Rhianna Jones
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View article: Strong SIV-specific memory NK cell responses formed in acute infection persist during chronic SIV infection 3354
Strong SIV-specific memory NK cell responses formed in acute infection persist during chronic SIV infection 3354 Open
Description Natural killer (NK) cells provide rapid and robust innate responses against viral infections. Multiple studies have shown that NK cells also mount antigen-specific recall responses. In nonhuman primates (NHP), antigen-specific …
View article: NK cells modulate in vivo control of SARS-CoV-2 replication and suppression of lung damage
NK cells modulate in vivo control of SARS-CoV-2 replication and suppression of lung damage Open
Natural killer (NK) cells play a critical role in virus control. However, it has remained largely unclear whether NK cell mobilization in SARS-CoV-2 infections is beneficial or pathologic. To address this deficit, we employed a validated e…
View article: Antigen-specific memory NK cell responses against HIV and influenza use the NKG2/HLA-E axis
Antigen-specific memory NK cell responses against HIV and influenza use the NKG2/HLA-E axis Open
Multiple studies have broadened the roles of natural killer (NK) cells functioning as purely innate lymphocytes by demonstrating that they are capable of putative antigen-specific immunological memory against multiple infectious agents inc…
View article: NK cells are critical for in vivo control of SARS-CoV-2 replication and suppression of lung damage
NK cells are critical for in vivo control of SARS-CoV-2 replication and suppression of lung damage Open
Natural killer (NK) cells play a critical role in virus control. However, it has remained largely unclear whether NK cell mobilization in SARS-CoV-2 infections is beneficial or pathologic. To address this deficit, we employed a validated e…
View article: Single-cell cloning of NK cells from rhesus macaques: a new methodology for in-depth analysis of MHC-E-dependent adaptive functions
Single-cell cloning of NK cells from rhesus macaques: a new methodology for in-depth analysis of MHC-E-dependent adaptive functions Open
Natural killer (NK) cells provide rapid and robust responses against a wide range of viral infections. More recently, multiple studies have shown that subsets of NK cells are also capable of antigen-specific recall to eliminate infected ce…
View article: Natural Killer Cells Regulate Acute SIV Replication, Dissemination, and Inflammation, but Do Not Impact Independent Transmission Events
Natural Killer Cells Regulate Acute SIV Replication, Dissemination, and Inflammation, but Do Not Impact Independent Transmission Events Open
Natural killer (NK) cells as major effector cells of the innate immune system can contribute significantly to human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) control. However, a specific role for NK cells in bloc…
View article: Increased IL-6 expression precedes reliable viral detection in the rhesus macaque brain during acute SIV infection
Increased IL-6 expression precedes reliable viral detection in the rhesus macaque brain during acute SIV infection Open
Knowledge of immune activation in the brain during acute HIV infection is crucial for the prevention and treatment of HIV-associated neurological disorders. We determined regional brain (basal ganglia, thalamus, and frontal cortex) immune …
View article: Probiotic supplementation reduces inflammatory profiles but does not prevent oral immune perturbations during SIV infection
Probiotic supplementation reduces inflammatory profiles but does not prevent oral immune perturbations during SIV infection Open
View article: Systemic and mucosal mobilization of granulocyte subsets during lentiviral infection
Systemic and mucosal mobilization of granulocyte subsets during lentiviral infection Open
Granulocytes mediate broad immunoprotection through phagocytosis, extracellular traps, release of cytotoxic granules, antibody effector functions and recruitment of other immune cells against pathogens. However, descriptions of granulocyte…
View article: Systemic and mucosal mobilization of granulocyte subsets during lentivirus infection
Systemic and mucosal mobilization of granulocyte subsets during lentivirus infection Open
Granulocytes mediate broad immunoprotection through phagocytosis, extracellular traps, release of cytotoxic granules, antibody effector functions and recruitment of other immune cells against pathogens. However, descriptions of granulocyte…
View article: Probiotic Supplementation Reduces Inflammatory Profiles But Does Not Prevent Oral Immune Perturbations During SIV Infection
Probiotic Supplementation Reduces Inflammatory Profiles But Does Not Prevent Oral Immune Perturbations During SIV Infection Open
HIV/SIV infections lead to massive loss of mucosal CD4+ T cells and breakdown of the epithelial mucosa resulting in severe microbial dysbiosis and chronic immune activation that ultimately drive disease progression. Moreover, disruption of…
View article: Characterization of Rhesus Macaque Liver-Resident CD49a+ NK Cells During Retrovirus Infections
Characterization of Rhesus Macaque Liver-Resident CD49a+ NK Cells During Retrovirus Infections Open
CD49a+ tissue resident NK cells have been implicated in memory-like NK cell responses, but while this population is well-characterized in mice and in humans, they are poorly described in non-human primates (NHP) which are partic…
View article: Functional Perturbation of Mucosal Group 3 Innate Lymphoid and Natural Killer Cells in Simian-Human Immunodeficiency Virus/Simian Immunodeficiency Virus-Infected Infant Rhesus Macaques
Functional Perturbation of Mucosal Group 3 Innate Lymphoid and Natural Killer Cells in Simian-Human Immunodeficiency Virus/Simian Immunodeficiency Virus-Infected Infant Rhesus Macaques Open
Vertical transmission of HIV from mother to child accounts for many of the new cases seen worldwide. There is currently no vaccine to mitigate this transmission, and there has been limited research on the effects that lentiviral infection …
View article: Progressive lentivirus infection induces natural killer cell receptor-expressing B cells in the gastrointestinal tract
Progressive lentivirus infection induces natural killer cell receptor-expressing B cells in the gastrointestinal tract Open
These results suggest a cell type expressing both natural killer and B-cell features exists in rhesus macaques and humans and are perturbed by HIV/SIV infection. The full functional niche remains unknown, but the unique phenotype and syste…
View article: Hepatic immunopathology during occult hepacivirus re-infection
Hepatic immunopathology during occult hepacivirus re-infection Open