tigecycline-resistant Enterobac…
View article: Comparison of three colloidal gold immunoassays and GeneXpert Carba-R for the detection of <i>Klebsiella pneumoniae bla</i> <sub>KPC-2</sub> variants
Comparison of three colloidal gold immunoassays and GeneXpert Carba-R for the detection of <i>Klebsiella pneumoniae bla</i> <sub>KPC-2</sub> variants Open
The increasing use of ceftazidime-avibactam has led to the emergence of a wide range of ceftazidime-avibactam-resistant bla KPC-2 variants. Particularly, the conventional carbapenemase phenotypic assay exhibited a high false-negative rate …
View article: Molecular mechanisms responsible KPC-135-mediated resistance to ceftazidime-avibactam in ST11-K47 hypervirulent <i>Klebsiella pneumoniae</i>
Molecular mechanisms responsible KPC-135-mediated resistance to ceftazidime-avibactam in ST11-K47 hypervirulent <i>Klebsiella pneumoniae</i> Open
Ceftazidime-avibactam resistance attributable to the blaKPC-2 gene mutation is increasingly documented in clinical settings. In this study, we characterized the mechanisms leading to the development of ceftazidime-avibact…
View article: In vitro mimicry of in vivo KPC mutations by ceftazidime-avibactam: phenotypes, mechanisms, genetic structure and kinetics of enzymatic hydrolysis
In vitro mimicry of in vivo KPC mutations by ceftazidime-avibactam: phenotypes, mechanisms, genetic structure and kinetics of enzymatic hydrolysis Open
Ceftazidime-avibactam (CZA) is employed for the treatment of infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-KP). Resistance to CZA is frequently linked to point mutations in the bla
View article: Carbapenem-resistant Klebsiella pneumoniae capsular types, antibiotic resistance and virulence factors in China: a longitudinal, multi-centre study
Carbapenem-resistant Klebsiella pneumoniae capsular types, antibiotic resistance and virulence factors in China: a longitudinal, multi-centre study Open
Epidemiological knowledge of circulating carbapenem-resistant Klebsiella pneumoniae (CRKP) is needed to develop effective strategies against this public health threat. Here we present a longitudinal analysis of 1,017 CRKP isolates recovere…
View article: <i>Klebsiella pneumoniae</i> carbapenemase variants: the new threat to global public health
<i>Klebsiella pneumoniae</i> carbapenemase variants: the new threat to global public health Open
SUMMARY Klebsiella pneumoniae carbapenemase (KPC) variants, which refer to the substitution, insertion, or deletion of amino acid sequence compared to wild bla KPC type, have reduced utility of ceftazidime-avibactam (CZA), a pioneer antimi…
View article: Assessment of cefiderocol disk diffusion versus broth microdilution results when tested against <i>Acinetobacter baumannii</i> complex clinical isolates
Assessment of cefiderocol disk diffusion versus broth microdilution results when tested against <i>Acinetobacter baumannii</i> complex clinical isolates Open
The aim of this study was to evaluate the correlation between inhibitory zones and minimum inhibitory concentrations (MICs) when testing cefiderocol against Acinetobacter baumannii complex using disk diffusion and the broth microdilution (…
View article: A Nationwide Genomic Study of Clinical Klebsiella pneumoniae Carrying <i>bla</i> <sub>OXA-232</sub> and <i>rmtF</i> in China
A Nationwide Genomic Study of Clinical Klebsiella pneumoniae Carrying <i>bla</i> <sub>OXA-232</sub> and <i>rmtF</i> in China Open
In recent years, the detection rate of carbapenem-resistant K. pneumoniae has increased and represents a major threat to clinical anti-infective therapy. Compared with KPC-type carbapenemases and NDM-type metallo-β-lactamases, OXA-48 famil…
View article: Current status and trends of antimicrobial resistance among clinical isolates in China: a retrospective study of CHINET from 2018 to 2022
Current status and trends of antimicrobial resistance among clinical isolates in China: a retrospective study of CHINET from 2018 to 2022 Open
Antimicrobial resistance (AMR) is a pressing issue in China, with antibiotic therapy becoming less effective against bacterial infections. To address this challenge, the China Antimicrobial Surveillance Network (CHINET) was established in …
View article: Setting of the tentative epidemiological cut-off values of contezolid for<i>Staphylococcus aureus</i>,<i>Enterococcus faecalis</i>,<i>Enterococcus faecium</i>,<i>Streptococcus pneumoniae</i>and<i>Streptococcus agalactiae</i>
Setting of the tentative epidemiological cut-off values of contezolid for<i>Staphylococcus aureus</i>,<i>Enterococcus faecalis</i>,<i>Enterococcus faecium</i>,<i>Streptococcus pneumoniae</i>and<i>Streptococcus agalactiae</i> Open
