Explanipedia

Behavioural interventions and theories to reduce antibiotic misuse in health care settings in low and middle-income countries between 2015-2025: a scoping review protocol Open

Reuben Kiggundu, Richard Ssenono, Joseph Ssebulime, Hope Mackline · 2025

Background Antimicrobial resistance (AMR) remains one of the leading causes of mortality in low- and middle-income countries (LMICs). A significant and modifiable contributor to AMR in these settings is the inappropriate prescribing of an…

Distribution and Factors Associated with Neisseria gonorrhoeae Cases in Kampala, Uganda, 2016–2020 Open

Fahad Lwigale, Conrad Tumwine, Reuben Kiggundu, Patrick Elungat, Hope Mackline , et al. · 2025

Background: Gonorrhoea is a common sexually transmitted infection with serious health consequences if not well-treated. Resistance to common therapeutic agents and limited diagnostics further heighten its burden on sexual and reproductive …

Cerebral Perfusion Pressures and Implications on Clinical Outcomes and Medical Management in Cryptococcal Meningitis Open

Mahsa Abassi, Cody R. Hou, Ann Fieberg, Biyue Dai, Abdu K Musubire , et al. · 2025

Background In cryptococcal meningitis, increased intracranial pressure (ICP) is associated with worse outcomes and increased mortality. We sought to understand how changes in ICP and mean arterial pressure (MAP) affect cerebral perfusion p…

Antimicrobial Resistance Patterns of Isolates from Bloodstream Infections at Jinja Regional Referral Hospital in Uganda Open

Fahad Lwigale, Grace Akello, Jonathan Mayito, Herman Mwanja, Reuben Kiggundu , et al. · 2025

Introduction Bloodstream infections (BSIs) are common acute syndromes of variable origin with high chances for extreme health effects including death. Empirical therapy is usually employed to manage the BSIs despite the high resistance to …

Strengthening Community Antimicrobial Stewardship in Africa: A Systematic Review of the Roles, Challenges, and Opportunities of Community Health and Animal Health Workers Open

Conrad Tumwine, Reuben Kiggundu, Fahad Lwaigale, Herman Mwanja, Hannigton Katumba , et al. · 2025

Antimicrobial resistance (AMR) remains a critical global health challenge, and is mainly due to inappropriate antimicrobial use in human and animal health sectors. This systematic review examines the roles of Community Animal Health Worker…

Therapeutic drug monitoring for antimicrobial agents for people living with HIV (TAP) Open

Christine Sekaggya‐Wiltshire, Eva Agnes Laker Odongpiny, Francis Williams Ojara, Christine Sekaggya‐Wiltshire, Reuben Kiggundu , et al. · 2025

Background Antimicrobial resistance (AMR) is a growing health concern, particularly in Africa, and is predicted to become the leading cause of death after cancer by 2050. Factors like overuse or inappropriate use of antibiotics contribute …

Utility of the WHO AWaRe classification in monitoring antibiotics use trends at select tertiary hospitals in Uganda: Evaluation of 2020-2023 Point Prevalence Surveys Open

Miss Suzan Nakasendwa, Miss Flavia Dhikusooka, Conrad Tumwine, Hope Mackline, Reuben Kiggundu , et al. · 2025

Introduction: Irrational use of antibiotics is a major driver of antimicrobial resistance (AMR). The WHO AWaRe classification was introduced as a tool to support antibiotic stewardship efforts to optimize antibiotic use and control AMR. We…

Evaluating the appropriateness of prescribing antibiotics among persons with HIV (PWH) enrolled in routine cohorts at the Infectious Diseases Institute Clinic, Kampala, Uganda: A study protocol Open

Brian Otaalo, Joseph Musaazi, Herman Mwanja, Derek Ngabirano, Reuben Kiggundu , et al. · 2025

Introduction Antimicrobial resistance is a global health threat and people living with HIV are at an increased risk. Inappropriate antibiotic use is one of the major driving factors for antimicrobial resistance, and a lot of irrational ant…

National-Level Consumption of Antimicrobials in the Veterinary Sector in Uganda: A Report on Analysis of Import Data for 2021 Open

Marion Murungi, Patrick Vudriko, Helen Byomire Ndagije, Diana Nakitto Kesi, Allan Serwanga , et al. · 2025

Background: Antimicrobials are crucial for animal health and food security. However, their overuse in animals can lead to the emergence of resistant microorganisms. Antimicrobial resistance (AMR) poses a global public health threat that im…

Therapeutic drug monitoring for antimicrobial agents for people living with HIV (TAP) Open

