Reeshu Gupta
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View article: Phytochemicals in overcoming venetoclax resistance in acute myeloid leukemia: mechanistic insights and therapeutic potential
Phytochemicals in overcoming venetoclax resistance in acute myeloid leukemia: mechanistic insights and therapeutic potential Open
This review critically examines the complex mechanisms underlying venetoclax resistance in acute myeloid leukemia (AML) and explores the therapeutic potential of phytochemicals in overcoming this resistance. Emerging evidence suggests that…
View article: In silico design of a multi-epitope pan vaccine targeting Schistosoma species
In silico design of a multi-epitope pan vaccine targeting Schistosoma species Open
View article: Remission with quadruplet therapy in rare immunoglobulin D lambda myeloma lacking CRAB features, with 13q deletion and monosomy 12
Remission with quadruplet therapy in rare immunoglobulin D lambda myeloma lacking CRAB features, with 13q deletion and monosomy 12 Open
Immunoglobulin D (IgD) multiple myeloma (MM) is a rare and aggressive subtype of plasma cell neoplasm, comprising <2% of cases. It often presents with atypical clinical features and may be misdiagnosed due to low levels of detectable M-pro…
View article: Symptomatic management and new therapeutic directions in Lesch‑Nyhan syndrome (Review)
Symptomatic management and new therapeutic directions in Lesch‑Nyhan syndrome (Review) Open
View article: Challenges and Strategies to Enhance Drug Efficacy of the Approved Drugs for Chemoresistant Triple-Negative Breast Cancer: A Narrative Review
Challenges and Strategies to Enhance Drug Efficacy of the Approved Drugs for Chemoresistant Triple-Negative Breast Cancer: A Narrative Review Open
Triple-negative breast cancer (TNBC) has been shown to have a high relapse rate, high incidence of distant metastases, poor overall survival and chemoresistance. Resistance can arise from various factors, including the induction of cancer …
View article: Recent advancements in therapeutic biomarkers, associated challenges and considerations to overcome these challenges in prostate cancer (Review)
Recent advancements in therapeutic biomarkers, associated challenges and considerations to overcome these challenges in prostate cancer (Review) Open
View article: Screening of Oncogenic Proteins and Development of a Multiepitope Peptide Vaccine Targeting AKT1 and PARP1 for Breast Cancer by Integrating Reverse Vaccinology and Immune-Informatics Approaches
Screening of Oncogenic Proteins and Development of a Multiepitope Peptide Vaccine Targeting AKT1 and PARP1 for Breast Cancer by Integrating Reverse Vaccinology and Immune-Informatics Approaches Open
These findings suggest that the designed vaccine holds promise as a therapeutic option for breast cancer. However, further in vitro and in vivo studies are necessary to validate its efficacy before advancing to clinical trials.
View article: Reverse Vaccinology and Immunoinformatics Strategy to Screen Oncogenic Proteins and Development of a Multiepitope Peptide Vaccine Targeting Protein Kinases against Oral Cancer: An in-silico Study
Reverse Vaccinology and Immunoinformatics Strategy to Screen Oncogenic Proteins and Development of a Multiepitope Peptide Vaccine Targeting Protein Kinases against Oral Cancer: An in-silico Study Open
We propose that the vaccine developed has high immunogenic potential and able to induce both cell mediated and humoral immunity against oral cancer.
View article: Acidic pH at physiological salinity enhances the antitumor efficacy of lenvatinib, a drug targeting vascular endothelial growth factor receptors
Acidic pH at physiological salinity enhances the antitumor efficacy of lenvatinib, a drug targeting vascular endothelial growth factor receptors Open
View article: Significance of VLPs in Vlp-circRNA vaccines: a vaccine candidate or delivery vehicle?