Objectives To set the tentative epidemiological cut-off values (TECOFFs) of contezolid for Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, Streptococcus pneumoniae and Streptococcus agalactiae based on the distributions…
View article: Performance of Ceftazidime-Avibactam 30/20-μg and 10/4-μg Disks for Susceptibility Testing of <i>Enterobacterales</i> and Pseudomonas aeruginosa
Performance of Ceftazidime-Avibactam 30/20-μg and 10/4-μg Disks for Susceptibility Testing of <i>Enterobacterales</i> and Pseudomonas aeruginosa Open
Multidrug-resistant Enterobacterales and P. aeruginosa strains have become a global public threat, with the emergence and prevalence of plasmid-mediated extended-spectrum β-lactamases (ESBLs), AmpC cephalosporinases, and carbapenemases dis…
View article: Multicenter Antimicrobial Resistance Surveillance of Clinical Isolates from Major Hospitals — China, 2022
Multicenter Antimicrobial Resistance Surveillance of Clinical Isolates from Major Hospitals — China, 2022 Open
Multidrug-resistant bacteria remain a significant public health challenge in clinical antimicrobial treatment. To effectively address bacterial resistance, it is essential to enhance both bacterial resistance surveillance and the prudent u…
View article: Identification of KPC-112 from an ST15 Klebsiella pneumoniae Strain Conferring Resistance to Ceftazidime-Avibactam
Identification of KPC-112 from an ST15 Klebsiella pneumoniae Strain Conferring Resistance to Ceftazidime-Avibactam Open
Carbapenem-resistant Enterobacterales (CRE) are one of the most serious antimicrobial resistance problems in the world, listed as an “urgent” threat by the U.S. Centers for Disease Control and Prevention.
View article: Activities of Eravacycline, Tedizolid, Norvancomycin, Nemonoxacin, Ceftaroline, and Comparators against 1,871 <i>Staphylococcus</i> and 1,068 <i>Enterococcus</i> Species Isolates from China: Updated Report of the CHINET Study 2019
Activities of Eravacycline, Tedizolid, Norvancomycin, Nemonoxacin, Ceftaroline, and Comparators against 1,871 <i>Staphylococcus</i> and 1,068 <i>Enterococcus</i> Species Isolates from China: Updated Report of the CHINET Study 2019 Open
Antimicrobial resistance has become a severe threat to global public health. According to statistics, nearly 700,000 people die from bacterial infections worldwide (J.
View article: <i>In Vitro</i> Activity of New β-Lactam–β-Lactamase Inhibitor Combinations and Comparators against Clinical Isolates of Gram-Negative Bacilli: Results from the China Antimicrobial Surveillance Network (CHINET) in 2019
<i>In Vitro</i> Activity of New β-Lactam–β-Lactamase Inhibitor Combinations and Comparators against Clinical Isolates of Gram-Negative Bacilli: Results from the China Antimicrobial Surveillance Network (CHINET) in 2019 Open
Enterobacterales , Pseudomonas aeruginosa , and Acinetobacter baumannii are the most common Gram-negative bacilli to cause nosocomial infections throughout the world. Due to their large public health and societal implications, carbapenem-r…
View article: High Prevalence and Overexpression of Fosfomycin-Resistant Gene fosX in Enterococcus faecium From China
High Prevalence and Overexpression of Fosfomycin-Resistant Gene fosX in Enterococcus faecium From China Open
Enterococc i are one of the main causes of gastrointestinal tract infections in the healthcare system and can develop resistance to fosfomycin through plasmid or chromosomally encoded fosfomycin resistance genes. To investigate the mechani…
View article: First Report of blaCTX–M–167, blaSHV–1, and blaTEM–1B Carrying Klebsiella pneumonia Showing High-Level Resistance to Carbapenems
First Report of blaCTX–M–167, blaSHV–1, and blaTEM–1B Carrying Klebsiella pneumonia Showing High-Level Resistance to Carbapenems Open
The prevalence of carbapenem-resistant Klebsiella pneumoniae is increasing. Although carbapenemase production is the main resistance mechanism of K. pneumonia to carbapenems, there are still some reports of non-carbapenemase-producing K.pn…
View article: Asp50Glu mutation in MurA results in fosfomycin resistance in Enterococcus faecium
Asp50Glu mutation in MurA results in fosfomycin resistance in Enterococcus faecium Open
View article: Characterization of the First Carbapenem-Resistant Pseudocitrobacter faecalis Harboring blaOXA-181 in China
Characterization of the First Carbapenem-Resistant Pseudocitrobacter faecalis Harboring blaOXA-181 in China Open
With the wide use of carbapenems, carbapenem-resistant Enterobacterales have been increasingly reported worldwide. In this study, one blaOXA-181-positive Pseudocitrobacter faecalis strain was isolated from the blood culture of a patient wi…
View article: Multiple Novel Ceftazidime-Avibactam-Resistant Variants of <i>bla</i> <sub>KPC-2</sub> -Positive Klebsiella pneumoniae in Two Patients
