Explanipedia

Evaluation of the Therapeutic Potential of Synthetic Growth Hormone-Releasing Hormone Antagonist MIA-690 as a Cognitive Modulator in a Mouse Model of Gulf War Illness Open

Luis Manuel Salgueiro-Tosta, Arumugam R. Jayakumar, William Kochen, Renzhi Cai, Wei Sha , et al. · 2025

Gulf War illness (GWI) is a multi-symptom disorder affecting veterans of the Persian Gulf operations. Persistent neuroendocrine dysregulation contributes to impairing cognitive capacity and generates anxiety-like behavior. Effective treatm…

Trends in cancer incidence and mortality in the process of metropolitanization of Shanghai, 1973–2017 Open

Jiejie Qin, Mengyin Wu, Shulin Zhao, Kai Gu, Renzhi Cai , et al. · 2025

Background Shanghai has become a modern and international metropolis. A more comprehensive understanding of cancer incidence and mortality rates and socioenvironmental factors is explored to develop effective cancer control policies in Sha…

Growth Hormone-Releasing Hormone (GHRH) Antagonist Peptides Combined with PI3K Isoform Inhibitors Enhance Cell Death in Prostate Cancer Open

Carlos Perez‐Stable, Alicia de las Pozas, Medhi Wangpaichitr, Wei Sha, Haibo Wang , et al. · 2025

Background. Antagonists of GHRH have experimental therapeutic value, but as single agents are not likely to improve clinical outcomes, especially in advanced prostate cancer resistant to androgen deprivation therapy. Our objective is to id…

Growth Hormone-Releasing Hormone Antagonists Increase Radiosensitivity in Non-Small Cell Lung Cancer Cells Open

Iacopo Gesmundo, Francesca Pedrolli, F.R. Giglioli, Florian Jazaj, Giuseppina Granato , et al. · 2025

Growth hormone-releasing hormone (GHRH) antagonists exert antitumor functions in different experimental cancers. However, their role in combination with radiotherapy in non-small cell lung cancer (NSCLC) remains unknown. Therefore, we inve…

Growth Hormone-Releasing Hormone (GHRH) Antagonist Peptides Combined with PI3K Isoform Inhibitors Enhances Cell Death in Prostate Cancer Open

Carlos Perez‐Stable, Alicia de las Pozas, Medhi Wangpaichitr, Wei Sha, Haibo Wang , et al. · 2025

Antagonists of GHRH have experimental therapeutic value but as single agents are not likely to improve clinical outcomes, especially in advanced prostate cancer resistant to androgen deprivation therapy. Our objective is to identify anti-c…

Author Correction: Growth hormone-releasing hormone and its analogues in health and disease Open

Riccarda Granata, Sheila Leone, Xianyang Zhang, Iacopo Gesmundo, Charlotte Steenblock , et al. · 2024

The development of growth hormone-releasing hormone analogs: Therapeutic advances in cancer, regenerative medicine, and metabolic disorders Open

Andrew V. Schally, Renzhi Cai, Xianyang Zhang, Wei Sha, Medhi Wangpaichitr · 2024

7765 Exploring the Synergistic Effect of GHRH Receptor Agonist MR-409 and Incretin-based Therapies in Type 1 Diabetes Using a Low-dose Streptozotocin Model Open

Marel Gonzalez Medina, Ruy A. Louzada, Valentina Pita-Grisanti, Manuel Blandino, Tengjiao Cui , et al. · 2024

Disclosure: M. Gonzalez Medina: None. R. Louzada: None. V. Pita-Grisanti: None. M. Blandino: None. T. Cui: None. W. Sha: Owner/Co-Owner; Self; WS. is co-inventor on GHRH agonists MR-409 patent, assigned to the University of Miami and the V…

Growth hormone–releasing hormone receptor antagonist MIA-602 attenuates cardiopulmonary injury induced by BSL-2 rVSV-SARS-CoV-2 in hACE2 mice Open

José Manuel Cóndor Capcha, Ali Kamiar, Emely Robleto, Ali G. Saad, Tengjiao Cui , et al. · 2023

COVID-19 pneumonia causes acute lung injury and acute respiratory distress syndrome (ALI/ARDS) characterized by early pulmonary endothelial and epithelial injuries with altered pulmonary diffusing capacity and obstructive or restrictive ph…

Effects of GHRH Deficiency and GHRH Antagonism on Emotional Disorders in Mice Open

Lucia Recinella, Maria Loreta Libero, Serena Veschi, Anna Piro, Guya Diletta Marconi , et al. · 2023

Growth hormone (GH)-releasing hormone (GHRH) has been suggested to play a crucial role in brain function. We aimed to further investigate the effects of a novel GHRH antagonist of the Miami (MIA) series, MIA-602, on emotional disorders and…

