Mohammad Mahdavi
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View article: Synthesis of piperazine-based benzimidazole derivatives as potent urease inhibitors and molecular docking studies
Synthesis of piperazine-based benzimidazole derivatives as potent urease inhibitors and molecular docking studies Open
The development of new bioactive compounds is important for progress in therapeutic research. In the present study, we describe the multistep synthetic approach to develop a library of novel benzimidazole analogs incorporating piperazine r…
View article: Development of mercapto-phenyl-1,2,4-triazole bearing thio-quinoline as a novel class of tyrosinase inhibitors: an in vitro and in silico study
Development of mercapto-phenyl-1,2,4-triazole bearing thio-quinoline as a novel class of tyrosinase inhibitors: an in vitro and in silico study Open
View article: Design and evaluation of substituted cinnamoyl piperidinyl acetate derivatives as potent cholinesterase inhibitors
Design and evaluation of substituted cinnamoyl piperidinyl acetate derivatives as potent cholinesterase inhibitors Open
In the pursuit of therapeutic agents for Alzheimer's disease (AD), this study employed a molecular hybridization strategy to design and synthesize substituted cinnamoyl piperidinyl acetates. A total of 17 novel derivatives were evaluated f…
View article: Synthesis and evaluation of quinolinvinyl-phenoxy-1,2,3-triazole-acetamide hybrids against breast cancer
Synthesis and evaluation of quinolinvinyl-phenoxy-1,2,3-triazole-acetamide hybrids against breast cancer Open
This work synthesized and evaluated a new series of quinolinvinyl-phenoxy-1,2,3-triazole-acetamide hybrids 9a-p against breast cancer cell lines, including MCF-7 and MDA-MB-231. Among 16 synthesized compounds, (E)-N-(4-chlorophenyl)-2-(4-(…
View article: Direct Hydroxylation of Benzene to Phenol over Vanadium Oxide Supported on Carbon Fibers Felt Containing Nitrogen
Direct Hydroxylation of Benzene to Phenol over Vanadium Oxide Supported on Carbon Fibers Felt Containing Nitrogen Open
Direct hydroxylation of benzene is a stable and promising strategy for phenol synthesis. In this project, VO (12.5 wt%)/N-CFF catalyst was synthesized by VO-nitrogen doped carbon and supported on carbon fibers felt simultaneously. The synt…
View article: Synthesis and evaluation of nitrochromene derivatives as potential antileishmanial therapeutics through biological and computational studies
Synthesis and evaluation of nitrochromene derivatives as potential antileishmanial therapeutics through biological and computational studies Open
View article: Substituted piperazine conjugated to quinoline-thiosemicarbazide as potent α-glucosidase inhibitors to target hyperglycemia
Substituted piperazine conjugated to quinoline-thiosemicarbazide as potent α-glucosidase inhibitors to target hyperglycemia Open
Diabetes mellitus, particularly type 2 diabetes, is a growing global health challenge characterized by chronic hyperglycemia due to insulin resistance. One therapeutic approach to managing this condition is the inhibition of α-glucosidase,…
View article: Synthesis, biological evaluations, and in silico assessments of phenylamino quinazolinones as tyrosinase inhibitors
Synthesis, biological evaluations, and in silico assessments of phenylamino quinazolinones as tyrosinase inhibitors Open
View article: Cinnamic acid conjugated with triazole acetamides as anti-Alzheimer and anti-melanogenesis candidates: an in vitro and in silico study
Cinnamic acid conjugated with triazole acetamides as anti-Alzheimer and anti-melanogenesis candidates: an in vitro and in silico study Open
View article: Green Synthesis of Imidazopyridine Tetracyclic Derivatives via the Groebke-Blackburn- Bienaymé Reaction Using Novel Functionalized Cellulose-Based Catalyst
Green Synthesis of Imidazopyridine Tetracyclic Derivatives via the Groebke-Blackburn- Bienaymé Reaction Using Novel Functionalized Cellulose-Based Catalyst Open
The widespread use of petroleum-based products has raised ecological and environmental concerns, leading to increased public interest in utilizing natural resources for the development of functional materials. Cellulose, derived from vario…
