Renyu Ding
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View article: Nationwide expert survey on transfusion and coagulation management strategies for bleeding critically ill patients in China
Nationwide expert survey on transfusion and coagulation management strategies for bleeding critically ill patients in China Open
This study aimed to investigate coagulation management strategies by experienced critical care physicians across China. The questionnaire was independently designed referencing current guidelines and literature, and refined through five ro…
View article: Association of healthy sleep patterns with incident sepsis: a large population-based prospective cohort study
Association of healthy sleep patterns with incident sepsis: a large population-based prospective cohort study Open
Findings from this cohort study suggest that a healthy sleep pattern may reduce the risk of developing sepsis, particularly among younger individuals.
View article: Global research trends on sepsis and septic shock during 2003–2022: A data-driven bibliometric analysis
Global research trends on sepsis and septic shock during 2003–2022: A data-driven bibliometric analysis Open
Background Sepsis is a major medical condition that contributes to substantial morbidity and mortality rates worldwide. Research to better understand and manage these complex conditions has intensified over the past two decades. This bibli…
View article: Chinese experts’ consensus on the application of intensive care big data
Chinese experts’ consensus on the application of intensive care big data Open
The development of intensive care medicine is inseparable from the diversified monitoring data. Intensive care medicine has been closely integrated with data since its birth. Critical care research requires an integrative approach that emb…
View article: Nanoparticles exhibiting virus-mimic surface topology for enhanced oral delivery
Nanoparticles exhibiting virus-mimic surface topology for enhanced oral delivery Open
The oral delivery of nano-drug delivery systems (Nano-DDS) remains a challenge. Taking inspirations from viruses, here we construct core–shell mesoporous silica nanoparticles (NPs, ~80 nm) with virus-like nanospikes (VSN) to simulate viral…
View article: Associations between the use of aspirin or other antiplatelet drugs and all-cause mortality among patients with COVID-19: A meta-analysis
Associations between the use of aspirin or other antiplatelet drugs and all-cause mortality among patients with COVID-19: A meta-analysis Open
Introduction: Whether aspirin or other antiplatelet drugs can reduce mortality among patients with coronavirus disease (COVID-19) remains controversial. Methods: We identified randomized controlled trials, prospective cohort studies, and r…
View article: Expert consensus on the diagnosis and treatment of severe and critical coronavirus disease 2019
Expert consensus on the diagnosis and treatment of severe and critical coronavirus disease 2019 Open
This consensus focuses on severe and critical coronavirus disease 2019 (COVID-19) mainly based on the consideration that mortality of severe and critical cases is higher than mild and moderate cases of COVID-19. Severe patients usually dev…
View article: Evaluation of the Molecular Mechanisms of Sepsis Using Proteomics
Evaluation of the Molecular Mechanisms of Sepsis Using Proteomics Open
Sepsis is a complex syndrome promoted by pathogenic and host factors; it is characterized by dysregulated host responses and multiple organ dysfunction, which can lead to death. However, its underlying molecular mechanisms remain unknown. …
View article: Retrospective Study of Critically Ill COVID-19 Patients With and Without Extracorporeal Membrane Oxygenation Support in Wuhan, China
Retrospective Study of Critically Ill COVID-19 Patients With and Without Extracorporeal Membrane Oxygenation Support in Wuhan, China Open
Background: Extracorporeal membrane oxygenation (ECMO) might benefit critically ill COVID-19 patients. But the considerations besides indications guiding ECMO initiation under extreme pressure during the COVID-19 epidemic was not clear. We…
View article: Shock in China 2018 (SIC-study): a cross-sectional survey
Shock in China 2018 (SIC-study): a cross-sectional survey Open
Shock is a serious disease with a high fatality rate and huge clinical costs. According to this epidemiological survey of shock in China 2018, we should clarify the factors related to the hospital death in shock cases.
View article: Elevated coinhibitory molecule TIGIT mediates T cell exhaustion in septic patients
Elevated coinhibitory molecule TIGIT mediates T cell exhaustion in septic patients Open
Background: Sepsis-induced T cell exhaustion that is characterized by upregulated coinhibitory molecules and decreased cytokines release plays a crucial role in the immunosuppression during sepsis. Although PD-1 has shown a promising targe…
View article: Total SOFA and SOFA Kidney are Associated with Short Term and Long term Outcoming of Sepsis-Associated Liver Injury
Total SOFA and SOFA Kidney are Associated with Short Term and Long term Outcoming of Sepsis-Associated Liver Injury Open
Background: Liver injury is considered as a common complication of sepsis. However, there are still few studies on short-term and long-term prognostic factors of sepsis-associated liver injury (SALI). The objective of our study is to condu…
View article: MicroRNA-34a Inhibition Alleviates Lung Injury in Cecal Ligation and Puncture Induced Septic Mice
MicroRNA-34a Inhibition Alleviates Lung Injury in Cecal Ligation and Puncture Induced Septic Mice Open
Sepsis is the leading cause of death in intensive care units. MicroRNA-34a (miR-34a) is involved in sepsis progression, while its underlying mechanisms on sepsis-induced lung injury remain obscure. Oxidative stress, pyroptosis, and inhibit…
View article: Birth Weight and Risk of Type 2 Diabetes Mellitus, Cardiovascular Disease, and Hypertension in Adults: A Meta‐Analysis of 7 646 267 Participants From 135 Studies
Birth Weight and Risk of Type 2 Diabetes Mellitus, Cardiovascular Disease, and Hypertension in Adults: A Meta‐Analysis of 7 646 267 Participants From 135 Studies Open
Background Low birth weight has been associated with increased risk of type 2 diabetes mellitus, cardiovascular disease, and hypertension, but the risk at high birth weight levels remains uncertain. This systematic review and meta‐analysis…
View article: Comparison of a new criteria for sepsis-induced coagulopathy and International Society on Thrombosis and Haemostasis disseminated intravascular coagulation score in critically ill patients with sepsis 3.0
Comparison of a new criteria for sepsis-induced coagulopathy and International Society on Thrombosis and Haemostasis disseminated intravascular coagulation score in critically ill patients with sepsis 3.0 Open
: Recently, new criteria for sepsis-induced coagulopathy (SIC) were developed, including the sequential organ failure assessment (SOFA) criteria. The objective of this study was to evaluate the new SIC criteria in patients diagnosed with s…
View article: The Central Role of the Inflammatory Response in Understanding the Heterogeneity of Sepsis-3
The Central Role of the Inflammatory Response in Understanding the Heterogeneity of Sepsis-3 Open
In sepsis-3, in contrast with sepsis-1, the definition “systemic inflammatory response” has been replaced with “dysregulated host response”, and “systemic inflammatory response syndrome” (SIRS) has been replaced with “sequential organ fail…
View article: Unfractionated heparin protects the protein C system against lipopolysaccharide‑induced damage in vivo and in vitro
Unfractionated heparin protects the protein C system against lipopolysaccharide‑induced damage in vivo and in vitro Open
Activation of protein C is greatly enhanced by the presence of thrombomodulin (TM) and endothelial protein C receptor (EPCR) on the endothelial surface. Impairment of the anticoagulant protein C system occurs during endotoxemia and contrib…