Growth hormone-releasing hormone antagonist MIA-602 inhibits inflammation induced by SARS-CoV-2 spike protein and bacterial lipopolysaccharide synergism in macrophages and human peripheral blood mononuclear cells Open

Giuseppina Granato, Iacopo Gesmundo, Francesca Pedrolli, Ramesh Kasarla, Laura Begani , et al. · 2023

COVID-19 is characterized by an excessive inflammatory response and macrophage hyperactivation, leading, in severe cases, to alveolar epithelial injury and acute respiratory distress syndrome. Recent studies have reported that SARS-CoV-2 s…

GHRH agonist MR-409 protects β-cells from streptozotocin-induced diabetes Open

Ruy A. Louzada, Manuel Blandino-Rosano, Sebastián Flores, Camila Lubaczeuski, Tengjiao Cui , et al. · 2023

Patients with type 1 diabetes (T1D) suffer from insufficient functional β-cell mass, which results from infiltration of inflammatory cells and cytokine-mediated β-cell death. Previous studies demonstrated the beneficial effects of agonists…

Efficacy of a growth hormone-releasing hormone agonist in a murine model of cardiometabolic heart failure with preserved ejection fraction Open

Rosemeire M. Kanashiro‐Takeuchi, Lauro M Takeuchi, Raúl A Dulce, Katarzyna Kaźmierczak, Wayne Balkan , et al. · 2023

This randomized study used rigorous hemodynamic tools to test the efficacy of a synthetic GHRH agonist to improve cardiac performance in a cardiometabolic HFpEF. Daily injection of the GHRH agonist, MR-356, reduced the HFpEF-like effects a…

Growth hormone-releasing hormone agonist attenuates vascular calcification in diabetic db/db mice Open

Hao-Lin Ren, Ruiping Cai, Ruize Xue, Yaoxia Zhang, Qian Xu , et al. · 2023

Introduction Vascular calcification (VC) is an independent risk factor for cardiovascular diseases. VC increases mortality of all-causes. VC is one of most common cardiovascular complications in type II diabetes. So far, no therapy has bee…

Agonist of growth hormone-releasing hormone improves the disease features of spinal muscular atrophy mice Open

Marina Boido, Iacopo Gesmundo, Anna Caretto, Francesca Pedrolli, Roberta Schellino , et al. · 2023

Spinal muscular atrophy (SMA) is a severe autosomal recessive neuromuscular disease affecting children and young adults, caused by mutations of the survival motor neuron 1 gene ( SMN1 ). SMA is characterized by the degeneration of spinal a…

Antagonist of Growth Hormone-Releasing Hormone Potentiates the Antitumor Effect of Pemetrexed and Cisplatin in Pleural Mesothelioma Open

Iacopo Gesmundo, Francesca Pedrolli, Nicoletta Vitale, Alessia Bertoldo, Giulia Orlando , et al. · 2022

Pleural mesothelioma (PM) is an aggressive cancer with poor prognosis and no effective therapies, mainly caused by exposure to asbestos. Antagonists of growth hormone-releasing hormone (GHRH) display strong antitumor effects in many experi…

Efficacy of a Growth Hormone-Releasing Hormone Agonist in a Murine Model of Cardiometabolic Heart Failure with Preserved Ejection Fraction Open

Rosemeire M. Kanashiro‐Takeuchi, Lauro M Takeuchi, Raúl A Dulce, Katarzyna Kaźmierczak, Wayne Balkan , et al. · 2022

Heart failure (HF) with preserved ejection fraction (HFpEF) represents a major unmet medical need owing to its diverse pathophysiology and lack of effective therapies. Potent synthetic, agonists (MR-356 and MR409) of growth hormone-releasi…

Synthetic growth hormone-releasing hormone agonist ameliorates the myocardial pathophysiology characteristic of heart failure with preserved ejection fraction Open

Raúl A Dulce, Rosemeire M. Kanashiro‐Takeuchi, Lauro M Takeuchi, Alessandro G. Salerno, Amarylis Wanschel , et al. · 2022

Aims To test the hypothesis that the activation of the growth hormone-releasing hormone (GHRH) receptor signalling pathway within the myocardium both prevents and reverses diastolic dysfunction and pathophysiologic features consistent with…

Synthesis of potent antagonists of receptors for growth hormone-releasing hormone with antitumor and anti-inflammatory activity Open

Renzhi Cai, Xianyang Zhang, Haibo Wang, Tengjiao Cui, Gábor Halmos , et al. · 2021

The syntheses and biological evaluation of GHRH antagonists of AVR series with high anticancer and anti-inflammatory activities are described. Compared to our previously reported GHRH antagonist 602 of MIAMI series, AVR analogs contain add…

