Reyhan Sönmez Flitman
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View article: Untargeted Metabolome- and Transcriptome-Wide Association Study Suggests Causal Genes Modulating Metabolite Concentrations in Urine
Untargeted Metabolome- and Transcriptome-Wide Association Study Suggests Causal Genes Modulating Metabolite Concentrations in Urine Open
Gene products can affect the concentrations of small molecules (aka "metabolites"), and conversely, some metabolites can modulate the concentrations of gene transcripts. While many specific instances of this interplay have been revealed, a…
View article: Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression Open
Trait-associated genetic variants affect complex phenotypes primarily via regulatory mechanisms on the transcriptome. To investigate the genetics of gene expression, we performed cis- and trans-expression quantitative trait locus (eQTL) an…
View article: Processed data used in transcriptome- metabolome-wide association study
Processed data used in transcriptome- metabolome-wide association study Open
Processed_RNASeq_RPKM.txt contains RPKM levels for 45484 genes quantified in 555 individuals from RNA-Seq of lymphoblastoid cell lines (LCLs). Processed_NMRpeaks_baseline.txt contains binned, normalized and standardised (z-scored) NMR peak…
View article: Processed data used in transcriptome- metabolome-wide association study
Processed data used in transcriptome- metabolome-wide association study Open
Processed_RNASeq_RPKM.txt contains RPKM levels for 45484 genes quantified in 555 individuals from RNA-Seq of lymphoblastoid cell lines (LCLs). Processed_NMRpeaks_baseline.txt contains binned, normalized and standardised (z-scored) NMR peak…
View article: Untargeted metabolome- and transcriptome-wide association study identifies causal genes modulating metabolite concentrations in urine
Untargeted metabolome- and transcriptome-wide association study identifies causal genes modulating metabolite concentrations in urine Open
Summary In this study we investigate the results of a metabolome- and transcriptome-wide association study to identify genes influencing the human metabolome. We used RNAseq data from lymphoblastoid cell lines (LCLs) derived from 555 Cauca…