View article: Isoindolinedione-Benzamide Pyridinium Derivatives for Targeting Alzheimer’s Disease
Isoindolinedione-Benzamide Pyridinium Derivatives for Targeting Alzheimer’s Disease Open
An Isoindolinedione-benzamide pyridinium derivatives were designed through a structure-based strategy and synthesized as novel multifunctional anti-Alzheimer agents. The inhibitory activities of all 17 derivatives against acetylcholinester…
View article: Efficient synthesis of novel phenanthroline-dimedone derivatives using Pd@HQBI-SPION as a versatile palladium-immobilized catalyst
Efficient synthesis of novel phenanthroline-dimedone derivatives using Pd@HQBI-SPION as a versatile palladium-immobilized catalyst Open
View article: Transition Metal‐Catalyzed C−H Activation/Functionalization of 8‐Methylquinolines
Transition Metal‐Catalyzed C−H Activation/Functionalization of 8‐Methylquinolines Open
8‐Methylquinoline is regarded as an ideal substrate to participate in diversely C(sp 3 )−H functionalization reactions. The presence of the chelating nitrogen atom enables 8‐methylquinoline to easily form cyclometallated complexes with var…
View article: Silver and Copper‐Catalyzed Cycloaddition Reactions of Isocyanide Esters
Silver and Copper‐Catalyzed Cycloaddition Reactions of Isocyanide Esters Open
Owing to multiple reactive sites, such as an acidic α‐carbon and an isocyano group, isocyanide esters can successfully participate in the synthesis of various five‐ and six‐membered N ‐heterocycles through the cycloaddition reactions under…
View article: Design of new α-glucosidase inhibitors based on the bis-4-hydroxycoumarin skeleton: Synthesis, evaluation, and in silico studies
Design of new α-glucosidase inhibitors based on the bis-4-hydroxycoumarin skeleton: Synthesis, evaluation, and in silico studies Open
View article: Design, synthesis, in vitro, and in silico anti-α-glucosidase assays of N-phenylacetamide-1,2,3-triazole-indole-2-carboxamide derivatives as new anti-diabetic agents
Design, synthesis, in vitro, and in silico anti-α-glucosidase assays of N-phenylacetamide-1,2,3-triazole-indole-2-carboxamide derivatives as new anti-diabetic agents Open
View article: Nitrophenylpiperazine derivatives as novel tyrosinase inhibitors: design, synthesis, and in silico evaluations
Nitrophenylpiperazine derivatives as novel tyrosinase inhibitors: design, synthesis, and in silico evaluations Open
View article: Fabrication of a magnetic nanocomposite based on natural hydrogel: Pectin, tragacanth gum, silk fibroin, and integrated graphitic carbon nitride for hyperthermia and biological features
Fabrication of a magnetic nanocomposite based on natural hydrogel: Pectin, tragacanth gum, silk fibroin, and integrated graphitic carbon nitride for hyperthermia and biological features Open
The current study aimed to design and synthesize a new magnetic nanobiocomposite and assess its potential for biological applications and hyperthermia. For this purpose, in the first step, the Pectin (PC) and Tragacanth gum (TG) polymer wa…
View article: Colorimetric pH-sensitive hydrogel film based on kappa-carrageenan containing quercetin or eucalyptus leaf extract for freshness monitoring of chicken meat
Colorimetric pH-sensitive hydrogel film based on kappa-carrageenan containing quercetin or eucalyptus leaf extract for freshness monitoring of chicken meat Open
In this study, we created new pH-sensitive hydrogel films using κ-carrageenan (CG) and either quercetin (QUE) or eucalyptus leaf extract (ELE) to monitor the spoilage of chicken meat. The ability to monitor and control freshness was confir…
View article: Evaluation of novel 2-(quinoline-2-ylthio)acetamide derivatives linked to diphenyl-imidazole as α-glucosidase inhibitors: Insights from in silico, in vitro, and in vivo studies on their anti-diabetic properties
Evaluation of novel 2-(quinoline-2-ylthio)acetamide derivatives linked to diphenyl-imidazole as α-glucosidase inhibitors: Insights from in silico, in vitro, and in vivo studies on their anti-diabetic properties Open
View article: Structure-based development of 3,5-dihydroxybenzoyl-hydrazineylidene as tyrosinase inhibitor; in vitro and in silico study
