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View article: Modifying inhibitor specificity for homologous enzymes by machine learning
Modifying inhibitor specificity for homologous enzymes by machine learning Open
Selective inhibitors are essential for targeted therapeutics and for probing enzyme functions in various biological systems. The two main challenges in identifying such protein‐based inhibitors lie in the extensive experimental effort requ…
View article: Mapping the sclerostin– <scp>LRP4</scp> binding interface identifies critical interaction hotspots in loops 1 and 3 of sclerostin
Mapping the sclerostin– <span>LRP4</span> binding interface identifies critical interaction hotspots in loops 1 and 3 of sclerostin Open
The interaction of sclerostin (Scl) with the low‐density lipoprotein receptor‐related protein 4 (LRP4) leads to a marked reduction in bone formation by inhibiting the Wnt/β‐catenin pathway. To characterize the Scl–LRP4 binding interface, w…
View article: Deep neural networks for predicting the affinity landscape of protein-protein interactions
Deep neural networks for predicting the affinity landscape of protein-protein interactions Open
Studies determining protein-protein interactions (PPIs) by deep mutational scanning have focused mainly on a narrow range of affinities within complexes and thus include only partial coverage of the mutation space of given proteins. By ins…