Multiple Novel Ceftazidime-Avibactam-Resistant Variants of <i>bla</i> <sub>KPC-2</sub> -Positive Klebsiella pneumoniae in Two Patients Open
Carbapenem-resistant K. pneumoniae which was classified as the most urgent threat by World Health Organization, is the most critical public health concern due to its high mortality rate. Recently, the rapid mutation of bla KPC has occurred…
View article: Ceftazidime–Avibactam in Combination with Imipenem as Salvage Therapy for ST11 KPC-33-Producing Klebsiella pneumoniae
Ceftazidime–Avibactam in Combination with Imipenem as Salvage Therapy for ST11 KPC-33-Producing Klebsiella pneumoniae Open
A 22-year-old man, after a hematopoietic stem cell transplant, suffered long-term pneumonia caused by blaKPC-2-positive K. pneumoniae and blaKPC-33-positive K. pneumoniae alternately and finally achieved pathogenic clearance and improvemen…
View article: <i>In Vitro</i> Activity of KBP-7072 against 536 Acinetobacter baumannii Complex Isolates Collected in China
<i>In Vitro</i> Activity of KBP-7072 against 536 Acinetobacter baumannii Complex Isolates Collected in China Open
It is reported that A. baumannii has emerged as an intractable nosocomial pathogen in hospitals especially when it develops resistance to carbapenems and other antibiotics, which limits treatment options and leads to high mortality. In Feb…
View article: Isolation of a Ceftazidime-Avibactam-Resistant <i>bla</i> <sub>KPC-71</sub> -Positive Klebsiella pneumoniae Clinical Isolate
Isolation of a Ceftazidime-Avibactam-Resistant <i>bla</i> <sub>KPC-71</sub> -Positive Klebsiella pneumoniae Clinical Isolate Open
Carbapenem-resistant Klebsiella pneumoniae with the characteristics of extensive drug resistance has been increasingly reported worldwide, accompanied by high mortality rates because the available therapeutic regimens for treatment of infe…
View article: Assessment of Ceftazidime-Avibactam 30/20-μg Disk, Etest versus Broth Microdilution Results When Tested against <i>Enterobacterales</i> Clinical Isolates
Assessment of Ceftazidime-Avibactam 30/20-μg Disk, Etest versus Broth Microdilution Results When Tested against <i>Enterobacterales</i> Clinical Isolates Open
Multidrug-resistant Gram-negative bacteria, especially for extended-spectrum β-lactamases-producing and carbapenemase-producing Enterobacterales , are disseminating rapidly around the world. Treatment options for these infections are limit…
View article: Occurrence of NDM-1, VIM-1, and OXA-10 Co-Producing Providencia rettgeri Clinical Isolate in China
Occurrence of NDM-1, VIM-1, and OXA-10 Co-Producing Providencia rettgeri Clinical Isolate in China Open
Providencia rettgeri is a nosocomial pathogen associated with urinary tract infections related to hospital-acquired Infections. In recent years, P. rettgeri clinical strains producing New Delhi Metallo-β-lactamase (NDM) and other β-lactama…
View article: First Report of blaOXA-677 with Enhanced Meropenem-Hydrolyzing Ability in Pseudomonas aeruginosa in China
First Report of blaOXA-677 with Enhanced Meropenem-Hydrolyzing Ability in Pseudomonas aeruginosa in China Open
We speculate that the OXA-10-like enzymes and the decrease of membrane permeability confer carbapenem resistance, and the V117 substitution in OXA-677 might lead to a higher resistance level of meropenem.
View article: First Report of blaIMP–4 and blaSRT–2 Coproducing Serratia marcescens Clinical Isolate in China
First Report of blaIMP–4 and blaSRT–2 Coproducing Serratia marcescens Clinical Isolate in China Open
Carbapenem-resistant Enterobacterales (CRE) has become a major therapeutic concern in clinical settings, and carbapenemase genes have been widely reported in various bacteria. In Serratia marcescens , class A group carbapenemases including…
View article: Sulbactam Enhances in vitro Activity of β-Lactam Antibiotics Against Acinetobacter baumannii
Sulbactam Enhances in vitro Activity of β-Lactam Antibiotics Against Acinetobacter baumannii Open
The increasing proportion of sulbactam could enhance antimicrobial activities of imipenem-sulbactam, ampicillin-sulbactam and cefoperazone-sulbactam combinations against A. baumannii clinical strains in China, with cefoperazone-sulb…
View article: Comparative Activities of Sitafloxacin Against Recent Clinical Isolates in Hospitals Across China
Comparative Activities of Sitafloxacin Against Recent Clinical Isolates in Hospitals Across China Open
Sitafloxacin is one of the newer generation fluoroquinolones. Considering the ever-changing antimicrobial resistance, it is necessary to monitor the activities of sitafloxacin against recent pathogenic isolates. Therefore, we determined th…