Christine Sekaggya‐Wiltshire, Eva Agnes Laker Odongpiny, Francis Williams Ojara, Christine Sekaggya‐Wiltshire, Reuben Kiggundu , et al. · 2024

Background Antimicrobial resistance (AMR) is a growing health concern, particularly in Africa, and is predicted to be the leading cause of death after cancer by 2050. Factors like overuse or inappropriate use of antibiotics, contribute to…

Progress on implementing the WHO-GLASS recommendations on priority pathogen-antibiotic sensitivity testing in Africa: A scoping review Open

Hope Mackline, Reuben Kiggundu, Dickson Tabajjwa, Conrad Tumwine, Fahad Lwigale , et al. · 2024

Introduction The World Health Organization global antimicrobial resistance surveillance system (GLASS) was rolled out in 2015 to guide antimicrobial resistance (AMR) surveillance. However, its implementation in Africa has not been fully ev…

Behavioral Nudges to Encourage Appropriate Antimicrobial Use Among Health Professionals in Uganda Open

Allison Ross, Philip J. Meacham, JP Waswa, Mohan P. Joshi, Tamara Hafner , et al. · 2024

Background/Objectives: Antimicrobial resistance (AMR) is a global public health concern exacerbated by inappropriate antimicrobial prescribing practices, particularly in low-resource settings such as Uganda. The research aimed to develop a…

Enhancing infection prevention and control through hand hygiene compliance in six Ugandan hospitals using quality improvement approaches Open

Hassan Kasujja, JP Waswa, Reuben Kiggundu, Marion Murungi, Grace Kwikiriza , et al. · 2024

Introduction Hand hygiene (HH) plays a crucial role in mitigating healthcare-associated infections. Improving HH compliance in healthcare facilities in resource-limited settings is urgently needed. Methods We implemented the World Health O…

Utility of syndromic surveillance for the surveillance of healthcare-associated infections in resource-limited settings: a narrative review Open

Herman Mwanja, JP Waswa, Reuben Kiggundu, Hope Mackline, Daniel Bulwadda , et al. · 2024

Globally, Healthcare-associated infections (HCAIs) pose a significant threat to patient safety and healthcare systems. In low- and middle-income countries (LMICs), the lack of adequate resources to manage HCAIs, as well as the weak healthc…

Engaging healthcare students in innovative approaches for antimicrobial resistance containment Open

Hassan Kasujja, Henry Kajumbula, Jonans Tusiimire, JP Waswa, Stella Nanyonga , et al. · 2024

No abstract available.

A bottom-up, One Health approach to assessing progress in the implementation of a national action plan for combatting antimicrobial resistance: a case study from Uganda Open

JP Waswa, Reuben Kiggundu, Hassan Kasujja, Patrick Vudriko, Hakim Sendagire , et al. · 2024

Antimicrobial resistance (AMR) is one of the greatest threats to public health, and it is spreading across the human health, animal health, and environmental sectors. Sole reliance on desk reviews and national-level stakeholder engagement …

Progress of Implementation of World Health Organization Global Antimicrobial Resistance Surveillance System Recommendations on Priority Pathogen-Antibiotic Sensitivity Testing in Africa: Protocol for a Scoping Review Open

Hope Mackline, Reuben Kiggundu, Dathan M. Byonanebye, Jonathan Mayito, Dickson Tabajjwa , et al. · 2024

Background Antimicrobial resistance (AMR) is a major global public health concern, particularly in low- and middle-income countries where resources and infrastructure for an adequate response are limited. The World Health Organization (WHO…

Combating Antimicrobial Resistance Through a Data-Driven Approach to Optimize Antibiotic Use and Improve Patient Outcomes: Protocol for a Mixed Methods Study Open

Jonathan Mayito, Conrad Tumwine, Ronald Galiwango, Elly Nuwamanya, Suzan Nakasendwa , et al. · 2024

Background It is projected that drug-resistant infections will lead to 10 million deaths annually by 2050 if left unabated. Despite this threat, surveillance data from resource-limited settings are scarce and often lack antimicrobial resis…

Restarting pre-exposure prophylaxis (PrEP) for HIV: a systematic review and meta-analysis Open

Reuben Kiggundu, Qi Rui Soh, Warittha Tieosapjaroen, Christopher K. Fairley, Joseph D Tucker , et al. · 2024

Australian National Health and Medical Research Council.

