Reza Dastvan
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View article: Structural dynamics of sphingosine kinase 1 regulation and inhibition
Structural dynamics of sphingosine kinase 1 regulation and inhibition Open
Sphingosine kinase 1 (SK1) generates sphingosine-1-phosphate, a bioactive lipid implicated in cancer and other diseases. Despite its clinical importance, the structural and dynamic basis of SK1 regulation and inhibition remains poorly unde…
View article: Kingfisher: An open‐sourced web‐based platform for the analysis of hydrogen exchange mass spectrometry data
Kingfisher: An open‐sourced web‐based platform for the analysis of hydrogen exchange mass spectrometry data Open
Hydrogen–deuterium exchange mass spectrometry (HDX‐MS) is now a critical tool in molecular biology and structural proteomics. It is routinely used to probe protein and conformational dynamics through a well‐established experiment where ami…
View article: The strand exchange domain of tumor suppressor PALB2 is intrinsically disordered and promotes oligomerization-dependent DNA compaction
The strand exchange domain of tumor suppressor PALB2 is intrinsically disordered and promotes oligomerization-dependent DNA compaction Open
The partner and localizer of BRCA2 (PALB2) is a scaffold protein linking BRCA1 with BRCA2 and RAD51 during homologous recombination (HR). PALB2 interaction with DNA strongly enhances HR in cells, while the PALB2 DNA-binding domain (PALB2-D…
View article: Partial wrapping of single-stranded DNA by replication protein A and modulation through phosphorylation
Partial wrapping of single-stranded DNA by replication protein A and modulation through phosphorylation Open
Single-stranded DNA (ssDNA) intermediates which emerge during DNA metabolic processes are shielded by replication protein A (RPA). RPA binds to ssDNA and acts as a gatekeeper to direct the ssDNA towards downstream DNA metabolic pathways wi…
View article: Computational structural prediction and chemical inhibition of the human mitochondrial pyruvate carrier protein heterodimer complex
Computational structural prediction and chemical inhibition of the human mitochondrial pyruvate carrier protein heterodimer complex Open
The mitochondrial pyruvate carrier (MPC) plays a role in numerous diseases including neurodegeneration, metabolically dependent cancers, and the development of insulin resistance. Several previous studies in genetic mouse models or with ex…
View article: Wrapping of single-stranded DNA by Replication Protein A and modulation through phosphorylation
Wrapping of single-stranded DNA by Replication Protein A and modulation through phosphorylation Open
Single-stranded DNA (ssDNA) intermediates, which emerge during DNA metabolic processes are shielded by Replication Protein A (RPA). RPA binds to ssDNA and acts as a gatekeeper, directing the ssDNA towards downstream DNA metabolic pathways …
View article: The PALB2 DNA-binding domain is an intrinsically disordered recombinase
The PALB2 DNA-binding domain is an intrinsically disordered recombinase Open
The Partner and Localizer of BRCA2 (PALB2) tumor suppressor is a scaffold protein that links BRCA1 with BRCA2 to initiate homologous recombination (HR). PALB2 interaction with DNA strongly enhances HR efficiency. The PALB2 DNA-binding doma…
View article: The strand exchange domain of tumor suppressor PALB2 is intrinsically disordered and promotes oligomerization-dependent DNA compaction.
The strand exchange domain of tumor suppressor PALB2 is intrinsically disordered and promotes oligomerization-dependent DNA compaction. Open
The Partner and Localizer of BRCA2 (PALB2) is a scaffold protein that links BRCA1 with BRCA2 to initiate homologous recombination (HR). PALB2 interaction with DNA strongly enhances HR efficiency in cells. The PALB2 DNA-binding domain (PALB…
View article: Proton-driven alternating access in a spinster transporter, an emerging family of broad-specificity efflux pumps
Proton-driven alternating access in a spinster transporter, an emerging family of broad-specificity efflux pumps Open
Spinster (Spns) lipid transporters are critical for transporting sphingosine-1-phosphate (S1P) across cellular membranes. In humans, Spns2 functions as the main S1P transporter in endothelial cells, making it a potential drug target for mo…
View article: Proton-driven alternating access in a spinster transporter, an emerging family of broad-specificity efflux pumps
Proton-driven alternating access in a spinster transporter, an emerging family of broad-specificity efflux pumps Open
Spinster (Spns) lipid transporters are critical for transporting sphingosine-1-phosphate (S1P) across cellular membranes. In humans, Spns2 functions as the main S1P transporter in endothelial cells, making it a potential drug target for mo…
View article: Decision letter: Structural intermediates observed only in intact Escherichia coli indicate a mechanism for TonB-dependent transport
Decision letter: Structural intermediates observed only in intact Escherichia coli indicate a mechanism for TonB-dependent transport Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Outer membrane TonB-dependent…
View article: Protonation-dependent conformational dynamics of the multidrug transporter EmrE
Protonation-dependent conformational dynamics of the multidrug transporter EmrE Open
Significance Small multidrug resistance (SMR) transporters play an important role in the protection of prokaryotes from cytotoxic molecules. They exploit the proton electrochemical gradient to drive the transport of these molecules out of …