Reza Abdi
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View article: Purin Metabolism Is Crucial for Regulatory T Cell Stability and Function
Purin Metabolism Is Crucial for Regulatory T Cell Stability and Function Open
Cellular metabolism intricately directs the differentiation, stability, and function of regulatory T cells (Tregs), which are pivotal in immune regulation. Metabolic reprogramming enables Tregs to adapt to diverse tissue environments; howe…
View article: Repetitive ischemic injuries to the kidneys result in lymph node fibrosis and impaired healing
Repetitive ischemic injuries to the kidneys result in lymph node fibrosis and impaired healing Open
View article: Impact of optimal anti-proteinuric therapy on the prevention of diabetic kidney disease progression
Impact of optimal anti-proteinuric therapy on the prevention of diabetic kidney disease progression Open
Diabetic kidney disease (DKD) is the leading global cause of end-stage renal disease (ESRD), with its prevalence rising, particularly in resource-limited settings. Antiproteinuric medications are central to DKD management, but their optima…
View article: John Putnam Merrill: the unsung Hero behind the first successful renal transplantation
John Putnam Merrill: the unsung Hero behind the first successful renal transplantation Open
The first successful renal transplantation, performed between the Herrick twins at Peter Bent Brigham Hospital (PBBH) in 1954, was the culmination of four decades of collaboration among an exceptional group of physician-scientists and hosp…
View article: Correction to “Polylactide‐cyclosporin A nanoparticles for targeted immunosuppression”
Correction to “Polylactide‐cyclosporin A nanoparticles for targeted immunosuppression” Open
View article: CXCL12+ fibroblastic reticular cells in lymph nodes facilitate immune tolerance by regulating T cell–mediated alloimmunity
CXCL12+ fibroblastic reticular cells in lymph nodes facilitate immune tolerance by regulating T cell–mediated alloimmunity Open
Fibroblastic reticular cells (FRCs) are the master regulators of the lymph node (LN) microenvironment. However, the role of specific FRC subsets in controlling alloimmune responses remains to be studied. Single-cell RNA sequencing (scRNA-S…
View article: Correction: Importance of Donor-Derived and Recipient-Derived Selectins in Cardiac Allograft Rejection
Correction: Importance of Donor-Derived and Recipient-Derived Selectins in Cardiac Allograft Rejection Open
View article: Retraction Note: Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells
Retraction Note: Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells Open
View article: Follicular regulatory T cells restrain kidney allograft rejection in mice by suppressing alloreactive B cells
Follicular regulatory T cells restrain kidney allograft rejection in mice by suppressing alloreactive B cells Open
Pathogenic antibodies produced by alloreactive B cells mediate antibody-mediated rejection after kidney transplantation, but the mechanisms remain poorly understood. Follicular regulatory T (Tfr) cells modulate follicular helper T cell-med…
View article: The inflammaging microenvironment induces dysfunctional rewiring of Tfh cell differentiation
The inflammaging microenvironment induces dysfunctional rewiring of Tfh cell differentiation Open
Humoral immunity is orchestrated by follicular helper T (Tfh) cells, which promote cognate B cells to produce high-affinity, protective antibodies. In aged individuals, humoral immunity after vaccination is diminished despite the presence …
View article: An Exosomal mRNA Urine Test for Detection and Risk Stratification of Human Kidney Transplant Rejection
An Exosomal mRNA Urine Test for Detection and Risk Stratification of Human Kidney Transplant Rejection Open
View article: Utilization Trends of Glucose-Lowering Medications Among Adult Kidney Transplant Recipients with Type 2 Diabetes in the United States
Utilization Trends of Glucose-Lowering Medications Among Adult Kidney Transplant Recipients with Type 2 Diabetes in the United States Open
Background: To date, there are limited studies describing the use of glucose-lowering medications (GLMs) in adult kidney transplant recipients (KTRs), and the uptake of sodium glucose cotransporter-2 inhibitors (SGLT2is) and glucagon-like …
View article: Regulatory T cells crosstalk with tumor cells and endothelium through lymphotoxin signaling
Regulatory T cells crosstalk with tumor cells and endothelium through lymphotoxin signaling Open
View article: Metabolic Reprogramming of Fibroblastic Reticular Cells in Immunity and Tolerance
Metabolic Reprogramming of Fibroblastic Reticular Cells in Immunity and Tolerance Open
Fibroblastic reticular cells (FRCs) are pivotal stromal components that maintain the structure of secondary lymphoid tissues and modulate the immune responses within the lymphoid microenvironment. In response to specific immune or inflamma…
View article: Comparison Static and Dynamic Ultrasound Techniques of DDH: The Role of the Patient's Position.
