Reza Ehsanian
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View article: Assessing the Efficacy of Alcohol Swabbing in Preventing Bacterial Colonization of Single-Use Vials: A Pilot Study
Assessing the Efficacy of Alcohol Swabbing in Preventing Bacterial Colonization of Single-Use Vials: A Pilot Study Open
Introduction Proceduralists who use single-use vials have adopted many of the same techniques for sterilizing multi-use vials, including swabbing the rubber tops with 70% isopropyl alcohol before drawing injectate. However, the lack of lit…
View article: Humanized anti-P2X4 scFv reduces ATP-induced P2X4 currents and modulates excitability in human DRG neurons
Humanized anti-P2X4 scFv reduces ATP-induced P2X4 currents and modulates excitability in human DRG neurons Open
Chronic pain affects nearly 100 million adults in the U.S., yet few novel therapeutics have emerged in recent decades. P2X4 receptor (P2X4R), implicated in pain signaling, represents a promising target. We evaluated a humanized single-chai…
View article: Gabapentin’s effect on human dorsal root ganglia: Donor-specific electrophysiological and transcriptomic profiles
Gabapentin’s effect on human dorsal root ganglia: Donor-specific electrophysiological and transcriptomic profiles Open
Neuropathic pain affects approximately 10% of the adult population and is commonly treated with gabapentin (GBP), a repurposed anticonvulsant drug. Despite its widespread use, GBP’s effectiveness varies significantly among patients, highli…
View article: Visceral pain-related acute actions of cerulein on mouse and human sensory neurons
Visceral pain-related acute actions of cerulein on mouse and human sensory neurons Open
Cerulein is an orthologue of cholecystokinin, which is often used to induce acute pancreatitis in pre-clinical studies. In these models, animals show signs of pain, and this is the most common complaint of patients with acute pancreatitis.…
View article: The effectiveness of fluoroscopically guided lumbar facet steroid joint injections: A systematic review
The effectiveness of fluoroscopically guided lumbar facet steroid joint injections: A systematic review Open
Pragmatic and observational studies suggest IASI may reduce pain and disability, while sham-controlled trials have not demonstrated efficacy. Given the very low quality of evidence, the true effect of IASI is highly uncertain. Further high…
View article: The circular RNA landscape of human dorsal root ganglia and its association with opioid exposure
The circular RNA landscape of human dorsal root ganglia and its association with opioid exposure Open
Opioids are among the most widely prescribed treatments for pain; however, prolonged use leads to adverse effects, including reduced analgesic efficacy (tolerance) and paradoxically heightened pain sensitivity (opioid-induced hyperalgesia,…
View article: Emergency room management of urolithiasis: a sex-based comparison
Emergency room management of urolithiasis: a sex-based comparison Open
In this single-center, propensity-matched analysis, we found no significant sex, race, or provider level of training-based differences in prescribing patterns for patients presenting with renal colic secondary to upper urinary tract stones…
View article: Machine Learning Elucidates Electrophysiological Properties Predictive of Multi- and Single-Firing Human and Mouse Dorsal Root Ganglia Neurons
Machine Learning Elucidates Electrophysiological Properties Predictive of Multi- and Single-Firing Human and Mouse Dorsal Root Ganglia Neurons Open
Human and mouse dorsal root ganglia (hDRG and mDRG) neurons are important tools in understanding the molecular and electrophysiological mechanisms that underlie nociception and drive pain behaviors. One of the simplest differences in firin…
View article: Genicular nerve radiofrequency ablation practice patterns: A survey study of the International Pain and Spine Interventional Society
Genicular nerve radiofrequency ablation practice patterns: A survey study of the International Pain and Spine Interventional Society Open
The study provides valuable insights into the current practice patterns of GnRFA among interventional pain physicians. While there is consensus on some aspects of patient selection and procedural techniques, significant variability exists …
View article: Contrast enhancing epidural fluid accumulation after percutaneous endoscopic lumbar discectomy: A case report of recurrent disc herniation within pseudocyst secondary to irrigation fluid
Contrast enhancing epidural fluid accumulation after percutaneous endoscopic lumbar discectomy: A case report of recurrent disc herniation within pseudocyst secondary to irrigation fluid Open
With the increasing utilization of PELD, it is important to acknowledge unique complications such as fluid accumulation from irrigation within the epidural space. Fluid accumulation can lead to contrast-enhancing pseudocyst formation, whic…
View article: Machine learning elucidates electrophysiological properties predictive of multi- and single-firing human and mouse dorsal root ganglia neurons
Machine learning elucidates electrophysiological properties predictive of multi- and single-firing human and mouse dorsal root ganglia neurons Open
Human and mouse dorsal root ganglia (hDRG and mDRG) neurons are important tools in understanding the molecular and electrophysiological mechanisms that underlie nociception and drive pain behaviors. One of the simplest differences in firin…
