Explanipedia

Histologic and Immunohistochemical Characterization of GA-Like Pathology in the Rat Subretinal Sodium Iodate Model Open

Poonam Naik, Rhonda Grebe, Imran Ahmed Bhutto, D. Scott McLeod, Malia M. Edwards · 2024

Despite its acute nature, the expansion of atrophy and the GA-like border in this rat model makes it ideal for studying disease progression and provides a treatment window to test potential therapeutics for GA.

Clinicopathologic Findings in Three Siblings With Geographic Atrophy Open

Malia M. Edwards, D. Scott McLeod, Mengxi Shen, Rhonda Grebe, Janet S. Sunness , et al. · 2023

This study demonstrates the importance of clinicohistopathologic correlation studies. It emphasizes the need to better understand how the symbiotic relationship between choriocapillaris and RPE, glial response, and calcified drusen impact …

Glial remodeling and choroidal vascular pathology in eyes from two donors with Choroideremia Open

Malia M. Edwards, D. Scott McLeod, Rhonda Grebe, Imran Ahmed Bhutto, Richa Dahake , et al. · 2022

Choroideremia (CHM) is a recessive, X-linked disease that affects 1 in 50,000 people worldwide. CHM causes night blindness in teenage years with vision loss progressing over the next two to three decades. While CHM is known to cause progre…

Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD Open

Urvi Gupta, Sayan Ghosh, Callen T. Wallace, Peng Shang, Ying Xin , et al. · 2022

In dry age-related macular degeneration (AMD), LCN2 (lipocalin 2) is upregulated. Whereas LCN2 has been implicated in AMD pathogenesis, the mechanism remains unknown. Here, we report that in retinal pigmented epithelial (RPE) cells, LCN2 r…

Topical Ketotifen Fumarate Inhibits Choroidal Mast Cell Degranulation and Loss of Retinal Pigment Epithelial Cells in Rat Model for Geographic Atrophy Open

Tomohiro Nizawa, Imran Ahmed Bhutto, Anupama Tiwari, Rhonda Grebe, Jesse Alt , et al. · 2021

The results of this study demonstrate that topical KTF successfully reduced GA-like phenotypes in a rat model and may provide a novel therapy for GA.

βA3/A1-crystallin regulates apical polarity and EGFR endocytosis in retinal pigmented epithelial cells Open

Peng Shang, Nadezda A. Stepicheva, Kenneth Teel, Austin McCauley, Christopher Scott Fitting , et al. · 2021

Topical Ketotifen fumarate inhibits mast cell degranulation and loss of retinal pigment epithelial cells in rat model for geographic atrophy Open

Tomohiro Niizawa, Imran Ahmed Bhutto, Anupama Tiwari, Rhonda Grebe, Jesse Alt , et al. · 2021

Increased expression of epithelial-to-mesenchymal transition markers in geographic atrophy Open

Anupama Tiwari, Imran Ahmed Bhutto, Malia M. Edwards, Rhonda Grebe, Gerard A. Lutty · 2020

Vascular progenitors generated from tankyrase inhibitor-regulated naïve diabetic human iPSC potentiate efficient revascularization of ischemic retina Open

Tea Soon Park, Ludovic Zimmerlin, Rebecca Evans-Moses, Justin Thomas, Jeffrey S. Huo , et al. · 2020

Modulating EGFR-MTORC1-autophagy as a potential therapy for persistent fetal vasculature (PFV) disease Open

Meysam Yazdankhah, Peng Shang, Sayan Ghosh, Imran Ahmed Bhutto, Nadezda A. Stepicheva , et al. · 2019

ACTB: actin, beta; CCND3: cyclin 3; CDK6: cyclin-dependent kinase 6; CHQ: chloroquine; COL4A1: collagen, type IV, alpha 1; CRYBA1: crystallin, beta A1; DAPI: 4'6-diamino-2-phenylindole; EGFR: epidermal growth factor receptor; GAPDH: glycer…

Müller cell remodeling and phagocytosis in Choroidoremia Open

Malia M. Edwards, Rhonda Grebe, Rajkumar Baldeosingh, Gerard A. Lutty · 2019

Vascular Progenitors Generated from Tankyrase Inhibitor-Regulated Naïve Diabetic Human iPSC Potentiate Efficient Revascularization of Ischemic Retina Open