Comparison Static and Dynamic Ultrasound Techniques of DDH: The Role of the Patient's Position. Open
In the ultrasound examination of DDH with static and dynamic techniques, the change in the alpha angle was not statistically significant. Therefore, the hand of the radiologist is open in measuring alpha angles and there is no need to emph…
View article: Stepwise differentiation of follicular helper T cells reveals distinct developmental and functional states
Stepwise differentiation of follicular helper T cells reveals distinct developmental and functional states Open
Follicular helper T (Tfh) cells are essential for the formation of high affinity antibodies after vaccination or infection. Although the signals responsible for initiating Tfh differentiation from naïve T cells have been studied, the signa…
View article: Author Correction: The immunoregulatory roles of non-haematopoietic cells in the kidney
Author Correction: The immunoregulatory roles of non-haematopoietic cells in the kidney Open
View article: The immunoregulatory roles of non-haematopoietic cells in the kidney
The immunoregulatory roles of non-haematopoietic cells in the kidney Open
View article: Transplanting old organs promotes senescence in young recipients
Transplanting old organs promotes senescence in young recipients Open
View article: IL-21–producing effector Tfh cells promote B cell alloimmunity in lymph nodes and kidney allografts
IL-21–producing effector Tfh cells promote B cell alloimmunity in lymph nodes and kidney allografts Open
Follicular helper T (Tfh) cells have been implicated in controlling rejection after allogeneic kidney transplantation, but the precise subsets, origins, and functions of Tfh cells in this process have not been fully characterized. Here we …
View article: Meningeal lymphatics and their role in CNS disorder treatment: moving past misconceptions
Meningeal lymphatics and their role in CNS disorder treatment: moving past misconceptions Open
The central nervous system (CNS) was previously thought to lack lymphatics and shielded from the free diffusion of molecular and cellular components by the blood–brain barrier (BBB) and the blood–cerebrospinal fluid barrier (BCB). However,…
View article: The Impact of T-cell Aging on Alloimmunity and Inflammaging
The Impact of T-cell Aging on Alloimmunity and Inflammaging Open
Aging affects immunity broadly through changes caused by immunosenescence, clinically resulting in augmented susceptibility to infections, autoimmunity, and cancer. The most striking alterations associated with immunosenescence have been o…
View article: Nanotargeted Delivery of Immune Therapeutics in Type 1 Diabetes
Nanotargeted Delivery of Immune Therapeutics in Type 1 Diabetes Open
Immune therapeutics holds great promise in the treatment of type 1 diabetes (T1D). Nonetheless, their progress is hampered by limited efficacy, equipoise, or issues of safety. To address this, a novel and specific nanodelivery platform for…
View article: Paul Russell: the transcendentalist surgeon of America
Paul Russell: the transcendentalist surgeon of America Open
I first met Dr. Russell in the Fall of 2000 at the Massachusetts General Hospital (MGH). I entered the Russell-Round-Room which was packed with surgeons and physicians of MGH, among whom there was no shortage of self-esteem. I came across …
View article: FRC transplantation restores lymph node conduit defects in laminin α4–deficient mice
FRC transplantation restores lymph node conduit defects in laminin α4–deficient mice Open
Fibroblastic reticular cells (FRCs) play important roles in tolerance by producing laminin α4 (Lama4) and altering lymph node (LN) structure and function. The present study revealed the specific roles of extracellular matrix Lama4 in regul…
View article: Glutathione‐Scavenging Nanoparticle‐Mediated PROTACs Delivery for Targeted Protein Degradation and Amplified Antitumor Effects
Glutathione‐Scavenging Nanoparticle‐Mediated PROTACs Delivery for Targeted Protein Degradation and Amplified Antitumor Effects Open
PROteolysis TArgeting Chimeras (PROTACs) are an emerging class of promising therapeutic modalities that selectively degrade intracellular proteins of interest by hijacking the ubiquitin‐proteasome system. However, the lack of techniques to…
View article: Uncovering a novel role of focal adhesion and interferon-gamma in cellular rejection of kidney allografts at single cell resolution
Uncovering a novel role of focal adhesion and interferon-gamma in cellular rejection of kidney allografts at single cell resolution Open
Background Kidney transplant recipients are currently treated with nonspecific immunosuppressants that cause severe systemic side effects. Current immunosuppressants were developed based on their effect on T-cell activation rather than the…
View article: Bifunctional cancer cell–based vaccine concomitantly drives direct tumor killing and antitumor immunity
Bifunctional cancer cell–based vaccine concomitantly drives direct tumor killing and antitumor immunity Open
The administration of inactivated tumor cells is known to induce a potent antitumor immune response; however, the efficacy of such an approach is limited by its inability to kill tumor cells before inducing the immune responses. Unlike ina…
View article: GLP1R Strives T Cell Negative Costimulation Through a rRNA Gene Repressor Interactome
GLP1R Strives T Cell Negative Costimulation Through a rRNA Gene Repressor Interactome Open
View article: Delivery of costimulatory blockade to lymph nodes promotes transplant acceptance in mice
Delivery of costimulatory blockade to lymph nodes promotes transplant acceptance in mice Open
The lymph node (LN) is the primary site of alloimmunity activation and regulation during transplantation. Here, we investigated how fibroblastic reticular cells (FRCs) facilitate the tolerance induced by anti-CD40L in a murine model of hea…