Restarting pre-exposure prophylaxis (PrEP) for HIV: a systematic review and meta-analysis Open

Reuben Kiggundu, Qi Rui Soh, Warittha Tieosapjaroen, Christopher K. Fairley, Joseph D. Tucker , et al. · 2024

Background: High coverage of pre-exposure prophylaxis (PrEP) will reduce HIV transmission and help end the HIV/AIDS pandemic. However, PrEP users face challenges, including long-term adherence. The study aimed to document the proportions o…

Combating Antimicrobial Resistance Through a Data-Driven Approach to Optimize Antibiotic Use and Improve Patient Outcomes: Protocol for a Mixed Methods Study (Preprint) Open

Jonathan Mayito, Conrad Tumwine, Ronald Galiwango, Elly Nuwamanya, Suzan Nakasendwa , et al. · 2024

BACKGROUND It is projected that drug-resistant infections will lead to 10 million deaths annually by 2050 if left unabated. Despite this threat, surveillance data from resource-limited settings are scarce and often lack antimicrobial resi…

Progress of Implementation of World Health Organization Global Antimicrobial Resistance Surveillance System Recommendations on Priority Pathogen-Antibiotic Sensitivity Testing in Africa: Protocol for a Scoping Review (Preprint) Open

Hope Mackline, Reuben Kiggundu, Dathan M. Byonanebye, Jonathan Mayito, Dickson Tabajjwa , et al. · 2024

BACKGROUND Antimicrobial resistance (AMR) is a major global public health concern, particularly in low- and middle-income countries where resources and infrastructure for an adequate response are limited. The World Health Organization (WH…

A One Health approach to fight antimicrobial resistance in Uganda: Implementation experience, results, and lessons learned Open

Reuben Kiggundu, JP Waswa, Niranjan Konduri, Hassan Kasujja, Marion Murungi , et al. · 2024

Addressing gaps in AMR awareness in the public: an evidence-based policy brief to guide school curriculum review in Uganda Open

JP Waswa, Reuben Kiggundu, Mohan P. Joshi, Joseph Mpagi, Hassan Kasujja , et al. · 2023

The government of Uganda, through its Ministry of Health, previously adopted curriculum review as a mechanism to respond to public health threats such as HIV/AIDS and include content in primary and secondary schools. This approach contribu…

Antimicrobial consumption surveillance in Uganda: Results from an analysis of national import data for the human health sector, 2018–2021 Open

Marion Murungi, Helen Byomire Ndagije, Reuben Kiggundu, Diana Nakitto Kesi, JP Waswa , et al. · 2023

The relatively high consumption of injectable antimicrobials and year over year increase in watch class AMC requires urgent stewardship interventions. Further work is needed to establish a system for longitudinal AMC surveillance that is w…

What is the appropriate antimicrobial use surveillance tool at the health facility level for Uganda and other low- and middle-income countries? Open

JP Waswa, Reuben Kiggundu, Niranjan Konduri, Hassan Kasujja, Lynn Lieberman Lawry , et al. · 2023

Background: An appropriate antimicrobial use (AMU) surveillance system provides critical data and evidence on which antimicrobial stewardship interventions are based. However, Uganda and most other low- and middle-income countries (LMICs) …

Development and evaluation of a continuous quality improvement programme for antimicrobial stewardship in six hospitals in Uganda Open

Reuben Kiggundu, JP Waswa, Hilma Nakambale, Francis Kakooza, Hassan Kassuja , et al. · 2023

Background Appropriate antimicrobial use is essential for antimicrobial stewardship (AMS). Ugandan hospitals are making efforts to improve antibiotic use, but improvements have not been sufficiently documented and evaluated. Methods Six Ug…

Moving from assessments to implementation: promising practices for strengthening multisectoral antimicrobial resistance containment capacity Open

Mohan P. Joshi, Fozo Alombah, Niranjan Konduri, Antoine Ndiaye, Ndinda Kusu , et al. · 2023

Antimicrobial susceptibility surveillance and antimicrobial resistance in Neisseria gonorrhoeae in Africa from 2001 to 2020: A mini-review Open

Francis Kakooza, Reuben Kiggundu, Gerald Mboowa, Patrick David Kateete, Olga Tendo Nsangi , et al. · 2023

Antimicrobial resistance (AMR) in Neisseria gonorrhoeae (NG), compromising gonorrhea treatment, is a global public health concern. Improved, quality-assured NG AMR monitoring at the global level is essential. This mini-review examined NG A…

Gaps in data collection for sex and gender must be addressed in point prevalence surveys on antibiotic use Open

Lynn Lieberman Lawry, Niranjan Konduri, Nkatha Gitonga, Reuben Kiggundu, Mame Mbaye , et al. · 2023

OPINION article Front. Antibiot., 17 March 2023Sec. Antibiotic Resistance Volume 2 - 2023 | https://doi.org/10.3389/frabi.2023.1154506

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