Antagonist of growth hormone-releasing hormone MIA-690 attenuates the progression and inhibits growth of colorectal cancer in mice Open

Lucia Recinella, Annalisa Chiavaroli, Serena Veschi, Valentina Di Valerio, Rossano Lattanzio , et al. · 2021

Agonistic analog of growth hormone–releasing hormone promotes neurofunctional recovery and neural regeneration in ischemic stroke Open

Yueyang Liu, Jingyu Yang, Xiaohang Che, Jianhua Huang, Xianyang Zhang , et al. · 2021

Significance Stroke is a leading cause of mortality and permanent disability in adults worldwide. Although most pharmacological neuroprotectants have beneficial effects in experimental studies, they fail in clinical trials. Here, we report…

Antagonists of Growth Hormone-Releasing Hormone Inhibit the Growth of Pituitary Adenoma Cells by Hampering Oncogenic Pathways and Promoting Apoptotic Signaling Open

Iacopo Gesmundo, Giuseppina Granato, Antonio C. Fuentes-Fayos, Clara V. Álvarez, Carlos Diéguez , et al. · 2021

Pituitary adenomas (PAs) are intracranial tumors, often associated with excessive hormonal secretion and severe comorbidities. Some patients are resistant to medical therapies; therefore, novel treatment options are needed. Antagonists of …

Protective effects of growth hormone-releasing hormone analogs in DSS-induced colitis in mice Open

Lucia Recinella, Annalisa Chiavaroli, Valentina Di Valerio, Serena Veschi, Giustino Orlando , et al. · 2021

Activity of the growth hormone‐releasing hormone antagonist MIA602 and its underlying mechanisms of action in sarcoidosis‐like granuloma Open

Chongxu Zhang, Runxia Tian, Emilee M Dreifus, Abdolrazagh Hashemi Shahraki, Gregory E. Holt , et al. · 2021

Objectives Growth hormone‐releasing hormone (GHRH) is a potent stimulator of growth hormone (GH) secretion from the pituitary gland. Although GHRH is essential for the growth of immune cells, the regulatory effects of its antagonist in gra…

Growth Hormone-Releasing Hormone in Lung Physiology and Pulmonary Disease Open

Chongxu Zhang, Tengjiao Cui, Renzhi Cai, Medhi Wangpaichitr, Mehdi Mirsaeidi , et al. · 2020

Growth hormone-releasing hormone (GHRH) is secreted primarily from the hypothalamus, but other tissues, including the lungs, produce it locally. GHRH stimulates the release and secretion of growth hormone (GH) by the pituitary and regulate…

Activity of the GHRH Antagonist MIA602 and its Underlying Mechanisms of Action in sarcoidosis Open

Chongxu Zhang, Runxia Tian, Emilee M Dreifus, Gregory E. Holt, Renzhi Cai , et al. · 2020

Growth hormone releasing hormone (GHRH) is a potent stimulator of GH secretion from the pituitary gland. Although GHRH is essential for the growth of immune cells, the regulatory effects of its antagonist in granulomatous disease remains u…

SAT-603 Growth Hormone-Releasing Hormone (GHRH) Antagonists Stimulate Feeding in Mice Open

Sheila Leone, Lucia Recinella, Annalisa Chiavaroli, Giustino Orlando, Claudio Ferrante , et al. · 2020

Growth hormone-releasing hormone (GHRH) is a hypothalamic neuropeptide which stimulates the synthesis and secretion of growth hormone (GH) in pituitary gland. GHRH was also found to modulate food intake in mammals. MIA-690 is a synthetic G…

Publisher Correction: Antinflammatory, antioxidant, and behavioral effects induced by administration of growth hormone-releasing hormone analogs in mice Open

Lucia Recinella, Annalisa Chiavaroli, Giustino Orlando, Claudio Ferrante, Guya Diletta Marconi , et al. · 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Synthetic Growth Hormone-Releasing Hormone Agonist as Novel Treatment for Heart Failure with Preserved Ejection Fraction Open

Raúl A Dulce, Rosemeire M. Kanashiro‐Takeuchi, Lauro M Takeuchi, Alessandro G. Salerno, Shathiyah Kulandavelu , et al. · 2020

Objective To test the hypothesis that the activation of the growth hormone-releasing hormone (GHRH) receptor signaling pathway within the myocardium both prevents and reverses heart failure with preserved ejection fraction (HFpEF). Backgro…

Antinflammatory, antioxidant, and behavioral effects induced by administration of growth hormone-releasing hormone analogs in mice Open

Lucia Recinella, Annalisa Chiavaroli, Giustino Orlando, Claudio Ferrante, Guya Diletta Marconi , et al. · 2020

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