Significance of VLPs in Vlp-circRNA vaccines: a vaccine candidate or delivery vehicle? Open
Circular RNAs (circRNAs) are a class of single-stranded RNAs with a closed loop lacking 5' and 3' ends. These circRNAs are translatable and, therefore, have a potential in developing vaccine. CircRNA vaccines have been shown to be more sta…
View article: Monkeypox (MPOX): Unmasking the Lesser-known Viral Threat
Monkeypox (MPOX): Unmasking the Lesser-known Viral Threat Open
Monkeypox (Mpox) is caused by a viral infection and has been endemic in several African states after the last outbreak throughout the world in 2003. This disease resurfaced in the year 2022 and has since spread worldwide, even in countries…
View article: Identification of common biomarkers affecting patient survival in cancers
Identification of common biomarkers affecting patient survival in cancers Open
The identification of genetic biomarkers that play a crucial role in cancer survival is challenging, but requires attention. The present study aimed to identify common biomarkers that affect the survival of patients with cancer. For this p…
View article: Identification and Evaluation of Survival-associated Common Chemoresistant Genes in Cancer
Identification and Evaluation of Survival-associated Common Chemoresistant Genes in Cancer Open
Background: Chemoresistance is a major challenge in the effective treatment of cancer patients. This study aimed to identify common chemoresistance-associated genes that impact cancer survival. Methods: RNA-sequencing datasets for colorect…
View article: Structural basis to identify a target site in Shiga toxin for the inhibitor discovery against growth of Shiga toxin-producing E. coli
Structural basis to identify a target site in Shiga toxin for the inhibitor discovery against growth of Shiga toxin-producing E. coli Open
Background Certain peptides that bind Shiga toxin 2 (Stx2) have been reported to treat Shiga toxin-producing Escherichia coli (STEC) infections. However, their mechanisms of action remain unknown. STEC infections lead to serious diseases, …
View article: Potential Role of Immature Platelet Fraction in Dengue Fever: A Narrative Review
Potential Role of Immature Platelet Fraction in Dengue Fever: A Narrative Review Open
Dengue fever has emerged as a major international public health concern with a dramatic global increase in its frequency over the past few decades. It may present as a mild illness to a life-threatening condition with the major pathophysio…
View article: First Full-Length Cloning of Human NaV1.7 in S. Cerevisiae-Based Novel D-Crypt Platform for its High-Scale Production
First Full-Length Cloning of Human NaV1.7 in S. Cerevisiae-Based Novel D-Crypt Platform for its High-Scale Production Open
NaV1.7, a voltage-gated sodium channel, induces chronic pain. Current research on the discovery of inhibitors against NaV1.7 is advancing with the hope of treating chronic pain conditions in patients suffering from various diseases. Howeve…
View article: Structural basis to identify a target site in Shiga-toxin for the inhibitor discovery against growth of Shiga toxin-producing E. coli
Structural basis to identify a target site in Shiga-toxin for the inhibitor discovery against growth of Shiga toxin-producing E. coli Open
Background: Certain peptides that can bind to Shiga toxin 2 (Stx2) have been reported to treat Shiga toxin-producing E. coli (STEC) infections. However, their mechanisms of action remain unknown. We used the PEP-FOLD server to predict the …
View article: Genomic Index of Sensitivity to Chemotherapy for Triple Negative Breast Cancer
Genomic Index of Sensitivity to Chemotherapy for Triple Negative Breast Cancer Open
CRI predicted survival benefits with reduced hazard rate.