Structure-based development of 3,5-dihydroxybenzoyl-hydrazineylidene as tyrosinase inhibitor; in vitro and in silico study Open
A series of new analogs of 3,5-dihydroxybenzoyl-hydrazineylidene conjugated to different methoxyphenyl triazole ( 11a-n ) synthesized using click reaction. The structures of all synthesized compounds were characterized by FTIR, 1 H, 13 C-N…
View article: Synthesis, in vitro potency of inhibition, enzyme kinetics and in silico studies of quinoline-based α-glucosidase inhibitors
Synthesis, in vitro potency of inhibition, enzyme kinetics and in silico studies of quinoline-based α-glucosidase inhibitors Open
Diabetes mellitus is a multifactorial global health disorder that is rising at an alarming rate. One effective therapeutic approach for controlling hyperglycemia associated with type-2 diabetes is to target α-glucosidase, which catalyzes s…
View article: Aryl-quinoline-4-carbonyl hydrazone bearing different 2-methoxyphenoxyacetamides as potent α-glucosidase inhibitors; molecular dynamics, kinetic and structure–activity relationship studies
Aryl-quinoline-4-carbonyl hydrazone bearing different 2-methoxyphenoxyacetamides as potent α-glucosidase inhibitors; molecular dynamics, kinetic and structure–activity relationship studies Open
View article: New benzothiazole-indole-1,2,3-triazole-N-phenylacetamide derivatives as cytotoxic agents: Design, synthesis, and in vitro cytotoxic evaluations
New benzothiazole-indole-1,2,3-triazole-N-phenylacetamide derivatives as cytotoxic agents: Design, synthesis, and in vitro cytotoxic evaluations Open
View article: Anti-Dna Virus Agent Cidofovir - Loaded Green Synthesized Cerium Oxide Nanoparticles (Nanoceria): Nucleic Acids (DNA and Rna) Binding Affinity and Cytotoxicity Effects
Anti-Dna Virus Agent Cidofovir - Loaded Green Synthesized Cerium Oxide Nanoparticles (Nanoceria): Nucleic Acids (DNA and Rna) Binding Affinity and Cytotoxicity Effects Open
View article: Copper supported modified magnetic carrageenan as a bio-based catalyst for the synthesis of novel scaffolds bearing the 1,2,3-triazole unit through the click reaction
Copper supported modified magnetic carrageenan as a bio-based catalyst for the synthesis of novel scaffolds bearing the 1,2,3-triazole unit through the click reaction Open
Design of a novel library of new 1,2,3-triazole-attached phenyl acetamides via molecular hybridization of propargyl and phenylacetamide derivatives using copper-supported modified magnetic carrageenan as a green heterogeneous catalyst.
View article: In vivo and in silico evaluations of a synthetic pyrano[3,2-c]quinoline derivative as a potent anti-diabetic agent
In vivo and in silico evaluations of a synthetic pyrano[3,2-c]quinoline derivative as a potent anti-diabetic agent Open
View article: Environmentally friendly catalyst- and solvent-free synthesis of 2-anilino nicotinic acids derivatives as potential lead COX inhibitors
Environmentally friendly catalyst- and solvent-free synthesis of 2-anilino nicotinic acids derivatives as potential lead COX inhibitors Open
View article: Thiazolopyrimidine derivatives as novel class of small molecule tyrosinase inhibitor
Thiazolopyrimidine derivatives as novel class of small molecule tyrosinase inhibitor Open
Tyrosinase, the rate-limiting enzyme of melanogenesis, plays a crucial role in hyperpigmentation. As a result, in this study, a novel class of thiazolopyrimidine derivatives was developed and synthesized as tyrosinase inhibitor. The struct…
View article: Efficient synthesis of 3-alkyl-2-(-1H-1,2,3-triazolyl)methyl)thio)-2,3-dihydroquinazolin-4(1H)-one derivative via multistep synthesis approach by novel Cu@Py-Oxa@SPION catalyst
Efficient synthesis of 3-alkyl-2-(-1H-1,2,3-triazolyl)methyl)thio)-2,3-dihydroquinazolin-4(1H)-one derivative via multistep synthesis approach by novel Cu@Py-Oxa@SPION catalyst Open
In this pared, an efficient method is introduced for the synthesis of 3-alkyl-2-(((4-(2-oxopropyl)-1 H -1,2,3-triazol-1-yl)alkyl)thio)-2,3-dihydroquinazolin-4(1 H )-one derivatives. These novel products have both 1,2,3-triazole and quinazo…