View article: Normality analysis of numeric rating scale scores in patients with chronic axial spine pain before and after medial branch blocks: a multicenter study
Normality analysis of numeric rating scale scores in patients with chronic axial spine pain before and after medial branch blocks: a multicenter study Open
Objective The statistical analysis typically used to compare pain before and after interventions assumes that scores are normally distributed. The present study evaluates whether numeric rating scale (NRS) scores, specifically NRS-11 score…
View article: A single-center real-world review of 10 kHz high-frequency spinal cord stimulation outcomes for treatment of chronic pain
A single-center real-world review of 10 kHz high-frequency spinal cord stimulation outcomes for treatment of chronic pain Open
Patient responder rates in this retrospective pragmatic real-world study of HF-SCS are consistent with previous industry-sponsored studies. However, improvements in quality-of-life measures and reduction in medication usage were not as rob…
View article: The Association Between Well-Being and Empathy in Medical Residents: A Cross-Sectional Survey
The Association Between Well-Being and Empathy in Medical Residents: A Cross-Sectional Survey Open
Objective: To evaluate the extent to which personal well-being may be associated with empathy, while controlling for potential confounders. Settings/Location: Residency programs throughout the United States. Subjects: A total of 407 medica…
View article: Improvement of the rapid response system at an acute rehabilitation hospital in New Mexico
Improvement of the rapid response system at an acute rehabilitation hospital in New Mexico Open
Aim: Enhance the Rapid Response System (RRS) in a free-standing acute rehabilitation hospital (ARH) by improving announcements, crash cart standardization and role assignments. Materials & methods: Pre-intervention (PreIQ) and post-interve…
View article: Electrophysiological analyses of human dorsal root ganglia and human induced pluripotent stem cell-derived sensory neurons from male and female donors
Electrophysiological analyses of human dorsal root ganglia and human induced pluripotent stem cell-derived sensory neurons from male and female donors Open
Human induced pluripotent stem cell-derived sensory neurons (hiPSC-SNs) and human dorsal root ganglia (hDRG) neurons are popular tools in the field of pain research; however, few groups make use of both approaches. For screening and analge…
View article: Supplementary Data from CK2 Modulation of NF-κB, TP53, and the Malignant Phenotype in Head and Neck Cancer by Anti-CK2 Oligonucleotides <i>In vitro</i> or <i>In vivo</i> via Sub–50-nm Nanocapsules
Supplementary Data from CK2 Modulation of NF-κB, TP53, and the Malignant Phenotype in Head and Neck Cancer by Anti-CK2 Oligonucleotides <i>In vitro</i> or <i>In vivo</i> via Sub–50-nm Nanocapsules Open
Supplementary Data from CK2 Modulation of NF-κB, TP53, and the Malignant Phenotype in Head and Neck Cancer by Anti-CK2 Oligonucleotides In vitro or In vivo via Sub–50-nm Nanocapsules
View article: Supplementary Data from Nuclear NF-κB p65 Phosphorylation at Serine 276 by Protein Kinase A Contributes to the Malignant Phenotype of Head and Neck Cancer
Supplementary Data from Nuclear NF-κB p65 Phosphorylation at Serine 276 by Protein Kinase A Contributes to the Malignant Phenotype of Head and Neck Cancer Open
Supplementary Data from Nuclear NF-κB p65 Phosphorylation at Serine 276 by Protein Kinase A Contributes to the Malignant Phenotype of Head and Neck Cancer
View article: Data from Nuclear NF-κB p65 Phosphorylation at Serine 276 by Protein Kinase A Contributes to the Malignant Phenotype of Head and Neck Cancer
Data from Nuclear NF-κB p65 Phosphorylation at Serine 276 by Protein Kinase A Contributes to the Malignant Phenotype of Head and Neck Cancer Open
Purpose: Aberrant nuclear activation and phosphorylation of the canonical NF-κB subunit RELA/p65 at Serine-536 by inhibitor κB kinase is prevalent in head and neck squamous cell carcinoma (HNSCC), but the role of other kinases in NF-κB act…
View article: Data from CK2 Modulation of NF-κB, TP53, and the Malignant Phenotype in Head and Neck Cancer by Anti-CK2 Oligonucleotides <i>In vitro</i> or <i>In vivo</i> via Sub–50-nm Nanocapsules
Data from CK2 Modulation of NF-κB, TP53, and the Malignant Phenotype in Head and Neck Cancer by Anti-CK2 Oligonucleotides <i>In vitro</i> or <i>In vivo</i> via Sub–50-nm Nanocapsules Open
Purpose: The aim of this study is to investigate the expression of CK2 subunits and CK2 effects on NF-κB–mediated and TP53-mediated signal activation and gene expression, the malignant phenotype, and chemosensitivity in head and neck squam…
View article: Data from CK2 Modulation of NF-κB, TP53, and the Malignant Phenotype in Head and Neck Cancer by Anti-CK2 Oligonucleotides <i>In vitro</i> or <i>In vivo</i> via Sub–50-nm Nanocapsules
Data from CK2 Modulation of NF-κB, TP53, and the Malignant Phenotype in Head and Neck Cancer by Anti-CK2 Oligonucleotides <i>In vitro</i> or <i>In vivo</i> via Sub–50-nm Nanocapsules Open
Purpose: The aim of this study is to investigate the expression of CK2 subunits and CK2 effects on NF-κB–mediated and TP53-mediated signal activation and gene expression, the malignant phenotype, and chemosensitivity in head and neck squam…