Reymundo Villa
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View article: Modulation of RNA splicing associated with Wnt signaling pathway using FD-895 and pladienolide B
Modulation of RNA splicing associated with Wnt signaling pathway using FD-895 and pladienolide B Open
Alterations in RNA splicing are associated with different malignancies, including leukemia, lymphoma, and solid tumors. The RNA splicing modulators such as FD-895 and pladienolide B have been investigated in different malignancies to targe…
View article: FD-895 and Pladienolide B Modulate RNA Splicing Associated With Wnt Signaling Pathway
FD-895 and Pladienolide B Modulate RNA Splicing Associated With Wnt Signaling Pathway Open
BackgroundAlterations in RNA splicing are associated with different malignancies including leukemia, lymphoma, and solid tumors. The RNA splicing modulators such as FD-895 and pladienolide B have been investigated in different malignancies…
View article: RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML
RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML Open
Age-related human hematopoietic stem cell (HSC) exhaustion and myeloid-lineage skewing promote oncogenic transformation of hematopoietic progenitor cells into therapy-resistant leukemia stem cells (LSCs) in secondary acute myeloid leukemia…