View article: VLP-ELISA for the Detection of IgG Antibodies against Spike, Envelope, and Membrane Antigens of SARS-CoV-2 in Indian Population
VLP-ELISA for the Detection of IgG Antibodies against Spike, Envelope, and Membrane Antigens of SARS-CoV-2 in Indian Population Open
Background: Serological methods to conduct epidemiological survey are often directed only against the spike protein. To overcome this limitation, we have designed PRAK-03202, a virus-like particle (VLP), by inserting three antigens (Spike,…
View article: Platforms, advances, and technical challenges in virus-like particles-based vaccines
Platforms, advances, and technical challenges in virus-like particles-based vaccines Open
Viral infectious diseases threaten human health and global stability. Several vaccine platforms, such as DNA, mRNA, recombinant viral vectors, and virus-like particle-based vaccines have been developed to counter these viral infectious dis…
View article: <i>In-silico</i> development of multi-epitope subunit vaccine against lymphatic filariasis
<i>In-silico</i> development of multi-epitope subunit vaccine against lymphatic filariasis Open
The World Health Organization in 2022 reported that more than 863 million people in 50 countries are at risk of developing lymphatic filariasis (LF), a disease caused by parasitic infection. Immune responses to parasites suggest that the d…
View article: Establishment of a three‑dimensional triculture model on the novel AXTEX‑4D™ platform
Establishment of a three‑dimensional triculture model on the novel AXTEX‑4D™ platform Open
Cancer can be fatal if it is not treated in a timely manner; therefore, there is a high demand for more specific oncology drugs. Unfortunately, drugs showing positive responses on a two‑dimensional (2D) culture platform do not often show t…
View article: PRAK-03202: A triple antigen virus-like particle vaccine candidate against SARS CoV-2
PRAK-03202: A triple antigen virus-like particle vaccine candidate against SARS CoV-2 Open
View article: Corrigendum to “PRAK-03202: A triple antigen virus-like particle vaccine candidate against SARS CoV-2”[Heliyon 7 (10) (October 2021) e08124]
Corrigendum to “PRAK-03202: A triple antigen virus-like particle vaccine candidate against SARS CoV-2”[Heliyon 7 (10) (October 2021) e08124] Open
View article: Recombinant Glycoprotein B of Equine herpesvirus Type 1 Elicits Protective Immune Response against Challenge in BALB/c Mouse Model
Recombinant Glycoprotein B of Equine herpesvirus Type 1 Elicits Protective Immune Response against Challenge in BALB/c Mouse Model Open
Background: Equine herpesvirus type 1 (EHV-1) is the most important viral pathogen of equines, causing respiratory illness, abortion, neonatal foal mortality and neurologic disorders. Large numbers of commercial EHV-1 vaccines are availabl…
View article: Recapitulating tumor microenvironment using preclinical 3D tissueoids model for accelerating cancer research and drug screening
Recapitulating tumor microenvironment using preclinical 3D tissueoids model for accelerating cancer research and drug screening Open
The formation of three-dimensional spheroid tumor model using the scaffold-based platforms has been demonstrated over many years now. 3D tumor models are generated mainly in non-scalable culture systems, using synthetic and biological scaf…
View article: AXTEX-4D™: A Novel 3D<i>ex vivo</i>platform for preclinical investigations of immunotherapy agents
AXTEX-4D™: A Novel 3D<i>ex vivo</i>platform for preclinical investigations of immunotherapy agents Open
The latest advancements in oncology are majorly focused on immuno-oncology (I-O) therapies. However, only ~7% of drugs are being approved from the preclinical discovery phase to phase 1. The most challenging issues in I-O is the problem of…
View article: PRAK-03202: A triple antigen VLP vaccine candidate against SARS CoV-2
PRAK-03202: A triple antigen VLP vaccine candidate against SARS CoV-2 Open
The rapid development of safe and effective vaccines against SARS CoV-2 is the need of the hour for the coronavirus outbreak. Here, we have developed PRAK-03202, the world’s first triple antigen VLP vaccine candidate in a highly characteri…
View article: An Amino Acid–Based Oral Rehydration Solution Regulates Radiation-Induced Intestinal Barrier Disruption in Mice
An Amino Acid–Based Oral Rehydration Solution Regulates Radiation-Induced Intestinal Barrier Disruption in Mice Open
View article: An amino acid-based oral rehydration solution (AA-ORS) enhanced intestinal epithelial proliferation in mice exposed to radiation
An amino acid-based oral rehydration solution (AA-ORS) enhanced intestinal epithelial proliferation in mice exposed to radiation Open