Tea Soon Park, Ludovic Zimmerlin, Rebecca Evans-Moses, Justin Thomas, Jeffrey S. Huo , et al. · 2019

Vascular regenerative therapies with conventional human induced pluripotent stem cells (hiPSC) currently remain limited by high interline variability of differentiation and poor efficiency for generating functionally transplantable vascula…

Modulating EGFR-MTORC1-autophagy as a potential therapy for persistent fetal vasculature (PFV) disease Open

Meysam Yazdankhah, Peng Shang, Sayan Ghosh, Imran Ahmed Bhutto, Nadezda A. Stepicheva , et al. · 2019

Persistent fetal vasculature (PFV) is a human disease that results from failure of the fetal vasculature to regress normally. The regulatory mechanisms responsible for fetal vascular regression remain obscure, as does the underlying cause …

Modulating EGFR-MTORC1-Autophagy as a potential therapy for Persistent Fetal Vasculature (PFV) disease Open

Meysam Yazdankhah, Peng Shang, Sayan Ghosh, Imran Ahmed Bhutto, Nadezda A. Stepicheva , et al. · 2019

Persistent fetal vasculature (PFV) is a human disease that results from failure of the fetal vasculature to regress normally. The regulatory mechanisms responsible for fetal vascular regression remain obscure, as does the underlying cause …

Understanding the role of glial cells (astrocytes and oligodendrocytes) in maintaining the homeostasis of the optic nerve Open

Meysam Yazdankhah, Rhonda Grebe, Emily G. Baxi, Imran Ahmed Bhutto, Stacey Hose , et al. · 2018

Analysis of choriocapillaris ultrastructure in macular regions of eyes obtained from patients with neovascular AMD, geographic atrophy, and pure one and ten chromosomal abnormalities Open

Rhonda Grebe, Irum Mughal, W. A. Bryden, Jing Tian, Malia M. Edwards , et al. · 2017

Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells Open

Karl Wahlin, Julien Maruotti, Srinivas R. Sripathi, J M Ball, Juan M Angueyra , et al. · 2017

The retinal degenerative diseases, which together constitute a leading cause of hereditary blindness worldwide, are largely untreatable. Development of reliable methods to culture complex retinal tissues from human pluripotent stem cells (…

Subretinal Glial Membranes in Eyes With Geographic Atrophy Open

Malia M. Edwards, D. Scott McLeod, Imran Ahmed Bhutto, Rhonda Grebe, Maeve Duffy , et al. · 2017

In eyes with GA, subretinal Müller cell membranes present in areas of RPE atrophy may be a Müller cell attempt to replace the ELM. These membranes could interfere with treatments such as stem cell therapy.

The amino acid transporter SLC36A4 regulates the amino acid pool in retinal pigmented epithelial cells and mediates the mechanistic target of rapamycin, complex 1 signaling Open

Peng Shang, Mallika Valapala, Rhonda Grebe, Stacey Hose, Sayan Ghosh , et al. · 2017

The dry (nonneovascular) form of age-related macular degeneration (AMD), a leading cause of blindness in the elderly, has few, if any, treatment options at present. It is characterized by early accumulation of cellular waste products in th…

βA3/A1-crystallin is essential for autophagic lysosomal reformation (ALR) in the retinal pigmented epithelial (RPE) cells Open

Peng Shang, Mallika Valapala, Sayan Ghosh, Rhonda Grebe, Stacey Hose , et al. · 2016

Müller cell processes occupy the subretinal space in geographic atrophy and Stargardt disease. Open

Malia M. Edwards, D. Scott McLeod, Imran Ahmed Bhutto, Rhonda Grebe, Mercedes B. Villalonga , et al. · 2016

Albumen Transport to Bruch's Membrane and RPE by Choriocapillaris Caveolae Open

Masataka Nakanishi, Rhonda Grebe, Imran Ahmed Bhutto, Malia M. Edwards, D. Scott McLeod , et al. · 2016

Normally, CC carefully regulates transport system of BSA from lumen to BM by caveolae-mediated transcytosis; however, endothelium cells of aged control WT mice have leaky tight junctions and lacked regulated BSA transport.

Lysosomes: Regulators of autophagy in the retinal pigmented epithelium Open

Debasish Sinha, Mallika Valapala, Peng Shang, Stacey Hose, Rhonda Grebe , et al. · 2015

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